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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

April 01, 2002; Volume 301,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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    Pharmacology and Toxicology of Astrocyte-Neuron Glutamate Transport and Cycling
    Ursula Sonnewald, Hong Qu and Michael Aschner
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 1-6; DOI: https://doi.org/10.1124/jpet.301.1.1
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    Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs
    Wolfgang Löscher and Heidrun Potschka
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 7-14; DOI: https://doi.org/10.1124/jpet.301.1.7

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Gender-Specific and Developmental Influences on the Expression of Rat Organic Anion Transporters
    Susan C. N. Buist, Nathan J. Cherrington, Supratim Choudhuri, Dylan P. Hartley and Curtis D. Klaassen
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 145-151; DOI: https://doi.org/10.1124/jpet.301.1.145
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    Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein
    Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 160-167; DOI: https://doi.org/10.1124/jpet.301.1.160
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    Identification of a Novel Route of Extraction of Sirolimus in Human Small Intestine: Roles of Metabolism and Secretion
    Mary F. Paine, Louis Y. Leung, H. K. Lim, Kecheng Liao, Aram Oganesian, Mei-Yi Zhang, Kenneth E. Thummel and Paul B. Watkins
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 174-186; DOI: https://doi.org/10.1124/jpet.301.1.174
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    Influence of Porcine Actinobacillus pleuropneumoniae Infection and Dexamethasone on the Pharmacokinetic Parameters of Enrofloxacin
    Lynn O. Post, Carol V. Cope, Dorothy E. Farrell, John D. Baker and Michael J. Myers
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 217-222; DOI: https://doi.org/10.1124/jpet.301.1.217
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    Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Transport of Prostaglandins
    Hiroaki Kimura, Michio Takeda, Shinichi Narikawa, Atsushi Enomoto, Kimiyoshi Ichida and Hitoshi Endou
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 293-298; DOI: https://doi.org/10.1124/jpet.301.1.293
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    Kinetic Interactions of Dopamine and Dobutamine with Human Catechol-O-methyltransferase and Monoamine Oxidase in Vitro
    Maohe Yan, Leslie T. Webster and Jeffrey L. Blumer
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 315-321; DOI: https://doi.org/10.1124/jpet.301.1.315
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    In Vitro Analysis of Human Drug Glucuronidation and Prediction of in Vivo Metabolic Clearance
    M. G. Soars, B. Burchell and R. J. Riley
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 382-390; DOI: https://doi.org/10.1124/jpet.301.1.382
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    Intranasal Delivery of Morphine
    L. Illum, P. Watts, A. N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis and S. S. Davis
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 391-400; DOI: https://doi.org/10.1124/jpet.301.1.391

BEHAVIORAL PHARMACOLOGY

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    Effects of (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a Selective Ligand for Nicotinic Acetylcholine Receptors, in Tests of Visual Attention and Distractibility in Rats and Monkeys
    A. V. Terry, V. B. Risbrough, J. J. Buccafusco and F. Menzaghi
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 284-292; DOI: https://doi.org/10.1124/jpet.301.1.284

