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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2003; Volume 304,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Drugs Targeting Alzheimer's Disease: Some Things Old and Some Things New
    Mary L. Michaelis
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 897-904; DOI: https://doi.org/10.1124/jpet.102.035840
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    Mechanisms of Renal Cell Repair and Regeneration after Acute Renal Failure
    Paul A. Nony and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 905-912; DOI: https://doi.org/10.1124/jpet.102.035022

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Mechanisms of Down-Regulation of CYP2E1 Expression by Inflammatory Cytokines in Rat Hepatoma Cells
    Jukka Hakkola, Yin Hu and Magnus Ingelman-Sundberg
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1048-1054; DOI: https://doi.org/10.1124/jpet.102.041582
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    Distribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux
    HaiQing Dai, Peter Marbach, Michel Lemaire, Michael Hayes and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1085-1092; DOI: https://doi.org/10.1124/jpet.102.045260
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    Pharmacokinetics and Interactions of a Novel Antagonist of Chemokine Receptor 5 (CCR5) with Ritonavir in Rats and Monkeys: Role of CYP3A and P-Glycoprotein
    Sanjeev Kumar, Gloria Y. Kwei, Grace K. Poon, Susan A. Iliff, Yanfeng Wang, Qing Chen, Ronald B. Franklin, Varsha Didolkar, Regina W. Wang, Masayo Yamazaki, Shuet-Hing Lee Chiu, Jiunn H. Lin, Paul G. Pearson and Thomas A. Baillie
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1161-1171; DOI: https://doi.org/10.1124/jpet.102.045096
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    Metabolism of Flavonoids via Enteric Recycling: Role of Intestinal Disposition
    Jun Chen, Huimin Lin and Ming Hu
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1228-1235; DOI: https://doi.org/10.1124/jpet.102.046409
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    Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport
    Shuzhong Zhang and Marilyn E. Morris
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1258-1267; DOI: https://doi.org/10.1124/jpet.102.044412
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    Active Transport of High-Affinity Choline and Nicotine Analogs into the Central Nervous System by the Blood-Brain Barrier Choline Transporter
    David D. Allen, Paul R. Lockman, Karen E. Roder, Linda P. Dwoskin and Peter A. Crooks
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1268-1274; DOI: https://doi.org/10.1124/jpet.102.045856
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    Pharmacology, Pharmacokinetics, and Metabolism of Acetothiolutamide, a Novel Nonsteroidal Agonist for the Androgen Receptor
    Donghua Yin, Huiping Xu, Yali He, Leonid I. Kirkovsky, Duane D. Miller and James T. Dalton
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1323-1333; DOI: https://doi.org/10.1124/jpet.102.040832

BEHAVIORAL PHARMACOLOGY

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    Discrimination of a Single Dose of Morphine Followed by Naltrexone: Substitution of Other Agonists for Morphine and Other Antagonists for Naltrexone in a Rat Model of Acute Dependence
    Stephen G. Holtzman
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1033-1041; DOI: https://doi.org/10.1124/jpet.102.044875
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    Behavioral Pharmacology of AR-A000002, a Novel, Selective 5-Hydroxytryptamine1B Antagonist
    T. J. Hudzik, M. Yanek, T. Porrey, J. Evenden, C. Paronis, M. Mastrangelo, C. Ryan, S. Ross and C. Stenfors
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1072-1084; DOI: https://doi.org/10.1124/jpet.102.045468

CARDIOVASCULAR

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    Soy-Derived Isoflavones Exert Opposing Actions on Guinea Pig Ventricular Myocytes
    Reginald Liew, J. Koudy Williams, Peter Collins and Kenneth T. MacLeod
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 985-993; DOI: https://doi.org/10.1124/jpet.102.042986
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    Prevention of Heart Failure in Rats by Trimetazidine Treatment: A Consequence of Accelerated Phospholipid Turnover?
    Imène Tabbi-Anneni, Cécile Helies-Toussaint, Didier Morin, Anne Bescond-Jacquet, Arnaud Lucien and Alain Grynberg
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1003-1009; DOI: https://doi.org/10.1124/jpet.102.042143
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    Modification of Noradrenaline Release in Pithed Spontaneously Hypertensive Rats by I1-Binding Sites in Addition to α2-Adrenoceptors
    Walter Raasch, Britta Jungbluth, Ulrich Schäfer, Walter Häuser and Peter Dominiak
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1063-1071; DOI: https://doi.org/10.1124/jpet.102.044966
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    Enhancement Effect under High-Glucose Conditions on U46619-Induced Spontaneous Phasic Contraction in Mouse Portal Vein
    Koji Nobe, Yasushi Sakai, Hiromi Nobe, Junko Takashima, Richard J. Paul and Kazutaka Momose
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1129-1142; DOI: https://doi.org/10.1124/jpet.102.040964
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    Minalrestat, an Aldose Reductase Inhibitor, Corrects the Impaired Microvascular Reactivity in Diabetes
    Eliana H. Akamine, Thomas C. Hohman, Dorothy Nigro, Maria Helena C. Carvalho, Rita de Cássia Tostes and Zuleica B. Fortes
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1236-1242; DOI: https://doi.org/10.1124/jpet.102.044693
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    The Nitric Oxide- and Prostaglandin-Independent Component of the Renal Vasodilator Effect of Thimerosal Is Mediated by Epoxyeicosatrienoic Acids
    Y.-J. Chen, H. Jiang and J. Quilley
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1292-1298; DOI: https://doi.org/10.1124/jpet.102.042671

