The Fallacy of Using Adrenochrome Reaction for Measurement of Reactive Oxygen Species Formed During Cytochrome P450-Mediated Metabolism of Xenobiotics

Dr. Dhiren R. Thakker, Division of Drug Delivery and Disposition, School of Pharmacy, Beard Hall CB 7360, Room 303B, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360. E-mail: dhiren_thakker{at}unc.edu

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Jan 2002	27	34	32
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Aug 2002	0	1	4
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May 2005	5	28	16
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Jul 2005	5	15	5
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Jul 2013	3	11	10
Aug 2013	1	4	6
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Jan 2014	2	4	6
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Apr 2014	4	4	16
May 2014	7	5	18
Jun 2014	3	9	11
Jul 2014	11	5	9
Aug 2014	3	0	9
Sep 2014	3	5	4
Oct 2014	1	5	3
Nov 2014	1	1	0
Dec 2014	4	1	2
Jan 2015	7	2	3
Feb 2015	1	2	2
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Apr 2015	2	4	7
May 2015	5	6	5
Jun 2015	0	9	4
Jul 2015	5	2	7
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May 2016	0	10	16
Jun 2016	4	4	9
Jul 2016	1	1	8
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Feb 2017	0	22	3
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Apr 2017	0	12	2
May 2017	1	14	6
Jun 2017	0	10	3
Jul 2017	2	8	2
Aug 2017	0	15	8
Sep 2017	0	8	20
Oct 2017	0	11	2
Nov 2017	0	13	5
Dec 2017	0	17	1
Jan 2018	0	16	94
Feb 2018	1	13	20
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Apr 2018	0	22	27
May 2018	0	14	13
Jun 2018	0	23	20
Jul 2018	0	15	8
Aug 2018	1	18	17
Sep 2018	0	18	6
Oct 2018	0	13	4
Nov 2018	0	17	5
Dec 2018	28	7	6
Jan 2019	98	5	4
Feb 2019	16	0	0
Mar 2019	23	0	0
Apr 2019	26	1	1
May 2019	8	0	0
Jun 2019	13	1	3
Jul 2019	12	0	0
Aug 2019	16	0	0
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Oct 2019	35	0	0
Nov 2019	28	0	0
Dec 2019	23	0	0
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May 2020	130	1	2
Jun 2020	83	0	0
Jul 2020	113	0	0
Aug 2020	64	3	3
Sep 2020	40	2	2
Oct 2020	54	1	1
Nov 2020	33	0	1
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Jan 2021	111	2	0
Feb 2021	97	1	0
Mar 2021	128	3	0
Apr 2021	137	1	0
May 2021	92	2	1
Jun 2021	60	3	1
Jul 2021	76	1	1
Aug 2021	80	1	0
Sep 2021	59	1	0
Oct 2021	114	2	0
Nov 2021	43	1	0
Dec 2021	55	1	4
Jan 2022	78	1	1
Feb 2022	39	1	2
Mar 2022	25	1	1
Apr 2022	49	1	10
May 2022	29	1	2
Jun 2022	29	1	2
Jul 2022	53	1	5
Aug 2022	12	0	1