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Research ArticleNEUROPHARMACOLOGY

Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist

Claudine Serradeil-Le Gal, Jean Wagnon, Jacques Simiand, Guy Griebel, Colette Lacour, Gilles Guillon, Claude Barberis, Gabrielle Brossard, Philippe Soubrié, Dino Nisato, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand and Gérard Le Fur
Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1122-1130; DOI: https://doi.org/10.1124/jpet.300.3.1122

Article Information

vol. 300 no. 3 1122-1130
DOI 
https://doi.org/10.1124/jpet.300.3.1122
PubMed 
11861823
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 1, 2001
  • Accepted November 20, 2001
  • Published online March 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Claudine Serradeil-Le Gal1,
  2. Jean Wagnon2,
  3. Jacques Simiand3,
  4. Guy Griebel3,
  5. Colette Lacour2,
  6. Gilles Guillon5,
  7. Claude Barberis5,
  8. Gabrielle Brossard1,
  9. Philippe Soubrié3,
  10. Dino Nisato2,
  11. Marc Pascal1,
  12. Rebecca Pruss1,
  13. Bernard Scatton4,
  14. Jean-Pierre Maffrand4 and
  15. Gérard Le Fur4
  1. 1Exploratory Research Department (C.S.-L.G., G.B., M.P., R.P.), 2Cardiovascular-Thrombose Research (J.W., C.L., D.N.), 3Central Nervous System Research Department (J.S., G.Gr., P.S.), and 4Discovery Research Division (J.P.M., B.S., G.LF), Sanofi-Synthelabo Recherche, Toulouse, Montpellier et Bagneux, France; and 5Institut National de la Santéet de la Recherche Médicale, Montpellier, France (G.Gu., C.B.)
  1. Dr. Claudine Serradeil-Le Gal, Sanofi-Synthelabo Recherche, Exploratory Research Department, 195 route d'Espagne, 31036 Toulouse Cedex, France. E-mail:claudine.serradeil{at}sanofi-synthelabo.com
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Research ArticleNEUROPHARMACOLOGY

Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist

Claudine Serradeil-Le Gal, Jean Wagnon, Jacques Simiand, Guy Griebel, Colette Lacour, Gilles Guillon, Claude Barberis, Gabrielle Brossard, Philippe Soubrié, Dino Nisato, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand and Gérard Le Fur
Journal of Pharmacology and Experimental Therapeutics March 1, 2002, 300 (3) 1122-1130; DOI: https://doi.org/10.1124/jpet.300.3.1122
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