Journal of Pharmacology and Experimental Therapeutics: 301 (2)

May 01, 2002; Volume 301,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Characteristics of the Fetal/Maternal Interface with Potential Usefulness in the Development of Future Immunological and Pharmacological Strategies
Kenneth L. Audus, Michael J. Soares and Joan S. Hunt

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 402-409; DOI: https://doi.org/10.1124/jpet.301.2.402
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Genetic Manipulation of Noradrenergic Neurons
Robert P. Carson and David Robertson

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 410-417; DOI: https://doi.org/10.1124/jpet.301.2.410

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Pharmacokinetic Analysis of in Vivo Disposition of Succinylated Proteins Targeted to Liver Nonparenchymal Cells via Scavenger Receptors: Importance of Molecular Size and Negative Charge Density for in Vivo Recognition by Receptors
Yasuomi Yamasaki, Kazuya Sumimoto, Makiya Nishikawa, Fumiyoshi Yamashita, Kiyoshi Yamaoka, Mitsuru Hashida and Yoshinobu Takakura

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 467-477; DOI: https://doi.org/10.1124/jpet.301.2.467
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Clinical Pharmacokinetics of 5-Aminolevulinic Acid in Healthy Volunteers and Patients at High Risk for Recurrent Bladder Cancer
James T. Dalton, Charles R. Yates, Donghua Yin, Arthur Straughn, Stuart L. Marcus, Allyn L. Golub and Marvin C. Meyer

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 507-512; DOI: https://doi.org/10.1124/jpet.301.2.507
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Tissue Expression, Ontogeny, and Inducibility of Rat Organic Anion Transporting Polypeptide 4
Ning Li, Dylan P. Hartley, Nathan J. Cherrington and Curtis D. Klaassen

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 551-560; DOI: https://doi.org/10.1124/jpet.301.2.551
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Short- and Long-Term Influences of Heavy Metals on Anionic Drug Efflux from Renal Proximal Tubule
Sylvie A. Terlouw, Claudia Graeff, Pascal H. E. Smeets, Gert Fricker, Frans G. M. Russel, Rosalinde Masereeuw and David S. Miller

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 578-585; DOI: https://doi.org/10.1124/jpet.301.2.578
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Intestinal Metabolism Promotes Regional Differences in Apical Uptake of Indinavir: Coupled Effect of P-Glycoprotein and Cytochrome P450 3A on Indinavir Membrane Permeability in Rat
Lilian Y. Li, Gordon L. Amidon, Jae Seung Kim, Tycho Heimbach, Filippos Kesisoglou, John T. Topliss and David Fleisher

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 586-593; DOI: https://doi.org/10.1124/jpet.301.2.586
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Accelerated Metabolism of Nicotine and Cotinine in Pregnant Smokers
Delia Dempsey, Peyton Jacob and Neal L. Benowitz

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 594-598; DOI: https://doi.org/10.1124/jpet.301.2.594
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Pharmacokinetic Advantage of Intrapericardially Applied Substances in the Rat
J. J. Rob Hermans, Helma van Essen, Harry A. J. Struijker-Boudier, Randolph M. Johnson, Felix Theeuwes and Jos F. M. Smits

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 672-678; DOI: https://doi.org/10.1124/jpet.301.2.672

ANNOUNCEMENT

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S. J. Enna

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 401; DOI: https://doi.org/10.1124/jpet.301.2.401

BEHAVIORAL PHARMACOLOGY

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Relative Reinforcing Strength of ThreeN-Methyl-d-Aspartate Antagonists with Different Onsets of Action
G. Winger, S. R. Hursh, K. L. Casey and J. H. Woods

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 690-697; DOI: https://doi.org/10.1124/jpet.301.2.690
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Relative Reinforcing Effects of Three Opioids with Different Durations of Action
M. C. Ko, J. Terner, S. Hursh, J. H. Woods and G. Winger

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 698-704; DOI: https://doi.org/10.1124/jpet.301.2.698

CARDIOVASCULAR

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Involvement of Rho-Kinase Pathway for Angiotensin II-Induced Plasminogen Activator Inhibitor-1 Gene Expression and Cardiovascular Remodeling in Hypertensive Rats
Naohiko Kobayashi, Shigefumi Nakano, Shin-ichiro Mita, Tsutomu Kobayashi, Takeaki Honda, Yusuke Tsubokou and Hiroaki Matsuoka

