Journal of Pharmacology and Experimental Therapeutics: 303 (1)

October 01, 2002; Volume 303,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Robert Schwarcz and Roberto Pellicciari

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 1-10; DOI: https://doi.org/10.1124/jpet.102.034439

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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A Novel Approach for the Increased Delivery of Pharmaceutical Agents to Peritoneum and Associated Lymph Nodes
William T. Phillips, Luis A. Medina, Robert Klipper and Beth Goins

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 11-16; DOI: https://doi.org/10.1124/jpet.102.037119
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Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by d-α-Tocopheryl Poly(Ethylene Glycol 1000) Succinate
Vincent J. Wacher, Jeffrey A. Silverman, Susan Wong, Paulina Tran-Tau, Amy O. Chan, Anne Chai, Xiang-Qing Yu, Daniel O'Mahony and Zeibun Ramtoola

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 308-313; DOI: https://doi.org/10.1124/jpet.102.036541
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Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein
Kazuto Yasuda, Lu-bin Lan, Dominique Sanglard, Katryn Furuya, John D. Schuetz and Erin G. Schuetz

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 323-332; DOI: https://doi.org/10.1124/jpet.102.037549
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A Cell-Based Reporter Gene Assay for Determining Induction of CYP3A4 in a High-Volume System
Judy Raucy, Lyndon Warfe, Mei-Fei Yueh and Scott W. Allen

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 412-423; DOI: https://doi.org/10.1124/jpet.102.038653

BEHAVIORAL PHARMACOLOGY

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Analgesic Effects of Intrathecal Administration of P2Y Nucleotide Receptor Agonists UTP and UDP in Normal and Neuropathic Pain Model Rats
Maiko Okada, Takayuki Nakagawa, Masabumi Minami and Masamichi Satoh

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 66-73; DOI: https://doi.org/10.1124/jpet.102.036079
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Reinforcing Strength of a Novel Dopamine Transporter Ligand: Pharmacodynamic and Pharmacokinetic Mechanisms
W. L. Woolverton, R. Ranaldi, Z. Wang, G. A. Ordway, I. A. Paul, P. Petukhov and A. Kozikowski

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 211-217; DOI: https://doi.org/10.1124/jpet.102.037812
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Characterization of Nociceptin/Orphanin FQ-Induced Pain Responses by the Novel Receptor AntagonistN-(4-Amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) Benzamide Monohydrochloride
Tadatoshi Muratani, Toshiaki Minami, Utako Enomoto, Masato Sakai, Emiko Okuda-Ashitaka, Kimihiro Kiyokane, Hidemaro Mori and Seiji Ito

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 424-430; DOI: https://doi.org/10.1124/jpet.102.036095

CARDIOVASCULAR

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Potent Suppression of Proliferation of A10 Vascular Smooth Muscle Cells by Combined Treatment with Lovastatin and 3-Allylfarnesol, an Inhibitor of Protein Farnesyltransferase
Raymond R. Mattingly, Richard A. Gibbs, Raymond E. Menard and John J. Reiners

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 74-81; DOI: https://doi.org/10.1124/jpet.102.036061
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In Vivo Characterization of the Mitochondrial Selective K_ATP Opener (3R)-trans-4-((4-Chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1-benzopyran-6-carbonitril Monohydrochloride (BMS-191095): Cardioprotective, Hemodynamic, and Electrophysiological Effects
Gary J. Grover, Albert J. D'Alonzo, Raymond B. Darbenzio, Charles S. Parham, Thomas A. Hess and Mohinder S. Bathala

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 132-140; DOI: https://doi.org/10.1124/jpet.102.036988
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Postischemic Recovery and Oxidative Stress Are Independent of Nitric-Oxide Synthases Modulation in Isolated Rat Heart
Catherine Vergely, Caroline Perrin-Sarrado, Gaëlle Clermont and Luc Rochette

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 149-157; DOI: https://doi.org/10.1124/jpet.102.036871
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Effects of Folate Treatment and Homocysteine Lowering on Resistance Vessel Reactivity in Atherosclerotic Subjects
Olaf Stanger, Hans-Juergen Semmelrock, Willibald Wonisch, Ursula Bös, Edmund Pabst and Thomas C. Wascher

