Journal of Pharmacology and Experimental Therapeutics: 304 (2)

February 01, 2003; Volume 304,Issue 2

PERSPECTIVES IN PHARMACOLOGY

You have access
Experimental Therapeutics in the Renaissance
Stata Norton

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 489-492; DOI: https://doi.org/10.1124/jpet.102.042291
You have access
Proteolytic Degradation of Nitric Oxide Synthase: Effect of Inhibitors and Role of hsp90-Based Chaperones
Yoichi Osawa, Ezra R. Lowe, Andrew C. Everett, Anwar Y. Dunbar and Scott S. Billecke

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 493-497; DOI: https://doi.org/10.1124/jpet.102.035055

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

You have access
Pharmacokinetics and Pharmacodynamics of Entacapone and Tolcapone after Acute and Repeated Administration: A Comparative Study in the Rat
Markus Forsberg, Marko Lehtonen, Minna Heikkinen, Jouko Savolainen, Tomi Järvinen and Pekka T. Männistö

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 498-506; DOI: https://doi.org/10.1124/jpet.102.042846
You have access
Assessing Safety and Efficacy of Directed P-Glycoprotein Inhibition to Improve the Pharmacokinetic Properties of Saquinavir Coadministered with Ritonavir
Maarten T. Huisman, Johan W. Smit, Hugh R. Wiltshire, Jos H. Beijnen and Alfred H. Schinkel

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 596-602; DOI: https://doi.org/10.1124/jpet.102.044388
You have access
Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A
Yoshihisa Shitara, Tomoo Itoh, Hitoshi Sato, Albert P. Li and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 610-616; DOI: https://doi.org/10.1124/jpet.102.041921
You have access
Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)
Elaine M. Leslie, Raymond J. Bowers, Roger G. Deeley and Susan P. C. Cole

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 643-653; DOI: https://doi.org/10.1124/jpet.102.044073
You have access
Regulation of CYP3A5 by Glucocorticoids and Cigarette Smoke in Human Lung-Derived Cells
Janne Hukkanen, Teemu Väisänen, Arja Lassila, Ritva Piipari, Sisko Anttila, Olavi Pelkonen, Hannu Raunio and Jukka Hakkola

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 745-752; DOI: https://doi.org/10.1124/jpet.102.038208
You have access
Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling
Seong Hoon Jang, M. Guillaume Wientjes and Jessie L.-S. Au

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 773-780; DOI: https://doi.org/10.1124/jpet.102.044172
You have access
Interactions of the Dipeptide Ester Prodrugs of Acyclovir with the Intestinal Oligopeptide Transporter: Competitive Inhibition of Glycylsarcosine Transport in Human Intestinal Cell Line-Caco-2
Banmeet S. Anand, Jignesh Patel and Ashim K. Mitra

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 781-791; DOI: https://doi.org/10.1124/jpet.102.044313
You have access
Pharmacokinetics of 5 (and 6)-Carboxy-2′,7′-Dichlorofluorescein and Its Diacetate Promoiety in the Liver
Maciej J. Zamek-Gliszczynski, Hao Xiong, Nita J. Patel, Ryan Z. Turncliff, Gary M. Pollack and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 801-809; DOI: https://doi.org/10.1124/jpet.102.044107

BEHAVIORAL PHARMACOLOGY

You have access
Changes in Urination/Defecation, Auditory Startle Response, and Startle-Induced Ultrasonic Vocalizations in Rats Undergoing Morphine Withdrawal: Similarities and Differences between Acute and Chronic Dependence
Mikhail Kalinichev and Stephen G. Holtzman

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 603-609; DOI: https://doi.org/10.1124/jpet.102.044206
You have access
The Corticotropin-Releasing Factor₁ Receptor Antagonist R121919 Attenuates the Behavioral and Endocrine Responses to Stress
David A. Gutman, Michael J. Owens, Kelly H. Skelton, K. V. Thrivikraman and Charles B. Nemeroff

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 874-880; DOI: https://doi.org/10.1124/jpet.102.042788

CARDIOVASCULAR

You have access
Contributions of Nitric Oxide and Prostanoids and Their Signaling Pathways to the Renal Medullary Vasodilator Effect of U46619 (9-11-Dideoxy-11α,9a-Epoxymethano-Prostaglandin F_2a) in the Rat
Adebayo O. Oyekan

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 507-512; DOI: https://doi.org/10.1124/jpet.102.040170
You have access
Antithrombotic Properties of SSR182289A, a New, Orally Active Thrombin Inhibitor
J. Lorrain, L. Millet, I. Lechaire, S. Lochot, P. Ferrari, C. Visconte, M. Sainte-Marie, C. Lunven, C. N. Berry, P. Schaeffer, J.-M. Herbert and S. E. O'Connor

