Journal of Pharmacology and Experimental Therapeutics: 305 (2)

May 01, 2003; Volume 305,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?
Lawrence H. Lash, Ronald N. Hines, Frank J. Gonzalez, Timothy R. Zacharewski and Mark A. Rothstein

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 403-409; DOI: https://doi.org/10.1124/jpet.102.039925
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The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics
Keith A. Gary, Kevin A. Sevarino, George G. Yarbrough, Arthur J. Prange and Andrew Winokur

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 410-416; DOI: https://doi.org/10.1124/jpet.102.044040

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Cytochrome P450 2E1 (CYP2E1) Is the Principal Enzyme Responsible for Urethane Metabolism: Comparative Studies Using CYP2E1-Null and Wild-Type Mice
Undi Hoffler, Hisham A. El-Masri and Burhan I. Ghanayem

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 557-564; DOI: https://doi.org/10.1124/jpet.103.049072
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Maternal Vaccination Against Nicotine Reduces Nicotine Distribution to Fetal Brain in Rats
D. E. Keyler, D. Shoeman, M. G. LeSage, A. D. Calvin and P. R. Pentel

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 587-592; DOI: https://doi.org/10.1124/jpet.102.046805
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Insights into Gender Bias: Rat Cytochrome P450 3A9
Sayeepriyadarshini Anakk, Chun Ying Ku, Mary Vore and Henry W. Strobel

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 703-709; DOI: https://doi.org/10.1124/jpet.102.048090
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Pharmacokinetic/Pharmacodynamic Modeling of the Antinociceptive Effects of (+)-Tramadol in the Rat: Role of Cytochrome P450 2D Activity
Marı́a J. Garrido, Onintza Sayar, Cristina Segura, Javier Rapado, Marı́a Carmen Dios-Viéitez, Marı́a Jesús Renedo and Iñaki F. Trocóniz

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 710-718; DOI: https://doi.org/10.1124/jpet.102.047779

BEHAVIORAL PHARMACOLOGY

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Anxiogenic Effects of Neurosteroid Exposure: Sex Differences and Altered GABA_A Receptor Pharmacology in Adult Rats
M. Gulinello and S. S. Smith

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 541-548; DOI: https://doi.org/10.1124/jpet.102.045120
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The Role of Several Kinases in Mice Tolerant to Δ⁹-Tetrahydrocannabinol
Matthew C. Lee, Forrest L. Smith, David L. Stevens and Sandra P. Welch

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 593-599; DOI: https://doi.org/10.1124/jpet.102.044446
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The Role of GABA_B Receptors in the Discriminative Stimulus Effects of γ-Hydroxybutyrate in Rats: Time Course and Antagonism Studies
Lawrence P. Carter, Lauren R. Flores, Huifang Wu, Weibin Chen, Andrew W. Unzeitig, Andy Coop and Charles P. France

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 668-674; DOI: https://doi.org/10.1124/jpet.102.047860
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A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand
Huifang Wu, Nick Zink, Lawrence P. Carter, Ashok K. Mehta, R. Jason Hernandez, Maharaj K. Ticku, Richard Lamb, Charles P. France and Andrew Coop

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 675-679; DOI: https://doi.org/10.1124/jpet.102.046797

CARDIOVASCULAR

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Regulation of the Cardiac Mitochondrial Membrane Potential by Retinoids
Irina Korichneva, John Waka and Ulrich Hammerling

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 426-433; DOI: https://doi.org/10.1124/jpet.103.048900
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α₂-Adrenoceptors Potentiate Angiotensin II- and Vasopressin-Induced Renal Vasoconstriction in Spontaneously Hypertensive Rats
Liping Gao, Chongxue Zhu and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 581-586; DOI: https://doi.org/10.1124/jpet.102.047647
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Norepinephrine Evoked by Potassium Depolarization Increases Interstitial Adenosine Concentration via Activation of ecto-5′-Nucleotidase in Rat Hearts
Toshio Obata, Hidetoshi Yonemochi and Makoto Arita

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 719-724; DOI: https://doi.org/10.1124/jpet.102.039917
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Donitriptan Selectively Decreases Jugular Venous Oxygen Saturation in the Anesthetized Pig: Further Insights into Its Mechanism of Action Relevant to Headache Relief
Robert Létienne, Yvan Verscheure, Michel Perez, Bruno Le Grand, Francis C. Colpaert and Gareth W. John

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 749-754; DOI: https://doi.org/10.1124/jpet.102.047225
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Diverse Toxicity Associated with Cardiac Na⁺/K⁺ Pump Inhibition: Evaluation of Electrophysiological Mechanisms
M. Rocchetti, A. Besana, G. Mostacciuolo, P. Ferrari, R. Micheletti and A. Zaza

