Advertisement
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein

Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 160-167; DOI: https://doi.org/10.1124/jpet.301.1.160

Article Information

vol. 301 no. 1 160-167
DOI 
https://doi.org/10.1124/jpet.301.1.160
PubMed 
11907170
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 18, 2001
  • Accepted December 26, 2001
  • Published online April 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hsia-lien Lin,
  2. Ute M. Kent and
  3. Paul F. Hollenberg
  1. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan
  1. Dr. Paul F. Hollenberg, Department of Pharmacology, University of Michigan School of Medicine, 2301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0632. E-mail: phollen{at}umich.edu
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: March 2002 to January 2021

AbstractFullPdf
Mar 2002322987
Apr 2002287696
May 200274569
Jun 200213043
Jul 200242128
Aug 200262734
Sep 200242444
Oct 200232335
Nov 200231424
Dec 200231724
Jan 200352018
Feb 200343522
Mar 200342125
Apr 200311229
May 200342926
Jun 200342724
Jul 200383016
Aug 200353018
Sep 200352727
Oct 20036913
Nov 200383221
Dec 200362921
Jan 2004133423
Feb 2004163824
Mar 2004123213
Apr 2004122913
May 2004123614
Jun 2004102521
Jul 2004213926
Aug 2004235042
Sep 2004194516
Oct 2004174414
Nov 2004184020
Dec 2004124216
Jan 2005195029
Feb 200584428
Mar 2005135931
Apr 200592018
May 200544728
Jun 200583119
Jul 200553726
Aug 200551918
Sep 200582014
Oct 2005112021
Nov 200564423
Dec 2005114123
Jan 200653717
Feb 200682712
Mar 200643317
Apr 200642415
May 200661610
Jun 200651816
Jul 20062239
Aug 200672218
Sep 200652319
Oct 200662419
Nov 200672427
Dec 2006103213
Jan 200782927
Feb 2007131929
Mar 200741523
Apr 2007102525
May 200791924
Jun 20076915
Jul 200771513
Aug 200721813
Sep 2007111919
Oct 200782021
Nov 200722713
Dec 20070146
Jan 200891612
Feb 20087178
Mar 2008132217
Apr 200882212
May 20084137
Jun 2008202412
Jul 2008252516
Aug 2008171516
Sep 2008191216
Oct 2008151315
Nov 2008243021
Dec 2008101214
Jan 200962317
Feb 2009489
Mar 2009181218
Apr 20095178
May 200961111
Jun 20096169
Jul 2009456
Aug 200961411
Sep 2009141310
Oct 2009141516
Nov 2009182224
Dec 2009101718
Jan 2010111019
Feb 20108116
Mar 2010111212
Apr 201014128
May 2010141516
Jun 20108107
Jul 2010398
Aug 2010171012
Sep 20105228
Oct 2010967
Nov 20109205
Dec 20105113
Jan 20111595
Feb 201110259
Mar 2011121514
Apr 2011121512
May 2011161915
Jun 20111287
Jul 2011181410
Aug 201130412
Sep 2011151713
Oct 2011112411
Nov 2011211914
Dec 20112399
Jan 2012142115
Feb 201210911
Mar 2012341416
Apr 2012171411
May 2012182115
Jun 201220610
Jul 201210147
Aug 2012141018
Sep 201217910
Oct 201215914
Nov 20121099
Dec 201216913
Jan 201312910
Feb 201314611
Mar 201320129
Apr 2013241012
May 201311611
Jun 2013777
Jul 2013531
Aug 20139106
Sep 20131178
Oct 20131565
Nov 20139108
Dec 2013945
Jan 2014543
Feb 20141467
Mar 20141014
Apr 2014668
May 2014141
Jun 20141876
Jul 201423104
Aug 2014655
Sep 2014874
Oct 2014924
Nov 201412610
Dec 20141263
Jan 20151346
Feb 2015554
Mar 20151199
Apr 20151557
May 2015857
Jun 2015575
Jul 20154810
Aug 2015678
Sep 2015675
Oct 2015824
Nov 20151144
Dec 20151066
Jan 2016141311
Feb 20161286
Mar 20162647
Apr 201641012
May 201651313
Jun 2016112116
Jul 2016565
Aug 2016355
Sep 2016883
Oct 20162103
Nov 2016495
Dec 2016112
Jan 20172105
Feb 20172163
Mar 20173158
Apr 2017065
May 2017192
Jun 20170116
Jul 20170154
Aug 20172169
Sep 20171139
Oct 201721010
Nov 20173256
Dec 201711517
Jan 20182259
Feb 20181128
Mar 201821714
Apr 20181186
May 201812010
Jun 20180164
Jul 201831311
Aug 2018085
Sep 20181243
Oct 20183148
Nov 201801810
Dec 2018272
Jan 20191652
Feb 2019621
Mar 20191621
Apr 2019546
May 2019957
Jun 20191225
Jul 2019752
Aug 20191022
Sep 20192713
Oct 20191912
Nov 20191832
Dec 20192273
Jan 20201341
Feb 2020922
Mar 2020321
Apr 2020700
May 2020951
Jun 2020510
Jul 20201622
Aug 2020331
Sep 20201220
Oct 20201110
Nov 2020710
Dec 20201283
Jan 202115205

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein

Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg
Journal of Pharmacology and Experimental Therapeutics April 1, 2002, 301 (1) 160-167; DOI: https://doi.org/10.1124/jpet.301.1.160
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Jump to section