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 459-466; DOI: https://doi.org/10.1124/jpet.301.2.459
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On the Role of Phosphatase in Regulation of Cardiac L-Type Calcium Current by Cyclic GMP
Jian-Bing Shen and Achilles J. Pappano

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 501-506; DOI: https://doi.org/10.1124/jpet.301.2.501
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Enhancement of Glutathione Cardioprotection by Ascorbic Acid in Myocardial Reperfusion Injury
Feng Gao, Chen-Lin Yao, Erhe Gao, Qi-Zhong Mo, Wen-Li Yan, Richard McLaughlin, Bernard L. Lopez, Theodore A. Christopher and Xin L. Ma

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 543-550; DOI: https://doi.org/10.1124/jpet.301.2.543
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A New Family of Thromboxane Receptor Antagonists with Secondary Thromboxane Synthase Inhibition
Cecil R. Pace-Asciak, Denis Reynaud, Peter Demin, Rukshana Aslam and Andrea Sun

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 618-624; DOI: https://doi.org/10.1124/jpet.301.2.618
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Subconductance Activity Induced by Quinidine and Quinidinium in Purified Cardiac Sarcoplasmic Reticulum Calcium Release Channels
Robert G. Tsushima, James E. Kelly and J. Andrew Wasserstrom

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 729-737; DOI: https://doi.org/10.1124/jpet.301.2.729

CELLULAR AND MOLECULAR

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Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel
Sean Ekins, William J. Crumb, R. Dustan Sarazan, James H. Wikel and Steven A. Wrighton

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 427-434; DOI: https://doi.org/10.1124/jpet.301.2.427
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The Role of Transmembrane Helix 5 in Agonist Binding to the Human H3 Receptor
Albert J. Uveges, Dianne Kowal, Yingxin Zhang, Taylor B. Spangler, John Dunlop, Simon Semus and Philip G. Jones

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 451-458; DOI: https://doi.org/10.1124/jpet.301.2.451
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Inhibition of cAMP Accumulation by κ-Receptor Activation in Isolated Iris-Ciliary Bodies: Role of Phosphodiesterase and Protein Kinase C
Juanita Dortch-Carnes and David E. Potter

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 599-604; DOI: https://doi.org/10.1124/jpet.301.2.599
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Geraniol, a Component of Plant Essential Oils, Sensitizes Human Colonic Cancer Cells to 5-Fluorouracil Treatment
S. Carnesecchi, K. Langley, F. Exinger, F. Gosse and F. Raul

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 625-630; DOI: https://doi.org/10.1124/jpet.301.2.625
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Nongenomic Regulation of the Kinetics of Exocytosis by Estrogens
José D. Machado, Carmen Alonso, Araceli Morales, José F. Gómez and Ricardo Borges

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 631-637; DOI: https://doi.org/10.1124/jpet.301.2.631
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P2Y₁₃: Identification and Characterization of a Novel Gαi-Coupled ADP Receptor from Human and Mouse
Fang L. Zhang, Lin Luo, Eric Gustafson, Kyle Palmer, Xudong Qiao, Xuedong Fan, Shijun Yang, Thomas M. Laz, Marvin Bayne and Frederick Monsma

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 705-713; DOI: https://doi.org/10.1124/jpet.301.2.705
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Allosteric Modulation of Muscarinic Receptor Signaling: Alcuronium-Induced Conversion of Pilocarpine from an Agonist into an Antagonist
Katrin Zahn, Niels Eckstein, Christian Tränkle, Wolfgang Sadée and Klaus Mohr

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 720-728; DOI: https://doi.org/10.1124/jpet.301.2.720
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Modulation of Cellular Expression of Glucocorticoid Receptor and Glucocorticoid Response Element-DNA Binding in Rat Brain during Alcohol Drinking and Withdrawal
Adip Roy, Navdha Mittal, Huaibo Zhang and Subhash C. Pandey

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 774-784; DOI: https://doi.org/10.1124/jpet.301.2.774

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Bryostatin 1 Increases 1-β-d-Arabinofuranosylcytosine-Induced Cytochromec Release and Apoptosis in Human Leukemia Cells Ectopically Expressing Bcl-x_L
Zhiliang Wang, Shujie Wang, Yun Dai and Steven Grant

