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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by d-α-Tocopheryl Poly(Ethylene Glycol 1000) Succinate

Vincent J. Wacher, Jeffrey A. Silverman, Susan Wong, Paulina Tran-Tau, Amy O. Chan, Anne Chai, Xiang-Qing Yu, Daniel O'Mahony and Zeibun Ramtoola
Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 308-313; DOI: https://doi.org/10.1124/jpet.102.036541

Article Information

vol. 303 no. 1 308-313
DOI 
https://doi.org/10.1124/jpet.102.036541
PubMed 
12235265
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 25, 2002
  • Accepted June 21, 2002
  • Published online October 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Vincent J. Wacher1,
  2. Jeffrey A. Silverman1,1,
  3. Susan Wong1,
  4. Paulina Tran-Tau1,
  5. Amy O. Chan1,
  6. Anne Chai1,
  7. Xiang-Qing Yu2,
  8. Daniel O'Mahony2 and
  9. Zeibun Ramtoola2
  1. 1AvMax Inc., South San Francisco, California (V.J.W., J.A.S., S.W., P.T.-T., A.O.C., A.C.) and 2Elan Pharmaceutical Technologies, Dublin, Ireland (X.-Q.Y., D.O.M., Z.R.)
  1. Dr. Vincent J. Wacher, Director of Corporate Development, Ontogen Corporation, 6451 El Camino Real, Carlsbad, CA 92009. E-mail:vwacher{at}worldnet.att.net
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by d-α-Tocopheryl Poly(Ethylene Glycol 1000) Succinate

Vincent J. Wacher, Jeffrey A. Silverman, Susan Wong, Paulina Tran-Tau, Amy O. Chan, Anne Chai, Xiang-Qing Yu, Daniel O'Mahony and Zeibun Ramtoola
Journal of Pharmacology and Experimental Therapeutics October 1, 2002, 303 (1) 308-313; DOI: https://doi.org/10.1124/jpet.102.036541
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