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 158-162; DOI: https://doi.org/10.1124/jpet.102.036715
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5-Hydroxytryptamine_2B Receptor Function Is Enhanced in the N ^ω-Nitro-l-arginine Hypertensive Rat
Amber Russell, Amy Banes, Hilary Berlin, Gregory D. Fink and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 179-187; DOI: https://doi.org/10.1124/jpet.102.037390
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The Hypotensive Action of Rilmenidine is Dependent on FunctionalN-Methyl-d-aspartate Receptor in the Rostral Ventrolateral Medulla of Conscious Spontaneously Hypertensive Rats
Jian Zhang and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 204-210; DOI: https://doi.org/10.1124/jpet.102.037333
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Inhibitory Effects of the Antiestrogen Agent Clomiphene on Cardiac Sarcolemmal Anionic and Cationic Currents
John J. Borg, Kathryn H. Yuill, Jules C. Hancox, Ian C. Spencer and Roland Z. Kozlowski

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 282-292; DOI: https://doi.org/10.1124/jpet.102.038901
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1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical Sodium-Codependent Bile Acid Transporter Inhibitor Alters Hepatic Cholesterol Metabolism and Lowers Plasma Low-Density Lipoprotein-Cholesterol Concentrations in Guinea Pigs
Kristy L. West, Tripurasundari Ramjiganesh, Suheeta Roy, Bradley T. Keller and Maria Luz Fernandez

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 293-299; DOI: https://doi.org/10.1124/jpet.102.038711
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Relationship between α₁-Adrenergic Receptor-Induced Contraction and Extracellular Signal-Regulated Kinase Activation in the Bovine Inferior Alveolar Artery
Chris Hague, Pedro J. Gonzalez-Cabrera, William B. Jeffries and Peter W. Abel

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 403-411; DOI: https://doi.org/10.1124/jpet.102.037531

CELLULAR AND MOLECULAR

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Activation of δ-Isoform of Protein Kinase C Is Required for Oxidant-Induced Disruption of Both the Microtubule Cytoskeleton and Permeability Barrier of Intestinal Epithelia
A. Banan, J. Z. Fields, A. Farhadi, D. A. Talmage, L. Zhang and A. Keshavarzian

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 17-28; DOI: https://doi.org/10.1124/jpet.102.037218
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Molecular Cloning and Functional Characterization of a Unique Mammalian Cardiac Na_v Channel Isoform with Low Sensitivity to the Synthetic Inactivation Inhibitor (−)-(S)-6-Amino-α-[(4-diphenylmethyl-1-piperazinyl)-methyl]-9H-purine-9-ethanol (SDZ 211-939)
Helena Denac, Meike Mevissen, Frank J. P. Kühn, Cornelia Kühn, Christophe T. Guionaud, Günter Scholtysik and Nikolaus G. Greeff

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 89-98; DOI: https://doi.org/10.1124/jpet.303.1.89
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DNA Damage Induces a Novel p53-Survivin Signaling Pathway Regulating Cell Cycle and Apoptosis in Acute Lymphoblastic Leukemia Cells
Muxiang Zhou, Lubing Gu, Fengzhi Li, Yerun Zhu, William G. Woods and Harry W. Findley

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 124-131; DOI: https://doi.org/10.1124/jpet.102.037192
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Tyrosine Kinase Inhibitors Suppress the Growth of Non-Hodgkin B Lymphomas
Hannah Ben-Bassat, Zipora Hartzstark, Rubina Levitzki, Benjamin Y. Klein, Zipora Shlomai, Aviv Gazit and Alexander Levitzki

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 163-171; DOI: https://doi.org/10.1124/jpet.102.036723
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Tonic Inhibitory Role for cAMP in α_1a-Adrenergic Receptor Coupling to Extracellular Signal-Regulated Kinases 1/2
Xiuxiang Jiao, Pedro J. Gonzalez-Cabrera, Lei Xiao, Michael E. Bradley, Peter W. Abel and William B. Jeffries

