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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2002; Volume 300,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes
    Ronald N. Hines and D. Gail McCarver
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 355-360; DOI: https://doi.org/10.1124/jpet.300.2.355
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    The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms
    D. Gail McCarver and Ronald N. Hines
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 361-366; DOI: https://doi.org/10.1124/jpet.300.2.361
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    Cyclooxygenase-2—10 Years Later
    Burkhard Hinz and Kay Brune
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 367-375; DOI: https://doi.org/10.1124/jpet.300.2.367

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Amodiaquine Clearance and Its Metabolism toN-Desethylamodiaquine Is Mediated by CYP2C8: A New High Affinity and Turnover Enzyme-Specific Probe Substrate
    Xue-Qing Li, Anders Björkman, Tommy B. Andersson, Marianne Ridderström and Collen M. Masimirembwa
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 399-407; DOI: https://doi.org/10.1124/jpet.300.2.399
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    The Fallacy of Using Adrenochrome Reaction for Measurement of Reactive Oxygen Species Formed During Cytochrome P450-Mediated Metabolism of Xenobiotics
    Cuiping Chen and Dhiren R. Thakker
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 417-420; DOI: https://doi.org/10.1124/jpet.300.2.417
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    Effect of 17-α-Ethynylestradiol on Activities of Cytochrome P450 2B (P450 2B) Enzymes: Characterization of Inactivation of P450s 2B1 and 2B6 and Identification of Metabolites
    Ute M. Kent, Danielle E. Mills, Rajendram V. Rajnarayanan, William L. Alworth and Paul F. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 549-558; DOI: https://doi.org/10.1124/jpet.300.2.549
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    P-Glycoprotein Inhibitors Enhance Saturable Uptake of Idarubicin in Rat Heart: Pharmacokinetic/Pharmacodynamic Modeling
    Michael Weiss and Wonku Kang
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 688-694; DOI: https://doi.org/10.1124/jpet.300.2.688

BEHAVIORAL

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    Discriminative Stimulus Effects of Benzodiazepine (BZ)1 Receptor-Selective Ligands in Rhesus Monkeys
    Lance R. McMahon, Lisa R. Gerak, Lawrence Carter, Chunrong Ma, James M. Cook and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 505-512; DOI: https://doi.org/10.1124/jpet.300.2.505

CARDIOVASCULAR

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    Cyclooxygenase Isozyme Expression and Intimal Hyperplasia in a Rat Model of Balloon Angioplasty
    Elizabeth Connolly, David J. Bouchier-Hayes, Elaine Kaye, Austin Leahy, Desmond Fitzgerald and Orina Belton
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 393-398; DOI: https://doi.org/10.1124/jpet.300.2.393
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    Angiotensin I-Converting Enzyme Inhibition Increases Cardiac Catecholamine Content and Reduces Monoamine Oxidase Activity via an Angiotensin Type 1 Receptor-Mediated Mechanism
    Walter Raasch, Torsten Bartels, Annabella Gieselberg, Andreas Dendorfer and Peter Dominiak
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 428-434; DOI: https://doi.org/10.1124/jpet.300.2.428
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    Defective Intracellular Calcium Handling in Monocrotaline-Induced Right Ventricular Hypertrophy: Protective Effect of Long-Term Endothelin-A Receptor Blockade with 2-Benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl-)- 4-oxobut-2-enoate-sodium (PD 155080)
    Friedrich Brunner, Gerald Wölkart and Stephen Haleen
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 442-449; DOI: https://doi.org/10.1124/jpet.300.2.442
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    The Antidepressant Drug Fluoxetine Is an Inhibitor of Human Ether-A-Go-Go-Related Gene (HERG) Potassium Channels
    Dierk Thomas, Bernd Gut, Gunnar Wendt-Nordahl and Johann Kiehn
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 543-548; DOI: https://doi.org/10.1124/jpet.300.2.543
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    EctoNucleotidase in Cardiac Sympathetic Nerve Endings Modulates ATP-Mediated Feedback of Norepinephrine Release
    Casilde Sesti, M. Johan Broekman, Joan H. F. Drosopoulos, Naziba Islam, Aaron J. Marcus and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 605-611; DOI: https://doi.org/10.1124/jpet.300.2.605
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    Mechanisms of Action of Antiarrhythmic Agent Bertosamil on hKv1.5 Channels and Outward Potassium Current in Human Atrial Myocytes
    David Godreau, Roger Vranckx and Stéphane N. Hatem
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 612-620; DOI: https://doi.org/10.1124/jpet.300.2.612
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    The Role of Muscarinic K+ Channels in the Negative Chronotropic Effect of a Muscarinic Agonist
    Mitsuhiko Yamada
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 681-687; DOI: https://doi.org/10.1124/jpet.300.2.681

