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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Pharmacokinetics and Pharmacodynamics of Entacapone and Tolcapone after Acute and Repeated Administration: A Comparative Study in the Rat

Markus Forsberg, Marko Lehtonen, Minna Heikkinen, Jouko Savolainen, Tomi Järvinen and Pekka T. Männistö
Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 498-506; DOI: https://doi.org/10.1124/jpet.102.042846

Article Information

vol. 304 no. 2 498-506
DOI 
https://doi.org/10.1124/jpet.102.042846
PubMed 
12538800
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 6, 2002
  • Accepted October 4, 2002
  • Published online February 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Markus Forsberg1,
  2. Marko Lehtonen2,
  3. Minna Heikkinen1,1,
  4. Jouko Savolainen2,
  5. Tomi Järvinen2 and
  6. Pekka T. Männistö1
  1. Departments of 1Pharmacology and Toxicology (M.F., M.H., P.T.M.) and 2Pharmaceutical Chemistry (M.L., J.S., T.J.), University of Kuopio, Kuopio, Finland
  1. Markus Forsberg, Department of Pharmacology and Toxicology, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland. E-mail:Markus.Forsberg{at}uku.fi
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Pharmacokinetics and Pharmacodynamics of Entacapone and Tolcapone after Acute and Repeated Administration: A Comparative Study in the Rat

Markus Forsberg, Marko Lehtonen, Minna Heikkinen, Jouko Savolainen, Tomi Järvinen and Pekka T. Männistö
Journal of Pharmacology and Experimental Therapeutics February 1, 2003, 304 (2) 498-506; DOI: https://doi.org/10.1124/jpet.102.042846
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