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 247-256; DOI: https://doi.org/10.1124/jpet.102.037747
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Dual Mechanisms for Ethanol-Induced Inhibition of Monocyte Chemotactic Protein-3 mRNA Expression in Activated Glial Cells
Liqiang Ren and Peter J. Syapin

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 265-272; DOI: https://doi.org/10.1124/jpet.102.035253
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Cross-Talk Between AT₁ and AT₂Angiotensin Receptors in Rat Anococcygeus Smooth Muscle
Márcio A. F. de Godoy and Ana M. de Oliveira

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 333-339; DOI: https://doi.org/10.1124/jpet.102.036970

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de Pointes
Peter Milberg, Lars Eckardt, Hans-Jürgen Bruns, Julia Biertz, Shahram Ramtin, Nico Reinsch, Dirk Fleischer, Paulus Kirchhof, Larissa Fabritz, Günter Breithardt and Wilhelm Haverkamp

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 218-225; DOI: https://doi.org/10.1124/jpet.102.037911
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Inhibition of Epidermal Growth Factor Receptor-Mediated Signaling by “Combi-Triazene” BJ2000, a New Probe for Combi-Targeting Postulates
Fouad Brahimi, Stephanie L. Matheson, Fabienne Dudouit, James P. Mcnamee, Ana M. Tari and Bertrand J. Jean-Claude

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 238-246; DOI: https://doi.org/10.1124/jpet.102.039099

ENDOCRINE AND REPRODUCTIVE

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Inhibition of Glucose- and Calcium-Induced Insulin Secretion from βTC3 Cells by Novel Inhibitors of Protein Isoprenylation
Rajesh Amin, Hai-Qing Chen, Marie Tannous, Richard Gibbs and Anjaneyulu Kowluru

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 82-88; DOI: https://doi.org/10.1124/jpet.102.036160
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Pharmacological Actions of a Novel, Potent, Tissue-Selective Benzopyran Estrogen
Elisabetta Galbiati, Paola Lorenza Caruso, Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, Maurizio Delcanale and Maurizio Civelli

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 196-203; DOI: https://doi.org/10.1124/jpet.102.038034
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Prenatal Opiate Withdrawal Activates the Chick Embryo Hypothalamic-Pituitary-Adrenal Axis and Dilates Vitelline Blood Vessels via Serotonin₂ Receptors
Lisa M. Schrott, Mary Irene Baumgart, Xuewei Zhang and Sheldon B. Sparber

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 257-264; DOI: https://doi.org/10.1124/jpet.102.037044

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Lithocholylcholine, a Bile Acid/Acetylcholine Hybrid, Is a Muscarinic Receptor Antagonist
Kunrong Cheng, Sandeep Khurana, Ying Chen, Richard H. Kennedy, Piotr Zimniak and Jean-Pierre Raufman

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 29-35; DOI: https://doi.org/10.1124/jpet.102.036376
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Effect of Cyclosporine A on Hepatic Compensatory Growth: Role of Calcium Status
Sébastien J. Provencher and Marielle Gascon-Barré

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 58-65; DOI: https://doi.org/10.1124/jpet.102.035980
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Role of Adenosine A₁ Receptor in Angiotensin II- and Norepinephrine-Induced Renal Vasoconstriction
Yasuharu Aki, Akira Nishiyama, Akira Miyatake, Shoji Kimura, Masakazu Kohno and Youichi Abe

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 117-123; DOI: https://doi.org/10.1124/jpet.102.037010
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Stereoselective Metabolism of Bufuralol Racemate and Enantiomers in Human Liver Microsomes
Shizuo Narimatsu, Chie Takemi, Daisuke Tsuzuki, Hiroyuki Kataoka, Shigeo Yamamoto, Noriaki Shimada, Satoshi Suzuki, Tetsuo Satoh, Urs A. Meyer and Frank J. Gonzalez