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 568-577; DOI: https://doi.org/10.1124/jpet.301.2.568
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Conjugates of Nucleoside Analogs with Lactosaminated Human Albumin to Selectively Increase the Drug Levels in Liver Blood: Requirements for a Regional Chemotherapy
Giuseppina Di Stefano, Marcella Lanza, Corrado Busi, Luigi Barbieri and Luigi Fiume

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 638-642; DOI: https://doi.org/10.1124/jpet.301.2.638

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Hepoxilin Analogs Inhibit Bleomycin-Induced Pulmonary Fibrosis in the Mouse
Robert P. Jankov, Xiaoping Luo, Peter Demin, Rukshana Aslam, Vicky Hannam, A. Keith Tanswell and Cecil R. Pace-Asciak

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 435-440; DOI: https://doi.org/10.1124/jpet.301.2.435
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Gastric Effects of Galanin and Its Interaction with Leptin on Brainstem Neuronal Activity
Chun-Su Yuan, Lucy Dey, Jing-Tian Xie and Han H. Aung

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 488-493; DOI: https://doi.org/10.1124/jpet.301.2.488
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Differential Actions of Peripheral Corticotropin-Releasing Factor (CRF), Urocortin II, and Urocortin III on Gastric Emptying and Colonic Transit in Mice: Role of CRF Receptor Subtypes 1 and 2
Vicente Martı́nez, Lixin Wang, Jean E. Rivier, Wylie Vale and Yvette Taché

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 611-617; DOI: https://doi.org/10.1124/jpet.301.2.611
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Muscarinic Receptor Knockout Mice: Role of Muscarinic Acetylcholine Receptors M₂, M₃, and M₄ in Carbamylcholine-Induced Gallbladder Contractility
Peter W. Stengel and Marlene L. Cohen

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 643-650; DOI: https://doi.org/10.1124/jpet.301.2.643

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists
Bernie Scallon, Ann Cai, Nancy Solowski, Amy Rosenberg, Xiao-Yu Song, David Shealy and Carrie Wagner

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 418-426; DOI: https://doi.org/10.1124/jpet.301.2.418
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Role of Cyclooxygenase-2 in Neuronal Cell Cycle Activity and Glutamate-Mediated Excitotoxicity
Mana Mirjany, Lap Ho and Giulio Maria Pasinetti

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 494-500; DOI: https://doi.org/10.1124/jpet.301.2.494
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Pharmacokinetics and Cell Trafficking Dynamics of 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol Hydrochloride (FTY720) in Cynomolgus Monkeys after Single Oral and Intravenous Doses
Hongshan Li, Guy M. L. Meno-Tetang, Kenji Chiba, Noriyuki Arima, Peter Heining and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 519-526; DOI: https://doi.org/10.1124/jpet.301.2.519
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Biochemical and Behavioral Characterization of Novel Methylphenidate Analogs
M. M. Schweri, H. M. Deutsch, A.T. Massey and S. G. Holtzman

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 527-535; DOI: https://doi.org/10.1124/jpet.301.2.527
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A Synthetic Isoquinoline Alkaloid, 1-(β-Naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), Reduces Inducible Nitric Oxide Synthase Expression and Improves Survival in a Rodent Model of Endotoxic Shock
Young Jin Kang, Sook Jae Seo, Hye Sook Yun-Choi, Duk Hyung Lee, Young-Myung Kim and Ki Churl Chang

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 561-567; DOI: https://doi.org/10.1124/jpet.301.2.561
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Anti-Inflammatory Effects of a Cyclosporine Receptor-Binding Compound, D-43787
Andreas Pahl, Meixia Zhang, Katalin Török, Hildegard Kuss, Ute Friedrich, Zoltan Magyar, Jozsef Szekely, Katalin Horvath, Kay Brune and Istvan Szelenyi

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 738-746; DOI: https://doi.org/10.1124/jpet.301.2.738
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Pulmonary Eosinophilia in a Murine Model of Allergic Inflammation Is Attenuated by Small Molecule α4β1 Antagonists
E. Kudlacz, C. Whitney, C. Andresen, A. Duplantier, G. Beckius, L. Chupak, A. Klein, K. Kraus and A. Milici

