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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2002; Volume 302,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Regulation of Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) and Its Role in Drug Disposition
    Phillip M. Gerk and Mary Vore
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 407-415; DOI: https://doi.org/10.1124/jpet.102.035014

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Effect of Hyperinsulinemia and Type 2 Diabetes-Like Hyperglycemia on Expression of Hepatic Cytochrome P450 and GlutathioneS-Transferase Isoforms in a New Zealand Obese-Derived Mouse Backcross Population
    Georgia J. Pass, Walter Becker, Reinhart Kluge, Katharina Linnartz, Leona Plum, Kirsten Giesen and Hans-Georg Joost
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 442-450; DOI: https://doi.org/10.1124/jpet.102.033553
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    Expression and Induction of CYP2C P450 Enzymes in Primary Cultures of Human Hepatocytes
    Judy L. Raucy, Lisa Mueller, Kui Duan, Scott W. Allen, Stephen Strom and Jerome M. Lasker
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 475-482; DOI: https://doi.org/10.1124/jpet.102.033837
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    Gender Difference in the Urinary Excretion of Organic Anions in Rats
    Yukio Kato, Kiyoka Kuge, Hiroyuki Kusuhara, Peter J. Meier and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 483-489; DOI: https://doi.org/10.1124/jpet.102.033878
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    Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin
    De-Sheng Wang, Johan W. Jonker, Yukio Kato, Hiroyuki Kusuhara, Alfred H. Schinkel and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 510-515; DOI: https://doi.org/10.1124/jpet.102.034140
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    Digoxin Uptake, Receptor Heterogeneity, and Inotropic Response in the Isolated Rat Heart: A Comprehensive Kinetic Model
    Wonku Kang and Michael Weiss
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 577-583; DOI: https://doi.org/10.1124/jpet.302.2.577
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    The Concordance of Early Antipyrine and Thiopental Distribution Kinetics
    Michael J. Avram, Tom C. Krejcie and Thomas K. Henthorn
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 594-600; DOI: https://doi.org/10.1124/jpet.102.034611
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    bis-Cholesteryl-Conjugated Phosphorothioate Oligodeoxynucleotides Are Highly Selectively Taken Up by the Liver
    Martin K. Bijsterbosch, Muthiah Manoharan, Rick Dorland, Richard van Veghel, Erik A. L. Biessen and Theo J. C. van Berkel
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 619-626; DOI: https://doi.org/10.1124/jpet.302.2.619
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    Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4
    Rajinder K. Bhardwaj, Hartmut Glaeser, Laurent Becquemont, Ulrich Klotz, Suresh K. Gupta and Martin F. Fromm
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 645-650; DOI: https://doi.org/10.1124/jpet.102.034728
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    Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters
    Michio Takeda, Suparat Khamdang, Shinichi Narikawa, Hiroaki Kimura, Makoto Hosoyamada, Seok Ho Cha, Takashi Sekine and Hitoshi Endou
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 666-671; DOI: https://doi.org/10.1124/jpet.102.034330
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    Effects of Blood Flow on the in Vivo Recovery of a Small Diffusible Molecule by Microdialysis in Human Skin
    G. F. Clough, P. Boutsiouki, M. K. Church and C. C. Michel
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 681-686; DOI: https://doi.org/10.1124/jpet.102.035634
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    Effect of Interleukin-2 on Intestinal P-glycoprotein Expression and Functionality in Mice
    Celine Veau, Laurence Faivre, Sylviane Tardivel, Mireille Soursac, Helene Banide, Bernard Lacour and Robert Farinotti
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 742-750; DOI: https://doi.org/10.1124/jpet.302.2.742
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    Genetic Polymorphisms of Human Organic Anion Transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele Frequencies in the Japanese Population and Functional Analysis
    Takashi Nozawa, Miki Nakajima, Ikumi Tamai, Kumiko Noda, Jun-ichi Nezu, Yoshimichi Sai, Akira Tsuji and Tsuyoshi Yokoi
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 804-813; DOI: https://doi.org/10.1124/jpet.302.2.804

