Journal of Pharmacology and Experimental Therapeutics: 303 (3)

December 01, 2002; Volume 303,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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Predicting Drug Absorption: How Nature Made It a Difficult Problem
Philip S. Burton, Jay T. Goodwin, Thomas J. Vidmar and Benny M. Amore

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 889-895; DOI: https://doi.org/10.1124/jpet.102.035006

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Poly(ethylene glycol)-Coated Hexadecylcyanoacrylate Nanospheres Display a Combined Effect for Brain Tumor Targeting
Irène Brigger, Jackie Morizet, Geneviève Aubert, Hélène Chacun, Marie-José Terrier-Lacombe, Patrick Couvreur and Gilles Vassal

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 928-936; DOI: https://doi.org/10.1124/jpet.102.039669
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Differential Regulation of Expression of Hepatic and Pulmonary Cytochrome P4501A Enzymes by 3-Methylcholanthrene in Mice Lacking theCYP1A2 Gene
Sudha R. Kondraganti, Weiwu Jiang and Bhagavatula Moorthy

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 945-951; DOI: https://doi.org/10.1124/jpet.102.039982
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The Cation Transporters rOCT1 and rOCT2 Interact with Bicarbonate but Play Only a Minor Role for Amantadine Uptake into Rat Renal Proximal Tubules
Kerry B. Goralski, Ganlu Lou, Matthew T. Prowse, Valentin Gorboulev, Christopher Volk, Hermann Koepsell and Daniel S. Sitar

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 959-968; DOI: https://doi.org/10.1124/jpet.102.038885
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Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide
Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans and Thomas A. Baillie

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 969-978; DOI: https://doi.org/10.1124/jpet.102.038992
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Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs
Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster, Stephen A. Wring, Larry J. Shampine, Cosette J. Serabjit-Singh, Kimberly K. Adkison and Joseph W. Polli

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1029-1037; DOI: https://doi.org/10.1124/jpet.102.039255
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Expression, Purification, Biochemical Characterization, and Comparative Function of Human Cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 Allelic Isoforms
Aiming Yu, Byron M. Kneller, Allan E. Rettie and Robert L. Haining

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1291-1300; DOI: https://doi.org/10.1124/jpet.102.039891

BEHAVIORAL PHARMACOLOGY

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Cocaine Is Self-Administered into the Shell but Not the Core of the Nucleus Accumbens of Wistar Rats
Zachary A. Rodd-Henricks, David L. McKinzie, Ting-Kai Li, James M. Murphy and William J. McBride

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1216-1226; DOI: https://doi.org/10.1124/jpet.102.038950

CARDIOVASCULAR

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Proteinase-Activated Receptor-2 (PAR2): Vascular Effects of a PAR2-Derived Activating Peptide via a Receptor Different than PAR2
John J. McGuire, Jiazhen Dai, Patricia Andrade-Gordon, Chris R. Triggle and Morley D. Hollenberg

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 985-992; DOI: https://doi.org/10.1124/jpet.102.040352
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Nonpeptide Factor Xa Inhibitors III: Effects of DPC423, an Orally-Active Pyrazole Antithrombotic Agent, on Arterial Thrombosis in Rabbits
Pancras C. Wong, Earl J. Crain, Carol A. Watson, Alverna M. Zaspel, Matthew R. Wright, Patrick Y. Lam, Donald J. P. Pinto, Ruth R. Wexler and Robert M. Knabb

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 993-1000; DOI: https://doi.org/10.1124/jpet.102.040089
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C-Reactive-Protein-Associated Increase in Myocardial Infarct Size After Ischemia/Reperfusion
Terrance D. Barrett, James K. Hennan, Rory M. Marks and Benedict R. Lucchesi

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1007-1013; DOI: https://doi.org/10.1124/jpet.102.040600
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Very-Low-Dose Combination of the Angiotensin-Converting Enzyme Inhibitor Perindopril and the Diuretic Indapamide Induces an Early and Sustained Increase in Neovascularization in Rat Ischemic Legs
Jean-Sébastien Silvestre, Nyam Kamsu-Kom, Michel Clergue, Micheline Duriez and Bernard I. Lévy