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 567-574; DOI: https://doi.org/10.1124/jpet.102.044610
You have access
Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial Infarction
Hongkui Jin, Renhui Yang, Wei Li, Annie K. Ogasawara, Ralph Schwall, David A. Eberhard, Zhong Zheng, David Kahn and Nicholas F. Paoni

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 654-660; DOI: https://doi.org/10.1124/jpet.102.041772
You have access
Papaverine Blocks hKv1.5 Channel Current and Human Atrial Ultrarapid Delayed Rectifier K⁺ Currents
Han Choe, Yu-Kyung Lee, Yong-Tae Lee, Huhn Choe, Seong-Hoon Ko, Chan-Uhng Joo, Min-Ho Kim, Gong-Soo Kim, Jae-Soon Eun, Jong-Hyun Kim, Soo-Wan Chae and Yong-Geun Kwak

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 706-712; DOI: https://doi.org/10.1124/jpet.102.042770
You have access
Norepinephrine-Induced Stimulation of p38 Mitogen-Activated Protein Kinase Is Mediated by Arachidonic Acid Metabolites Generated by Activation of Cytosolic Phospholipase A₂ in Vascular Smooth Muscle Cells
Shailaja Kalyankrishna and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 761-772; DOI: https://doi.org/10.1124/jpet.102.040949
You have access
A Novel Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppressed Intimal Hyperplasia after Balloon Injury
Shinji Takai, Hiroshi Sakonjo, Kohzo Fukuda, Denan Jin, Masato Sakaguchi, Keiichi Kamoshita, Koichi Ishida, Yoshikazu Sukenaga and Mizuo Miyazaki

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 841-844; DOI: https://doi.org/10.1124/jpet.102.042580
You have access
Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates
Claudia K. Derian, Bruce P. Damiano, Michael F. Addo, Andrew L. Darrow, Michael R. D'Andrea, Mark Nedelman, Han-Cheng Zhang, Bruce E. Maryanoff and Patricia Andrade-Gordon

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 855-861; DOI: https://doi.org/10.1124/jpet.102.042663
You have access
Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization
Ignacio Moreno, Ricardo Caballero, Teresa González, Cristina Arias, Carmen Valenzuela, Isabel Iriepa, Enrique Gálvez, Juan Tamargo and Eva Delpón

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 862-873; DOI: https://doi.org/10.1124/jpet.102.042325

CELLULAR AND MOLECULAR

You have access
Chronic Nicotine Treatment Leads to Sustained Stimulation of Tyrosine Hydroxylase Gene Transcription Rate in Rat Adrenal Medulla
Baoyong Sun, Carol R. Sterling and A. William Tank

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 575-588; DOI: https://doi.org/10.1124/jpet.102.043596
You have access
The Effect of O ⁶-Alkylguanine-DNA Alkyltransferase and Mismatch Repair Activities on the Sensitivity of Human Melanoma Cells to Temozolomide, 1,3-bis(2-Chloroethyl)1-nitrosourea, and Cisplatin
Rita Pepponi, Giancarlo Marra, Maria Pia Fuggetta, Sabrina Falcinelli, Elena Pagani, Enzo Bonmassar, Josef Jiricny and Stefania D'Atri

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 661-668; DOI: https://doi.org/10.1124/jpet.102.043950
You have access
Role of Phospholipase C-β in the Modulation of Epithelial Tight Junction Permeability
Peter D. Ward, Hui Ouyang and Dhiren R. Thakker

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 689-698; DOI: https://doi.org/10.1124/jpet.102.043638
You have access
Amifostine Inhibits Angiogenesis in Vivo
Efstathia Giannopoulou, Panagiotis Katsoris, Dimitris Kardamakis and Evangelia Papadimitriou

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 729-737; DOI: https://doi.org/10.1124/jpet.102.042838
You have access
Inhibition of Nucleoside Transport by Protein Kinase Inhibitors
Min Huang, Yanhong Wang, Susan B. Cogut, Beverly S. Mitchell and Lee M. Graves

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 753-760; DOI: https://doi.org/10.1124/jpet.102.044214
You have access
Agmatine Is Efficiently Transported by Non-Neuronal Monoamine Transporters Extraneuronal Monoamine Transporter (EMT) and Organic Cation Transporter 2 (OCT2)
Dirk Gründemann, Christian Hahne, Reinhard Berkels and Edgar Schömig

