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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2003; Volume 304,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Experimental Therapeutics in the Renaissance
    Stata Norton
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 489-492; DOI: https://doi.org/10.1124/jpet.102.042291
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    Proteolytic Degradation of Nitric Oxide Synthase: Effect of Inhibitors and Role of hsp90-Based Chaperones
    Yoichi Osawa, Ezra R. Lowe, Andrew C. Everett, Anwar Y. Dunbar and Scott S. Billecke
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 493-497; DOI: https://doi.org/10.1124/jpet.102.035055

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Pharmacokinetics and Pharmacodynamics of Entacapone and Tolcapone after Acute and Repeated Administration: A Comparative Study in the Rat
    Markus Forsberg, Marko Lehtonen, Minna Heikkinen, Jouko Savolainen, Tomi Järvinen and Pekka T. Männistö
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 498-506; DOI: https://doi.org/10.1124/jpet.102.042846
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    Assessing Safety and Efficacy of Directed P-Glycoprotein Inhibition to Improve the Pharmacokinetic Properties of Saquinavir Coadministered with Ritonavir
    Maarten T. Huisman, Johan W. Smit, Hugh R. Wiltshire, Jos H. Beijnen and Alfred H. Schinkel
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 596-602; DOI: https://doi.org/10.1124/jpet.102.044388
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    Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A
    Yoshihisa Shitara, Tomoo Itoh, Hitoshi Sato, Albert P. Li and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 610-616; DOI: https://doi.org/10.1124/jpet.102.041921
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    Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)
    Elaine M. Leslie, Raymond J. Bowers, Roger G. Deeley and Susan P. C. Cole
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 643-653; DOI: https://doi.org/10.1124/jpet.102.044073
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    Regulation of CYP3A5 by Glucocorticoids and Cigarette Smoke in Human Lung-Derived Cells
    Janne Hukkanen, Teemu Väisänen, Arja Lassila, Ritva Piipari, Sisko Anttila, Olavi Pelkonen, Hannu Raunio and Jukka Hakkola
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 745-752; DOI: https://doi.org/10.1124/jpet.102.038208
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    Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling
    Seong Hoon Jang, M. Guillaume Wientjes and Jessie L.-S. Au
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 773-780; DOI: https://doi.org/10.1124/jpet.102.044172
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    Interactions of the Dipeptide Ester Prodrugs of Acyclovir with the Intestinal Oligopeptide Transporter: Competitive Inhibition of Glycylsarcosine Transport in Human Intestinal Cell Line-Caco-2
    Banmeet S. Anand, Jignesh Patel and Ashim K. Mitra
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 781-791; DOI: https://doi.org/10.1124/jpet.102.044313
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    Pharmacokinetics of 5 (and 6)-Carboxy-2′,7′-Dichlorofluorescein and Its Diacetate Promoiety in the Liver
    Maciej J. Zamek-Gliszczynski, Hao Xiong, Nita J. Patel, Ryan Z. Turncliff, Gary M. Pollack and Kim L. R. Brouwer
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 801-809; DOI: https://doi.org/10.1124/jpet.102.044107

BEHAVIORAL PHARMACOLOGY

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    Changes in Urination/Defecation, Auditory Startle Response, and Startle-Induced Ultrasonic Vocalizations in Rats Undergoing Morphine Withdrawal: Similarities and Differences between Acute and Chronic Dependence
    Mikhail Kalinichev and Stephen G. Holtzman
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 603-609; DOI: https://doi.org/10.1124/jpet.102.044206
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    The Corticotropin-Releasing Factor1 Receptor Antagonist R121919 Attenuates the Behavioral and Endocrine Responses to Stress
    David A. Gutman, Michael J. Owens, Kelly H. Skelton, K. V. Thrivikraman and Charles B. Nemeroff
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 874-880; DOI: https://doi.org/10.1124/jpet.102.042788

