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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2002; Volume 303,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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    Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
    Robert Schwarcz and Roberto Pellicciari
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 1-10; DOI: https://doi.org/10.1124/jpet.102.034439

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    A Novel Approach for the Increased Delivery of Pharmaceutical Agents to Peritoneum and Associated Lymph Nodes
    William T. Phillips, Luis A. Medina, Robert Klipper and Beth Goins
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 11-16; DOI: https://doi.org/10.1124/jpet.102.037119
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    Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by d-α-Tocopheryl Poly(Ethylene Glycol 1000) Succinate
    Vincent J. Wacher, Jeffrey A. Silverman, Susan Wong, Paulina Tran-Tau, Amy O. Chan, Anne Chai, Xiang-Qing Yu, Daniel O'Mahony and Zeibun Ramtoola
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 308-313; DOI: https://doi.org/10.1124/jpet.102.036541
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    Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein
    Kazuto Yasuda, Lu-bin Lan, Dominique Sanglard, Katryn Furuya, John D. Schuetz and Erin G. Schuetz
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 323-332; DOI: https://doi.org/10.1124/jpet.102.037549
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    A Cell-Based Reporter Gene Assay for Determining Induction of CYP3A4 in a High-Volume System
    Judy Raucy, Lyndon Warfe, Mei-Fei Yueh and Scott W. Allen
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 412-423; DOI: https://doi.org/10.1124/jpet.102.038653

BEHAVIORAL PHARMACOLOGY

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    Analgesic Effects of Intrathecal Administration of P2Y Nucleotide Receptor Agonists UTP and UDP in Normal and Neuropathic Pain Model Rats
    Maiko Okada, Takayuki Nakagawa, Masabumi Minami and Masamichi Satoh
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 66-73; DOI: https://doi.org/10.1124/jpet.102.036079
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    Reinforcing Strength of a Novel Dopamine Transporter Ligand: Pharmacodynamic and Pharmacokinetic Mechanisms
    W. L. Woolverton, R. Ranaldi, Z. Wang, G. A. Ordway, I. A. Paul, P. Petukhov and A. Kozikowski
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 211-217; DOI: https://doi.org/10.1124/jpet.102.037812
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    Characterization of Nociceptin/Orphanin FQ-Induced Pain Responses by the Novel Receptor AntagonistN-(4-Amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) Benzamide Monohydrochloride
    Tadatoshi Muratani, Toshiaki Minami, Utako Enomoto, Masato Sakai, Emiko Okuda-Ashitaka, Kimihiro Kiyokane, Hidemaro Mori and Seiji Ito
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 424-430; DOI: https://doi.org/10.1124/jpet.102.036095