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1038-1043; DOI: https://doi.org/10.1124/jpet.102.040014
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Comparative Analysis of Various Platelet Glycoprotein IIb/IIIa Antagonists on Shear-Induced Platelet Activation and Adhesion
Xinkang Wang, Robert T. Dorsam, Adam Lauver, Hugh Wang, Frank A. Barbera, Sandra Gibbs, David Varon, Naphtali Savion, Steven M. Friedman and Giora Z. Feuerstein

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1114-1120; DOI: https://doi.org/10.1124/jpet.102.038513
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Presynaptic Effects of Moxonidine in Isolated Buffer Perfused Rat Hearts: Role of Imidazoline-1 Receptors and α₂-Adrenoceptors
Ulrich Schäfer, Christof Burgdorf, Astrid Engelhardt, Thomas Kurz and Gert Richardt

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1163-1170; DOI: https://doi.org/10.1124/jpet.102.041657
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SSR182289A, a Novel, Orally Active Thrombin Inhibitor: In Vitro Profile and ex Vivo Anticoagulant Activity
Christopher N. Berry, Gilbert Lassalle, Catherine Lunven, Jean-Michel Altenburger, Frédérique Guilbert, Alain Lalé, Jean-Pascal Hérault, Catherine Lecoffre, Christian Pfersdorff, Jean-Marc Herbert and Stephen E. O'Connor

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1189-1198; DOI: https://doi.org/10.1124/jpet.102.040667
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Stimulated Tyrosine Phosphorylation of Phosphatidylinositol 3-Kinase Causes Acidic pH-Induced Contraction in Spontaneously Hypertensive Rat Aorta
Dileep Kumar Rohra, Tohru Yamakuni, Ken-Ichi Furukawa, Noe Ishii, Takashi Shinkawa, Toshiaki Isobe and Yasushi Ohizumi

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1255-1264; DOI: https://doi.org/10.1124/jpet.102.041475

CELLULAR AND MOLECULAR

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The Fibroblast Growth Factor Receptor Is at the Site of Convergence between μ-Opioid Receptor and Growth Factor Signaling Pathways in Rat C6 Glioma Cells
Mariana M. Belcheva, Paul D. Haas, Yun Tan, Virginia M. Heaton and Carmine J. Coscia

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 909-918; DOI: https://doi.org/10.1124/jpet.102.038554
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Yohimbine Dimers Exhibiting Selectivity for the Human α_2c-Adrenoceptor Subtype
Shilpa G. Lalchandani, Longping Lei, Weiping Zheng, Mustafa M. Suni, Bob M. Moore, Stephen B. Liggett, Duane D. Miller and Dennis R. Feller

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 979-984; DOI: https://doi.org/10.1124/jpet.102.039057
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Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress
Pamela Esposito, Nathan Chandler, Kristiana Kandere, Subimal Basu, Stanley Jacobson, Raymond Connolly, David Tutor and Theoharis C. Theoharides

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1061-1066; DOI: https://doi.org/10.1124/jpet.102.038497
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Epileptiform Synchronization and GABA_B Receptor Antagonism in the Juvenile Rat Hippocampus
Rita Motalli, Margherita D'Antuono, Jacques Louvel, Irene Kurcewicz, Giovanna D'Arcangelo, Virginia Tancredi, Mario Manfredi, René Pumain and Massimo Avoli

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1102-1113; DOI: https://doi.org/10.1124/jpet.102.040782
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Inhibition of Mitogenic Stimulant-Induced Activation of Thymocytes with Zinc Tetrakis-(N-Methyl-4′-Pyridyl) Porphyrinato
Jihee Lee Kang, Hui Su Lee, Hae Jin Jung, Hee Jae Kim, Jong Sik Hah and Vincent Castranova

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1138-1144; DOI: https://doi.org/10.1124/jpet.102.039123
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A Novel Mechanism of Neurokinin-1 Receptor Resensitization
V. J. Bennett, S. A. Perrine and M. A. Simmons

