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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein

Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 160-167; DOI: https://doi.org/10.1124/jpet.301.1.160

Article Information

vol. 301 no. 1 160-167
DOI 
https://doi.org/10.1124/jpet.301.1.160
PubMed 
11907170
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 18, 2001
  • Accepted December 26, 2001
  • Published online April 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hsia-lien Lin,
  2. Ute M. Kent and
  3. Paul F. Hollenberg
  1. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan
  1. Dr. Paul F. Hollenberg, Department of Pharmacology, University of Michigan School of Medicine, 2301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0632. E-mail: phollen{at}umich.edu
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein

Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics April 1, 2002, 301 (1) 160-167; DOI: https://doi.org/10.1124/jpet.301.1.160
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