CARDIOVASCULAR

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    Contributions of Nitric Oxide and Prostanoids and Their Signaling Pathways to the Renal Medullary Vasodilator Effect of U46619 (9-11-Dideoxy-11α,9a-Epoxymethano-Prostaglandin F2a) in the Rat
    Adebayo O. Oyekan
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 507-512; DOI: https://doi.org/10.1124/jpet.102.040170
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    Antithrombotic Properties of SSR182289A, a New, Orally Active Thrombin Inhibitor
    J. Lorrain, L. Millet, I. Lechaire, S. Lochot, P. Ferrari, C. Visconte, M. Sainte-Marie, C. Lunven, C. N. Berry, P. Schaeffer, J.-M. Herbert and S. E. O'Connor
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 567-574; DOI: https://doi.org/10.1124/jpet.102.044610
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    Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial Infarction
    Hongkui Jin, Renhui Yang, Wei Li, Annie K. Ogasawara, Ralph Schwall, David A. Eberhard, Zhong Zheng, David Kahn and Nicholas F. Paoni
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 654-660; DOI: https://doi.org/10.1124/jpet.102.041772
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    Papaverine Blocks hKv1.5 Channel Current and Human Atrial Ultrarapid Delayed Rectifier K+ Currents
    Han Choe, Yu-Kyung Lee, Yong-Tae Lee, Huhn Choe, Seong-Hoon Ko, Chan-Uhng Joo, Min-Ho Kim, Gong-Soo Kim, Jae-Soon Eun, Jong-Hyun Kim, Soo-Wan Chae and Yong-Geun Kwak
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 706-712; DOI: https://doi.org/10.1124/jpet.102.042770
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    Norepinephrine-Induced Stimulation of p38 Mitogen-Activated Protein Kinase Is Mediated by Arachidonic Acid Metabolites Generated by Activation of Cytosolic Phospholipase A2 in Vascular Smooth Muscle Cells
    Shailaja Kalyankrishna and Kafait U. Malik
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 761-772; DOI: https://doi.org/10.1124/jpet.102.040949
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    A Novel Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppressed Intimal Hyperplasia after Balloon Injury
    Shinji Takai, Hiroshi Sakonjo, Kohzo Fukuda, Denan Jin, Masato Sakaguchi, Keiichi Kamoshita, Koichi Ishida, Yoshikazu Sukenaga and Mizuo Miyazaki
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 841-844; DOI: https://doi.org/10.1124/jpet.102.042580
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    Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates
    Claudia K. Derian, Bruce P. Damiano, Michael F. Addo, Andrew L. Darrow, Michael R. D'Andrea, Mark Nedelman, Han-Cheng Zhang, Bruce E. Maryanoff and Patricia Andrade-Gordon
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 855-861; DOI: https://doi.org/10.1124/jpet.102.042663
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    Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization
    Ignacio Moreno, Ricardo Caballero, Teresa González, Cristina Arias, Carmen Valenzuela, Isabel Iriepa, Enrique Gálvez, Juan Tamargo and Eva Delpón
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 862-873; DOI: https://doi.org/10.1124/jpet.102.042325

CELLULAR AND MOLECULAR

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    Chronic Nicotine Treatment Leads to Sustained Stimulation of Tyrosine Hydroxylase Gene Transcription Rate in Rat Adrenal Medulla
    Baoyong Sun, Carol R. Sterling and A. William Tank
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 575-588; DOI: https://doi.org/10.1124/jpet.102.043596
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    The Effect of O 6-Alkylguanine-DNA Alkyltransferase and Mismatch Repair Activities on the Sensitivity of Human Melanoma Cells to Temozolomide, 1,3-bis(2-Chloroethyl)1-nitrosourea, and Cisplatin
    Rita Pepponi, Giancarlo Marra, Maria Pia Fuggetta, Sabrina Falcinelli, Elena Pagani, Enzo Bonmassar, Josef Jiricny and Stefania D'Atri
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 661-668; DOI: https://doi.org/10.1124/jpet.102.043950
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    Role of Phospholipase C-β in the Modulation of Epithelial Tight Junction Permeability
    Peter D. Ward, Hui Ouyang and Dhiren R. Thakker
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 689-698; DOI: https://doi.org/10.1124/jpet.102.043638
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    Amifostine Inhibits Angiogenesis in Vivo
    Efstathia Giannopoulou, Panagiotis Katsoris, Dimitris Kardamakis and Evangelia Papadimitriou
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 729-737; DOI: https://doi.org/10.1124/jpet.102.042838
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    Inhibition of Nucleoside Transport by Protein Kinase Inhibitors
    Min Huang, Yanhong Wang, Susan B. Cogut, Beverly S. Mitchell and Lee M. Graves
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 753-760; DOI: https://doi.org/10.1124/jpet.102.044214
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    Agmatine Is Efficiently Transported by Non-Neuronal Monoamine Transporters Extraneuronal Monoamine Transporter (EMT) and Organic Cation Transporter 2 (OCT2)
    Dirk Gründemann, Christian Hahne, Reinhard Berkels and Edgar Schömig
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 810-817; DOI: https://doi.org/10.1124/jpet.102.044404
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    Inhibition of Histone Deacetylases by Chlamydocin Induces Apoptosis and Proteasome-Mediated Degradation of Survivin
    Stefanie De Schepper, Hélène Bruwiere, Tinne Verhulst, Ulf Steller, Luc Andries, Walter Wouters, Michel Janicot, Janine Arts and Jim Van heusden
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 881-888; DOI: https://doi.org/10.1124/jpet.102.042903

