Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide
Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans and Thomas A. Baillie
Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 969-978; DOI: https://doi.org/10.1124/jpet.102.038992
Sanjeev Kumar
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey
Koppara Samuel
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey
Ramaswamy Subramanian
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey
Matthew P. Braun
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey
Ralph A. Stearns
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey
Shuet-Hing Lee Chiu
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey
David C. Evans
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey
Thomas A. Baillie
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey

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In this issue
Journal of Pharmacology and Experimental Therapeutics
Vol. 303, Issue 3
1 Dec 2002
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide
Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans and Thomas A. Baillie
Journal of Pharmacology and Experimental Therapeutics December 1, 2002, 303 (3) 969-978; DOI: https://doi.org/10.1124/jpet.102.038992
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide
Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans and Thomas A. Baillie
Journal of Pharmacology and Experimental Therapeutics December 1, 2002, 303 (3) 969-978; DOI: https://doi.org/10.1124/jpet.102.038992