CARDIOVASCULAR

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    Potent Suppression of Proliferation of A10 Vascular Smooth Muscle Cells by Combined Treatment with Lovastatin and 3-Allylfarnesol, an Inhibitor of Protein Farnesyltransferase
    Raymond R. Mattingly, Richard A. Gibbs, Raymond E. Menard and John J. Reiners
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 74-81; DOI: https://doi.org/10.1124/jpet.102.036061
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    In Vivo Characterization of the Mitochondrial Selective KATP Opener (3R)-trans-4-((4-Chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1-benzopyran-6-carbonitril Monohydrochloride (BMS-191095): Cardioprotective, Hemodynamic, and Electrophysiological Effects
    Gary J. Grover, Albert J. D'Alonzo, Raymond B. Darbenzio, Charles S. Parham, Thomas A. Hess and Mohinder S. Bathala
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 132-140; DOI: https://doi.org/10.1124/jpet.102.036988
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    Postischemic Recovery and Oxidative Stress Are Independent of Nitric-Oxide Synthases Modulation in Isolated Rat Heart
    Catherine Vergely, Caroline Perrin-Sarrado, Gaëlle Clermont and Luc Rochette
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 149-157; DOI: https://doi.org/10.1124/jpet.102.036871
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    Effects of Folate Treatment and Homocysteine Lowering on Resistance Vessel Reactivity in Atherosclerotic Subjects
    Olaf Stanger, Hans-Juergen Semmelrock, Willibald Wonisch, Ursula Bös, Edmund Pabst and Thomas C. Wascher
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 158-162; DOI: https://doi.org/10.1124/jpet.102.036715
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    5-Hydroxytryptamine2B Receptor Function Is Enhanced in the N ω-Nitro-l-arginine Hypertensive Rat
    Amber Russell, Amy Banes, Hilary Berlin, Gregory D. Fink and Stephanie W. Watts
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 179-187; DOI: https://doi.org/10.1124/jpet.102.037390
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    The Hypotensive Action of Rilmenidine is Dependent on FunctionalN-Methyl-d-aspartate Receptor in the Rostral Ventrolateral Medulla of Conscious Spontaneously Hypertensive Rats
    Jian Zhang and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 204-210; DOI: https://doi.org/10.1124/jpet.102.037333
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    Inhibitory Effects of the Antiestrogen Agent Clomiphene on Cardiac Sarcolemmal Anionic and Cationic Currents
    John J. Borg, Kathryn H. Yuill, Jules C. Hancox, Ian C. Spencer and Roland Z. Kozlowski
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 282-292; DOI: https://doi.org/10.1124/jpet.102.038901
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    1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical Sodium-Codependent Bile Acid Transporter Inhibitor Alters Hepatic Cholesterol Metabolism and Lowers Plasma Low-Density Lipoprotein-Cholesterol Concentrations in Guinea Pigs
    Kristy L. West, Tripurasundari Ramjiganesh, Suheeta Roy, Bradley T. Keller and Maria Luz Fernandez
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 293-299; DOI: https://doi.org/10.1124/jpet.102.038711
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    Relationship between α1-Adrenergic Receptor-Induced Contraction and Extracellular Signal-Regulated Kinase Activation in the Bovine Inferior Alveolar Artery
    Chris Hague, Pedro J. Gonzalez-Cabrera, William B. Jeffries and Peter W. Abel
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 403-411; DOI: https://doi.org/10.1124/jpet.102.037531

CELLULAR AND MOLECULAR

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    Activation of δ-Isoform of Protein Kinase C Is Required for Oxidant-Induced Disruption of Both the Microtubule Cytoskeleton and Permeability Barrier of Intestinal Epithelia
    A. Banan, J. Z. Fields, A. Farhadi, D. A. Talmage, L. Zhang and A. Keshavarzian
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 17-28; DOI: https://doi.org/10.1124/jpet.102.037218
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    Molecular Cloning and Functional Characterization of a Unique Mammalian Cardiac Nav Channel Isoform with Low Sensitivity to the Synthetic Inactivation Inhibitor (−)-(S)-6-Amino-α-[(4-diphenylmethyl-1-piperazinyl)-methyl]-9H-purine-9-ethanol (SDZ 211-939)
    Helena Denac, Meike Mevissen, Frank J. P. Kühn, Cornelia Kühn, Christophe T. Guionaud, Günter Scholtysik and Nikolaus G. Greeff
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 89-98; DOI: https://doi.org/10.1124/jpet.303.1.89
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    DNA Damage Induces a Novel p53-Survivin Signaling Pathway Regulating Cell Cycle and Apoptosis in Acute Lymphoblastic Leukemia Cells
    Muxiang Zhou, Lubing Gu, Fengzhi Li, Yerun Zhu, William G. Woods and Harry W. Findley
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 124-131; DOI: https://doi.org/10.1124/jpet.102.037192
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    Tyrosine Kinase Inhibitors Suppress the Growth of Non-Hodgkin B Lymphomas
    Hannah Ben-Bassat, Zipora Hartzstark, Rubina Levitzki, Benjamin Y. Klein, Zipora Shlomai, Aviv Gazit and Alexander Levitzki
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 163-171; DOI: https://doi.org/10.1124/jpet.102.036723
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    Tonic Inhibitory Role for cAMP in α1a-Adrenergic Receptor Coupling to Extracellular Signal-Regulated Kinases 1/2
    Xiuxiang Jiao, Pedro J. Gonzalez-Cabrera, Lei Xiao, Michael E. Bradley, Peter W. Abel and William B. Jeffries
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 247-256; DOI: https://doi.org/10.1124/jpet.102.037747
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    Dual Mechanisms for Ethanol-Induced Inhibition of Monocyte Chemotactic Protein-3 mRNA Expression in Activated Glial Cells
    Liqiang Ren and Peter J. Syapin
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 265-272; DOI: https://doi.org/10.1124/jpet.102.035253
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    Cross-Talk Between AT1 and AT2Angiotensin Receptors in Rat Anococcygeus Smooth Muscle
    Márcio A. F. de Godoy and Ana M. de Oliveira
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 333-339; DOI: https://doi.org/10.1124/jpet.102.036970

