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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2003; Volume 306,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Nociceptin/Orphanin FQ and Its Receptor—Potential Targets for Pain Therapy?
    Hanns Ulrich Zeilhofer and Girolamo Calò
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 423-429; DOI: https://doi.org/10.1124/jpet.102.046979

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    A Differential Pharmacokinetic Analysis of the Erythropoietin Receptor Population in Newborn and Adult Sheep
    P. Veng-Pedersen, S. Chapel, N. H. Al-Huniti, R. L. Schmidt, E. M. Sedars, R. J. Hohl and J. A. Widness
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 532-537; DOI: https://doi.org/10.1124/jpet.103.052431
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    Modulation of P-glycoprotein Transport Activity in the Mouse Blood-Brain Barrier by Rifampin
    Jian Zong and Gary M. Pollack
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 556-562; DOI: https://doi.org/10.1124/jpet.103.049452
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    Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients
    Hideto Jinno, Mayumi Saeki, Yoshiro Saito, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Kimie Sai, Nahoko Kaniwa, Masanori Ando, Kuniaki Shirao, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Shogo Ozawa and Jun-ichi Sawada
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 688-693; DOI: https://doi.org/10.1124/jpet.103.051250
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    Involvement of Human Organic Anion Transporting Polypeptide OATP-B (SLC21A9) in pH-Dependent Transport across Intestinal Apical Membrane
    Daisuke Kobayashi, Takashi Nozawa, Kozue Imai, Jun-ichi Nezu, Akira Tsuji and Ikumi Tamai
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 703-708; DOI: https://doi.org/10.1124/jpet.103.051300
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    Threonine-205 in the F Helix of P450 2B1 Contributes to Androgen 16β-Hydroxylation Activity and Mechanism-Based Inactivation
    Hsia-Lien Lin, Haoming Zhang, Lucy Waskell and Paul F. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 744-751; DOI: https://doi.org/10.1124/jpet.103.050260
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    Gene Expression in the Human Intestine and Correlation with Oral Valacyclovir Pharmacokinetic Parameters
    Christopher P. Landowski, Duxin Sun, David R. Foster, Sujatha S. Menon, Jeffrey L. Barnett, Lynda S. Welage, Chandrasekharan Ramachandran and Gordon L. Amidon
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 778-786; DOI: https://doi.org/10.1124/jpet.103.051011

BEHAVIORAL PHARMACOLOGY

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    Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics
    Yukinori Nagakura, Masamichi Okada, Atsuyuki Kohara, Tetsuo Kiso, Takashi Toya, Akihiko Iwai, Fumikazu Wanibuchi and Tokio Yamaguchi
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 490-497; DOI: https://doi.org/10.1124/jpet.103.050781
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    Continuous Administration of the 5-Hydroxytryptamine1A Agonist (3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl) -amino]-methyl}piperidin-1-yl]-methadone (F 13640) Attenuates Allodynia-Like Behavior in a Rat Model of Trigeminal Neuropathic Pain
    Kristof Deseure, Wouter Koek, Hugo Adriaensen and Francis C. Colpaert
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 505-514; DOI: https://doi.org/10.1124/jpet.103.050286
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    Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy
    Vasudeva Raghavendra, Flobert Tanga and Joyce A. DeLeo
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 624-630; DOI: https://doi.org/10.1124/jpet.103.052407

