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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Identification of a Novel Route of Extraction of Sirolimus in Human Small Intestine: Roles of Metabolism and Secretion

Mary F. Paine, Louis Y. Leung, H. K. Lim, Kecheng Liao, Aram Oganesian, Mei-Yi Zhang, Kenneth E. Thummel and Paul B. Watkins
Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 174-186; DOI: https://doi.org/10.1124/jpet.301.1.174
Mary F. Paine
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Louis Y. Leung
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H. K. Lim
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Kecheng Liao
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Aram Oganesian
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Mei-Yi Zhang
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Kenneth E. Thummel
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Paul B. Watkins
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Article Information

vol. 301 no. 1 174-186
DOI 
https://doi.org/10.1124/jpet.301.1.174
PubMed 
11907172

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 27, 2001
  • Accepted December 20, 2001
  • Published online April 1, 2002.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mary F. Paine1,
  2. Louis Y. Leung2,
  3. H. K. Lim1,2,
  4. Kecheng Liao2,
  5. Aram Oganesian2,
  6. Mei-Yi Zhang2,
  7. Kenneth E. Thummel3 and
  8. Paul B. Watkins1
  1. 1General Clinical Research Center and Division of Pharmacotherapy, University of North Carolina, Chapel Hill, North Carolina (M.F.P., P.B.W); 2Drug Safety and Metabolism, Wyeth-Ayerst Research, Collegeville, Pennsylvania (L.Y.L., H.K.L., K.L., A.O., M.-Y.Z.); and 3Department of Pharmaceutics, University of Washington, Seattle, Washington (K.E.T.)
  1. Paul B. Watkins, M.D., General Clinical Research Center, Room 3005 Main Bldg., Campus Box 7600, University of North Carolina Hospitals, Chapel Hill, NC 27599-7600. E-mail: pbwatkins{at}med.unc.edu
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Journal of Pharmacology and Experimental Therapeutics: 301 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 301, Issue 1
1 Apr 2002
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Identification of a Novel Route of Extraction of Sirolimus in Human Small Intestine: Roles of Metabolism and Secretion

Mary F. Paine, Louis Y. Leung, H. K. Lim, Kecheng Liao, Aram Oganesian, Mei-Yi Zhang, Kenneth E. Thummel and Paul B. Watkins
Journal of Pharmacology and Experimental Therapeutics April 1, 2002, 301 (1) 174-186; DOI: https://doi.org/10.1124/jpet.301.1.174

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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Identification of a Novel Route of Extraction of Sirolimus in Human Small Intestine: Roles of Metabolism and Secretion

Mary F. Paine, Louis Y. Leung, H. K. Lim, Kecheng Liao, Aram Oganesian, Mei-Yi Zhang, Kenneth E. Thummel and Paul B. Watkins
Journal of Pharmacology and Experimental Therapeutics April 1, 2002, 301 (1) 174-186; DOI: https://doi.org/10.1124/jpet.301.1.174
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