Journal of Pharmacology and Experimental Therapeutics: 305 (3)

June 01, 2003; Volume 305,Issue 3

ANNOUNCEMENTS

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Announcement
Brian M. Cox

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 799;

PERSPECTIVES IN PHARMACOLOGY

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Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans
David S. Goldstein, Graeme Eisenhofer and Irwin J. Kopin

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 800-811; DOI: https://doi.org/10.1124/jpet.103.049270

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Examination of the Functional Activity of P-glycoprotein in the Rat Placental Barrier Using Rhodamine 123
Petr Pavek, Frantisek Staud, Zdenek Fendrich, Hana Sklenarova, Antonin Libra, Martina Novotna, Martin Kopecky, Milan Nobilis and Vladimir Semecky

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1239-1250; DOI: https://doi.org/10.1124/jpet.102.048470
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In Vivo CYP3A4 Heteroactivation Is a Possible Mechanism for the Drug Interaction between Felbamate and Carbamazepine
Ann-Charlotte Egnell, Brian Houston and Scott Boyer

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1251-1262; DOI: https://doi.org/10.1124/jpet.102.047530

BEHAVIORAL PHARMACOLOGY

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Modulation of Oral Morphine Antinociceptive Tolerance and Naloxone-Precipitated Withdrawal Signs by Oral Δ⁹-Tetrahydrocannabinol
Diana L. Cichewicz and Sandra P. Welch

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 812-817; DOI: https://doi.org/10.1124/jpet.102.046870
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Use of Irreversible Antagonists to Determine the Relative Efficacy of μ-Opioids in a Pigeon Drug Discrimination Procedure: Comparison of β-Funaltrexamine and Clocinnamox
Andrew C. Barrett, Eric S. Smith and Mitchell J. Picker

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1061-1070; DOI: https://doi.org/10.1124/jpet.102.047068
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Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice
Miyako Yoshida, Shigehiro Ohdo, Hiroshi Takane, Yuki Tomiyoshi, Ayaka Matsuo, Eiji Yukawa and Shun Higuchi

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1200-1205; DOI: https://doi.org/10.1124/jpet.103.049031

CARDIOVASCULAR

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Angiotensin II Type 1 Receptor Antagonists Inhibit Basal As Well As Low-Density Lipoprotein and Platelet-Activating Factor-Stimulated Human Monocyte Chemoattractant Protein-1
Julie M. Proudfoot, Kevin D. Croft, Ian B. Puddey and Lawrence J. Beilin

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 846-853; DOI: https://doi.org/10.1124/jpet.102.047795
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Cyclosporine Induces Progressive Attenuation of Baroreceptor Heart Rate Response and Cumulative Pressor Response in Conscious Unrestrained Rats
Hossam A. Shaltout and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 966-973; DOI: https://doi.org/10.1124/jpet.102.048447
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Streptozotocin-Induced Diabetes Increases Disulfide Bond Formation on Cardiac Ryanodine Receptor (RyR2)
Keshore R. Bidasee, Karuna Nallani, Henry R. Besch and U. Deniz Dincer

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 989-998; DOI: https://doi.org/10.1124/jpet.102.046201
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Cytosolic Ca²⁺ and Phosphoinositide Hydrolysis Linked to Constitutively Active α_1d-Adrenoceptors in Vascular Smooth Muscle
Regina Gisbert, Francisco Pérez-Vizcaino, Angel L. Cogolludo, María Antonia Noguera, María Dolores Ivorra, Juan Tamargo and Pilar D'Ocon

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1006-1014; DOI: https://doi.org/10.1124/jpet.102.046169
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Differential Cardiovascular Regulatory Activities of the α_1B- and α_1D-Adrenoceptor Subtypes
Dan Chalothorn, Dan F. McCune, Stephanie E. Edelmann, Kimimasa Tobita, Bradley B. Keller, Robert D. Lasley, Dianne M. Perez, Akito Tanoue, Gozoh Tsujimoto, Ginell R. Post and Michael T. Piascik

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1045-1053; DOI: https://doi.org/10.1124/jpet.102.048553
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Vasodilatory and Electrophysiological Actions of 8-iso-Prostaglandin E₂ in Porcine Coronary Artery
Y. Zhang, T. Tazzeo, S. Hirota and L. J. Janssen