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 765-771; DOI: https://doi.org/10.1124/jpet.102.047696
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Pharmacological Characterization of a Novel Antiglaucoma Agent, Bimatoprost (AGN 192024)
D. F. Woodward, A. H.-P. Krauss, J. Chen, Y. Liang, C. Li, C. E. Protzman, A. Bogardus, R. Chen, K. M. Kedzie, H. A. Krauss, D. W. Gil, A. Kharlamb, L. A. Wheeler, D. Babusis, D. Welty, D. D.-S. Tang-Liu, M. Cherukury, S. W. Andrews, R. M. Burk and M. E. Garst

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 772-785; DOI: https://doi.org/10.1124/jpet.102.047837

CELLULAR AND MOLECULAR

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Direct Interactions between the Heterotrimeric G Protein Subunit Gβ5 and the G Protein γ Subunit-Like Domain-Containing Regulator of G Protein Signaling 11: Gain of Function of Cyan Fluorescent Protein-Tagged Gγ3
Janice Y. Zhou, Peter T. Toth and Richard J. Miller

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 460-466; DOI: https://doi.org/10.1124/jpet.102.048637
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Early Mitochondrial Hyperpolarization and Intracellular Alkalinization in Lactacystin-Induced Apoptosis of Retinal Pigment Epithelial Cells
Jong-M. Kim, Hae R. Bae, Bong S. Park, Je M. Lee, Hee B. Ahn, Jee H. Rho, Kyung W. Yoo, Woo C. Park, Sae H. Rho, Hee S. Yoon and Young Hyun Yoo

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 474-481; DOI: https://doi.org/10.1124/jpet.102.047811
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The δ-Isoform of Protein Kinase C Causes Inducible Nitric-Oxide Synthase and Nitric Oxide Up-Regulation: Key Mechanism for Oxidant-Induced Carbonylation, Nitration, and Disassembly of the Microtubule Cytoskeleton and Hyperpermeability of Barrier of Intestinal Epithelia
A. Banan, A. Farhadi, J. Z. Fields, L. J. Zhang, M. Shaikh and A. Keshavarzian

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 482-494; DOI: https://doi.org/10.1124/jpet.102.047308
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Distinct Recognition of OX₁ and OX₂Receptors by Orexin Peptides
Sylwia Ammoun, Tomas Holmqvist, Ramin Shariatmadari, Hendrica B. Oonk, Michel Detheux, Marc Parmentier, Karl E. O. Åkerman and Jyrki P. Kukkonen

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 507-514; DOI: https://doi.org/10.1124/jpet.102.048025
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Differential Regulation of the Human κ Opioid Receptor by Agonists: Etorphine and Levorphanol Reduced Dynorphin A- and U50,488H-Induced Internalization and Phosphorylation
Jian-Guo Li, Fengqin Zhang, Xi-Lu Jin and Lee-Yuan Liu-Chen

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 531-540; DOI: https://doi.org/10.1124/jpet.102.045559
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Rac1 and Superoxide Are Required for the Expression of Cell Adhesion Molecules Induced by Tumor Necrosis Factor-α in Endothelial Cells
Xi-Lin Chen, Qiang Zhang, Ruozhi Zhao, Xiaoyu Ding, Pradyumna E. Tummala and Russell M. Medford

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 573-580; DOI: https://doi.org/10.1124/jpet.102.047894
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Activation of Peroxisome Proliferator-Activated Receptor γ Does Not Explain the Antiproliferative Activity of the Nonsteroidal Anti-Inflammatory Drug Indomethacin on Human Colorectal Cancer Cells
G. Hawcroft, S. H. Gardner and M. A. Hull

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 632-637; DOI: https://doi.org/10.1124/jpet.103.048769
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Flavonoid Baicalein Attenuates Activation-Induced Cell Death of Brain Microglia
Kyoungho Suk, Heasuk Lee, Sang Soo Kang, Gyeong Jae Cho and Wan Sung Choi

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 638-645; DOI: https://doi.org/10.1124/jpet.102.047373
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Pharmacology of δ2 Glutamate Receptors: Effects of Pentamidine and Protons
Keith Williams, Michael Dattilo, Thomas N. Sabado, Keiko Kashiwagi and Kazuei Igarashi.