CARDIOVASCULAR

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    Muscarinic Cholinergic and β-Adrenergic Contribution to Hindquarters Vasodilation and Cardiac Responses to Cocaine
    Mark M. Knuepfer
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 515-522; DOI: https://doi.org/10.1124/jpet.103.051177
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    Evidence for a Ceiling of Cardioprotection with a Nitric Oxide Donor-Induced Delayed Preconditioning in Rabbits
    Renaud Tissier, Karim Aouam, Alain Berdeaux and Bijan Ghaleh
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 528-531; DOI: https://doi.org/10.1124/jpet.103.052563
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    Effects of in Vivo Lipopolysaccharide Infusion on Vasoconstrictor Function of Rat Isolated Mesentery, Kidney, and Aorta
    Matthew R. Farmer, Richard E. Roberts, Sheila M. Gardiner and Vera Ralevic
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 538-545; DOI: https://doi.org/10.1124/jpet.103.051805
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    Interleukin-2 Increases Activity of Sarcoplasmic Reticulum Ca2+-ATPase, but Decreases Its Sensitivity to Calcium in Rat Cardiomyocytes
    Chun-Mei Cao, Qiang Xia, Iain C. Bruce, Xiong Zhang, Chen Fu and Jun-Zhu Chen
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 572-580; DOI: https://doi.org/10.1124/jpet.102.048264
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    Glycoprotein IIb/IIIa Receptor Antagonist (2S)-2-[(2-Naphthyl-sulfonyl)amino]-3-{[2-({4-(4-piperidinyl)-2-[2-(4-piperidinyl)ethyl] butanoyl}amino)acetyl]amino}propanoic Acid Dihydrochloride (CRL42796), in Combination with Aspirin and/or Enoxaparin, Prevents Coronary Artery Rethrombosis after Successful Thrombolytic Treatment by Recombinant Tissue Plasminogen Activator
    Ting-Ting Hong, Edward M. Driscoll, Andrew J. White, Ardaman Sherigill, Thierry A. Giboulot and Benedict R. Lucchesi
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 616-623; DOI: https://doi.org/10.1124/jpet.103.052886
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    A Growth Hormone Secretagogue Prevents Ischemic-Induced Mortality Independently of the Growth Hormone Pathway in Dogs with Chronic Dilated Cardiomyopathy
    You-Tang Shen, Joseph J. Lynch, Richard J. Hargreaves and Robert J. Gould
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 815-820; DOI: https://doi.org/10.1124/jpet.103.050997

CELLULAR AND MOLECULAR

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    Morphine and Endomorphins Differentially Regulate μ-Opioid Receptor mRNA in SHSY-5Y Human Neuroblastoma Cells
    Xin Yu, Xin Mao, Allan D. Blake, Wen Xin Li and Sulie L. Chang
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 447-454; DOI: https://doi.org/10.1124/jpet.103.048694
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    Expression and Molecular Pharmacology of the Mouse CRTH2 Receptor
    Aaron N. Hata, Roy Zent, Matthew D. Breyer and Richard M. Breyer
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 463-470; DOI: https://doi.org/10.1124/jpet.103.050955
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    Mutational Uncoupling of α1A-Adrenergic Receptors from G Proteins Also Uncouples Mitogenic and Transcriptional Responses in PC12 Cells
    Deborah Lee, Anna Robeva, Zhongjian Chen and Kenneth P. Minneman
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 471-477; DOI: https://doi.org/10.1124/jpet.103.050500
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    Identification of Residues That Confer α-Conotoxin-PnIA Sensitivity on the α3 Subunit of Neuronal Nicotinic Acetylcholine Receptors
    Drew Everhart, Edward Reiller, Armen Mirzoian, J. Michael McIntosh, Arun Malhotra and Charles W. Luetje
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 664-670; DOI: https://doi.org/10.1124/jpet.103.051656
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    Neocarzinostatin Induces an Effective p53-Dependent Response in Human Papillomavirus-Positive Cervical Cancer Cells
    Adriana Bañuelos, Elba Reyes, Rodolfo Ocadiz, Elizabeth Alvarez, Martha Moreno, Alberto Monroy and Patricio Gariglio
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 671-680; DOI: https://doi.org/10.1124/jpet.103.051557
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    Involvement of Endocytic Organelles in the Subcellular Trafficking and Localization of Riboflavin
    Se-Ne Huang, Mitch A. Phelps and Peter W. Swaan
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 681-687; DOI: https://doi.org/10.1124/jpet.103.051581
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    PAT5A: A Partial Agonist of Peroxisome Proliferator-Activated Receptor γ Is a Potent Antidiabetic Thiazolidinedione Yet Weakly Adipogenic
    Parimal Misra, Ranjan Chakrabarti, Reeba K. Vikramadithyan, Gopalakrishnan Bolusu, Suresh Juluri, Jagadheshan Hiriyan, Cynthia Gershome, Abdul Rajjak, Papreddy Kashireddy, Songtao Yu, Sailesh Surapureddi, Chao Qi, Yi-Jun Zhu, M. Sambasiva Rao, Janardan K. Reddy and Rajagopalan Ramanujam
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 763-771; DOI: https://doi.org/10.1124/jpet.103.049791

ENDOCRINE AND REPRODUCTIVE

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    The Role of I1-Imidazoline and α2-Adrenergic Receptors in the Modulation of Glucose Metabolism in the Spontaneously Hypertensive Obese Rat Model of Metabolic Syndrome X
    Rodney A. Velliquette and Paul Ernsberger
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 646-657; DOI: https://doi.org/10.1124/jpet.103.050468
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    Functional Melatonin Receptors in Rat Ovaries at Various Stages of the Estrous Cycle
    Jose M. Soares, Monica I. Masana, Çağatay Erşahin and Margarita L. Dubocovich
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 694-702; DOI: https://doi.org/10.1124/jpet.103.049916

