Journal of Pharmacology and Experimental Therapeutics: 305 (1)

April 01, 2003; Volume 305,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse
J. D. Salamone, M. Correa, S. Mingote and S. M. Weber

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 1-8; DOI: https://doi.org/10.1124/jpet.102.035063
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Metabolic Control of Excessive Extracellular Nucleotide Accumulation by CD39/Ecto-Nucleotidase-1: Implications for Ischemic Vascular Diseases
Aaron J. Marcus, M. Johan Broekman, Joan H. F. Drosopoulos, Naziba Islam, David J. Pinsky, Casilde Sesti and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 9-16; DOI: https://doi.org/10.1124/jpet.102.043729

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Delivery of Peptide Drugs to the Brain by Adenovirus-Mediated Heterologous Expression of Human Oligopeptide Transporter at the Blood-Brain Barrier
Hidekazu Toyobuku, Yoshimichi Sai, Toru Kagami, Ikumi Tamai and Akira Tsuji

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 40-47; DOI: https://doi.org/10.1124/jpet.102.046243
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A Kinetic Evaluation of the Absorption, Efflux, and Metabolism of Verapamil in the Autoperfused Rat Jejunum
Brendan M. Johnson, Weiqing Chen, Ronald T. Borchardt, William N. Charman and Christopher J. H. Porter

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 151-158; DOI: https://doi.org/10.1124/jpet.102.045328
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In Vivo Mechanistic Studies on the Metabolic Activation of 2-Phenylpropionic Acid in Rat
Chunze Li, Mark P. Grillo and Leslie Z. Benet

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 250-256; DOI: https://doi.org/10.1124/jpet.102.043174
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Moment Analysis of Metabolic Heterogeneity: Conjugation of Benzoate with Glycine in Rat Liver Studied by Multiple Indicator Dilution Technique
Andreas J. Schwab, Lei Tao, Manjinder Kang, Lingjie Meng and K. Sandy Pang

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 279-289; DOI: https://doi.org/10.1124/jpet.102.044024
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In Vivo Modulation of Intestinal CYP3A Metabolism by P-Glycoprotein: Studies Using the Rat Single-Pass Intestinal Perfusion Model
Carolyn L. Cummins, Laurent Salphati, Michael J. Reid and Leslie Z. Benet

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 306-314; DOI: https://doi.org/10.1124/jpet.102.044719
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Insulin and Glucagon Regulation of GlutathioneS-Transferase Expression in Primary Cultured Rat Hepatocytes
Sang K. Kim, Kimberley J. Woodcroft and Raymond F. Novak

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 353-361; DOI: https://doi.org/10.1124/jpet.102.045153

BEHAVIORAL PHARMACOLOGY

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Activation of κ-Opioid Receptors Inhibits Pruritus Evoked by Subcutaneous or Intrathecal Administration of Morphine in Monkeys
M. C. Holden Ko, Heeseung Lee, Michael S. Song, Katarzyna Sobczyk-Kojiro, Henry I. Mosberg, Shiroh Kishioka, James H. Woods and Norah N. Naughton

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 173-179; DOI: https://doi.org/10.1124/jpet.102.044909
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Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
Stephen D. Mague, Andrea M. Pliakas, Mark S. Todtenkopf, Hilarie C. Tomasiewicz, Yan Zhang, William C. Stevens, Robert M. Jones, Philip S. Portoghese and William A. Carlezon

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 323-330; DOI: https://doi.org/10.1124/jpet.102.046433
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Ambient Temperature Influences Core Body Temperature Response in Rat Lines Bred for Differences in Sensitivity to 8-Hydroxy-dipropylaminotetralin
Andrea C. Nicholas and Lewis S. Seiden

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 368-374; DOI: https://doi.org/10.1124/jpet.102.045088
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Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat
Koki Inoue, Glenn R. Valdez, Teresa M. Reyes, Lindsay E. Reinhardt, Antoine Tabarin, Jean Rivier, Wylie W. Vale, Paul E. Sawchenko, George F. Koob and Eric P. Zorrilla

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 385-393; DOI: https://doi.org/10.1124/jpet.102.047712

CARDIOVASCULAR

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A Novel Chymase Inhibitor, 4-[1-{[bis-(4-Methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), Suppressed Cardiac Fibrosis in Cardiomyopathic Hamsters
Shinji Takai, Denan Jin, Masato Sakaguchi, Satoru Katayama, Michiko Muramatsu, Minoru Sakaguchi, Eiko Matsumura, Shokei Kim and Mizuo Miyazaki