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 747-752; DOI: https://doi.org/10.1124/jpet.301.2.747

NEUROPHARMACOLOGY

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Modulation of the Rat Hippocampal Dinucleotide Receptor by Adenosine Receptor Activation
Miguel Dı́az-Hernández, M. Fátima Pereira, Jesús Pintor, Rodrigo A. Cunha, J. A. Ribeiro and Marı́a Teresa Miras-Portugal

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 441-450; DOI: https://doi.org/10.1124/jpet.301.2.441
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The Role of Superoxide and Nuclear Factor-κB Signaling inN-Methyl-d-aspartate-Induced Necrosis and Apoptosis
Justin McInnis, Cheng Wang, Noelle Anastasio, Mikael Hultman, YanPing Ye, Daniela Salvemini and Kenneth M. Johnson

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 478-487; DOI: https://doi.org/10.1124/jpet.301.2.478
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Dynorphin A_1–17-Induced Feeding: Pharmacological Characterization Using Selective Opioid Antagonists and Antisense Probes in Rats
Robert M. Silva, Henya C. Grossman, Maria M. Hadjimarkou, Grace C. Rossi, Gavril W. Pasternak and Richard J. Bodnar

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 513-518; DOI: https://doi.org/10.1124/jpet.301.2.513
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Correlation of Neurokinin (NK) 1 Receptor Occupancy in Gerbil Striatum with Behavioral Effects of NK1 Antagonists
Ruth A. Duffy, Geoffrey B. Varty, Cynthia A. Morgan and Jean E. Lachowicz

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 536-542; DOI: https://doi.org/10.1124/jpet.301.2.536
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Enhanced Neuroprotective Effects of Basic Fibroblast Growth Factor in Regional Brain Ischemia after Conjugation to a Blood-Brain Barrier Delivery Vector
Bi-Wei Song, Harry V. Vinters, Dafang Wu and William M. Pardridge

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 605-610; DOI: https://doi.org/10.1124/jpet.301.2.605
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Characterization of Nicotinic Agonist-Induced [³H]Dopamine Release from Synaptosomes Prepared from Four Mouse Brain Regions
Sharon R. Grady, Karen L. Murphy, Jian Cao, Michael J. Marks, J. Michael McIntosh and Allan C. Collins

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 651-660; DOI: https://doi.org/10.1124/jpet.301.2.651
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Agonist, Antagonist, and Inverse Agonist Characteristics of TIPP (H-Tyr-Tic-Phe-Phe-OH), a Selective δ-Opioid Receptor Ligand
Nancy A. Martin, Michael B. Ruckle, Stephanie L. VanHoof and Paul L. Prather

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 661-671; DOI: https://doi.org/10.1124/jpet.301.2.661
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Resorcinol Derivatives: A Novel Template for the Development of Cannabinoid CB₁/CB₂ and CB₂-Selective Agonists
Jenny L. Wiley, Irina D. Beletskaya, Edward W. Ng, Zongmin Dai, Peter J. Crocker, Anu Mahadevan, Raj K. Razdan and Billy R. Martin

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 679-689; DOI: https://doi.org/10.1124/jpet.301.2.679
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Dual Modulation of Striatal Acetylcholine Release by Hyperforin, a Constituent of St. John's Wort
Marie-Luise Buchholzer, Claudia Dvorak, Shyam S. Chatterjee and Jochen Klein

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 714-719; DOI: https://doi.org/10.1124/jpet.301.2.714
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Propargylamines Induce Antiapoptotic New Protein Synthesis in Serum- and Nerve Growth Factor (NGF)-Withdrawn, NGF-Differentiated PC-12 Cells
W. G. Tatton, R. M. E. Chalmers-Redman, W. J. H. Ju, M. Mammen, G. W. Carlile, A. W. Pong and N. A. Tatton

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 753-764; DOI: https://doi.org/10.1124/jpet.301.2.753
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Enhanced Inhibition of a Mutant Neuronal Nicotinic Acetylcholine Receptor by Agonists: Protection of Function by (E)-N-Methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403)
Roger L. Papke

Journal of Pharmacology and Experimental Therapeutics May 2002, 301 (2) 765-773; DOI: https://doi.org/10.1124/jpet.301.2.765

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

ANNOUNCEMENT

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

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