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Renal Action of Acute Chloroquine and Paracetamol Administration in the Anesthetized, Fluid-Balanced Rat
    Mohamed H. Ahmed, Richard J. Balment and Nick Ashton
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 478-483; DOI: https://doi.org/10.1124/jpet.103.051037
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    Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo
    Tadashi Tsubouchi, Takaharu Saito, Fujie Mizutani, Toshie Yamauchi and Yuji Iwanaga
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 787-793; DOI: https://doi.org/10.1124/jpet.102.048603

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    The Expression of δ- and κ-Opioid Receptor Is Enhanced during Intestinal Inflammation in Mice
    Olga Pol, José R. Palacio and Margarita M. Puig
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 455-462; DOI: https://doi.org/10.1124/jpet.103.049346
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    Dissection of the Anti-Inflammatory Effect of the Core and C-Terminal (KPV) α-Melanocyte-Stimulating Hormone Peptides
    Stephen J. Getting, Helgi B. Schiöth and Mauro Perretti
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 631-637; DOI: https://doi.org/10.1124/jpet.103.051623
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    A Lymphocyte-Generated Fragment of Vasoactive Intestinal Peptide with VPAC1 Agonist Activity and VPAC2 Antagonist Effects
    Monica A. Summers, M. Sue O'Dorisio, Mary O. Cox, Maria Lara-Marquez and Edward J. Goetzl
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 638-645; DOI: https://doi.org/10.1124/jpet.103.050583