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1054-1060; DOI: https://doi.org/10.1124/jpet.103.049353
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AGI-1067: A Multifunctional Phenolic Antioxidant, Lipid Modulator, Anti-Inflammatory and Antiatherosclerotic Agent
Cynthia L. Sundell, Patricia K. Somers, Charles Q. Meng, Lee K. Hoong, Ki-Ling Suen, Russell R. Hill, Laura K. Landers, Angela Chapman, Dustie Butteiger, Moira Jones, David Edwards, Alan Daugherty, Martin A. Wasserman, R. Wayne Alexander, Russell M. Medford and Uday Saxena

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1116-1123; DOI: https://doi.org/10.1124/jpet.102.048132
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Pb²⁺ Inhibition of Sympathetic α₇-Nicotinic Acetylcholine Receptor-Mediated Nitrergic Neurogenic Dilation in Porcine Basilar Arteries
Min-Liang Si and Tony Jer-Fu Lee

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1124-1131; DOI: https://doi.org/10.1124/jpet.102.046854

CELLULAR AND MOLECULAR

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Role of Prostaglandin I₂ in the Gene Expression Induced by Mechanical Stress in Spinal Ligament Cells Derived from Patients with Ossification of the Posterior Longitudinal Ligament
Hirotaka Ohishi, Ken-Ichi Furukawa, Koei Iwasaki, Kazumasa Ueyama, Akihiro Okada, Shigeru Motomura, Seiko Harata and Satoshi Toh

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 818-824; DOI: https://doi.org/10.1124/jpet.102.047142
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Suppression of Cytochrome P450 3A Protein Levels by Proteasome Inhibitors
Richard C. Zangar, Thomas A. Kocarek, Shang Shen, Nikki Bollinger, Michael S. Dahn and Donna W. Lee

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 872-879; DOI: https://doi.org/10.1124/jpet.102.044628
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Ligand-Selective Activation of μ-Opioid Receptor: Demonstrated with Deletion and Single Amino Acid Mutations of Third Intracellular Loop Domain
Vipa Chaipatikul, Horace H. Loh and P. Y. Law

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 909-918; DOI: https://doi.org/10.1124/jpet.102.046219
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Peroxisome Proliferator-Activated Receptor Ligands Affect Growth-Related Gene Expression in Human Leukemic Cells
Stefano Laurora, Stefania Pizzimenti, Federica Briatore, Alessandra Fraioli, Maddalena Maggio, Patrizia Reffo, Carlo Ferretti, Mario Umberto Dianzani and Giuseppina Barrera

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 932-942; DOI: https://doi.org/10.1124/jpet.103.049098
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Insulin Mimetic Action of Synthetic Phosphorylated Peptide Inhibitors of Glycogen Synthase Kinase-3
Batya Plotkin, Oksana Kaidanovich, Ilana Talior and Hagit Eldar-Finkelman

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 974-980; DOI: https://doi.org/10.1124/jpet.102.047381
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Dissimilar Pharmacological Responses by a New Series of Imidazoline Derivatives at Precoupled and Ligand-Activated α_2A-Adrenoceptor States: Evidence for Effector Pathway-Dependent Differential Antagonism
Petrus J. Pauwels, Isabelle Rauly and Thierry Wurch

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1015-1023; DOI: https://doi.org/10.1124/jpet.102.048215
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Multiple Differences in Agonist and Antagonist Pharmacology between Human and Guinea Pig Histamine H₁-Receptor
Roland Seifert, Katharina Wenzel-Seifert, Tilmann Bürckstümmer, Heinz H. Pertz, Walter Schunack, Stefan Dove, Armin Buschauer and Sigurd Elz

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1104-1115; DOI: https://doi.org/10.1124/jpet.103.049619
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Functional Properties of Homomeric, Human α7-Nicotinic Acetylcholine Receptors Heterologously Expressed in the SH-EP1 Human Epithelial Cell Line
Lingke Zhao, Yen-Ping Kuo, Andrew A. George, Jian-Hong Peng, Madhuri Singh Purandare, Katherine M. Schroeder, Ronald J. Lukas and Jie Wu