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 17-23; DOI: https://doi.org/10.1124/jpet.102.045179
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Low-Molecular-Weight Fucoidan Promotes Therapeutic Revascularization in a Rat Model of Critical Hindlimb Ischemia
Charles-Edouard Luyt, Anne Meddahi-Pellé, Benoit Ho-Tin-Noe, Sylvia Colliec-Jouault, Jean Guezennec, Liliane Louedec, Hervé Prats, Marie-Paule Jacob, Mary Osborne-Pellegrin, Didier Letourneur and Jean-Baptiste Michel

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 24-30; DOI: https://doi.org/10.1124/jpet.102.046144
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Beneficial Effects of Sampatrilat, a Novel Vasopeptidase Inhibitor, on Cardiac Remodeling and Function of Rats with Chronic Heart Failure following Left Coronary Artery Ligation
Toshiyuki Maki, Yoshihisa Nasa, Kouichi Tanonaka, Masaya Takahashi and Satoshi Takeo

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 97-105; DOI: https://doi.org/10.1124/jpet.102.042747
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Effect of Chronic Treatment with Vitamin E on Endothelial Dysfunction in a Type I in Vivo Diabetes Mellitus Model and in Vitro
S. Dhein, A. Kabat, A. Olbrich, P. Rösen, H. Schröder and F.-W. Mohr

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 114-122; DOI: https://doi.org/10.1124/jpet.102.045740
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N-[3-(R)-Tetrahydrofuranyl]-6-aminopurine Riboside, an A₁ Adenosine Receptor Agonist, Antagonizes Catecholamine-Induced Lipolysis without Cardiovascular Effects in Awake Rats
Heather Fraser, Zhenhai Gao, Mark J. Ozeck and Luiz Belardinelli

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 225-231; DOI: https://doi.org/10.1124/jpet.102.046821
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Amiodarone-Induced Postrepolarization Refractoriness Suppresses Induction of Ventricular Fibrillation
Paulus Kirchhof, Hubertus Degen, Michael R. Franz, Lars Eckardt, Larissa Fabritz, Peter Milberg, Stephanie Läer, Joachim Neumann, Günter Breithardt and Wilhelm Haverkamp

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 257-263; DOI: https://doi.org/10.1124/jpet.102.046755
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Sexual Dimorphism in Cafeteria Diet-Induced Hypertension Is Associated with Gender-Related Difference in Renal Leptin Receptor Down-Regulation
Gwenn Coatmellec-Taglioni, Jean-Pierre Dausse, Yves Giudicelli and Catherine Ribière

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 362-367; DOI: https://doi.org/10.1124/jpet.102.045682
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Role of Cytochrome P4501B1 in Benzo[a]pyrene Bioactivation to DNA-Binding Metabolites in Mouse Vascular Smooth Muscle Cells: Evidence from ³²P-Postlabeling for Formation of 3-Hydroxybenzo[a]pyrene and Benzo[a]pyrene-3,6-quinone as Major Proximate Genotoxic Intermediates
Bhagavatula Moorthy, Kimberly P. Miller, Weiwu Jiang, E. Spencer Williams, Sudha R. Kondraganti and Kenneth S. Ramos

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 394-401; DOI: https://doi.org/10.1124/jpet.102.044271

CELLULAR AND MOLECULAR

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The Novel Neuroprotective Action of Sulfasalazine through Blockade of NMDA Receptors
Bo Rum Ryu, Young Ae Lee, Seok Joon Won, Ji-Hyun Noh, Su-Youne Chang, Jun-Mo Chung, Jun Sub Choi, Choun Ki Joo, Sung Hwa Yoon and Byoung Joo Gwag

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 48-56; DOI: https://doi.org/10.1124/jpet.102.042606

ENDOCRINE AND REPRODUCTIVE

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Is 11β-Hydroxysteroid Dehydrogenase Type 1 a Therapeutic Target? Effects of Carbenoxolone in Lean and Obese Zucker Rats
Dawn E. W. Livingstone and Brian R. Walker

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 167-172; DOI: https://doi.org/10.1124/jpet.102.044842
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Structure-Activity Study of LVV-Hemorphin-7: Angiotensin AT₄ Receptor Ligand and Inhibitor of Insulin-Regulated Aminopeptidase
Joohyung Lee, Tomris Mustafa, Sharon G. McDowall, Frederick A. O. Mendelsohn, Michelle Brennan, Rebecca A. Lew, Anthony L. Albiston and Siew Yeen Chai

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 205-211; DOI: https://doi.org/10.1124/jpet.102.045492
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Ca_v1.3 Is Preferentially Coupled to Glucose-Stimulated Insulin Secretion in the Pancreatic β-Cell Line INS-1
Guohong Liu, Nejmi Dilmac, Nathan Hilliard and Gregory H. Hockerman

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 271-278; DOI: https://doi.org/10.1124/jpet.102.046334