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 172-178; DOI: https://doi.org/10.1124/jpet.102.036533
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Lipopolysaccharide-Induced Acute Renal Failure in Conscious Rats: Effects of Specific Phosphodiesterase Type 3 and 4 Inhibition
Thomas E. N. Jonassen, Martin Græbe, Dominique Promeneur, Søren Nielsen, Sten Christensen and Niels V. Olsen

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 364-374; DOI: https://doi.org/10.1124/jpet.102.036194
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(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. I. In Vitro Characterization
Murali Gopalakrishnan, Steven A. Buckner, Kristi L. Whiteaker, Char-Chang Shieh, Eduardo J. Molinari, Ivan Milicic, Anthony V. Daza, Rachel Davis-Taber, Victoria E. Scott, Donna Sellers, Russ Chess-Williams, Christopher R. Chapple, Yi Liu, Dong Liu, Jorge D. Brioni, James P. Sullivan, Michael Williams, William A. Carroll and Michael J. Coghlan

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 379-386; DOI: https://doi.org/10.1124/jpet.102.034538
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(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization
Michael E. Brune, Thomas A. Fey, Jorge D. Brioni, James P. Sullivan, Michael Williams, William A. Carroll, Michael J. Coghlan and Murali Gopalakrishnan

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 387-394; DOI: https://doi.org/10.1124/jpet.102.034553

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Nonpeptide Antagonists of AT1 Receptor for Angiotensin II Delay the Onset of Acute Respiratory Distress Syndrome
Silvina Raiden, Karen Nahmod, Vı́ctor Nahmod, Guillermo Semeniuk, Yanina Pereira, Clarisa Alvarez, Mirta Giordano and Jorge R. Geffner

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 45-51; DOI: https://doi.org/10.1124/jpet.102.037382
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PPA250 [3-(2,4-Difluorophenyl)-6-{2-[4-(1H-imidazol-1-ylmethyl) Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Effective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-Inflammatory Effect in Animal Models of Chronic Arthritis
Mari Ohtsuka, Fujiko Konno, Haruyoshi Honda, Takayuki Oikawa, Masago Ishikawa, Nobuhisa Iwase, Kazuo Isomae, Fumio Ishii, Hiromichi Hemmi and Susumu Sato

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 52-57; DOI: https://doi.org/10.1124/jpet.102.035857
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Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20S,21-Epoxy-resibufogenin-3-formate
Masahiko Hayashi, Mun-Chual Rho, Akiko Fukami, Akiko Enomoto, Shinobu Nonaka, Yoshino Sekiguchi, Tadashi Yanagisawa, Ayano Yamashita, Toshihiko Nogawa, Yoshiaki Kamano and Kanki Komiyama

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 104-109; DOI: https://doi.org/10.1124/jpet.102.036137
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Angiotensin-Converting Enzyme Inhibitor-Associated Angioedema Is Characterized by a Slower Degradation of des-Arginine⁹-Bradykinin
Giuseppe Molinaro, Massimo Cugno, Mélissa Perez, Yves Lepage, Nicole Gervais, Angelo Agostoni and Albert Adam

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 232-237; DOI: https://doi.org/10.1124/jpet.102.038067
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Inflammatory Cytokines, but Not Bile Acids, Regulate Expression of Murine Hepatic Anion Transporters in Endotoxemia
Georgy Hartmann, Annie K. Y. Cheung and Micheline Piquette-Miller

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 273-281; DOI: https://doi.org/10.1124/jpet.102.039404
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Histamine H₄ and H₂ Receptors Control Histamine-Induced Interleukin-16 Release from Human CD8⁺ T Cells
Florian Gantner, Katsuya Sakai, Michael W. Tusche, William W. Cruikshank, David M. Center and Kevin B. Bacon

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 300-307; DOI: https://doi.org/10.1124/jpet.102.036939
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Decrease in Efficacy and Potency of Nonsteroidal Anti-Inflammatory Drugs by Chronic Δ⁹-Tetrahydrocannabinol Administration
Rene Anikwue, John W. Huffman, Zachary L. Martin and Sandra P. Welch