CARDIOVASCULAR

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    Sustained Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Vascular Response to Injury
    Haisong Ju, Sandhya Nerurkar, Charles F. Sauermelch, Alan R. Olzinski, Rosanna Mirabile, Dawn Zimmerman, John C. Lee, Jerry Adams, Joseph Sisko, Marinella Berova and Robert N. Willette
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 15-20; DOI: https://doi.org/10.1124/jpet.301.1.15
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    The Angiotensin Type 1 Receptor Antagonist, Eprosartan, Attenuates the Progression of Renal Disease in Spontaneously Hypertensive Stroke-Prone Rats with Accelerated Hypertension
    Christian T. Abrahamsen, Frank C. Barone, Wallace G. Campbell, Allen H. Nelson, Lisa C. Contino, Mark A. Pullen, Eugene T. Grygielko, Richard M. Edwards, Nicholas J. Laping and David P. Brooks
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 21-28; DOI: https://doi.org/10.1124/jpet.301.1.21
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    Differential Effects of Bucindolol and Carvedilol on Noradenaline-Induced Hypertrophic Response in Ventricular Cardiomyocytes of Adult Rats
    Klaus Pönicke, Ingrid Heinroth-Hoffmann and Otto-Erich Brodde
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 71-76; DOI: https://doi.org/10.1124/jpet.301.1.71
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    Altered Cardiovascular Responses in Mice Lacking the M1 Muscarinic Acetylcholine Receptor
    Sandrine N. Hardouin, Keith N. Richmond, Andrew Zimmerman, Susan E. Hamilton, Eric O. Feigl and Neil M. Nathanson
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 129-137; DOI: https://doi.org/10.1124/jpet.301.1.129
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    Cardiovascular Responses Elicited by the “Binge” Administration of Methamphetamine
    Kurt J. Varner, Brian A. Ogden, Joseph Delcarpio and Suzanne Meleg-Smith
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 152-159; DOI: https://doi.org/10.1124/jpet.301.1.152
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    In Vivo α1-Adrenergic Lipolytic Activity in Subcutaneous Adipose Tissue of Obese Subjects
    M. Flechtner-Mors, C. P. Jenkinson, A. Alt, G. Adler and H. H. Ditschuneit
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 229-233; DOI: https://doi.org/10.1124/jpet.301.1.229
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    Differential Effects of Sarcolemmal and Mitochondrial KATP Channels Activated by 17β-Estradiol on Reperfusion Arrhythmias and Infarct Sizes in Canine Hearts
    Chang-Her Tsai, Sheng-Fang Su, Tsai-Fwu Chou and Tsung-Ming Lee
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 234-240; DOI: https://doi.org/10.1124/jpet.301.1.234
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    Inhibitors of Pentose Phosphate Pathway Cause Vasodilation: Involvement of Voltage-Gated Potassium Channels
    Sachin A. Gupte, Kai-Xun Li, Takao Okada, Koichi Sato and Masahiko Oka
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 299-305; DOI: https://doi.org/10.1124/jpet.301.1.299
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    Cyclosporine Adversely Affects Baroreflexes via Inhibition of Testosterone Modulation of Cardiac Vagal Control
    Mahmoud M. El-Mas, Elham A. Afify, Amal G. Omar and Fouad M. Sharabi
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 346-354; DOI: https://doi.org/10.1124/jpet.301.1.346

CELLULAR AND MOLECULAR

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    β1-Selective Agonist (−)-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(−)-RO363] Differentially Interacts with Key Amino Acids Responsible for β1-Selective Binding in Resting and Active States
    Yoshiyuki Sugimoto, Reiko Fujisawa, Ryuji Tanimura, Anne Laure Lattion, Susanna Cotecchia, Gozoh Tsujimoto, Taku Nagao and Hitoshi Kurose
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 51-58; DOI: https://doi.org/10.1124/jpet.301.1.51
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    Ethanol Stimulates cAMP-Responsive Element (CRE)-Mediated Transcription via CRE-Binding Protein and cAMP-Dependent Protein Kinase
    Orna Asher, Thomas D. Cunningham, Lina Yao, Adrienne S. Gordon and Ivan Diamond
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 66-70; DOI: https://doi.org/10.1124/jpet.301.1.66
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    Activation of Endogenous Nitric Oxide Synthase Coupled with Methacholine-Induced Exocytosis in Rat Parotid Acinar Cells
    Yasuko Ishikawa, Hirokazu Iida, Mariusz T. Skowronski and Hajime Ishida
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 355-363; DOI: https://doi.org/10.1124/jpet.301.1.355

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Novel Glutathione-Dependent Thiopurine Prodrugs: Evidence for Enhanced Cytotoxicity in Tumor Cells and for Decreased Bone Marrow Toxicity in Mice
    Sjofn Gunnarsdottir, Marian Rucki and Adnan A. Elfarra
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 77-86; DOI: https://doi.org/10.1124/jpet.301.1.77
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    Dose Optimization of a Doxorubicin Prodrug (HMR 1826) in Isolated Perfused Human Lungs: Low Tumor pH Promotes Prodrug Activation by β-Glucuronidase
    Thomas E. Mürdter, Godehard Friedel, Janne T. Backman, Monika McClellan, Monika Schick, Manfred Gerken, Klaus Bosslet, Peter Fritz, Heikki Toomes, Heyo K. Kroemer and Bernhard Sperker
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 223-228; DOI: https://doi.org/10.1124/jpet.301.1.223

ENDOCRINE AND REPRODUCTIVE

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    Pharmacological Profile of a New, Potent, and Long-Acting Gonadotropin-Releasing Hormone Antagonist: Degarelix
    Pierre Broqua, Pierre J.-M. Riviere, P. Michael Conn, Jean E. Rivier, Michel L. Aubert and Jean-Louis Junien
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 95-102; DOI: https://doi.org/10.1124/jpet.301.1.95
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    Role of Protein Kinase C in Control of Ethanol-Modulated β-Endorphin Release from Hypothalamic Neurons in Primary Cultures
    Alok De, Nadka Boyadjieva and Dipak K. Sarkar
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 119-128; DOI: https://doi.org/10.1124/jpet.301.1.119