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de Pointes
    Peter Milberg, Lars Eckardt, Hans-Jürgen Bruns, Julia Biertz, Shahram Ramtin, Nico Reinsch, Dirk Fleischer, Paulus Kirchhof, Larissa Fabritz, Günter Breithardt and Wilhelm Haverkamp
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 218-225; DOI: https://doi.org/10.1124/jpet.102.037911
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    Inhibition of Epidermal Growth Factor Receptor-Mediated Signaling by “Combi-Triazene” BJ2000, a New Probe for Combi-Targeting Postulates
    Fouad Brahimi, Stephanie L. Matheson, Fabienne Dudouit, James P. Mcnamee, Ana M. Tari and Bertrand J. Jean-Claude
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 238-246; DOI: https://doi.org/10.1124/jpet.102.039099

ENDOCRINE AND REPRODUCTIVE

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    Inhibition of Glucose- and Calcium-Induced Insulin Secretion from βTC3 Cells by Novel Inhibitors of Protein Isoprenylation
    Rajesh Amin, Hai-Qing Chen, Marie Tannous, Richard Gibbs and Anjaneyulu Kowluru
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 82-88; DOI: https://doi.org/10.1124/jpet.102.036160
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    Pharmacological Actions of a Novel, Potent, Tissue-Selective Benzopyran Estrogen
    Elisabetta Galbiati, Paola Lorenza Caruso, Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, Maurizio Delcanale and Maurizio Civelli
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 196-203; DOI: https://doi.org/10.1124/jpet.102.038034
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    Prenatal Opiate Withdrawal Activates the Chick Embryo Hypothalamic-Pituitary-Adrenal Axis and Dilates Vitelline Blood Vessels via Serotonin2 Receptors
    Lisa M. Schrott, Mary Irene Baumgart, Xuewei Zhang and Sheldon B. Sparber
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 257-264; DOI: https://doi.org/10.1124/jpet.102.037044

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Lithocholylcholine, a Bile Acid/Acetylcholine Hybrid, Is a Muscarinic Receptor Antagonist
    Kunrong Cheng, Sandeep Khurana, Ying Chen, Richard H. Kennedy, Piotr Zimniak and Jean-Pierre Raufman
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 29-35; DOI: https://doi.org/10.1124/jpet.102.036376
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    Effect of Cyclosporine A on Hepatic Compensatory Growth: Role of Calcium Status
    Sébastien J. Provencher and Marielle Gascon-Barré
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 58-65; DOI: https://doi.org/10.1124/jpet.102.035980
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    Role of Adenosine A1 Receptor in Angiotensin II- and Norepinephrine-Induced Renal Vasoconstriction
    Yasuharu Aki, Akira Nishiyama, Akira Miyatake, Shoji Kimura, Masakazu Kohno and Youichi Abe
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 117-123; DOI: https://doi.org/10.1124/jpet.102.037010
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    Stereoselective Metabolism of Bufuralol Racemate and Enantiomers in Human Liver Microsomes
    Shizuo Narimatsu, Chie Takemi, Daisuke Tsuzuki, Hiroyuki Kataoka, Shigeo Yamamoto, Noriaki Shimada, Satoshi Suzuki, Tetsuo Satoh, Urs A. Meyer and Frank J. Gonzalez
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 172-178; DOI: https://doi.org/10.1124/jpet.102.036533
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    Lipopolysaccharide-Induced Acute Renal Failure in Conscious Rats: Effects of Specific Phosphodiesterase Type 3 and 4 Inhibition
    Thomas E. N. Jonassen, Martin Græbe, Dominique Promeneur, Søren Nielsen, Sten Christensen and Niels V. Olsen
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 364-374; DOI: https://doi.org/10.1124/jpet.102.036194
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    (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. I. In Vitro Characterization
    Murali Gopalakrishnan, Steven A. Buckner, Kristi L. Whiteaker, Char-Chang Shieh, Eduardo J. Molinari, Ivan Milicic, Anthony V. Daza, Rachel Davis-Taber, Victoria E. Scott, Donna Sellers, Russ Chess-Williams, Christopher R. Chapple, Yi Liu, Dong Liu, Jorge D. Brioni, James P. Sullivan, Michael Williams, William A. Carroll and Michael J. Coghlan
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 379-386; DOI: https://doi.org/10.1124/jpet.102.034538
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    (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization
    Michael E. Brune, Thomas A. Fey, Jorge D. Brioni, James P. Sullivan, Michael Williams, William A. Carroll, Michael J. Coghlan and Murali Gopalakrishnan
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 387-394; DOI: https://doi.org/10.1124/jpet.102.034553