BEHAVIORAL PHARMACOLOGY

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    Effects of Antidepressants in Rats Trained to Discriminate Centrally Administered Isoproterenol
    Alicia M. Crissman and James M. O'Donnell
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 606-611; DOI: https://doi.org/10.1124/jpet.102.034686
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    SL65.0155, A Novel 5-Hydroxytryptamine4 Receptor Partial Agonist with Potent Cognition-Enhancing Properties
    Paul C. Moser, Olivier E. Bergis, Samir Jegham, Alistair Lochead, Elee Duconseille, Jean-Paul Terranova, Dominique Caille, Isabelle Berque-Bestel, Frank Lezoualc'h, Rodolphe Fischmeister, Aline Dumuis, Joel Bockaert, Pascal George, Philippe Soubrié and Bernard Scatton
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 731-741; DOI: https://doi.org/10.1124/jpet.102.034249
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    Characterization of Epibatidine Binding to Medial Habenula: Potential Role in Analgesia
    Per Plenge, Erling T. Mellerup and Gitta Wörtwein
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 759-765; DOI: https://doi.org/10.1124/jpet.102.033498

CARDIOVASCULAR

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    Gender Differences in Hypothalamic Tyrosine Hydroxylase and α2-Adrenoceptor Subtype Gene Expression in Cafeteria Diet-Induced Hypertension and Consequences of Neonatal Androgenization
    Charles Plut, Catherine Ribiere, Yves Giudicelli and Jean-Pierre Dausse
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 525-531; DOI: https://doi.org/10.1124/jpet.302.2.525
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    Ischemia Promotes Renin Activation and Angiotensin Formation in Sympathetic Nerve Terminals Isolated from the Human Heart: Contribution to Carrier-Mediated Norepinephrine Release
    Nahid Seyedi, Motohiro Koyama, Christina J. Mackins and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 539-544; DOI: https://doi.org/10.1124/jpet.302.2.539
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    Modulation of the Human Kv1.5 Channel by Protein Kinase C Activation: Role of the Kvβ1.2 Subunit
    Christine P. Williams, NingNing Hu, Wangzhen Shen, Amy B. Mashburn and Katherine T. Murray
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 545-550; DOI: https://doi.org/10.1124/jpet.102.033357
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    Statins Modulate Oxidized Low-Density Lipoprotein-Mediated Adhesion Molecule Expression in Human Coronary Artery Endothelial Cells: Role of LOX-1
    Dayuan Li, Hongjiang Chen, Francesco Romeo, Tatsuya Sawamura, Tom Saldeen and Jawahar L. Mehta
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 601-605; DOI: https://doi.org/10.1124/jpet.102.034959
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    The Endothelin A Receptor Antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) Reverse the Hypoxic Pulmonary Vasoconstriction in the Perinatal Lamb
    Yashu Coe, Stephen J. Haleen, Kathleen M. Welch, You-An Liu and Flavio Coceani
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 672-680; DOI: https://doi.org/10.1124/jpet.302.2.672
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    Renal Cytochrome P450 Oxygenases and Preglomerular Vascular Response to Arachidonic Acid and Endothelin-1 Following Ischemia/Reperfusion
    Hantz Hercule and Adebayo Oyekan
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 717-724; DOI: https://doi.org/10.1124/jpet.302.2.717
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    Suppression of Adenosine A3 Receptor-Mediated Hypotension and Mast Cell Degranulation in the Rat by Dexamethasone
    Jason P. Hannon, Bruno Tigani, Henk-Jan Schuurman and John R. Fozard
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 725-730; DOI: https://doi.org/10.1124/jpet.102.035790
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    Vasoactivity of Diadenosine Polyphosphates in Human Small Mesenteric Resistance Arteries
    Martin Steinmetz, Ann-Kathrin Janssen, Franz Pelster, Karl Heinz Rahn and Eberhard Schlatter
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 787-794; DOI: https://doi.org/10.1124/jpet.302.2.787
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    The Relationship of Clinical QT Prolongation to Outcome in the Conscious Dog Using a Beat-to-Beat QT-RR Interval Assessment
    Anthony A. Fossa, Michael J. DePasquale, David L. Raunig, Michael J. Avery and Derek J. Leishman
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 828-833; DOI: https://doi.org/10.1124/jpet.102.035220