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Optimizing the Dosing Schedule of TNP-470 [O-(Chloroacetyl-carbamoyl) Fumagillol] Enhances Its Antitumor and Antiangiogenic Efficacies
    Satoru Koyanagi, Hiroo Nakagawa, Yukako Kuramoto, Shigehiro Ohdo, Shinji Soeda and Hiroshi Shimeno
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 669-674; DOI: https://doi.org/10.1124/jpet.102.043562
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    p53-Mediated Regulation of Expression of a Rabbit Liver Carboxylesterase Confers Sensitivity to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
    Monika Wierdl, Christopher L. Morton, Linda C. Harris, Mary K. Danks, John D. Schuetz and Philip M. Potter
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 699-705; DOI: https://doi.org/10.1124/jpet.102.044149
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    The Effect of Endotoxin and Dexamethasone on Enrofloxacin Pharmacokinetic Parameters in Swine
    Lynn O. Post, Dorothy E. Farrell, Carol V. Cope, John D. Baker and Michael J. Myers
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 889-895; DOI: https://doi.org/10.1124/jpet.102.042416

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver
    Monika Hitzl, Kathrin Klein, Ulrich M. Zanger, Peter Fritz, Andreas K. Nüssler, Peter Neuhaus and Martin F. Fromm
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 524-530; DOI: https://doi.org/10.1124/jpet.102.043547
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    Interaction of Cysteine Conjugates with Human and Rabbit Organic Anion Transporter 1
    Carlotta E. Groves, Lynn Muñoz, Andrew Bahn, Gerhard Burckhardt and Stephen H. Wright
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 560-566; DOI: https://doi.org/10.1124/jpet.102.043455
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    M1 Receptor-Mediated Nitric Oxide-Dependent Relaxation Unmasked in Stomach Fundus from M3 Receptor Knockout Mice
    Peter W. Stengel and Marlene L. Cohen
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 675-682; DOI: https://doi.org/10.1124/jpet.102.042283
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    Inhibition of Rho-Kinase Reduces Renal Na-H Exchanger Activity and Causes Natriuresis in Rat
    Kenta Nishiki, Shuichi Tsuruoka, Atsuhiro Kawaguchi, Kohichi Sugimoto, George J. Schwartz, Makoto Suzuki, Masashi Imai and Akio Fujimura
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 723-728; DOI: https://doi.org/10.1124/jpet.102.041871
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    The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle
    Tong Wang
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 833-840; DOI: https://doi.org/10.1124/jpet.102.043380

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Inhibition of Prostaglandin H2 Synthases by Salicylate Is Dependent on the Oxidative State of the Enzymes
    David M. Aronoff, Olivier Boutaud, Lawrence J. Marnett and John A. Oates
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 589-595; DOI: https://doi.org/10.1124/jpet.102.042853
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    Histamine Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production in an Intercellular Adhesion Molecule-1- and B7.1-Dependent Manner
    Toshihiko Morichika, Hideo Kohka Takahashi, Hiromi Iwagaki, Tadashi Yoshino, Ryuji Tamura, Minori Yokoyama, Shuji Mori, Tadaatsu Akagi, Masahiro Nishibori and Noriaki Tanaka
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 624-633; DOI: https://doi.org/10.1124/jpet.102.042515
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    Effect of β2-Adrenergic Receptor Stimulation on Interleukin-18-Induced Intercellular Adhesion Molecule-1 Expression and Cytokine Production
    Hideo Kohka Takahashi, Toshihiko Morichika, Hiromi Iwagaki, Tadashi Yoshino, Ryuji Tamura, Shinnya Saito, Shuji Mori, Tadaatsu Akagi, Noriaki Tanaka and Masahiro Nishibori
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 634-642; DOI: https://doi.org/10.1124/jpet.102.042622
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    Endocannabinoids Induce Ileitis in Rats via the Capsaicin Receptor (VR1)
    Douglas C. McVey, Patricia C. Schmid, Harald H. O. Schmid and Steven R. Vigna
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 713-722; DOI: https://doi.org/10.1124/jpet.102.043893

