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Research ArticleNEUROPHARMACOLOGY

Modeling of Relationships between Pharmacokinetics and Blockade of Agonist-Induced Elevation of Intraurethral Pressure and Mean Arterial Pressure in Conscious Dogs Treated with α1-Adrenoceptor Antagonists

David G. Witte, Michael E. Brune, Sweta P. Katwala, Ivan Milicic, Deanne Stolarik, Yu-Hua Hui, Kennan C. Marsh, James F. Kerwin Jr., Michael D. Meyer and Arthur A. Hancock
Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 495-504; DOI: https://doi.org/10.1124/jpet.300.2.495

Article Information

vol. 300 no. 2 495-504
DOI 
https://doi.org/10.1124/jpet.300.2.495
PubMed 
11805209
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 24, 2001
  • Accepted October 21, 2001
  • Published online February 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David G. Witte,
  2. Michael E. Brune,
  3. Sweta P. Katwala,
  4. Ivan Milicic,
  5. Deanne Stolarik,
  6. Yu-Hua Hui,
  7. Kennan C. Marsh,
  8. James F. Kerwin, Jr.,
  9. Michael D. Meyer and
  10. Arthur A. Hancock
  1. Pharmaceutical Products Discovery, Neurological Urological Disease Research, Abbott Laboratories, Abbott Park, Illinois
  1. David Witte, D-47MN, AP9A/2, Abbott Laboratories, 100 Abbott Park Rd., Abbott Park, IL 60064-6123. E-mail: david.g.witte{at}abbott.com
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Research ArticleNEUROPHARMACOLOGY

Modeling of Relationships between Pharmacokinetics and Blockade of Agonist-Induced Elevation of Intraurethral Pressure and Mean Arterial Pressure in Conscious Dogs Treated with α1-Adrenoceptor Antagonists

David G. Witte, Michael E. Brune, Sweta P. Katwala, Ivan Milicic, Deanne Stolarik, Yu-Hua Hui, Kennan C. Marsh, James F. Kerwin, Michael D. Meyer and Arthur A. Hancock
Journal of Pharmacology and Experimental Therapeutics February 1, 2002, 300 (2) 495-504; DOI: https://doi.org/10.1124/jpet.300.2.495
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