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 740-748; DOI: https://doi.org/10.1124/jpet.102.045799
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An Unusual Form of the Association Binding Kinetics ofN-[³H]Methylscopolamine to the Split Muscarinic M_2trunk/M_2tail Receptor
Francesca Novi, Marco Scarselli, Giovanni U. Corsini and Roberto Maggio

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 786-795; DOI: https://doi.org/10.1124/jpet.102.045393

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Distinct Effects of Dinuclear Ruthenium(III) Complexes on Cell Proliferation and on Cell Cycle Regulation in Human and Murine Tumor Cell Lines
Alberta Bergamo, Gabriele Stocco, Barbara Gava, Moreno Cocchietto, Enzo Alessio, Barbara Serli, Elisabetta Iengo and Gianni Sava

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 725-732; DOI: https://doi.org/10.1124/jpet.102.047803

ENDOCRINE AND REPRODUCTIVE

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Effect of Ursodeoxycholic Acid on the Impairment Induced by Maternal Cholestasis in the Rat Placenta-Maternal Liver Tandem Excretory Pathway
M. A. Serrano, R. I. R. Macias, M. Vallejo, O. Briz, A. Bravo, M. J. Pascual, M. V. St-Pierre, B. Stieger, P. J. Meier and J. J. G. Marin

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 515-524; DOI: https://doi.org/10.1124/jpet.102.047977
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Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor
Jo Ann Janovick, Mark Goulet, Eugene Bush, Jonathan Greer, David G. Wettlaufer and P. Michael Conn

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 608-614; DOI: https://doi.org/10.1124/jpet.102.048454
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Biological Characterization of a Novel, Orally Active Small Molecule Gonadotropin-Releasing Hormone (GnRH) Antagonist Using Castrated and Intact Rats
Kenna L. Anderes, David R. Luthin, Rosemary Castillo, Eugenia A. Kraynov, Mary Castro, Karen Nared-Hood, Margaret L. Gregory, Ved P. Pathak, Lance C. Christie, Genevieve Paderes, Haresh Vazir, Qiang Ye, Mark B. Anderson and John M. May

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 688-695; DOI: https://doi.org/10.1124/jpet.102.046656

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Acute Mechanism of Medium Chain Fatty Acid-Induced Enhancement of Airway Epithelial Permeability
Carolyn B. Coyne, Carla M. P. Ribeiro, Richard C. Boucher and Larry G. Johnson

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 440-450; DOI: https://doi.org/10.1124/jpet.102.047654
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Biochemical and Pharmacological Characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a Novel, Orally Active Elastase Inhibitor
Zoltán Kapui, Márton Varga, Katalin Urban-Szabó, Endre Mikus, Tibor Szabó, Judit Szeredi, Sándor Bátori, Olivier Finance and Péter Arányi

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 451-459; DOI: https://doi.org/10.1124/jpet.102.044263
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The Specific Type-4 Phosphodiesterase Inhibitor Mesopram Alleviates Experimental Colitis in Mice
Florian Loher, Kathrin Schmall, Philipp Freytag, Nikola Landauer, Roland Hallwachs, Christian Bauer, Britta Siegmund, Florian Rieder, Hans-Anton Lehr, Marc Dauer, Joachim Friedrich Kapp, Stefan Endres and Andreas Eigler

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 549-556; DOI: https://doi.org/10.1124/jpet.102.039529
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Functional and Molecular Characterization of β-Adrenoceptors in the Internal Anal Sphincter
Sandeep Rathi, Shiva Kazerounian, Kuldip Banwait, Stephanie Schulz, Scott A. Waldman and Satish Rattan

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 615-624; DOI: https://doi.org/10.1124/jpet.102.048462
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Interaction of the Growth Hormone-Releasing Peptides Ghrelin and Growth Hormone-Releasing Peptide-6 with the Motilin Receptor in the Rabbit Gastric Antrum
Inge Depoortere, Theo Thijs, Leen Thielemans, Patrick Robberecht and Theo L. Peeters

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 660-667; DOI: https://doi.org/10.1124/jpet.102.047563
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Kinin-Induced Anion-Dependent Secretion in Porcine Ileum: Characterization and Involvement of Opioid- and Cannabinoid-Sensitive Enteric Neural Circuits
Benedict T. Green, Andrew Calvin, Scott M. O'Grady and David R. Brown

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 733-739; DOI: https://doi.org/10.1124/jpet.102.047829

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Thrombin and Protease-Activated Receptor-1 Agonists Promote Lipopolysaccharide-Induced Hepatocellular Injury in Perfused Livers
Bryan L. Copple, Frederic Moulin, Umesh M. Hanumegowda, Patricia E. Ganey and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 417-425; DOI: https://doi.org/10.1124/jpet.102.046391

NEUROPHARMACOLOGY

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The Effects of Chronic Treatment with the Mood Stabilizers Valproic Acid and Lithium on Corticotropin-Releasing Factor Neuronal Systems
Michelle L. Gilmor, Kelly H. Skelton, Charles B. Nemeroff and Michael J. Owens