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Elucidation of Vasoactive Intestinal Peptide Pharmacophore for VPAC1 Receptors in Human, Rat, and Guinea Pig
    Hisato Igarashi, Tetsuhide Ito, Wei Hou, Samuel A. Mantey, Tapas K. Pradhan, Charles D. Ulrich, Simon J. Hocart, David H. Coy and Robert T. Jensen
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 37-50; DOI: https://doi.org/10.1124/jpet.301.1.37

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    New Cytokine Delivery System Using Gelatin Microspheres Containing Interleukin-10 for Experimental Inflammatory Bowel Disease
    Hiroshi Nakase, Kazuichi Okazaki, Yasuhiko Tabata, Makoto Ozeki, Norihiko Watanabe, Masaya Ohana, Suguru Uose, Kazushige Uchida, Toshiki Nishi, Minoru Mastuura, Hiroyuki Tamaki, Toshiyuki Itoh, Chiharu Kawanami and Tsutomu Chiba
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 59-65; DOI: https://doi.org/10.1124/jpet.301.1.59
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    Priming of Alveolar Macrophage Respiratory Burst by H2O2 Is Prevented by Phosphatidylcholine-Specific Phospholipase C Inhibitor Tricyclodecan-9-yl-xanthate (D609)
    Julio Girón-Calle, Kousthub Srivatsa and Henry Jay Forman
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 87-94; DOI: https://doi.org/10.1124/jpet.301.1.87
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    Inhibitors of ATP-Binding Cassette Transporters Suppress Interleukin-12 p40 Production and Major Histocompatibility Complex II Up-Regulation in Macrophages
    György Haskó, Edwin A. Deitch, Zoltán H. Németh, David G. Kuhel and Csaba Szabó
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 103-110; DOI: https://doi.org/10.1124/jpet.301.1.103
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    Pharmacological Profile of a Novel Phosphodiesterase 4 Inhibitor, 4-(8-Benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic Acid (NVP-ABE171), a 1,7-Naphthyridine Derivative, with Anti-Inflammatory Activities
    Alexandre Trifilieff, Daniel Wyss, Christoph Walker, Lazzaro Mazzoni and Rene Hersperger
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 241-248; DOI: https://doi.org/10.1124/jpet.301.1.241
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    The Selective Phosphodiesterase 4 Inhibitor RP 73-401 Reduced Matrix Metalloproteinase 9 Activity and Transforming Growth Factor-β Release During Acute Lung Injury in Mice: The Role of the Balance Between Tumor Necrosis Factor-α and Interleukin-10
    Marianne Corbel, Noëlla Germain, Jérôme Lanchou, Sophie Molet, Patricia M. R. e Silva, Marco A. Martins, Elisabeth Boichot and Vincent Lagente
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 258-265; DOI: https://doi.org/10.1124/jpet.301.1.258