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1132-1141; DOI: https://doi.org/10.1124/jpet.103.048777
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Antiangiogenic Effect of KR-31372 by Apoptosis via Mediation of Mitochondrial K_ATP Channel Opening and the Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation
Ki Young Kim, Yung Woo Shin, Sun-Ok Kim, Hong Lim, Sung-Eun Yoo and Ki Whan Hong

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1142-1149; DOI: https://doi.org/10.1124/jpet.103.048819
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Nucleotide-Induced Restoration of Conjunctival Chloride and Fluid Secretion in Adenovirus Type 5-Infected Pigmented Rabbit Eyes
Ashutosh A. Kulkarni, Melvin D. Trousdale, Douglas Stevenson, Hovhannes J. Gukasyan, Michael H. I. Shiue, Kwang-Jin Kim, Russell W. Read and Vincent H. L. Lee

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1206-1211; DOI: https://doi.org/10.1124/jpet.103.049221

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Pharmacodynamic-Mediated Effects of the Angiogenesis Inhibitor SU5416 on the Tumor Disposition of Temozolomide in Subcutaneous and Intracerebral Glioma Xenograft Models
Jianguo Ma, Shaolan Li, Karin Reed, Ping Guo and James M. Gallo

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 833-839; DOI: https://doi.org/10.1124/jpet.102.048587
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Kinetics of NAD(P)H:Quinone Oxidoreductase I (NQO1) Inhibition by Mitomycin C in Vitro and in Vivo
Daniel L. Gustafson, David Siegel, Jeffrey C. Rastatter, Andrea L. Merz, Jacqueline C. Parpal, Jadwiga K. Kepa, David Ross and Michael E. Long

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1079-1086; DOI: https://doi.org/10.1124/jpet.103.050070

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Nitric Oxide Production Modulates Cyclosporin A-Induced Distal Renal Tubular Acidosis in the Rat
Shuichi Tsuruoka, George J. Schwartz, Michi Wakaumi, Kenta Nishiki, Hisashi Yamamoto, Jeffrey M. Purkerson and Akio Fujimura

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 840-845; DOI: https://doi.org/10.1124/jpet.102.048207
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Prevention of Alterations in Intestinal Permeability Is Involved in Zinc Inhibition of Acute Ethanol-Induced Liver Damage in Mice
Jason C. Lambert, Zhanxiang Zhou, Lipeng Wang, Zhenyuan Song, Craig J. Mcclain and Y. James Kang

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 880-886; DOI: https://doi.org/10.1124/jpet.102.047852
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Pharmacological Characterization of the Novel Histamine H₃-Receptor Antagonist N-(3,5-Dichlorophenyl)-N′-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)
Robbie L. Mcleod, Charlie A. Rizzo, Robert E. West, Robert Aslanian, Kevin Mccormick, Matthew Bryant, Yunsheng Hsieh, Walter Korfmacher, Garfield G. Mingo, LoriAnn Varty, Shirley M. Williams, Neng-Yang Shih, Robert W. Egan and John A. Hey

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1037-1044; DOI: https://doi.org/10.1124/jpet.103.049254
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Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat
Maki Hasegawa, Hiroyuki Kusuhara, Hitoshi Endou and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1087-1097; DOI: https://doi.org/10.1124/jpet.102.046847
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Melphalan Antitumor Efficacy and Hepatotoxicity: The Effect of Variable Infusion Duration in the Hepatic Artery
Joost Rothbarth, Ruud A. Woutersen, Rolf W. Sparidans, Cornelis J. H. van de Velde and Gerard J. Mulder

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1098-1103; DOI: https://doi.org/10.1124/jpet.103.049379
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A Novel Free Radical Scavenger, Edarabone, Protects Against Cisplatin-Induced Acute Renal Damage in Vitro and in Vivo
Minoru Satoh, Naoki Kashihara, Sohachi Fujimoto, Hideyuki Horike, Takehiko Tokura, Tamehachi Namikoshi, Tamaki Sasaki and Hirofumi Makino

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1183-1190; DOI: https://doi.org/10.1124/jpet.102.047522
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Role of Cyclooxygenase-1 and -2, Phospholipase C, and Protein Kinase C in Prostaglandin-Mediated Gastroprotection
Brigitta M. Peskar, Nadia Sawka, Karlheinz Ehrlich and Bernhard A. Peskar