CELLULAR AND MOLECULAR

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    Modulation of Neuronal Nicotinic Acetylcholine Receptors by Mercury
    Armen Mirzoian and Charles W. Luetje
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 560-567; DOI: https://doi.org/10.1124/jpet.102.035154
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    Molecular Actions of (S)-Desmethylzopiclone (SEP-174559), an Anxiolytic Metabolite of Zopiclone
    Mark W. Fleck
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 612-618; DOI: https://doi.org/10.1124/jpet.102.033886
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    Antisense Oligonucleotides Selectively Regulate Aspartyl β-Hydroxylase and Its Truncated Protein Isoform in Vitro but Distribute Poorly into A549 Tumors in Vivo
    Siew Peng Ho, Michael S. Scully, Candice M. Krauthauser, Eric J. Wexler, Mark D. Stow, Joseph E. Dinchuk, Janet S. Kerr and Paul A. Friedman
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 795-803; DOI: https://doi.org/10.1124/jpet.302.2.795

ENDOCRINE AND REPRODUCTIVE

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    Prevention of Latently Expressed CYP2C11, CYP3A2, and Growth Hormone Defects in Neonatally Monosodium Glutamate-Treated Male Rats by the N-Methyl-d-Aspartate Receptor Antagonist Dizocilpine Maleate
    Antje Kaufhold, Prabhat K. Nigam, Ravindra N. Dhir and Bernard H. Shapiro
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 490-496; DOI: https://doi.org/10.1124/jpet.102.034785
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    Persistent Suppression of Hepatic CYP2A1 Expression and Serum Triiodothyronine Levels by Tamoxifen in Intact Female Rats: Dose-Response Analysis and Comparison with 4-Hydroxytamoxifen, Fulvestrant (ICI 182,780), and 17β-Estradiol-3-benzoate
    Ludger M. Ickenstein and Stelvio M. Bandiera
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 584-593; DOI: https://doi.org/10.1124/jpet.102.034744

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Transport Mechanisms of Nicotine across the Human Intestinal Epithelial Cell Line Caco-2
    Atsuko Fukada, Hideyuki Saito and Ken-ichi Inui
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 532-538; DOI: https://doi.org/10.1124/jpet.102.034629
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    Roles of Substance P Receptors in Human Colon Circular Muscle: Alterations in Diverticular Disease
    Lu Liu, Fei Shang, Irit Markus and Elizabeth Burcher
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 627-635; DOI: https://doi.org/10.1124/jpet.102.034702
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    Inhibition of Human and Pig Ureter Motility in Vitro and in Vivo by the K+ Channel Openers PKF 217-744b and Nicorandil
    Ruth Weiss, Meike Mevissen, Daniela S. Hauser, Günter Scholtysik, Christopher J. Portier, Bernhard Walter, Urs E. Studer and Hansjörg Danuser
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 651-658; DOI: https://doi.org/10.1124/jpet.302.2.651
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    Antinerve Growth Factor Treatment Prevents Intestinal Dysmotility in Trichinella spiralis-Infected Rats
    D. Torrents, R. Torres, F. de Mora and P. Vergara
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 659-665; DOI: https://doi.org/10.1124/jpet.102.035287
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    Goblet Cell Hyperplasia, Airway Function, and Leukocyte Infiltration after Chronic Lipopolysaccharide Exposure in Conscious Guinea Pigs: Effects of Rolipram and Dexamethasone
    Toby J. Toward and Kenneth J. Broadley
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 814-821; DOI: https://doi.org/10.1124/jpet.102.033951