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 810-817; DOI: https://doi.org/10.1124/jpet.102.044404
You have access
Inhibition of Histone Deacetylases by Chlamydocin Induces Apoptosis and Proteasome-Mediated Degradation of Survivin
Stefanie De Schepper, Hélène Bruwiere, Tinne Verhulst, Ulf Steller, Luc Andries, Walter Wouters, Michel Janicot, Janine Arts and Jim Van heusden

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 881-888; DOI: https://doi.org/10.1124/jpet.102.042903

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

You have access
Optimizing the Dosing Schedule of TNP-470 [O-(Chloroacetyl-carbamoyl) Fumagillol] Enhances Its Antitumor and Antiangiogenic Efficacies
Satoru Koyanagi, Hiroo Nakagawa, Yukako Kuramoto, Shigehiro Ohdo, Shinji Soeda and Hiroshi Shimeno

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 669-674; DOI: https://doi.org/10.1124/jpet.102.043562
You have access
p53-Mediated Regulation of Expression of a Rabbit Liver Carboxylesterase Confers Sensitivity to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
Monika Wierdl, Christopher L. Morton, Linda C. Harris, Mary K. Danks, John D. Schuetz and Philip M. Potter

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 699-705; DOI: https://doi.org/10.1124/jpet.102.044149
You have access
The Effect of Endotoxin and Dexamethasone on Enrofloxacin Pharmacokinetic Parameters in Swine
Lynn O. Post, Dorothy E. Farrell, Carol V. Cope, John D. Baker and Michael J. Myers

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 889-895; DOI: https://doi.org/10.1124/jpet.102.042416

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

You have access
Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver
Monika Hitzl, Kathrin Klein, Ulrich M. Zanger, Peter Fritz, Andreas K. Nüssler, Peter Neuhaus and Martin F. Fromm

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 524-530; DOI: https://doi.org/10.1124/jpet.102.043547
You have access
Interaction of Cysteine Conjugates with Human and Rabbit Organic Anion Transporter 1
Carlotta E. Groves, Lynn Muñoz, Andrew Bahn, Gerhard Burckhardt and Stephen H. Wright

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 560-566; DOI: https://doi.org/10.1124/jpet.102.043455
You have access
M₁ Receptor-Mediated Nitric Oxide-Dependent Relaxation Unmasked in Stomach Fundus from M₃ Receptor Knockout Mice
Peter W. Stengel and Marlene L. Cohen

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 675-682; DOI: https://doi.org/10.1124/jpet.102.042283
You have access
Inhibition of Rho-Kinase Reduces Renal Na-H Exchanger Activity and Causes Natriuresis in Rat
Kenta Nishiki, Shuichi Tsuruoka, Atsuhiro Kawaguchi, Kohichi Sugimoto, George J. Schwartz, Makoto Suzuki, Masashi Imai and Akio Fujimura

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 723-728; DOI: https://doi.org/10.1124/jpet.102.041871
You have access
The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle
Tong Wang

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 833-840; DOI: https://doi.org/10.1124/jpet.102.043380

INFLAMMATION AND IMMUNOPHARMACOLOGY

You have access
Inhibition of Prostaglandin H₂ Synthases by Salicylate Is Dependent on the Oxidative State of the Enzymes
David M. Aronoff, Olivier Boutaud, Lawrence J. Marnett and John A. Oates

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 589-595; DOI: https://doi.org/10.1124/jpet.102.042853
You have access
Histamine Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production in an Intercellular Adhesion Molecule-1- and B7.1-Dependent Manner
Toshihiko Morichika, Hideo Kohka Takahashi, Hiromi Iwagaki, Tadashi Yoshino, Ryuji Tamura, Minori Yokoyama, Shuji Mori, Tadaatsu Akagi, Masahiro Nishibori and Noriaki Tanaka

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 624-633; DOI: https://doi.org/10.1124/jpet.102.042515
You have access
Effect of β2-Adrenergic Receptor Stimulation on Interleukin-18-Induced Intercellular Adhesion Molecule-1 Expression and Cytokine Production
Hideo Kohka Takahashi, Toshihiko Morichika, Hiromi Iwagaki, Tadashi Yoshino, Ryuji Tamura, Shinnya Saito, Shuji Mori, Tadaatsu Akagi, Noriaki Tanaka and Masahiro Nishibori

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 634-642; DOI: https://doi.org/10.1124/jpet.102.042622
You have access
Endocannabinoids Induce Ileitis in Rats via the Capsaicin Receptor (VR1)
Douglas C. McVey, Patricia C. Schmid, Harald H. O. Schmid and Steven R. Vigna