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1233-1238; DOI: https://doi.org/10.1124/jpet.103.049650

INFLAMMATION AND IMMUNOPHARMACOLOGY

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A Diarylheptanoid from Lesser Galangal (Alpinia officinarum) Inhibits Proinflammatory Mediators via Inhibition of Mitogen-Activated Protein Kinase, p44/42, and Transcription Factor Nuclear Factor-κB
Prem N. Yadav, Zhihua Liu and Mohamed M. Rafi

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 925-931; DOI: https://doi.org/10.1124/jpet.103.049171
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Phenyl N-tert-Butylnitrone Down-Regulates Interleukin-1β-Stimulated Matrix Metalloproteinase-13 Gene Expression in Human Chondrocytes: Suppression of c-Jun NH₂-Terminal Kinase, p38-Mitogen-Activated Protein Kinase and Activating Protein-1
Salahuddin Ahmed, Ayesha Rahman, Absarul Hasnain, Victor M. Goldberg and Tariq M. Haqqi

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 981-988; DOI: https://doi.org/10.1124/jpet.102.048611
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An Assessment of the Mechanistic Differences Between Two Integrin α₄β₁ Inhibitors, the Monoclonal Antibody TA-2 and the Small Molecule BIO5192, in Rat Experimental Autoimmune Encephalomyelitis
D. R. Leone, K. Giza, A. Gill, B. M. Dolinski, W. Yang, S. Perper, D. M. Scott, W.-C. Lee, M. Cornebise, K. Wortham, C. Nickerson-Nutter, L. L. Chen, D. LePage, J. C. Spell, E. T. Whalley, R. C. Petter, S. P. Adams, R. R. Lobb and R. B. Pepinsky

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1150-1162; DOI: https://doi.org/10.1124/jpet.102.047332
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Histamine H₄ Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells
Claudia L. Hofstra, Pragnya J. Desai, Robin L. Thurmond and Wai-Ping Fung-Leung

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1212-1221; DOI: https://doi.org/10.1124/jpet.102.046581
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Enhancement of Cytokine Production and AP-1 Transcriptional Activity in T Cells by Thalidomide-Related Immunomodulatory Drugs
Peter H. Schafer, Anita K. Gandhi, Michelle A. Loveland, Roger S. Chen, Hon-Wah Man, Paul P. M. Schnetkamp, Gregor Wolbring, Sowmya Govinda, Laura G. Corral, Faribourz Payvandi, George W. Muller and David I. Stirling

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1222-1232; DOI: https://doi.org/10.1124/jpet.102.048496

NEUROPHARMACOLOGY

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Prolactin Releasing Peptide Has High Affinity and Efficacy at Neuropeptide FF2 Receptors
Mia Engström, Annika Brandt, Siegfried Wurster, Juha-Matti Savola and Pertti Panula

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 825-832; DOI: https://doi.org/10.1124/jpet.102.047118
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GABA_A Receptor α1 and β2 Subunit Null Mutant Mice: Behavioral Responses to Ethanol
Y. A. Blednov, D. Walker, H. Alva, K. Creech, G. Findlay and R. A. Harris

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 854-863; DOI: https://doi.org/10.1124/jpet.103.049478
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The γ-Secretase Inhibitor N-[N-(3,5-Difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl Ester Reduces Aβ Levels in Vivo in Plasma and Cerebrospinal Fluid in Young (Plaque-Free) and Aged (Plaque-Bearing) Tg2576 Mice
Thomas A. Lanz, Carol S. Himes, Giovanni Pallante, Lisa Adams, Shinji Yamazaki, Ben Amore and Kalpana M. Merchant

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 864-871; DOI: https://doi.org/10.1124/jpet.102.048280
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Two Novel and Selective Nonimidazole Histamine H₃ Receptor Antagonists A-304121 and A-317920: I. In Vitro Pharmacological Effects
Timothy A. Esbenshade, Kathleen M. Krueger, Thomas R. Miller, Chae Hee Kang, Lynne I. Denny, David G. Witte, Betty B. Yao, Gerard B. Fox, Ramin Faghih, Youssef L. Bennani, Michael Williams and Arthur A. Hancock

