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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?

Lawrence H. Lash, Ronald N. Hines, Frank J. Gonzalez, Timothy R. Zacharewski and Mark A. Rothstein
Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 403-409; DOI: https://doi.org/10.1124/jpet.102.039925
Lawrence H. Lash
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Ronald N. Hines
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Frank J. Gonzalez
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Timothy R. Zacharewski
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Mark A. Rothstein
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Article Information

vol. 305 no. 2 403-409
DOI 
https://doi.org/10.1124/jpet.102.039925
PubMed 
12606672

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 9, 2002
  • Accepted January 22, 2003
  • Published online May 1, 2003.

Article Versions

  • Earlier version (January 24, 2003 - 15:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lawrence H. Lash1,
  2. Ronald N. Hines2,
  3. Frank J. Gonzalez3,
  4. Timothy R. Zacharewski4 and
  5. Mark A. Rothstein5
  1. 1Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan (L.H.L.); 2Birth Defects Research Center, Departments of Pediatrics and Pharmacology/Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin (R.N.H.); 3Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland (F.J.G.); 4Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan (T.R.Z.); and 5Institute for Bioethics, Health Policy and Law, University of Louisville School of Medicine, Louisville, Kentucky (M.A.R.)
  1. Dr. Lawrence H. Lash, Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201. E-mail:l.h.lash{at}wayne.edu
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Journal of Pharmacology and Experimental Therapeutics: 305 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 305, Issue 2
1 May 2003
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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?

Lawrence H. Lash, Ronald N. Hines, Frank J. Gonzalez, Timothy R. Zacharewski and Mark A. Rothstein
Journal of Pharmacology and Experimental Therapeutics May 1, 2003, 305 (2) 403-409; DOI: https://doi.org/10.1124/jpet.102.039925

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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?

Lawrence H. Lash, Ronald N. Hines, Frank J. Gonzalez, Timothy R. Zacharewski and Mark A. Rothstein
Journal of Pharmacology and Experimental Therapeutics May 1, 2003, 305 (2) 403-409; DOI: https://doi.org/10.1124/jpet.102.039925
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  • Article
    • Abstract
    • Pharmacogenetics and Susceptibility to Toxic Chemicals: Historical Perspective, Current Status and Future Challenges
    • Use of Gene Knockout and Transgenic Mice to Study the Roles of Xenobiotic-Metabolizing Enzymes in Toxicology
    • Gene Expression Profiling in Mechanistic and Predictive Toxicology
    • Ethical and Legal Implications of Pharmacogenetics
    • Conclusions
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    • References
  • Figures & Data
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