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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide

Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans and Thomas A. Baillie
Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 969-978; DOI: https://doi.org/10.1124/jpet.102.038992
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide

Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans and Thomas A. Baillie
Journal of Pharmacology and Experimental Therapeutics December 1, 2002, 303 (3) 969-978; DOI: https://doi.org/10.1124/jpet.102.038992
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