CELLULAR AND MOLECULAR

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    Selective Cyclooxygenase-2 Inhibition Does Not Alter Keratinocyte Wound Responses in the Mouse Epidermis after Abrasion
    Medora M. Hardy, Eric A. G. Blomme, Andrew Lisowski, Kevin S. Chinn, Amy Jones, Janet M. Harmon, Alan Opsahl, Richard L. Ornberg and Catherine S. Tripp
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 959-967; DOI: https://doi.org/10.1124/jpet.102.044545
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    Bradykinin B2 Receptor Activates Extracellular Signal-Regulated Protein Kinase in mIMCD-3 Cells via Epidermal Growth Factor Receptor Transactivation
    Yurii V. Mukhin, Evgeny A. Garnovsky, Michael E. Ullian and Maria N. Garnovskaya
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 968-977; DOI: https://doi.org/10.1124/jpet.102.043943
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    Distinct Effects of Ketone Bodies on Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate-1 Phosphorylation in Adrenal Chromaffin Cells
    Hiroki Yokoo, Tomokazu Saitoh, Seiji Shiraishi, Toshihiko Yanagita, Takashi Sugano, Shin-Ichi Minami, Hideyuki Kobayashi and Akihiko Wada
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 994-1002; DOI: https://doi.org/10.1124/jpet.102.044115
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    Nateglinide, a d-Phenylalanine Derivative Lacking Either a Sulfonylurea or Benzamido Moiety, Specifically Inhibits Pancreatic β-Cell-Type KATP Channels
    Motohiko Chachin, Mitsuhiko Yamada, Akikazu Fujita, Tetsuro Matsuoka, Kenji Matsushita and Yoshihisa Kurachi
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1025-1032; DOI: https://doi.org/10.1124/jpet.102.044917
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    Isostrychnopentamine, an Indolomonoterpenic Alkaloid fromStrychnos usambarensis, Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells
    Michel Frédérich, Mohamed Bentires-Alj, Monique Tits, Luc Angenot, Roland Greimers, Jacques Gielen, Vincent Bours and Marie-Paule Merville
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1103-1110; DOI: https://doi.org/10.1124/jpet.102.044867
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    Selective Tryptic Cleavage at the Tethered Ligand Site of the Amino Terminal Domain of Proteinase-Activated Receptor-2 in Intact Cells
    Bahjat Al-Ani and Morley D. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1120-1128; DOI: https://doi.org/10.1124/jpet.102.043844
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    Dual Action of n-Butanol on Neuronal Nicotinic α4β2 Acetylcholine Receptors
    Yi Zuo, Jay Z. Yeh and Toshio Narahashi
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1143-1152; DOI: https://doi.org/10.1124/jpet.102.044537
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    Opposite Effects of Rofecoxib on Nuclear Factor-κB and Activating Protein-1 Activation
    Ellen Niederberger, Irmgard Tegeder, Christine Schäfer, Maic Seegel, Sabine Grösch and Gerd Geisslinger
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1153-1160; DOI: https://doi.org/10.1124/jpet.102.044016
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    Regulation of Semicarbazide-Sensitive Amine Oxidase Expression by Tumor Necrosis Factor-α in Adipocytes: Functional Consequences on Glucose Transport
    Nathalie Mercier, Marthe Moldes, Khadija El Hadri and Bruno Fève
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1197-1208; DOI: https://doi.org/10.1124/jpet.102.044420
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    Molecular Determinants of Melanocortin 4 Receptor Ligand Binding and MC4/MC3 Receptor Selectivity
    Sarah A. Nickolls, Mary I. Cismowski, Xiaochuan Wang, Meira Wolff, Paul J. Conlon and Richard A. Maki
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1217-1227; DOI: https://doi.org/10.1124/jpet.102.044974
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    Effects of Large Clostridial Cytotoxins on Activation of RBL 2H3-hm1 Mast Cells Indicate Common and Different Roles of Rac in FcεRI and M1-Receptor Signaling
    Nabil Djouder, Eduardo Aneiros, Adolfo Cavalié and Klaus Aktories
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1243-1250; DOI: https://doi.org/10.1124/jpet.102.045351
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    Up-Regulation of Regulator of G Protein Signaling 4 Expression in a Model of Neuropathic Pain and Insensitivity to Morphine
    Martine Garnier, Paola F. Zaratin, Giovanna Ficalora, Maurizio Valente, Laura Fontanella, Man-Hee Rhee, Kendall J. Blumer and Mark A. Scheideler
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1299-1306; DOI: https://doi.org/10.1124/jpet.102.043471