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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The 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitor Pravastatin Reduces Disease Activity and Inflammation in Dextran-Sulfate Induced Colitis
Makoto Sasaki, Sulaiman Bharwani, Paul Jordan, Takashi Joh, Kenneth Manas, April Warren, Hirohisa Harada, Patsy Carter, John W. Elrod, Michael Wolcott, Matthew B. Grisham and J. Steven Alexander

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 78-85; DOI: https://doi.org/10.1124/jpet.102.044099
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Increased Relaxant Action of Forskolin and Isoproterenol against Muscarinic Agonist-Induced Contractions in Smooth Muscle from M₂ Receptor Knockout Mice
Minoru Matsui, Michael T. Griffin, Darakhshanda Shehnaz, Makoto M. Taketo and Frederick J. Ehlert

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 106-113; DOI: https://doi.org/10.1124/jpet.102.044701
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Renal Function in a Rat Model of Analgesic Nephropathy: Effect of Chloroquine
Mohamed H. Ahmed, Nick Ashton and Richard J. Balment

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 123-130; DOI: https://doi.org/10.1124/jpet.102.047233
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δ-Aminolevulinic Acid Transport in Cancer Cells of the Human Extrahepatic Biliary Duct
Jana Neumann and Matthias Brandsch

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 219-224; DOI: https://doi.org/10.1124/jpet.102.046573
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Significant Role of Ceramide Pathway in Experimental Gastric Ulcer Formation in Rats
Keita Uehara, Soichiro Miura, Tetsu Takeuchi, Takao Taki, Manabu Nakashita, Masayuki Adachi, Toshiaki Inamura, Toshiko Ogawa, Yasutada Akiba, Hidekazu Suzuki, Hiroshi Nagata and Hiromasa Ishii

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 232-239; DOI: https://doi.org/10.1124/jpet.102.045195
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Inhibition of Cyclooxygenases Reduces Complement-Induced Glomerular Epithelial Cell Injury and Proteinuria in Passive Heymann Nephritis
Tomoko Takano, Andrey V. Cybulsky, William A. Cupples, David O. Ajikobi, Joan Papillon and Lamine Aoudjit

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 240-249; DOI: https://doi.org/10.1124/jpet.102.043604

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Neurokinin-1 Receptor Antagonists CP-96,345 and L-733,060 Protect Mice from Cytokine-Mediated Liver Injury
Renate Bang, Gabriele Sass, Alexandra K. Kiemer, Angelika M. Vollmar, Winfried L. Neuhuber and Gisa Tiegs

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 31-39; DOI: https://doi.org/10.1124/jpet.102.043539
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Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment
Masayuki Fujino, Naoko Funeshima, Yusuke Kitazawa, Hiromitsu Kimura, Hiroshi Amemiya, Seiichi Suzuki and Xiao-Kang Li

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 70-77; DOI: https://doi.org/10.1124/jpet.102.045658
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Gabexate Mesilate, a Synthetic Protease Inhibitor, Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Inhibiting Activation of Both Nuclear Factor-κB and Activator Protein-1 in Human Monocytes
Mehtap Yuksel, Kenji Okajima, Mitsuhiro Uchiba and Hiroaki Okabe

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 298-305; DOI: https://doi.org/10.1124/jpet.102.041988
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Suppression of Hepatic CYP3A1/2 and CYP2C11 by Cyclosporine Is Not Mediated by Altering Growth Hormone Levels
Shirley K. Lu, Shellie M. Callahan and Lane J. Brunner

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 331-337; DOI: https://doi.org/10.1124/jpet.102.044776
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An Orally Bioavailable Small Molecule Antagonist of CRTH2, Ramatroban (BAY u3405), Inhibits Prostaglandin D₂-Induced Eosinophil Migration in Vitro
Hiromi Sugimoto, Michitaka Shichijo, Takashi Iino, Yoshihisa Manabe, Akihiko Watanabe, Makoto Shimazaki, Florian Gantner and Kevin B. Bacon

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 347-352; DOI: https://doi.org/10.1124/jpet.102.046748

NEUROPHARMACOLOGY

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Pharmacological Characterization of a Novel Nonpeptide Antagonist Radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([³H]SN003) for Corticotropin-Releasing Factor₁ Receptors
Ge Zhang, Ning Huang, Yu-Wen Li, Xiaoping Qi, Anne P. Marshall, Xiao-Xin Yan, Geraldine Hill, Cynthia Rominger, Shimoga R. Prakash, Rajagopal Bakthavatchalam, David H. Rominger, Paul J. Gilligan and Robert Zaczek

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 57-69; DOI: https://doi.org/10.1124/jpet.102.046128
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Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy
Yu-Wen Li, Geraldine Hill, Harvey Wong, Natasha Kelly, Kathryn Ward, Marie Pierdomenico, Shelly Ren, Paul Gilligan, Scott Grossman, George Trainor, Rebecca Taub, John McElroy and Robert Zazcek

