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Research ArticleCARDIOVASCULAR

Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates

Claudia K. Derian, Bruce P. Damiano, Michael F. Addo, Andrew L. Darrow, Michael R. D'Andrea, Mark Nedelman, Han-Cheng Zhang, Bruce E. Maryanoff and Patricia Andrade-Gordon
Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 855-861; DOI: https://doi.org/10.1124/jpet.102.042663
Claudia K. Derian
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Bruce P. Damiano
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Michael F. Addo
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Andrew L. Darrow
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Michael R. D'Andrea
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Mark Nedelman
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Han-Cheng Zhang
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Bruce E. Maryanoff
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Patricia Andrade-Gordon
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Article Information

vol. 304 no. 2 855-861
DOI 
https://doi.org/10.1124/jpet.102.042663
PubMed 
12538843

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 12, 2002
  • Accepted October 24, 2002
  • Published online February 1, 2003.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Claudia K. Derian1,
  2. Bruce P. Damiano1,
  3. Michael F. Addo1,
  4. Andrew L. Darrow1,
  5. Michael R. D'Andrea1,
  6. Mark Nedelman2,
  7. Han-Cheng Zhang1,
  8. Bruce E. Maryanoff1 and
  9. Patricia Andrade-Gordon1
  1. 1Johnson & Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania (C.K.D., B.P.D., M.F.A., A.L.D., M.R.D., H.-C.Z., B.E.M., P.A.-G.); and 2Charles River Laboratories, Worcester, Massachusetts (M.N.)
  1. Dr. Patricia Andrade-Gordon, Vice President, Drug Discovery, Johnson Johnson Pharmaceutical Research and Development, Welsh and McKean Rds., P.O. Box 776, Spring House, PA 19477. E-mail: pandrade{at}prdus.jnj.com
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Journal of Pharmacology and Experimental Therapeutics: 304 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 304, Issue 2
1 Feb 2003
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Research ArticleCARDIOVASCULAR

Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates

Claudia K. Derian, Bruce P. Damiano, Michael F. Addo, Andrew L. Darrow, Michael R. D'Andrea, Mark Nedelman, Han-Cheng Zhang, Bruce E. Maryanoff and Patricia Andrade-Gordon
Journal of Pharmacology and Experimental Therapeutics February 1, 2003, 304 (2) 855-861; DOI: https://doi.org/10.1124/jpet.102.042663

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Research ArticleCARDIOVASCULAR

Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates

Claudia K. Derian, Bruce P. Damiano, Michael F. Addo, Andrew L. Darrow, Michael R. D'Andrea, Mark Nedelman, Han-Cheng Zhang, Bruce E. Maryanoff and Patricia Andrade-Gordon
Journal of Pharmacology and Experimental Therapeutics February 1, 2003, 304 (2) 855-861; DOI: https://doi.org/10.1124/jpet.102.042663
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