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Δ9-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo
    Robert J. McKallip, Catherine Lombard, Billy R. Martin, Mitzi Nagarkatti and Prakash S. Nagarkatti
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 451-465; DOI: https://doi.org/10.1124/jpet.102.033506
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    Proteinase-Activated Receptor (PAR)-1 and -2 Agonists Induce Mediator Release from Mast Cells by Pathways Distinct from PAR-1 and PAR-2
    Grant R. Stenton, Osamu Nohara, René E. Déry, Harissios Vliagoftis, Mark Gilchrist, Ankur Johri, John L. Wallace, Morley D. Hollenberg, Redwan Moqbel and A. Dean Befus
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 466-474; DOI: https://doi.org/10.1124/jpet.302.2.466

NEUROPHARMACOLOGY

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    Dopamine Modulates the Function of Group II and Group III Metabotropic Glutamate Receptors in the Substantia Nigra Pars Reticulata
    Marion Wittmann, Michael J. Marino and P. Jeffrey Conn
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 433-441; DOI: https://doi.org/10.1124/jpet.102.033266
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    A Single Methamphetamine Administration Rapidly Decreases Vesicular Dopamine Uptake
    Jeffrey M. Brown, Evan L. Riddle, Verónica Sandoval, Raul K. Weston, Jarom E. Hanson, Michael J. Crosby, Yvette V. Ugarte, James W. Gibb, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 497-501; DOI: https://doi.org/10.1124/jpet.302.2.497
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    Orphanin FQ/Nociceptin-Mediated Desensitization of Opioid Receptor-Like 1 Receptor and μ Opioid Receptors Involves Protein Kinase C: A Molecular Mechanism for Heterologous Cross-Talk
    Chitra D. Mandyam, Deepak R. Thakker, Jennifer L. Christensen and Kelly M. Standifer
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 502-509; DOI: https://doi.org/10.1124/jpet.102.033159
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    Alcohol-Induced c-Fos Expression in the Edinger-Westphal Nucleus: Pharmacological and Signal Transduction Mechanisms
    Ryan K. Bachtell, Natalia O. Tsivkovskaia and Andrey E. Ryabinin
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 516-524; DOI: https://doi.org/10.1124/jpet.102.036046
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    The Effect of Chronic Ethanol Consumption and Withdrawal on μ-Opioid and Dopamine D1 and D2 Receptor Density in Fawn-Hooded Rat Brain
    Elvan Djouma and Andrew J. Lawrence
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 551-559; DOI: https://doi.org/10.1124/jpet.102.035915
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    Morphine-3β-d-glucuronide Suppresses Inhibitory Synaptic Transmission in Rat Substantia Gelatinosa
    Timothy D. Moran and Peter A. Smith
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 568-576; DOI: https://doi.org/10.1124/jpet.102.035626
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    Correlation between Anticonvulsant Activity and Inhibitory Action on Glial γ-Aminobutyric Acid Uptake of the Highly Selective Mouse γ-Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and ItsN-Alkylated Analogs
    H. Steve White, Alan Sarup, Tina Bolvig, Anders S. Kristensen, Gitte Petersen, Nathan Nelson, Darryl S. Pickering, Orla M. Larsson, Bente Frølund, Povl Krogsgaard-Larsen and Arne Schousboe
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 636-644; DOI: https://doi.org/10.1124/jpet.102.034819
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    Reboxetine: Functional Inhibition of Monoamine Transporters and Nicotinic Acetylcholine Receptors
    Dennis K. Miller, Erik H. F. Wong, M. Dathan Chesnut and Linda P. Dwoskin
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 687-695; DOI: https://doi.org/10.1124/jpet.302.2.687
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    Pharmacological Profile of (2R-trans)-4-[1-[3,5-bis(Trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an Orally and Centrally Active Neurokinin-1 Receptor Antagonist
    A. A. H. P. Megens, D. Ashton, J. C. A. Vermeire, P. C. M. Vermote, K. A. Hens, L. C. Hillen, J. F. Fransen, M. Mahieu, L. Heylen, J. E. Leysen, M. R. Jurzak and F. Janssens
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 696-709; DOI: https://doi.org/10.1124/jpet.102.034348
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    Cocaine Metabolism Accelerated by a Re-Engineered Human Butyrylcholinesterase
    Hong Sun, Maryann L. Shen, Yuan-Ping Pang, Oksana Lockridge and Stephen Brimijoin
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 710-716; DOI: https://doi.org/10.1124/jpet.302.2.710
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    Appetite-Boosting Property of Pro-Melanin-Concentrating Hormone131–165 (Neuropeptide-Glutamic Acid-Isoleucine) Is Associated with Proteolytic Resistance
    Laurence Maulon-Feraille, Odile Della Zuana, Thomas Suply, Carole Rovere-Jovene, Valérie Audinot, Nigel Levens, Jean A. Boutin, Jacques Duhault and Jean-Louis Nahon
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 766-773; DOI: https://doi.org/10.1124/jpet.302.2.766
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    Chronic Morphine-Induced Changes in μ-Opioid Receptors and G Proteins of Different Subcellular Loci in Rat Brain
    G. Fábián, B. Bozó, M. Szikszay, G. Horváth, C. J. Coscia and M. Szücs
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 774-780; DOI: https://doi.org/10.1124/jpet.102.036152
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    Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure
    William A. Banks, Matthias Tschöp, Sandra M. Robinson and Mark L. Heiman
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 822-827; DOI: https://doi.org/10.1124/jpet.102.034827

