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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

Yoshihisa Shitara, Tomoo Itoh, Hitoshi Sato, Albert P. Li and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 610-616; DOI: https://doi.org/10.1124/jpet.102.041921

Article Information

vol. 304 no. 2 610-616
DOI 
https://doi.org/10.1124/jpet.102.041921
PubMed 
12538813
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 23, 2002
  • Accepted October 28, 2002
  • Published online February 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshihisa Shitara1,2,
  2. Tomoo Itoh3,
  3. Hitoshi Sato4,
  4. Albert P. Li2,5 and
  5. Yuichi Sugiyama
  1. 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (Y.Sh., Y.Su.); 2Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Saitama, Japan (Y.Sh., Y.Su.); 3School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan (T.I.); 4Faculty of Pharmaceutical Sciences, Showa University, Tokyo, Japan (H.S.); and 5In Vitro Technologies, Inc., Baltimore, Maryland (A.P.L.)
  1. Dr. Yuichi Sugiyama, Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

Yoshihisa Shitara, Tomoo Itoh, Hitoshi Sato, Albert P. Li and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics February 1, 2003, 304 (2) 610-616; DOI: https://doi.org/10.1124/jpet.102.041921
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