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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Cytochrome P450 2E1 (CYP2E1) Is the Principal Enzyme Responsible for Urethane Metabolism: Comparative Studies Using CYP2E1-Null and Wild-Type Mice

Undi Hoffler, Hisham A. El-Masri and Burhan I. Ghanayem
Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 557-564; DOI: https://doi.org/10.1124/jpet.103.049072

Article Information

vol. 305 no. 2 557-564
DOI 
https://doi.org/10.1124/jpet.103.049072
PubMed 
12704224
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 9, 2003
  • Accepted January 15, 2003
  • Published online May 1, 2003.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Undi Hoffler1,3,
  2. Hisham A. El-Masri2 and
  3. Burhan I. Ghanayem1,3
  1. 1Department of Pharmacology, Meharry Medical College, Nashville, Tennessee (U.H., B.I.G.); 2Computational Toxicology Laboratory, Division of Toxicology, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia (H.A.E.); and 3Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (U.H., B.I.G.)
  1. Dr. Burhan I. Ghanayem, Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709. E-mail: ghanayem{at}niehs.nih.gov
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Cytochrome P450 2E1 (CYP2E1) Is the Principal Enzyme Responsible for Urethane Metabolism: Comparative Studies Using CYP2E1-Null and Wild-Type Mice

Undi Hoffler, Hisham A. El-Masri and Burhan I. Ghanayem
Journal of Pharmacology and Experimental Therapeutics May 1, 2003, 305 (2) 557-564; DOI: https://doi.org/10.1124/jpet.103.049072
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