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 713-722; DOI: https://doi.org/10.1124/jpet.102.043893

NEUROPHARMACOLOGY

You have access
Persistent Effects of Delayed Treatment with Nefiracetam on the Water Maze Task in Rats with Sustained Cerebral Ischemia
Satoshi Takeo, Tomoko Fukatsu, Keiko Miyake-Takagi, Norio Takagi, Makiko Niimura, Akira Nagakura, Tsuyoshi Ando and Kouichi Tanonaka

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 513-523; DOI: https://doi.org/10.1124/jpet.102.043653
You have access
Kv1.1 Channels of Dorsal Root Ganglion Neurons Are Inhibited byn-Butyl-p-aminobenzoate, a Promising Anesthetic for the Treatment of Chronic Pain
J. P. Beekwilder, M. E. O'Leary, L. P. van den Broek, G. Th. H. Van Kempen, D. L. Ypey and R. J. Van den Berg

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 531-538; DOI: https://doi.org/10.1124/jpet.102.042135
You have access
The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine
Ai-Ming Yu, Camille P. Granvil, Robert L. Haining, Kristopher W. Krausz, Javier Corchero, Adrian Küpfer, Jeffrey R. Idle and Frank J. Gonzalez

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 539-546; DOI: https://doi.org/10.1124/jpet.102.043786
You have access
The Heritability of Antinociception: Common Pharmacogenetic Mediation of Five Neurochemically Distinct Analgesics
Sonya G. Wilson, Shad B. Smith, Elissa J. Chesler, Kimberly A. Melton, Jeremiah J. Haas, Bryan Mitton, Kate Strasburg, Lawrence Hubert, Sandra L. Rodriguez-Zas and Jeffrey S. Mogil

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 547-559; DOI: https://doi.org/10.1124/jpet.102.041889
You have access
Neuroprotective Effects ofl -Arginine Administration after Cortical Impact Injury in Rats: Dose Response and Time Window
Leela Cherian, Geeta Chacko, Clay Goodman and Claudia S. Robertson

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 617-623; DOI: https://doi.org/10.1124/jpet.102.043430
You have access
(2S,3R)β-Methyl-2′,6′-dimethyltyrosine-l-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-l-Tic-OH] Is a Potent, Selective δ-Opioid Receptor Antagonist in Mouse Brain
Keiko Hosohata, Eva V. Varga, Josue Alfaro-Lopez, Xuejun Tang, Todd W. Vanderah, Frank Porreca, Victor J. Hruby, William R. Roeske and Henry I. Yamamura

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 683-688; DOI: https://doi.org/10.1124/jpet.102.042929
You have access
Influence of Ovarian Sex Steroids on Spinal Methionine-Enkephalin Release: Comparison with Dynorphin Reveals Asymmetrical Regulation
Daya S. Gupta and Alan R. Gintzler

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 738-744; DOI: https://doi.org/10.1124/jpet.102.042689
You have access
Levodopa Is Toxic to Dopamine Neurons in an in Vitro but Not an in Vivo Model of Oxidative Stress
Catherine Mytilineou, Ruth H. Walker, Ruth JnoBaptiste and C. Warren Olanow

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 792-800; DOI: https://doi.org/10.1124/jpet.102.042267
You have access
Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor
Shigeyuki Chaki, Shiho Hirota, Takeo Funakoshi, Yoshiko Suzuki, Sayoko Suetake, Taketoshi Okubo, Takaaki Ishii, Atsuro Nakazato and Shigeru Okuyama

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 818-826; DOI: https://doi.org/10.1124/jpet.102.044826
You have access
Systemic and Spinal Analgesic Activity of a δ-Opioid-Selective Lanthionine Enkephalin Analog
Camilla I. Svensson, Yosup Rew, Shelle Malkmus, Peter W. Schiller, Joseph P. Taulane, Murray Goodman and Tony L. Yaksh

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 827-832; DOI: https://doi.org/10.1124/jpet.102.039750
You have access
Optimal Structure Requirements for Pluronic Block Copolymers in Modifying P-glycoprotein Drug Efflux Transporter Activity in Bovine Brain Microvessel Endothelial Cells
Elena V. Batrakova, Shu Li, Valery Yu Alakhov, Donald W. Miller and Alexander V. Kabanov

Journal of Pharmacology and Experimental Therapeutics February 2003, 304 (2) 845-854; DOI: https://doi.org/10.1124/jpet.102.043307

Main menu

User menu

Search

Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals