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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2002; Volume 300,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Excitotoxicity: Perspectives Based onN-Methyl-d-Aspartate Receptor Subtypes
    David R. Lynch and Rodney P. Guttmann
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 717-723; DOI: https://doi.org/10.1124/jpet.300.3.717
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    Structure-Functional Diversity of Human L-Type Ca2+Channel: Perspectives for New Pharmacological Targets
    Darrell R. Abernethy and Nikolai M. Soldatov
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 724-728; DOI: https://doi.org/10.1124/jpet.300.3.724
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    Role of Inflammatory Mediators in Thrombogenesis
    Ronald J. Shebuski and Kenneth S. Kilgore
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 729-735; DOI: https://doi.org/10.1124/jpet.300.3.729

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature
    Arnaud Scherpereel, Jonathan J. Rome, Rainer Wiewrodt, Simon C. Watkins, David Winslow Harshaw, Sean Alder, Melpo Christofidou-Solomidou, Elliott Haut, Juan-Carlos Murciano, Marian Nakada, Steven M. Albelda and Vladimir R. Muzykantov
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 777-786; DOI: https://doi.org/10.1124/jpet.300.3.777
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    Enhanced Induction of Cytochrome P450 Enzymes and CAR Binding in TNF (p55−/−/p75−/−) Double Receptor Knockout Mice Following Phenobarbital Treatment
    Peter J. Van Ess, Mark P. Mattson and Robert A. Blouin
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 824-830; DOI: https://doi.org/10.1124/jpet.300.3.824
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    NADPH-Dependent Metabolism of Estrone by Human Liver Microsomes
    Anthony J. Lee, Laura H. Mills, Joseph W. Kosh, Allan H. Conney and Bao Ting Zhu
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 838-849; DOI: https://doi.org/10.1124/jpet.300.3.838
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    Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Antiviral Transport
    Michio Takeda, Suparat Khamdang, Shinichi Narikawa, Hiroaki Kimura, Yasuna Kobayashi, Toshinori Yamamoto, Seok Ho Cha, Takashi Sekine and Hitoshi Endou
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 918-924; DOI: https://doi.org/10.1124/jpet.300.3.918
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    Prevention of Antibody-Mediated Elimination of Ligand-Targeted Liposomes by Using Poly(Ethylene glycol)-Modified Lipids
    Wai Ming Li, Lawrence D. Mayer and Marcel B. Bally
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 976-983; DOI: https://doi.org/10.1124/jpet.300.3.976
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    Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4
    Carolyn L. Cummins, Wolfgang Jacobsen and Leslie Z. Benet
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1036-1045; DOI: https://doi.org/10.1124/jpet.300.3.1036
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    Pharmacokinetic Role of P-Glycoprotein in Oral Bioavailability and Intestinal Secretion of Grepafloxacin in Vivo
    Hiroaki Yamaguchi, Ikuko Yano, Hideyuki Saito and Ken-ichi Inui
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1063-1069; DOI: https://doi.org/10.1124/jpet.300.3.1063

BEHAVIORAL PHARMACOLOGY

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    Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys
    Paul W. Czoty, Brett C. Ginsburg and Leonard L. Howell
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 831-837; DOI: https://doi.org/10.1124/jpet.300.3.831
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    Daily Treatment with Diazepam Differentially Modifies Sensitivity to the Effects of γ-Aminobutyric AcidA Modulators on Schedule-Controlled Responding in Rhesus Monkeys
    Lance R. McMahon and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1017-1025; DOI: https://doi.org/10.1124/jpet.300.3.1017
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    Effects of μ-Opioid Agonists on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rhesus Monkeys: Role of μ-Agonist Efficacy
    S. Stevens Negus and Nancy K. Mello
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1111-1121; DOI: https://doi.org/10.1124/jpet.300.3.1111