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Nonpeptide Antagonists of AT1 Receptor for Angiotensin II Delay the Onset of Acute Respiratory Distress Syndrome
    Silvina Raiden, Karen Nahmod, Vı́ctor Nahmod, Guillermo Semeniuk, Yanina Pereira, Clarisa Alvarez, Mirta Giordano and Jorge R. Geffner
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 45-51; DOI: https://doi.org/10.1124/jpet.102.037382
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    PPA250 [3-(2,4-Difluorophenyl)-6-{2-[4-(1H-imidazol-1-ylmethyl) Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Effective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-Inflammatory Effect in Animal Models of Chronic Arthritis
    Mari Ohtsuka, Fujiko Konno, Haruyoshi Honda, Takayuki Oikawa, Masago Ishikawa, Nobuhisa Iwase, Kazuo Isomae, Fumio Ishii, Hiromichi Hemmi and Susumu Sato
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 52-57; DOI: https://doi.org/10.1124/jpet.102.035857
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    Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20S,21-Epoxy-resibufogenin-3-formate
    Masahiko Hayashi, Mun-Chual Rho, Akiko Fukami, Akiko Enomoto, Shinobu Nonaka, Yoshino Sekiguchi, Tadashi Yanagisawa, Ayano Yamashita, Toshihiko Nogawa, Yoshiaki Kamano and Kanki Komiyama
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 104-109; DOI: https://doi.org/10.1124/jpet.102.036137
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    Angiotensin-Converting Enzyme Inhibitor-Associated Angioedema Is Characterized by a Slower Degradation of des-Arginine9-Bradykinin
    Giuseppe Molinaro, Massimo Cugno, Mélissa Perez, Yves Lepage, Nicole Gervais, Angelo Agostoni and Albert Adam
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 232-237; DOI: https://doi.org/10.1124/jpet.102.038067
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    Inflammatory Cytokines, but Not Bile Acids, Regulate Expression of Murine Hepatic Anion Transporters in Endotoxemia
    Georgy Hartmann, Annie K. Y. Cheung and Micheline Piquette-Miller
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 273-281; DOI: https://doi.org/10.1124/jpet.102.039404
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    Histamine H4 and H2 Receptors Control Histamine-Induced Interleukin-16 Release from Human CD8+ T Cells
    Florian Gantner, Katsuya Sakai, Michael W. Tusche, William W. Cruikshank, David M. Center and Kevin B. Bacon
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 300-307; DOI: https://doi.org/10.1124/jpet.102.036939
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    Decrease in Efficacy and Potency of Nonsteroidal Anti-Inflammatory Drugs by Chronic Δ9-Tetrahydrocannabinol Administration
    Rene Anikwue, John W. Huffman, Zachary L. Martin and Sandra P. Welch
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 340-346; DOI: https://doi.org/10.1124/jpet.303.1.340

