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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster, Stephen A. Wring, Larry J. Shampine, Cosette J. Serabjit-Singh, Kimberly K. Adkison and Joseph W. Polli
Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1029-1037; DOI: https://doi.org/10.1124/jpet.102.039255
Kelly M. Mahar Doan
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Joan E. Humphreys
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Lindsey O. Webster
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Stephen A. Wring
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Larry J. Shampine
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Cosette J. Serabjit-Singh
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Kimberly K. Adkison
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Joseph W. Polli
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
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Article Information

vol. 303 no. 3 1029-1037
DOI 
https://doi.org/10.1124/jpet.102.039255
PubMed 
12438524

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 21, 2002
  • Accepted July 15, 2002
  • Published online December 1, 2002.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kelly M. Mahar Doan1,
  2. Joan E. Humphreys,
  3. Lindsey O. Webster,
  4. Stephen A. Wring,
  5. Larry J. Shampine,
  6. Cosette J. Serabjit-Singh,
  7. Kimberly K. Adkison, and
  8. Joseph W. Polli
  1. Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina
  1. Dr. Joseph W. Polli, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc., P.O. Box 13398, Room: MAI.A3666.3E, Research Triangle Park, NC 27709. E-mail: joseph.w.polli{at}gsk.com
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Journal of Pharmacology and Experimental Therapeutics: 303 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 303, Issue 3
1 Dec 2002
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster, Stephen A. Wring, Larry J. Shampine, Cosette J. Serabjit-Singh, Kimberly K. Adkison and Joseph W. Polli
Journal of Pharmacology and Experimental Therapeutics December 1, 2002, 303 (3) 1029-1037; DOI: https://doi.org/10.1124/jpet.102.039255

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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster, Stephen A. Wring, Larry J. Shampine, Cosette J. Serabjit-Singh, Kimberly K. Adkison and Joseph W. Polli
Journal of Pharmacology and Experimental Therapeutics December 1, 2002, 303 (3) 1029-1037; DOI: https://doi.org/10.1124/jpet.102.039255
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