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1155-1162; DOI: https://doi.org/10.1124/jpet.102.040378
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Calcium and Protein Kinase C (PKC)-Related Kinase Mediate α_1A-Adrenergic Receptor-Stimulated Activation of Phospholipase D in Rat-1 Cells, Independent of PKC
Jean-Hugues Parmentier, Aftab Ahmed, Ying Ruan, Gautam K. Gandhi, Abdelwahab E. Saeed and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1206-1215; DOI: https://doi.org/10.1124/jpet.102.041384
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Tyramine Stimulates Glucose Uptake in Insulin-Sensitive Tissues in Vitro and in Vivo via Its Oxidation by Amine Oxidases
Nathalie Morin, Virgile Visentin, Denis Calise, Luc Marti, Antonio Zorzano, Xavier Testar, Philippe Valet, Yvan Fischer and Christian Carpéné

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1238-1247; DOI: https://doi.org/10.1124/jpet.102.040592
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Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect
Khosrow Kashfi, Yaser Rayyan, Leon L. Qiao, Jennie L. Williams, Jie Chen, Piero del Soldato, Frank Traganos and Basil Rigas

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1273-1282; DOI: https://doi.org/10.1124/jpet.102.042754
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Developmental Changes in Opioid Peptides and Their Receptors inCpe ^fat/Cpe ^fatMice Lacking Peptide Processing Enzyme Carboxypeptidase E
Mikhail Boudarine, Oleg Yegorov, Anna Sterling-Dubrovsky, Lakshmi A. Devi and Yemiliya Berman

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1317-1324; DOI: https://doi.org/10.1124/jpet.102.037663

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Region-Dependent Modulation of Intestinal Permeability by Drug Efflux Transporters: In Vitro Studies in mdr1a(−/−) Mouse Intestine
R. H. Stephens, J. Tanianis-Hughes, N. B. Higgs, M. Humphrey and G. Warhurst

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1095-1101; DOI: https://doi.org/10.1124/jpet.102.041236
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Antisense Oligonucleotides to poly(ADP-ribose) Polymerase-2 Ameliorate Colitis in Interleukin-10-Deficient Mice
Ian Popoff, Humberto Jijon, Brett Monia, Michele Tavernini, Michael Ma, Rob McKay and Karen Madsen

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1145-1154; DOI: https://doi.org/10.1124/jpet.102.039768
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Role of Cyclooxygenase (COX)-1 and COX-2 Inhibition in Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage in Rats: Relation to Various Pathogenic Events
Akiko Tanaka, Shoko Hase, Tohru Miyazawa, Ryoko Ohno and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1248-1254; DOI: https://doi.org/10.1124/jpet.102.041715
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Signal Transduction Pathways Involved in the Mechanical Responses to Protease-Activated Receptors in Rat Colon
Flavia Mulè, Maria Carmela Baffi, Mariarita Falzone and Maria Carmela Cerra

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1265-1272; DOI: https://doi.org/10.1124/jpet.102.041301
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Lansoprazole Induces Mucosal Protection through Gastrin Receptor-Dependent Up-Regulation of Cyclooxygenase-2 in Rats
Shingo Tsuji, Wei-Hao Sun, Masahiko Tsujii, Naoki Kawai, Arata Kimura, Yoshimi Kakiuchi, Shoichi Yasumaru, Masato Komori, Hiroaki Murata, Yutaka Sasaki, Sunao Kawano and Masatsugu Hori

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1301-1308; DOI: https://doi.org/10.1124/jpet.102.035204

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Origins of Prostaglandin E₂: Involvements of Cyclooxygenase (COX)-1 and COX-2 in Human and Rat Systems
Francesco Giuliano and Timothy D. Warner

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1001-1006; DOI: https://doi.org/10.1124/jpet.102.041244
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Inhibition of Allergic Dermal Inflammation by the Novel Imidazopyridazine Derivative TAK-427 in a Guinea Pig Experimental Model of Eczema
Shigeru Fukuda, Katsuo Midoro, Takayuki Kamei, Michiyo Gyoten, Yasuhiko Kawano, Yasuko Ashida and Hideaki Nagaya