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 86-96; DOI: https://doi.org/10.1124/jpet.102.045914
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l-Homocysteine Sulfinic Acid and Other Acidic Homocysteine Derivatives Are Potent and Selective Metabotropic Glutamate Receptor Agonists
Qi Shi, Jason E. Savage, Sandra J. Hufeisen, Laura Rauser, Ewa Grajkowska, Paul Ernsberger, Jarda T. Wroblewski, Joseph H. Nadeau and Bryan L. Roth

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 131-142; DOI: https://doi.org/10.1124/jpet.102.047092
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Mixed Cocaine Agonist/Antagonist Properties of (+)-Methyl 4β-(4-Chlorophenyl)-1-methylpiperidine-3α-carboxylate, a Piperidine-Based Analog of Cocaine
Alan P. Kozikowski, Kenneth M. Johnson, Olivier Deschaux, Bidhan C. Bandyopadhyay, Gian Luca Araldi, Gilberto Carmona, Patrik Munzar, Miles P. Smith, Robert L. Balster, Patrick M. Beardsley and Srihari R. Tella

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 143-150; DOI: https://doi.org/10.1124/jpet.102.046318
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Individual Differences in Cocaine-Induced Locomotor Sensitization in Low and High Cocaine Locomotor-Responding Rats Are Associated with Differential Inhibition of Dopamine Clearance in Nucleus Accumbens
Jilla Sabeti, Greg A. Gerhardt and Nancy R. Zahniser

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 180-190; DOI: https://doi.org/10.1124/jpet.102.047258
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Differential Regulation of GABA_B Receptor Subunit Expression and Function
S. A. Sands, K. E. McCarson and S. J. Enna

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 191-196; DOI: https://doi.org/10.1124/jpet.102.046342
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Inhibition of P-Glycoprotein by Newer Antidepressants
Johanna Weiss, Sven-Maria Gregor Dormann, Meret Martin-Facklam, Christian Johannes Kerpen, Nahal Ketabi-Kiyanvash and Walter Emil Haefeli

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 197-204; DOI: https://doi.org/10.1124/jpet.102.046532
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Dextromethorphan Protects Dopaminergic Neurons against Inflammation-Mediated Degeneration through Inhibition of Microglial Activation
Yuxin Liu, Liya Qin, Guorong Li, Wei Zhang, Lijia An, Bin Liu and Jau-Shyong Hong

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 212-218; DOI: https://doi.org/10.1124/jpet.102.043166
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Ethanol Differentially Enhances Hippocampal GABA_AReceptor-Mediated Responses in Protein Kinase Cγ (PKCγ) and PKCε Null Mice
W. R. Proctor, W. Poelchen, Barbara J. Bowers, Jeanne M. Wehner, R. O. Messing and T. V. Dunwiddie

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 264-270; DOI: https://doi.org/10.1124/jpet.102.045450
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Stress-Induced Suppression of the Immune System after Withdrawal from Chronic Cocaine
Albert H. Avila, Camille A. Morgan and Barbara M. Bayer

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 290-297; DOI: https://doi.org/10.1124/jpet.102.045989
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Contribution of Individual Cytochrome P450 Isozymes to theO-Demethylation of the Psychotropic β-Carboline Alkaloids Harmaline and Harmine
Ai-Ming Yu, Jeffrey R. Idle, Kristopher W. Krausz, Adrian Küpfer and Frank J. Gonzalez

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 315-322; DOI: https://doi.org/10.1124/jpet.102.047050
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Piribedil Enhances Frontocortical and Hippocampal Release of Acetylcholine in Freely Moving Rats by Blockade of α_2A-Adrenoceptors: A Dialysis Comparison to Talipexole and Quinelorane in the Absence of Acetylcholinesterase Inhibitors
A. Gobert, B. Di Cara, L. Cistarelli and M. J. Millan

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 338-346; DOI: https://doi.org/10.1124/jpet.102.046383
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Repeated Exposures to Subthreshold Doses of Chlorpyrifos in Rats: Hippocampal Damage, Impaired Axonal Transport, and Deficits in Spatial Learning
A. V. Terry, J. D. Stone, J. J. Buccafusco, D. W. Sickles, A. Sood and M. A. Prendergast

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 375-384; DOI: https://doi.org/10.1124/jpet.102.041897

TOXICOLOGY

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Hypothalamic-Pituitary-Thyroid Axis and Sympathetic Nervous System Involvement in Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy)
Jon E. Sprague, Matthew L. Banks, Valerie J. Cook and Edward M. Mills

Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 159-166; DOI: https://doi.org/10.1124/jpet.102.044982

Erratum

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Correction to “Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates”
Journal of Pharmacology and Experimental Therapeutics April 2003, 305 (1) 402;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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