CARDIOVASCULAR

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    Nitric Oxide Synthase Expression in Hypertension Induced by Inhibition of Glutathione Synthase
    Xin J. Zhou, Nosratola D. Vaziri, Xiu Q. Wang, Fred G. Silva and Zoltan Laszik
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 762-767; DOI: https://doi.org/10.1124/jpet.300.3.762
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    Bucindolol Exerts Agonistic Activity on the Propranolol-Insensitive State of β1-Adrenoceptors in Human Myocardium
    Andreas Bundkirchen, Klara Brixius, Birgit Bölck and Robert H. G. Schwinger
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 794-801; DOI: https://doi.org/10.1124/jpet.300.3.794
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    Activation of Poly(ADP-Ribose) Polymerase Contributes to Development of Doxorubicin-Induced Heart Failure
    P. Pacher, L. Liaudet, P. Bai, L. Virag, J. G. Mabley, G. Haskó and C. Szabó
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 862-867; DOI: https://doi.org/10.1124/jpet.300.3.862
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    Signals of Oxidant-Induced Cardiomyocyte Hypertrophy: Key Activation of p70 S6 Kinase-1 and Phosphoinositide 3-Kinase
    Victoria C. Tu, Joseph J. Bahl and Qin M. Chen
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1101-1110; DOI: https://doi.org/10.1124/jpet.300.3.1101

CELLULAR AND MOLECULAR

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    Neurotoxic Mechanisms by Alzheimer's Disease-Linked N141I Mutant Presenilin 2
    Yuichi Hashimoto, Takako Niikura, Yuko Ito, Yoshiko Kita, Kenzo Terashita and Ikuo Nishimoto
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 736-745; DOI: https://doi.org/10.1124/jpet.300.3.736
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    Homologous Mutations Near the Junction of the Sixth Transmembrane Domain and the Third Extracellular Loop Lead to Constitutive Activity and Enhanced Agonist Affinity at all Muscarinic Receptor Subtypes
    Diane J. Ford, Anthony Essex, Tracy A. Spalding, Ethan S. Burstein and John Ellis
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 810-817; DOI: https://doi.org/10.1124/jpet.300.3.810
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    Inorganic Lead Activates the Mitogen-Activated Protein Kinase Kinase-Mitogen-Activated Protein Kinase-p90RSK Signaling Pathway in Human Astrocytoma Cells via a Protein Kinase C-Dependent Mechanism
    Hailing Lu, Marina Guizzetti and Lucio G. Costa
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 818-823; DOI: https://doi.org/10.1124/jpet.300.3.818
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    Differential Modulation of Signaling Pathways and Apoptosis ofras-Transformed 10T1/2 Cells by the Depsipeptide FR901228
    Kellie A. Fecteau, Jianxun Mei and Hwa-Chain R. Wang
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 890-899; DOI: https://doi.org/10.1124/jpet.300.3.890
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    Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K+ Channels in Guinea Pig Urinary Bladder Smooth Muscle
    Sujatha M. Gopalakrishnan, Steven A. Buckner, Ivan Milicic, Duncan R. Groebe, Kristi L. Whiteaker, David J. Burns, Usha Warrior and Murali Gopalakrishnan
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 910-917; DOI: https://doi.org/10.1124/jpet.300.3.910
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    Distinct Pathways of Apoptosis Triggered by FTY720, Etoposide, and Anti-Fas Antibody in Human T-Lymphoma Cell Line (Jurkat Cells)
    Masayuki Fujino, Xiao-Kang Li, Yusuke Kitazawa, Lei Guo, Mikiko Kawasaki, Naoko Funeshima, Takashi Amano and Seiichi Suzuki
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 939-945; DOI: https://doi.org/10.1124/jpet.300.3.939
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    A Novel Neurotrophic Property of Glucagon-Like Peptide 1: A Promoter of Nerve Growth Factor-Mediated Differentiation in PC12 Cells
    TracyAnn Perry, Debomoy K. Lahiri, Demao Chen, Jie Zhou, Karen T. Y. Shaw, Josephine M. Egan and Nigel H. Greig
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 958-966; DOI: https://doi.org/10.1124/jpet.300.3.958
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    The Platelet-Activating Factor Receptor Activates the Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Induces Proliferation of Epidermal Cells through an Epidermal Growth Factor-Receptor-Dependent Pathway
    Silvio A. Marques, Lady C. Dy, Michael D. Southall, Quiaofang Yi, Eva Smietana, Reuben Kapur, Mariangela Marques, Jeffrey B. Travers and Dan F. Spandau
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1026-1035; DOI: https://doi.org/10.1124/jpet.300.3.1026
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    Induction of Apoptosis by 1,4-Benzothiazine Analogs in Mouse Thymocytes
    C. Marchetti, S. Ulisse, S. Bruscoli, F. P. Russo, G. Migliorati, F. Schiaffella, M. G. Cifone, C. Riccardi and R. Fringuelli
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1053-1062; DOI: https://doi.org/10.1124/jpet.300.3.1053

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Methotrexate Exacerbates Tumor Progression in a Murine Model of Chronic Myeloid Leukemia
    Colin L. Sweeney, Miechaleen D. Diers, Joel L. Frandsen, Roland Gunther, Catherine M. Verfaillie and R. Scott McIvor
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1075-1084; DOI: https://doi.org/10.1124/jpet.300.3.1075

ENDOCRINE AND REPRODUCTIVE

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    Effects of 3-Phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a Novel Nonsteroidal Estrogen Agonist/Antagonist, on Reproductive and Nonreproductive Tissue
    Elisabetta Galbiati, Paola Lorenza Caruso, Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, Maurizio Delcanale and Maurizio Civelli
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 802-809; DOI: https://doi.org/10.1124/jpet.300.3.802
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    Nicotine Reduces the Incidence of Type I Diabetes in Mice
    J. G. Mabley, P. Pacher, G. J. Southan, A. L. Salzman and C. Szabó
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 876-881; DOI: https://doi.org/10.1124/jpet.300.3.876

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Functional Involvement of Rat Organic Anion Transporter 3 (rOat3;Slc22a8) in the Renal Uptake of Organic Anions
    Maki Hasegawa, Hiroyuki Kusuhara, Daisuke Sugiyama, Kousei Ito, Shirou Ueda, Hitoshi Endou and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 746-753; DOI: https://doi.org/10.1124/jpet.300.3.746
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    Effects of Tachykinin NK1 Receptor Antagonists on the Viscerosensory Response Caused by Colorectal Distention in Rabbits
    Shiho Okano, Yoshinori Ikeura and Nobuhiro Inatomi
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 925-931; DOI: https://doi.org/10.1124/jpet.300.3.925
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    Peripheral Activity of a New NK1 Receptor Antagonist TAK-637 in the Gastrointestinal Tract
    Kalina Venkova, D. M. Sutkowski-Markmann and Beverley Greenwood-Van Meerveld
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1046-1052; DOI: https://doi.org/10.1124/jpet.300.3.1046

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Up-Regulation of Cyclooxygenase-2 by Inhibition of Cyclooxygenase-1: A Key to Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage
    Akiko Tanaka, Shoko Hase, Tohru Miyazawa and Koji Takeuchi
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 754-761; DOI: https://doi.org/10.1124/jpet.300.3.754
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    Leukotriene B4 Production in Human Mononuclear Phagocytes Is Modulated by Interleukin-4-Induced 15-Lipoxygenase
    Mirella Profita, Angelo Sala, Liboria Siena, Peter M. Henson, Robert C. Murphy, Alessandra Paternò, Anna Bonanno, Loredana Riccobono, Angela Mirabella, Giovanni Bonsignore and Antonio M. Vignola
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 868-875; DOI: https://doi.org/10.1124/jpet.300.3.868
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    The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation
    José Eduardo Da Silva-Santos, Maria Cláudia Santos-Silva, Fernando de Queiroz Cunha and Jamil Assreuy
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 946-951; DOI: https://doi.org/10.1124/jpet.300.3.946
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    Close Relationship between the Platelet Activation Marker CD62 and the Granular Release of Platelet-Derived Growth Factor
    Jochen Graff, Ute Klinkhardt, Valérie B. Schini-Kerth, Sebastian Harder, Nicole Franz, Steffen Bassus and Carl M. Kirchmaier
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 952-957; DOI: https://doi.org/10.1124/jpet.300.3.952