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1283-1290; DOI: https://doi.org/10.1124/jpet.102.040105
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Inhibition of Human T Cell Activation by Novel Src Kinase Inhibitors Is Dependent upon the Complexity of the Signal Delivered to the Cell
Stephen Rapecki and Rodger Allen

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1325-1333; DOI: https://doi.org/10.1124/jpet.102.038380
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Phase I Trial of ISIS 104838, a 2′-Methoxyethyl Modified Antisense Oligonucleotide Targeting Tumor Necrosis Factor-α
K. Lea Sewell, Richard S. Geary, Brenda F. Baker, Josephine M. Glover, Timothy G. K. Mant, Rosie Z. Yu, Joseph A. Tami and F. Andrew Dorr

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1334-1343; DOI: https://doi.org/10.1124/jpet.102.036749

NEUROPHARMACOLOGY

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Involvement of α7 Nicotinic Acetylcholine Receptors in Gene Expression of Dopamine Biosynthetic Enzymes in Rat Brain
Lidia Serova and Esther L. Sabban

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 896-903; DOI: https://doi.org/10.1124/jpet.102.039198
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The Group II Metabotropic Glutamate Receptor Agonist (−)-2-Oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and Clozapine Reverse Phencyclidine-Induced Behaviors in Monoamine-Depleted Rats
Chad J. Swanson and Darryle D. Schoepp

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 919-927; DOI: https://doi.org/10.1124/jpet.102.038422
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Ethanol Antagonizes Kainate Receptor-Mediated Inhibition of Evoked GABA_A Inhibitory Postsynaptic Currents in the Rat Hippocampal CA1 Region
T. L. Crowder, O. J. Ariwodola and J. L. Weiner

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 937-944; DOI: https://doi.org/10.1124/jpet.102.038471
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Dopamine, but Not Norepinephrine or Serotonin, Reuptake Inhibition Reverses Motor Deficits in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Primates
Matthew J. Hansard, Lance A. Smith, Michael J. Jackson, Sharon C. Cheetham and Peter Jenner

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 952-958; DOI: https://doi.org/10.1124/jpet.102.039743
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Changes in GABA_A Receptor Gene Expression Induced by Withdrawal of, but Not by Long-Term Exposure to, Ganaxolone in Cultured Rat Cerebellar Granule Cells
Maria Paola Mascia, Francesca Biggio, Luisa Mancuso, Stefano Cabras, Pier Luigi Cocco, Giorgio Gorini, Annalisa Manca, Carla Marra, Robert H. Purdy, Paolo Follesa and Giovanni Biggio

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1014-1020; DOI: https://doi.org/10.1124/jpet.102.040063
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Role of Spinal Nitric Oxide in the Inhibitory Effect of [d-Pen²,d-Pen⁵]-Enkephalin on Ascending Dorsal Horn Neurons in Normal and Diabetic Rats
Ghous M. Khan, De-Pei Li, Shao-Rui Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1021-1028; DOI: https://doi.org/10.1124/jpet.102.040865
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[³H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization
Jeffery J. Anderson, Sara P. Rao, Blake Rowe, Darlene R. Giracello, Greg Holtz, Deborah F. Chapman, Lida Tehrani, Margaret J. Bradbury, Nicholas D. P. Cosford and Mark A. Varney

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1044-1051; DOI: https://doi.org/10.1124/jpet.102.040618
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Functional Properties of the High-Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist (4-Hydroxy-5-iodo-3-methoxyphenylacetate ester) Iodo-Resiniferatoxin
Guy R. Seabrook, Kathy G. Sutton, Wolfgang Jarolimek, Gregory J. Hollingworth, Simon Teague, Janine Webb, Natalie Clark, Susan Boyce, Julie Kerby, Zahid Ali, Margaret Chou, Richard Middleton, Gregory Kaczorowski and A. Brian Jones

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1052-1060; DOI: https://doi.org/10.1124/jpet.102.040394
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Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action
Amy C. Arai, Yan-Fang Xia, Gary Rogers, Gary Lynch and Markus Kessler

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1075-1085; DOI: https://doi.org/10.1124/jpet.102.040360
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Ocular Hypotensive Action of Topical Flunarizine in the Rabbit: Role of ς₁ Recognition Sites
Gabriele Campana, Claudio Bucolo, Giovanna Murari and Santi Spampinato