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    A Long-Acting Suicide Gene Toxin, 6-Methylpurine, Inhibits Slow Growing Tumors after a Single Administration
    Vijayakrishna K. Gadi, Sherrie D. Alexander, William R. Waud, Paula W. Allan, William B. Parker and Eric J. Sorscher
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1280-1284; DOI: https://doi.org/10.1124/jpet.102.044743
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    Phosphorylation of 4′-thio-β-d-Arabinofuranosylcytosine and Its Analogs by Human Deoxycytidine Kinase
    Hitoshi Someya, Sue C. Shaddix, Kamal N. Tiwari, John A. Secrist and William B. Parker
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1314-1322; DOI: https://doi.org/10.1124/jpet.102.045435

ENDOCRINE AND REPRODUCTIVE

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    Pharmacodynamics of Selective Androgen Receptor Modulators
    Donghua Yin, Wenqing Gao, Jeffrey D. Kearbey, Huiping Xu, Kiwon Chung, Yali He, Craig A. Marhefka, Karen A. Veverka, Duane D. Miller and James T. Dalton
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1334-1340; DOI: https://doi.org/10.1124/jpet.102.040840

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Facilitation by Endogenous Prostaglandins of Capsaicin-Induced Gastric Protection in Rodents through EP2 and IP Receptors
    Koji Takeuchi, Shinichi Kato, Masanori Takeeda, Yoshihiro Ogawa, Masato Nakashima and Masahiro Matsumoto
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1055-1062; DOI: https://doi.org/10.1124/jpet.102.044156
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    A Role for TRPV1 in Bradykinin-Induced Excitation of Vagal Airway Afferent Nerve Terminals
    Michael J. Carr, Marian Kollarik, Sonya N. Meeker and Bradley J. Undem
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1275-1279; DOI: https://doi.org/10.1124/jpet.102.043422

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Small Molecule Antagonists of Complement Receptor Type 3 Block Adhesion and Adhesion-Dependent Oxidative Burst in Human Polymorphonuclear Leukocytes
    Vinay S. Bansal, Sanskruti Vaidya, Elizabeth P. Somers, Mansi Kanuga, Diane Shevell, Renee Weikel and Patricia A. Detmers
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1016-1024; DOI: https://doi.org/10.1124/jpet.102.045286
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    Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist
    Maureen Mullarkey, Jeffrey R. Rose, John Bristol, Tsutomu Kawata, Akufumi Kimura, Seiichi Kobayashi, Melinda Przetak, Jesse Chow, Fabian Gusovsky, William J. Christ and Daniel P. Rossignol
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1093-1102; DOI: https://doi.org/10.1124/jpet.102.044487
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    Modulatory Effect of Bolinaquinone, a Marine Sesquiterpenoid, on Acute and Chronic Inflammatory Processes
    Rut Lucas, Clelia Giannini, Maria Valeria D'auria and Miguel Payá
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1172-1180; DOI: https://doi.org/10.1124/jpet.102.045278
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    Pharmacological Assessment of the Nitric-Oxide Synthase Isoform Involved in Eosinophilic Inflammation in a Rat Model of Sephadex-Induced Airway Inflammation
    Mark A. Birrell, Kerryn McCluskie, El-Bdaoui Haddad, Cliff H. Battram, Stephen E. Webber, Martyn L. Foster, Magdi H. Yacoub and Maria G. Belvisi
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1285-1291; DOI: https://doi.org/10.1124/jpet.102.044339