NEUROPHARMACOLOGY

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    Effect of Chronic Administration ofR-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone Mesylate (WIN55,212-2) or Δ9-Tetrahydrocannabinol on Cannabinoid Receptor Adaptation in Mice
    Laura J. Sim-Selley and Billy R. Martin
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 36-44; DOI: https://doi.org/10.1124/jpet.102.035618
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    Muscarinic Agonist-Mediated Increases in Serum Corticosterone Levels Are Abolished in M2 Muscarinic Acetylcholine Receptor Knockout Mice
    S. K. Hemrick-Luecke, F. P. Bymaster, D. C. Evans, J. Wess and C. C. Felder
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 99-103; DOI: https://doi.org/10.1124/jpet.102.036020
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    Peptide Antagonists of Ethanol Inhibition of L1-Mediated Cell-Cell Adhesion
    Michael F. Wilkemeyer, Carrie E. Menkari, Catherine Y. Spong and Michael E. Charness
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 110-116; DOI: https://doi.org/10.1124/jpet.102.036277
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    Nociceptin/Orphanin FQ Modulation of Ionic Conductances in Rat Basal Forebrain Neurons
    J. H. Chin, K. Harris, D. MacTavish and J. H. Jhamandas
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 188-195; DOI: https://doi.org/10.1124/jpet.102.037945
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    Nonopioid and Neuropathy-Specific Analgesic Action of the Nootropic Drug Nefiracetam in Mice
    Md. Harunor Rashid and Hiroshi Ueda
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 226-231; DOI: https://doi.org/10.1124/jpet.102.037952
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    Inhibition of Improgan Antinociception by the Cannabinoid (CB)1 AntagonistN-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): Lack of Obligatory Role for Endocannabinoids Acting at CB1 Receptors
    L. B. Hough, J. W. Nalwalk, R. Stadel, H. Timmerman, R. Leurs, B. C. Paria, X. Wang and S. K. Dey
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 314-322; DOI: https://doi.org/10.1124/jpet.102.036251
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    Modulation of Hippocampal Glutamatergic Transmission by ATP Is Dependent on Adenosine A1 Receptors
    Susan A. Masino, Lihong Diao, Peter Illes, Nancy R. Zahniser, Gaynor A. Larson, Björn Johansson, Bertil B. Fredholm and Thomas V. Dunwiddie
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 356-363; DOI: https://doi.org/10.1124/jpet.102.036731
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    Role of the Nitric Oxide Pathway in κ-Opioid-Induced Hypothermia in Rats
    Khalid Benamar, Ellen B. Geller and Martin W. Adler
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 375-378; DOI: https://doi.org/10.1124/jpet.102.036269
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    N-Methyl-d-aspartate Antagonists and WIN 55212-2 [4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a Cannabinoid Agonist, Interact to Produce Synergistic Hypothermia
    S. M. Rawls, A. Cowan, R. J. Tallarida, Ellen B. Geller and Martin W. Adler
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 395-402; DOI: https://doi.org/10.1124/jpet.102.037473

TOXICOLOGY

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    Primaquine-Induced Hemolytic Anemia: Effect of 6-Methoxy-8-hydroxylaminoquinoline on Rat Erythrocyte Sulfhydryl Status, Membrane Lipids, Cytoskeletal Proteins, and Morphology
    Laura J. C. Bolchoz, Jason D. Morrow, David J. Jollow and David C. McMillan
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 141-148; DOI: https://doi.org/10.1124/jpet.102.036921
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    Differential Effects of Linoleic Acid Metabolites on Cardiac Sodium Current
    Maddison D. Harrell and Joseph R. Stimers
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 347-355; DOI: https://doi.org/10.1124/jpet.102.038166

ASPET MEETING REPORT

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    Meeting Report for the ASPET Ray Fuller Symposium: Lower Urinary Tract Disorders: Physiology, Pharmacology, and Therapeutic Approaches
    Martin C. Michel and Jorge D. Brioni
    Journal of Pharmacology and Experimental Therapeutics October 2002, 303 (1) 431-437; DOI: https://doi.org/10.1124/jpet.303.1.431
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Journal of Pharmacology and Experimental Therapeutics: 303 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 303, Issue 1
1 Oct 2002
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • ASPET MEETING REPORT
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