TOXICOLOGY

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    Genetic Polymorphisms of the Human CYP2A13 Gene: Identification of Single-Nucleotide Polymorphisms and Functional Characterization of an Arg257Cys Variant
    Xiuling Zhang, Ting Su, Qing-Yu Zhang, Jun Gu, Michele Caggana, Hongming Li and Xinxin Ding
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 416-423; DOI: https://doi.org/10.1124/jpet.302.2.416
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    Effects of Methylmercury on Human Neuronal L-Type Calcium Channels Transiently Expressed in Human Embryonic Kidney Cells (HEK-293)
    Shuangqing Peng, Ravindra K. Hajela and William D. Atchison
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 424-432; DOI: https://doi.org/10.1124/jpet.102.032748
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    Wild-Type and A328W Mutant Human Butyrylcholinesterase Tetramers Expressed in Chinese Hamster Ovary Cells Have a 16-Hour Half-Life in the Circulation and Protect Mice from Cocaine Toxicity
    Ellen G. Duysen, Cynthia F. Bartels and Oksana Lockridge
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 751-758; DOI: https://doi.org/10.1124/jpet.102.033746
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    The Activation of Neuronal Nitric-Oxide Synthase by Various Divalent Cations
    John Weaver, Supatra Porasuphatana, Pei Tsai, Guan-Liang Cao, Theodore A. Budzichowski, Linda J. Roman and Gerald M. Rosen
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 781-786; DOI: https://doi.org/10.1124/jpet.102.035337

Errata

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    Corrections to “July 2002 Table of Contents”
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 834; DOI: https://doi.org/10.1124/jpet.302.2.834
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    Correction to “Characterization of the Transport Properties of Organic Anion Transporting Polypeptide 1 (oatp1) and Na+/Taurocholate Cotransporting Polypeptide (Ntcp): Comparative Studies on the Inhibitory Effect of Their Possible Substrates in Hepatocytes and cDNA-Transfected COS-7 Cells”
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 835;
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    Correction to “Clocinnamox Distinguishes Opioid Agonists According to Relative Efficacy in Normal and Morphine-Treated Rats Trained to Discriminate Morphine”
    Journal of Pharmacology and Experimental Therapeutics August 2002, 302 (2) 836;
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Journal of Pharmacology and Experimental Therapeutics: 302 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 302, Issue 2
1 Aug 2002
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Errata
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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