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 340-346; DOI: https://doi.org/10.1124/jpet.303.1.340

NEUROPHARMACOLOGY

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Effect of Chronic Administration ofR-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone Mesylate (WIN55,212-2) or Δ⁹-Tetrahydrocannabinol on Cannabinoid Receptor Adaptation in Mice
Laura J. Sim-Selley and Billy R. Martin

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 36-44; DOI: https://doi.org/10.1124/jpet.102.035618
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Muscarinic Agonist-Mediated Increases in Serum Corticosterone Levels Are Abolished in M₂ Muscarinic Acetylcholine Receptor Knockout Mice
S. K. Hemrick-Luecke, F. P. Bymaster, D. C. Evans, J. Wess and C. C. Felder

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 99-103; DOI: https://doi.org/10.1124/jpet.102.036020
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Peptide Antagonists of Ethanol Inhibition of L1-Mediated Cell-Cell Adhesion
Michael F. Wilkemeyer, Carrie E. Menkari, Catherine Y. Spong and Michael E. Charness

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 110-116; DOI: https://doi.org/10.1124/jpet.102.036277
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Nociceptin/Orphanin FQ Modulation of Ionic Conductances in Rat Basal Forebrain Neurons
J. H. Chin, K. Harris, D. MacTavish and J. H. Jhamandas

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 188-195; DOI: https://doi.org/10.1124/jpet.102.037945
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Nonopioid and Neuropathy-Specific Analgesic Action of the Nootropic Drug Nefiracetam in Mice
Md. Harunor Rashid and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 226-231; DOI: https://doi.org/10.1124/jpet.102.037952
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Inhibition of Improgan Antinociception by the Cannabinoid (CB)₁ AntagonistN-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): Lack of Obligatory Role for Endocannabinoids Acting at CB₁ Receptors
L. B. Hough, J. W. Nalwalk, R. Stadel, H. Timmerman, R. Leurs, B. C. Paria, X. Wang and S. K. Dey

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 314-322; DOI: https://doi.org/10.1124/jpet.102.036251
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Modulation of Hippocampal Glutamatergic Transmission by ATP Is Dependent on Adenosine A₁ Receptors
Susan A. Masino, Lihong Diao, Peter Illes, Nancy R. Zahniser, Gaynor A. Larson, Björn Johansson, Bertil B. Fredholm and Thomas V. Dunwiddie

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 356-363; DOI: https://doi.org/10.1124/jpet.102.036731
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Role of the Nitric Oxide Pathway in κ-Opioid-Induced Hypothermia in Rats
Khalid Benamar, Ellen B. Geller and Martin W. Adler

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 375-378; DOI: https://doi.org/10.1124/jpet.102.036269
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N-Methyl-d-aspartate Antagonists and WIN 55212-2 [4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a Cannabinoid Agonist, Interact to Produce Synergistic Hypothermia
S. M. Rawls, A. Cowan, R. J. Tallarida, Ellen B. Geller and Martin W. Adler

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 395-402; DOI: https://doi.org/10.1124/jpet.102.037473

TOXICOLOGY

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Primaquine-Induced Hemolytic Anemia: Effect of 6-Methoxy-8-hydroxylaminoquinoline on Rat Erythrocyte Sulfhydryl Status, Membrane Lipids, Cytoskeletal Proteins, and Morphology
Laura J. C. Bolchoz, Jason D. Morrow, David J. Jollow and David C. McMillan

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 141-148; DOI: https://doi.org/10.1124/jpet.102.036921
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Differential Effects of Linoleic Acid Metabolites on Cardiac Sodium Current
Maddison D. Harrell and Joseph R. Stimers

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 347-355; DOI: https://doi.org/10.1124/jpet.102.038166

ASPET MEETING REPORT

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Meeting Report for the ASPET Ray Fuller Symposium: Lower Urinary Tract Disorders: Physiology, Pharmacology, and Therapeutic Approaches
Martin C. Michel and Jorge D. Brioni

Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 431-437; DOI: https://doi.org/10.1124/jpet.303.1.431

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

ASPET MEETING REPORT

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