NEUROPHARMACOLOGY

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    Characterization of the Binding of [3H][Dmt1]H-Dmt-d-Arg-Phe-Lys-NH2, a Highly Potent Opioid Peptide
    Claire L. Neilan, Adam J. Janvey, Elizabeth Bolan, Irena Berezowska, Thi M.-D. Nguyen, Peter W. Schiller and Gavril W. Pasternak
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 430-436; DOI: https://doi.org/10.1124/jpet.103.049742
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    Ethanol Excitation of Dopaminergic Ventral Tegmental Area Neurons Is Blocked by Quinidine
    Sarah B. Appel, Zhaoping Liu, Maureen A. McElvain and Mark S. Brodie
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 437-446; DOI: https://doi.org/10.1124/jpet.103.050963
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    Role of Nitric-Oxide Synthase Isoforms in Nitrous Oxide Antinociception in Mice
    Masago Ishikawa and Raymond M. Quock
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 484-489; DOI: https://doi.org/10.1124/jpet.103.049551
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    Vinpocetine Is a Potent Blocker of Rat NaV1.8 Tetrodotoxin-Resistant Sodium Channels
    Xiaoping Zhou, Xiao-Wei Dong, James Crona, Maureen Maguire and Tony Priestley
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 498-504; DOI: https://doi.org/10.1124/jpet.103.051086
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    Ethanol Inhibits α-Amino-3-hydyroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Function in Central Nervous System Neurons by Stabilizing Desensitization
    Tommi Möykkynen, Esa R. Korpi and David M. Lovinger
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 546-555; DOI: https://doi.org/10.1124/jpet.103.050666
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    Chronic Fluoxetine Differentially Affects 5-Hydroxytryptamine2A Receptor Signaling in Frontal Cortex, Oxytocin- and Corticotropin-Releasing Factor-Containing Neurons in Rat Paraventricular Nucleus
    K. J. Damjanoska, L. D. Van de Kar, G. H. Kindel, Y. Zhang, D. N. D'Souza, F. Garcia, G. Battaglia and N. A. Muma
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 563-571; DOI: https://doi.org/10.1124/jpet.103.050534
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    Suppressed Prolactin Response to Dynorphin A1–13 in Methadone-Maintained Versus Control Subjects
    Gavin Bart, Lisa Borg, James H. Schluger, Mark Green, Ann Ho and Mary Jeanne Kreek
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 581-587; DOI: https://doi.org/10.1124/jpet.103.050682
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    Neuroprotective Effects of (S)-N-[4-[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8 -tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl]-2 -thiophenecarboximid-amide (BN 80933), an Inhibitor of Neuronal Nitric-Oxide Synthase and an Antioxidant, in Model of Transient Focal Cerebral Ischemia in Mice
    Li Ding-Zhou, Catherine Marchand-Verrecchia, Bruno Palmier, Nicole Croci, Pierre-Etienne Chabrier, Michel Plotkine and Isabelle Margaill
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 588-594; DOI: https://doi.org/10.1124/jpet.103.051490
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    A Mutation in Transmembrane Domain II of the 5-Hydroxytryptamine3A Receptor Stabilizes Channel Opening and Alters Alcohol Modulatory Actions
    J. S. Sessoms-Sikes, Margaret E. Hamilton, Li-Xin Liu, David M. Lovinger and Tina K. Machu
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 595-604; DOI: https://doi.org/10.1124/jpet.103.050542
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    Regulation of Septo-Hippocampal Activity by 5-Hydroxytryptamine2C Receptors
    Mihály Hajós, William E. Hoffmann and Royal J. Weaver
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 605-615; DOI: https://doi.org/10.1124/jpet.103.051169
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    Nifedipine-Mediated Mobilization of Intracellular Calcium Stores Increases Spontaneous Neurotransmitter Release at Neonatal Rat Motor Nerve Terminals
    J. Piriz, M. D. Rosato Siri, R. Pagani and O. D. Uchitel
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 658-663; DOI: https://doi.org/10.1124/jpet.103.051524
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    Increased Expression of Vanilloid Receptor 1 on Myelinated Primary Afferent Neurons Contributes to the Antihyperalgesic Effect of Capsaicin Cream in Diabetic Neuropathic Pain in Mice
    Md Harunor Rashid, Makoto Inoue, Shiho Bakoshi and Hiroshi Ueda
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 709-717; DOI: https://doi.org/10.1124/jpet.103.050948
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    σ-1 Receptors (σ1 Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export
    Teruo Hayashi and Tsung-Ping Su
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 718-725; DOI: https://doi.org/10.1124/jpet.103.051284
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    Intracellular Dynamics of σ-1 Receptors (σ1 Binding Sites) in NG108-15 Cells
    Teruo Hayashi and Tsung-Ping Su
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 726-733; DOI: https://doi.org/10.1124/jpet.103.051292
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    Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin2C (5-HT2C) Receptors in Rat Prefrontal Cortex
    Malgorzata Filip and Kathryn A. Cunningham
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 734-743; DOI: https://doi.org/10.1124/jpet.102.045716
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    LY503430, a Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional, Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson's Disease
    Tracey K. Murray, Katherine Whalley, Christine S. Robinson, Mark A. Ward, Caroline A. Hicks, David Lodge, Jim L. Vandergriff, Polly Baumbarger, Edward Siuda, Mary Gates, Ann M. Ogden, Phil Skolnick, Dennis M. Zimmerman, Eric S. Nisenbaum, David Bleakman and Michael J. O'Neill
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 752-762; DOI: https://doi.org/10.1124/jpet.103.049445
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    Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons
    Yuki Takada, Atsushi Yonezawa, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Hachiro Sugimoto and Akinori Akaike
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 772-777; DOI: https://doi.org/10.1124/jpet.103.050104
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    Mediation of Corticotropin Releasing Factor Type 1 Receptor Phosphorylation and Desensitization by Protein Kinase C: A Possible Role in Stress Adaptation
    Richard L. Hauger, J. Alberto Olivares-Reyes, Sandra Braun, Kevin J. Catt and Frank M. Dautzenberg
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 794-803; DOI: https://doi.org/10.1124/jpet.103.050088
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    Antinociceptive Activity of the N-Methyl-d-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain
    Gino Villetti, Marco Bergamaschi, Franco Bassani, Pier Tonino Bolzoni, Marisa Maiorino, Claudio Pietra, Ivano Rondelli, Philippe Chamiot-Clerc, Michele Simonato and Mario Barbieri
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 804-814; DOI: https://doi.org/10.1124/jpet.103.050039

TOXICOLOGY

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    Oxidative Stress-Induced Homologous Recombination As a Novel Mechanism for Phenytoin-Initiated Toxicity
    Louise M. Winn, Perry M. Kim and Jac A. Nickoloff
    Journal of Pharmacology and Experimental Therapeutics August 2003, 306 (2) 523-527; DOI: https://doi.org/10.1124/jpet.103.052639
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Journal of Pharmacology and Experimental Therapeutics: 306 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 306, Issue 2
1 Aug 2003
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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