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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein

Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 160-167; DOI: https://doi.org/10.1124/jpet.301.1.160
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein

Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics April 1, 2002, 301 (1) 160-167; DOI: https://doi.org/10.1124/jpet.301.1.160
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