NEUROPHARMACOLOGY

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    5-Hydroxytryptamine 1A Receptor Activation Protects againstN-Methyl-d-aspartate-Induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures
    Lalitha Madhavan, William J. Freed, Vellareddy Anantharam and Anumantha G. Kanthasamy
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 913-923; DOI: https://doi.org/10.1124/jpet.102.044370
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    Serine 329 of the μ-Opioid Receptor Interacts Differently with Agonists
    Joost Pil and Jan Tytgat
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 924-930; DOI: https://doi.org/10.1124/jpet.102.040113
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    Short-Term Exposure to Melatonin Differentially Affects the Functional Sensitivity and Trafficking of the hMT1 and hMT2 Melatonin Receptors
    M. J. Gerdin, M. I. Masana, D. Ren, R. J. Miller and M. L. Dubocovich
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 931-939; DOI: https://doi.org/10.1124/jpet.102.044990
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    Novel Expression of Vanilloid Receptor 1 on Capsaicin-Insensitive Fibers Accounts for the Analgesic Effect of Capsaicin Cream in Neuropathic Pain
    Md Harunor Rashid, Makoto Inoue, Saori Kondo, Toshiko Kawashima, Shiho Bakoshi and Hiroshi Ueda
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 940-948; DOI: https://doi.org/10.1124/jpet.102.046250
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    Fluoxetine Increases GABAA Receptor Activity through a Novel Modulatory Site
    Richard T. Robinson, Brandon C. Drafts and Janet L. Fisher
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 978-984; DOI: https://doi.org/10.1124/jpet.102.044834
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    Antinociceptive Synergy between Δ9-Tetrahydrocannabinol and Opioids after Oral Administration
    Diana L. Cichewicz and Erin A. McCarthy
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1010-1015; DOI: https://doi.org/10.1124/jpet.102.045575
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    3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e), a Novel Calmodulin Antagonist, Reduces Brain Edema through the Inhibition of Enhanced Blood-Brain Barrier Permeability after Transient Focal Ischemia
    Toshiyuki Sato, Yoshiyuki Morishima and Yasufumi Shirasaki
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1042-1047; DOI: https://doi.org/10.1124/jpet.102.045039
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    Methylphenidate Alters Vesicular Monoamine Transport and Prevents Methamphetamine-Induced Dopaminergic Deficits
    Verónica Sandoval, Evan L. Riddle, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1181-1187; DOI: https://doi.org/10.1124/jpet.102.045005
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    Selective Depression by General Anesthetics of Glutamate Versus GABA Release from Isolated Cortical Nerve Terminals
    Robert I. Westphalen and Hugh C. Hemmings
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1188-1196; DOI: https://doi.org/10.1124/jpet.102.044685
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    Neuroendocrine Evidence That (S)-2-(Chloro-5-fluoro-indol- l-yl)-1-methylethylamine Fumarate (Ro 60-0175) Is Not a Selective 5-Hydroxytryptamine2C Receptor Agonist
    K. J. Damjanoska, N. A. Muma, Y. Zhang, D. N. D'Souza, F. Garcia, G. A. Carrasco, G. H. Kindel, K. A. Haskins, M. Shankaran, B. R. Petersen and L. D. Van De Kar
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1209-1216; DOI: https://doi.org/10.1124/jpet.102.043489
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    Dose-Dependent EEG Effects of Zolpidem Provide Evidence for GABAA Receptor Subtype Selectivity in Vivo
    S. A. G. Visser, F. L. C. Wolters, P. H. van der Graaf, L. A. Peletier and M. Danhof
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1251-1257; DOI: https://doi.org/10.1124/jpet.102.044859

TOXICOLOGY

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    Evidence for Interactions between Intracellular Calcium Stores during Methylmercury-Induced Intracellular Calcium Dysregulation in Rat Cerebellar Granule Neurons
    Tobi L. Limke, James K. L. Otero-Montañez and William D. Atchison
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 949-958; DOI: https://doi.org/10.1124/jpet.102.042457
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    Delayed Neurologic and Behavioral Effects of Subtoxic Doses of Cholinesterase Inhibitors
    Oscar U. Scremin, Tsung-Ming Shih, Ly Huynh, Margareth Roch, Ruth Booth and Donald J. Jenden
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1111-1119; DOI: https://doi.org/10.1124/jpet.102.044818
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    Adenosine A1 Receptor AgonistN 6-Cyclopentyladenosine Affects the Inactivation of Acetylcholinesterase in Blood and Brain by Sarin
    Tjerk J. H. Bueters, Marloes J. A. Joosen, Herman P. M. van Helden, Ad P. IJzerman and Meindert Danhof
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1307-1313; DOI: https://doi.org/10.1124/jpet.102.044644

Erratum

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    Correction to “Influence of Ovarian Sex Steroids on Spinal Methionine-Enkephalin Release: Comparison with Dynorphin Reveals Asymmetrical Regulation”
    Journal of Pharmacology and Experimental Therapeutics March 2003, 304 (3) 1341;
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Journal of Pharmacology and Experimental Therapeutics: 304 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 304, Issue 3
1 Mar 2003
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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