NEUROPHARMACOLOGY

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    Persistent Effects of Delayed Treatment with Nefiracetam on the Water Maze Task in Rats with Sustained Cerebral Ischemia
    Satoshi Takeo, Tomoko Fukatsu, Keiko Miyake-Takagi, Norio Takagi, Makiko Niimura, Akira Nagakura, Tsuyoshi Ando and Kouichi Tanonaka
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 513-523; DOI: https://doi.org/10.1124/jpet.102.043653
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    Kv1.1 Channels of Dorsal Root Ganglion Neurons Are Inhibited byn-Butyl-p-aminobenzoate, a Promising Anesthetic for the Treatment of Chronic Pain
    J. P. Beekwilder, M. E. O'Leary, L. P. van den Broek, G. Th. H. Van Kempen, D. L. Ypey and R. J. Van den Berg
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 531-538; DOI: https://doi.org/10.1124/jpet.102.042135
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    The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine
    Ai-Ming Yu, Camille P. Granvil, Robert L. Haining, Kristopher W. Krausz, Javier Corchero, Adrian Küpfer, Jeffrey R. Idle and Frank J. Gonzalez
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 539-546; DOI: https://doi.org/10.1124/jpet.102.043786
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    The Heritability of Antinociception: Common Pharmacogenetic Mediation of Five Neurochemically Distinct Analgesics
    Sonya G. Wilson, Shad B. Smith, Elissa J. Chesler, Kimberly A. Melton, Jeremiah J. Haas, Bryan Mitton, Kate Strasburg, Lawrence Hubert, Sandra L. Rodriguez-Zas and Jeffrey S. Mogil
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 547-559; DOI: https://doi.org/10.1124/jpet.102.041889
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    Neuroprotective Effects ofl -Arginine Administration after Cortical Impact Injury in Rats: Dose Response and Time Window
    Leela Cherian, Geeta Chacko, Clay Goodman and Claudia S. Robertson
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 617-623; DOI: https://doi.org/10.1124/jpet.102.043430
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    (2S,3R)β-Methyl-2′,6′-dimethyltyrosine-l-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-l-Tic-OH] Is a Potent, Selective δ-Opioid Receptor Antagonist in Mouse Brain
    Keiko Hosohata, Eva V. Varga, Josue Alfaro-Lopez, Xuejun Tang, Todd W. Vanderah, Frank Porreca, Victor J. Hruby, William R. Roeske and Henry I. Yamamura
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 683-688; DOI: https://doi.org/10.1124/jpet.102.042929
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    Influence of Ovarian Sex Steroids on Spinal Methionine-Enkephalin Release: Comparison with Dynorphin Reveals Asymmetrical Regulation
    Daya S. Gupta and Alan R. Gintzler
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 738-744; DOI: https://doi.org/10.1124/jpet.102.042689
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    Levodopa Is Toxic to Dopamine Neurons in an in Vitro but Not an in Vivo Model of Oxidative Stress
    Catherine Mytilineou, Ruth H. Walker, Ruth JnoBaptiste and C. Warren Olanow
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 792-800; DOI: https://doi.org/10.1124/jpet.102.042267
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    Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor
    Shigeyuki Chaki, Shiho Hirota, Takeo Funakoshi, Yoshiko Suzuki, Sayoko Suetake, Taketoshi Okubo, Takaaki Ishii, Atsuro Nakazato and Shigeru Okuyama
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 818-826; DOI: https://doi.org/10.1124/jpet.102.044826
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    Systemic and Spinal Analgesic Activity of a δ-Opioid-Selective Lanthionine Enkephalin Analog
    Camilla I. Svensson, Yosup Rew, Shelle Malkmus, Peter W. Schiller, Joseph P. Taulane, Murray Goodman and Tony L. Yaksh
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 827-832; DOI: https://doi.org/10.1124/jpet.102.039750
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    Optimal Structure Requirements for Pluronic Block Copolymers in Modifying P-glycoprotein Drug Efflux Transporter Activity in Bovine Brain Microvessel Endothelial Cells
    Elena V. Batrakova, Shu Li, Valery Yu Alakhov, Donald W. Miller and Alexander V. Kabanov
    Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 845-854; DOI: https://doi.org/10.1124/jpet.102.043307
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Journal of Pharmacology and Experimental Therapeutics: 304 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 304, Issue 2
1 Feb 2003
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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