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 434-439; DOI: https://doi.org/10.1124/jpet.102.045419
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Mapping the Cerebral Monoamine Oxidase Type A: Positron Emission Tomography Characterization of the Reversible Selective Inhibitor [¹¹C]Befloxatone
Michel Bottlaender, Frédéric Dollé, Ilonka Guenther, Dimitri Roumenov, Chantal Fuseau, Yann Bramoulle, Olivier Curet, Jamir Jegham, Jean-Louis Pinquier, Pascal George and Heric Valette

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 467-473; DOI: https://doi.org/10.1124/jpet.102.046953
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In Vivo Pain-Inhibitory Role of Nociceptin/Orphanin FQ in Spinal Cord
Makoto Inoue, Toshiko Kawashima, Hiroshi Takeshima, Girolamo Calo, Atsuko Inoue, Yoshihiro Nakata and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 495-501; DOI: https://doi.org/10.1124/jpet.102.046326
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Block of Na⁺,K⁺-ATPase and Induction of Hybrid Death by 4-Aminopyridine in Cultured Cortical Neurons
Xue Qing Wang, Ai Ying Xiao, Aizhen Yang, Lori LaRose, Ling Wei and Shan Ping Yu

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 502-506; DOI: https://doi.org/10.1124/jpet.102.045013
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Melatonin Nocturnal Surge Modulates Nicotinic Receptors and Nicotine-Induced [³H]Glutamate Release in Rat Cerebellum Slices
Regina P. Markus, Jussara M. Santos, Wagner Zago and Lı́via A. C. Renó

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 525-530; DOI: https://doi.org/10.1124/jpet.102.045625
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Inhibitor Binding to Type 4 Phosphodiesterase (PDE4) Assessed Using [³H]Piclamilast and [³H]Rolipram
Yu Zhao, Han-Ting Zhang and James M. O'Donnell

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 565-572; DOI: https://doi.org/10.1124/jpet.102.047407
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Deletion of GABA_A Receptor α1 Subunit-containing Receptors Alters Responses to Ethanol and Other Anesthetics
J. E. Kralic, M. Wheeler, K. Renzi, C. Ferguson, T. K. O'Buckley, A. C. Grobin, A. L. Morrow and G. E. Homanics

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 600-607; DOI: https://doi.org/10.1124/jpet.102.048124
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Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy
Shitij Kapur, Susan C. VanderSpek, Barbara A. Brownlee and José N. Nobrega

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 625-631; DOI: https://doi.org/10.1124/jpet.102.046987
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Iberiotoxin-Induced Block of Ca²⁺-Activated K⁺ Channels Induces Dihydropyridine Sensitivity of ACh Release from Mammalian Motor Nerve Terminals
Michael T. Flink and William D. Atchison

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 646-652; DOI: https://doi.org/10.1124/jpet.102.046102
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Activation of β₂- and β₃-Adrenergic Receptors Increases Brain Tryptophan
Natalie R. Lenard, Thomas W. Gettys and Adrian J. Dunn

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 653-659; DOI: https://doi.org/10.1124/jpet.102.048249
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Dendritic Glutamate-Induced Bursting in the Prefrontal Cortex: Further Characterization and Effects of Phencyclidine
Wei-Xing Shi and Xue-Xiang Zhang

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 680-687; DOI: https://doi.org/10.1124/jpet.102.046359
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Endogenous Opioid Peptides Contribute to Antinociceptive Potency of Intrathecal [Dmt¹]DALDA
Hazel H. Szeto, Yi Soong, Dunli Wu, XuanXuan Qian and Guo-Min Zhao

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 696-702; DOI: https://doi.org/10.1124/jpet.102.048561
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The Heritability of Antinociception II: Pharmacogenetic Mediation of Three Over-the-Counter Analgesics in Mice
Sonya G. Wilson, Camron D. Bryant, William R. Lariviere, Michael S. Olsen, Belinda E. Giles, Elissa J. Chesler and Jeffrey S. Mogil

Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 755-764; DOI: https://doi.org/10.1124/jpet.102.047902

Errata

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Correction to “α₄β₇/α₄β₁Dual Integrin Antagonists Block α₄β₇-Dependent Adhesion under Shear Flow”
Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 796;
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Correction to “Up-Regulation of Regulator of G Protein Signaling 4 Expression in a Model of Neuropathic Pain and Insensitivity to Morphine”
Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 797;
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Correction to “Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)”
Journal of Pharmacology and Experimental Therapeutics May 2003, 305 (2) 798;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

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