NEUROPHARMACOLOGY

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    Prevention of in Vivo Excitotoxicity by a Family of Trialkylglycines, a Novel Class of Neuroprotectants
    Carmina Montoliu, Marc Humet, Juan-José Canales, Jozef Burda, Rosa Planells-Cases, Francisco Sánchez-Baeza, Teresa Carbonell, Enrique Pérez-Payá, Angel Messeguer, Antonio Ferrer-Montiel and Vicente Felipo
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 29-36; DOI: https://doi.org/10.1124/jpet.301.1.29
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    3,4-Methylenedioxymethamphetamine Produces Glycogenolysis and Increases the Extracellular Concentration of Glucose in the Rat Brain
    Altaf S. Darvesh, Mahalakshmi Shankaran and Gary A. Gudelsky
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 138-144; DOI: https://doi.org/10.1124/jpet.301.1.138
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    Tranexamic Acid, a Widely Used Antifibrinolytic Agent, Causes Convulsions by a γ-Aminobutyric AcidA Receptor Antagonistic Effect
    Roman Furtmüller, Michael G. Schlag, Michael Berger, Rudolf Hopf, Sigismund Huck, Werner Sieghart and Heinz Redl
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 168-173; DOI: https://doi.org/10.1124/jpet.301.1.168
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    Effects of Acute and Subchronic Administration of Dexefaroxan, an α2-Adrenoceptor Antagonist, on Memory Performance in Young Adult and Aged Rodents
    Philippe Chopin, Francis C. Colpaert and Marc Marien
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 187-196; DOI: https://doi.org/10.1124/jpet.301.1.187
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    Differential Effects of Haloperidol and Clozapine on [3H]cAMP Binding, Protein Kinase A (PKA) Activity, and mRNA and Protein Expression of Selective Regulatory and Catalytic Subunit Isoforms of PKA in Rat Brain
    Yogesh Dwivedi, Hooriyah S. Rizavi and Ghanshyam N. Pandey
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 197-209; DOI: https://doi.org/10.1124/jpet.301.1.197
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    Neuroprotective Effect of (2S,3S,4R)-N"-cyano-N-(6-amino-3, 4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N′-benzylguanidine (KR-31378), a Benzopyran Analog, against Focal Ischemic Brain Damage in Rats
    Ki Whan Hong, Ki Young Kim, Jeong Hyun Lee, Hwa Kyoung Shin, Yong Geun Kwak, Sun-Ok Kim, Hong Lim and Sung-Eun Yoo
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 210-216; DOI: https://doi.org/10.1124/jpet.301.1.210
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    Attenuation of Scopolamine-Induced and Age-Associated Memory Impairments by the Sigma and 5-Hydroxytryptamine1A Receptor Agonist OPC-14523 (1-{3-[4-(3-chlorophenyl)-1-piperazinyl]propyl}-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate)
    Katsura Tottori, Masami Nakai, Yasufumi Uwahodo, Takashi Miwa, Sakiko Yamada, Yasuo Oshiro, Tetsuro Kikuchi and C. Anthony Altar
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 249-257; DOI: https://doi.org/10.1124/jpet.301.1.249
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    Intravenous Buprenorphine Self-Administration by Detoxified Heroin Abusers
    Sandra D. Comer, Eric D. Collins and Marian W. Fischman
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 266-276; DOI: https://doi.org/10.1124/jpet.301.1.266
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    In Utero Ethanol Suppresses Cerebellar Activator Protein-1 and Nuclear Factor-κB Transcriptional Activation in a Rat Fetal Alcohol Syndrome Model
    George K. Acquaah-Mensah, James P. Kehrer and Steven W. Leslie
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 277-283; DOI: https://doi.org/10.1124/jpet.301.1.277
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    ς2-Receptor Regulation of Dopamine Transporter via Activation of Protein Kinase C
    Alicia E. Derbez, Rupal M. Mody and Linda L. Werling
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 306-314; DOI: https://doi.org/10.1124/jpet.301.1.306
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    4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine Hydrochloride (SSR125543A): A Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. I. Biochemical and Pharmacological Characterization
    Danielle Gully, Michel Geslin, Laurence Serva, Evelyne Fontaine, Pierre Roger, Christine Lair, Valerie Darre, Claudine Marcy, Pierre-Eric Rouby, Jacques Simiand, Josette Guitard, Georgette Gout, Regis Steinberg, Daniel Rodier, Guy Griebel, Philippe Soubrie, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand and Gerard Le Fur
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 322-332; DOI: https://doi.org/10.1124/jpet.301.1.322
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    4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders
    Guy Griebel, Jacques Simiand, Régis Steinberg, Mireille Jung, Danielle Gully, Pierre Roger, Michel Geslin, Bernard Scatton, Jean-Pierre Maffrand and Philippe Soubrié
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 333-345; DOI: https://doi.org/10.1124/jpet.301.1.333
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    Characterization of μ, κ, and δ Opioid Binding in Amphibian Whole Brain Tissue Homogenates
    Leslie C. Newman, Steven S. Sands, David R. Wallace and Craig W. Stevens
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 364-370; DOI: https://doi.org/10.1124/jpet.301.1.364
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    Alterations in Responses of Ventral Pallidal Neurons to Excitatory Amino Acids after Long-Term Dopamine Depletion
    Michael S. Turner, Laurence Mignon and T. Celeste Napier
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 371-381; DOI: https://doi.org/10.1124/jpet.301.1.371

TOXICOLOGY

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    Adenovirus-Mediated Overexpression of Catalase in the Cytosolic or Mitochondrial Compartment Protects against Toxicity Caused by Glutathione Depletion in HepG2 Cells Expressing CYP2E1
    Montserrat Marı́, Jingxiang Bai and Arthur I. Cederbaum
    Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 111-118; DOI: https://doi.org/10.1124/jpet.301.1.111
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Journal of Pharmacology and Experimental Therapeutics: 301 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 301, Issue 1
1 Apr 2002
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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