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1086-1094; DOI: https://doi.org/10.1124/jpet.102.040584
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Pharmacokinetic-Pharmacodynamic Modeling of Buspirone and Its Metabolite 1-(2-Pyrimidinyl)-piperazine in Rats
Klaas P. Zuideveld, Jasna Rusiç-Pavletiç, Hugo J. Maas, Lambertus A. Peletier, Piet H. Van der Graaf and Meindert Danhof

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1130-1137; DOI: https://doi.org/10.1124/jpet.102.036798
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SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}- 4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin-1 Receptor: I. Biochemical and Pharmacological Characterization
Xavier Emonds-Alt, Vincenzo Proietto, Régis Steinberg, Florence Oury-Donat, Xavier Vigé, Pol Vilain, Emmanuel Naline, Samira Daoui, Charles Advenier, Gérard Le Fur, Jean-Pierre Maffrand, Philippe Soubrié and Marc Pascal

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1171-1179; DOI: https://doi.org/10.1124/jpet.102.040162
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SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}-4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin 1 Receptor: II. Neurochemical and Behavioral Characterization
Régis Steinberg, Richard Alonso, Liliane Rouquier, Christophe Desvignes, Jean-Claude Michaud, Annie Cudennec, Mireille Jung, Jacques Simiand, Guy Griebel, Xavier Emonds-Alt, Gérard Le Fur and Philippe Soubrié

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1180-1188; DOI: https://doi.org/10.1124/jpet.102.040279
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Injury Type-Specific Calcium Channel α₂δ-1 Subunit Up-Regulation in Rat Neuropathic Pain Models Correlates with Antiallodynic Effects of Gabapentin
Z. D. Luo, N. A. Calcutt, E. S. Higuera, C. R. Valder, Y.-H. Song, C. I. Svensson and R. R. Myers

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1199-1205; DOI: https://doi.org/10.1124/jpet.102.041574
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Nerve Growth Factor-Induced Neurite Sprouting in PC12 Cells Involves ς-1 Receptors: Implications for Antidepressants
Minoru Takebayashi, Teruo Hayashi and Tsung-Ping Su

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1227-1237; DOI: https://doi.org/10.1124/jpet.102.041970
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Effect of Dopamine Uptake Inhibition on Brain Catecholamine Levels and Locomotion in Catechol-O-methyltransferase-Disrupted Mice
Marko Huotari, Miklos Santha, Louis R. Lucas, Maria Karayiorgou, Joseph A. Gogos and Pekka T. Männistö

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1309-1316; DOI: https://doi.org/10.1124/jpet.102.043042

TOXICOLOGY

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Interleukin-1 and Tumor Necrosis Factor Antagonists Attenuate Ethanol-Induced Inhibition of Bone Formation in a Rat Model of Distraction Osteogenesis
Daniel S. Perrien, Elizabeth C. Brown, Terry W. Fletcher, David J. Irby, James Aronson, Guan G. Gao, Robert A. Skinner, William R. Hogue, Ulrich Feige, Larry J. Suva, Martin J. J. Ronis, Thomas M. Badger and Charles K. Lumpkin

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 904-908; DOI: https://doi.org/10.1124/jpet.102.039636
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The Sea Anemone Toxins BgII and BgIII Prolong the Inactivation Time Course of the Tetrodotoxin-Sensitive Sodium Current in Rat Dorsal Root Ganglion Neurons
Emilio Salceda, Anoland Garateix and Enrique Soto

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1067-1074; DOI: https://doi.org/10.1124/jpet.102.038570
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Primaquine-Induced Hemolytic Anemia: Formation of Free Radicals in Rat Erythrocytes Exposed to 6-Methoxy-8-hydroxylaminoquinoline
Laura J. C. Bolchoz, Andrew K. Gelasco, David J. Jollow and David C. McMillan

Journal of Pharmacology and Experimental Therapeutics December 2002, 303 (3) 1121-1129; DOI: https://doi.org/10.1124/jpet.102.041459

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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