NEUROPHARMACOLOGY

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    Neuroprotective Effect of Cilostazol against Focal Cerebral Ischemia via Antiapoptotic Action in Rats
    Jae Moon Choi, Hwa Kyoung Shin, Ki Young Kim, Jeong Hyun Lee and Ki Whan Hong
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 787-793; DOI: https://doi.org/10.1124/jpet.300.3.787
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    Effects of Individual and Concurrent Stimulation of Striatal D1 and D2 Dopamine Receptors on Electrophysiological and Behavioral Output from Rat Basal Ganglia
    Barbara L. Waszczak, Lynn P. Martin, Heather E. Finlay, Natalie Zahr and James R. Stellar
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 850-861; DOI: https://doi.org/10.1124/jpet.300.3.850
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    Reversal of Ethanol-Seeking Behavior by D1 and D2 Antagonists in an Animal Model of Relapse: Differences in Antagonist Potency in Previously Ethanol-Dependent versus Nondependent Rats
    Xiu Liu and Friedbert Weiss
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 882-889; DOI: https://doi.org/10.1124/jpet.300.3.882
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    Predominance of δ-Opioid-Binding Sites in the Porcine Enteric Nervous System
    DeWayne Townsend and David R. Brown
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 900-909; DOI: https://doi.org/10.1124/jpet.300.3.900
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    Endogenous Opioids in Dopaminergic Cell Body Regions Modulate Amphetamine-Induced Increases in Extracellular Dopamine Levels in the Terminal Regions
    Christina A. Schad, Joseph B. Justice and Stephen G. Holtzman
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 932-938; DOI: https://doi.org/10.1124/jpet.300.3.932
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    Protein Kinase C Modulation of Ethanol Inhibition of Glycine-Activated Current in Dissociated Neurons of Rat Ventral Tegmental Area
    Liang Tao and Jiang Hong Ye
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 967-975; DOI: https://doi.org/10.1124/jpet.300.3.967
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    A Structure/Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid
    Vincenzo Di Marzo, Graeme Griffin, Luciano De Petrocellis, Ines Brandi, Tiziana Bisogno, William Williams, Mark C. Grier, Sanjitha Kulasegram, Anu Mahadevan, Raj K. Razdan and Billy R. Martin
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 984-991; DOI: https://doi.org/10.1124/jpet.300.3.984
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    Determinants of Ligand Selectivity at the κ-Receptor Based on The Structure of the Orphanin FQ Receptor
    Constance E. Owens and Huda Akil
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 992-999; DOI: https://doi.org/10.1124/jpet.300.3.992
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    The Protein Kinase A Inhibitor H89 Acts on Cell Morphology by Inhibiting Rho Kinase
    Jost Leemhuis, Stephanie Boutillier, Gudula Schmidt and Dieter K. Meyer
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1000-1007; DOI: https://doi.org/10.1124/jpet.300.3.1000
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    Amphetamine Inhibits theN-Methyl-d-Aspartate Receptor-Mediated Responses by Directly Interacting with The Receptor/Channel Complex
    Geng-Chang Yeh, Jin-Chung Chen, Hsiu-Chuan Tsai, Hsueh-Hsia Wu, Chao-Yu Lin, Ping-Ching Hsu and Yu-Chen Peng
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1008-1016; DOI: https://doi.org/10.1124/jpet.300.3.1008
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    ς1 Receptor Modulation of Opioid Analgesia in the Mouse
    Jianfeng Mei and Gavril W. Pasternak
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1070-1074; DOI: https://doi.org/10.1124/jpet.300.3.1070
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    Regulation of Corticotropin-Releasing Factor Neuronal Systems and Hypothalamic-Pituitary-Adrenal Axis Activity by Stress and Chronic Antidepressant Treatment
    Steven C. Stout, Michael J. Owens and Charles B. Nemeroff
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1085-1092; DOI: https://doi.org/10.1124/jpet.300.3.1085
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    Methylenedioxymethamphetamine Decreases Plasmalemmal and Vesicular Dopamine Transport: Mechanisms and Implications for Neurotoxicity
    J. Paul Hansen, Evan L. Riddle, Verónica Sandoval, Jeffrey M. Brown, James W. Gibb, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1093-1100; DOI: https://doi.org/10.1124/jpet.300.3.1093
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    Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist
    Claudine Serradeil-Le Gal, Jean Wagnon, Jacques Simiand, Guy Griebel, Colette Lacour, Gilles Guillon, Claude Barberis, Gabrielle Brossard, Philippe Soubrié, Dino Nisato, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand and Gérard Le Fur
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1122-1130; DOI: https://doi.org/10.1124/jpet.300.3.1122

TOXICOLOGY

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    Thalidomide Modulates Nuclear Redox Status and Preferentially Depletes Glutathione in Rabbit Limb versus Rat Limb
    Jason M. Hansen, Katie K. Harris, Martin A. Philbert and Craig Harris
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 768-776; DOI: https://doi.org/10.1124/jpet.300.3.768

Errata

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    Correction to “Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster”
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1131;
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    Correction to “Interaction of the Sulfonylthiourea HMR 1833 with Sulfonylurea Receptors and Recombinant ATP-Sensitive K+ Channels: Comparison with Glibenclamide”
    Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1132;
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Journal of Pharmacology and Experimental Therapeutics: 300 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 300, Issue 3
1 Mar 2002
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Errata
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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