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 887-896; DOI: https://doi.org/10.1124/jpet.102.047183
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Two Novel and Selective Nonimidazole H₃ Receptor Antagonists A-304121 and A-317920: II. In Vivo Behavioral and Neurophysiological Characterization
Gerard B. Fox, Jia Bao Pan, Richard J. Radek, Angela M. Lewis, R. Scott Bitner, Timothy A. Esbenshade, Ramin Faghih, Youssef L. Bennani, Michael Williams, Betty B. Yao, Michael W. Decker and Arthur A. Hancock

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 897-908; DOI: https://doi.org/10.1124/jpet.102.047241
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Nonopioid Actions of U50,488 Enantiomers Contribute to Their Peripheral Cutaneous Antinociceptive Effects
S. K. Joshi and G. F. Gebhart

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 919-924; DOI: https://doi.org/10.1124/jpet.103.049023
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Novel Isoquinolinone-Derived Inhibitors of Poly(ADP-ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia
Alberto Chiarugi, Elena Meli, Maura Calvani, Roberta Picca, Roberto Baronti, Emidio Camaioni, Gabriele Costantino, Maura Marinozzi, Domenico E. Pellegrini-Giampietro, Roberto Pellicciari and Flavio Moroni

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 943-949; DOI: https://doi.org/10.1124/jpet.103.048934
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Allosteric Adenosine Receptor Modulation Reduces Hypersensitivity Following Peripheral Inflammation by a Central Mechanism
Xinhui Li, Dawn Conklin, Hui-Lin Pan and James C. Eisenach

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 950-955; DOI: https://doi.org/10.1124/jpet.102.047951
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Calcium-Dependent Inhibition of Synaptosomal Serotonin Transport by the α₂-Adrenoceptor Agonist 5-Bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304)
Twum-Ampofo Ansah, Sammanda Ramamoorthy, Sylvia Montañez, Lynette C. Daws and Randy D. Blakely

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 956-965; DOI: https://doi.org/10.1124/jpet.102.047134
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Chronic Administration of Haloperidol and Olanzapine Attenuates Ketamine-Induced Brain Metabolic Activation
Gary E. Duncan, Seiya Miyamoto and Jeffrey A. Lieberman

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 999-1005; DOI: https://doi.org/10.1124/jpet.102.048140
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Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors
Marek Samochocki, Anja Höffle, Andreas Fehrenbacher, Ruth Jostock, Jürgen Ludwig, Claudia Christner, Martin Radina, Marion Zerlin, Christoph Ullmer, Edna F. R. Pereira, Hermann Lübbert, Edson X. Albuquerque and Alfred Maelicke

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1024-1036; DOI: https://doi.org/10.1124/jpet.102.045773
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Nicotinic Receptors Differentially Regulate N-Methyl-d-aspartate Damage in Acute Hippocampal Slices
P. A. Ferchmin, Dinely Perez, Vesna A. Eterovic and Jean de Vellis

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1071-1078; DOI: https://doi.org/10.1124/jpet.102.048173
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(+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepinephrine Transporters
Richard B. Rothman, Robert D. Clark, John S. Partilla and Michael H. Baumann

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1191-1199; DOI: https://doi.org/10.1124/jpet.103.049684

TOXICOLOGY

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Roles of Necrosis, Apoptosis, and Mitochondrial Dysfunction in S-(1,2-Dichlorovinyl)-L-cysteine Sulfoxide-Induced Cytotoxicity in Primary Cultures of Human Renal Proximal Tubular Cells
Lawrence H. Lash, David A. Putt, Sarah E. Hueni, Renee J. Krause and Adnan A. Elfarra

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1163-1172; DOI: https://doi.org/10.1124/jpet.102.046185
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Mechanism and Implications of Brown Adipose Tissue Proliferation in Rats and Monkeys Treated with the Thiazolidinedione Darglitazone, a Potent Peroxisome Proliferator-Activated Receptor-γ Agonist
Michael D. Aleo, Gregg R. Lundeen, David K. Blackwell, Ward M. Smith, Gerald L. Coleman, Stanley W. Stadnicki and William M. Kluwe

Journal of Pharmacology and Experimental Therapeutics June 2003, 305 (3) 1173-1182; DOI: https://doi.org/10.1124/jpet.102.042648

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Table of Contents

ANNOUNCEMENTS

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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