CELLULAR AND MOLECULAR

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    Mechanisms of Ligand-Induced Desensitization of the 5-Hydroxytryptamine2A Receptor
    Nicole R. Sullivan Hanley and Julie G. Hensler
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 468-477; DOI: https://doi.org/10.1124/jpet.300.2.468
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    Methyl Jasmonate-Induced Stimulation of Sarcoplasmic Reticulum Ca2+-ATPase Affects Contractile Responses in Rat Slow-Twitch Skeletal Muscle
    Wissam H. Joumaa, Aicha Bouhlel, William Même and Claude Léoty
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 638-646; DOI: https://doi.org/10.1124/jpet.300.2.638
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    Heteromultimeric P2X1/2 Receptors Show a Novel Sensitivity to Extracellular pH
    Sean G. Brown, Andrea Townsend-Nicholson, Kenneth A. Jacobson, Geoffrey Burnstock and Brian F. King
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 673-680; DOI: https://doi.org/10.1124/jpet.300.2.673
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    Modified Proteinase-Activated Receptor-1 and -2 Derived Peptides Inhibit Proteinase-Activated Receptor-2 Activation by Trypsin
    Bahjat Al-Ani, Mahmoud Saifeddine, Suranga J. Wijesuriya and Morley D. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 702-708; DOI: https://doi.org/10.1124/jpet.300.2.702

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Excitatory Mechanism of Deflationary Slowly Adapting Pulmonary Stretch Receptors in the Rat Lung
    Shigeji Matsumoto, Mizuho Ikeda, Toshimi Nishikawa, Shinki Yoshida, Takeshi Tanimoto, Masahiro Ito, Chikako Saiki and Mamoru Takeda
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 597-604; DOI: https://doi.org/10.1124/jpet.300.2.597

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Novel Lipid Mediator Regulators of Endothelial Cell Proliferation and Migration: Aspirin-Triggered-15R-Lipoxin A4 and Lipoxin A4
    Iolanda M. Fierro, Jeffery L. Kutok and Charles N. Serhan
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 385-392; DOI: https://doi.org/10.1124/jpet.300.2.385
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    Prevention of Lipopolysaccharide-Induced Apoptosis by (2S,3S,4R)-N"-Cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N′-benzylguanidine, a Benzopyran Analog, in Endothelial Cells
    Ki Young Kim, Byeong Gee Kim, Sun-Ok Kim, Sung-Eun Yoo, Yong-Geun Kwak, Soo-Wan Chae and Ki Whan Hong
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 535-542; DOI: https://doi.org/10.1124/jpet.300.2.535
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    Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. I. Differential Regulation of Lipopolysaccharide-Mediated Proinflammatory Cytokine (Interleukin-6 and Tumor Necrosis Factor-α) Biosynthesis in Alveolar Epithelial Cells
    John J. Haddad, Stephen C. Land, William O. Tarnow-Mordi, Marek Zembala, Danuta Kowalczyk and Ryszard Lauterbach
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 559-566; DOI: https://doi.org/10.1124/jpet.300.2.559
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    Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. II. Evidence for the Involvement of an Inhibitory-κB/Nuclear Factor-κB-Sensitive Pathway in Alveolar Epithelial Cells
    John J. Haddad, Stephen C. Land, William O. Tarnow-Mordi, Marek Zembala, Danuta Kowalczyk and Ryszard Lauterbach
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 567-576; DOI: https://doi.org/10.1124/jpet.300.2.567
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    Pharmacological Characterization of SC-57461A (3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid HCl), a Potent and Selective Inhibitor of Leukotriene A4Hydrolase I: In Vitro Studies
    Leslie J. Askonas, James F. Kachur, Doreen Villani-Price, Chi-Dean D. Liang, Mark A. Russell and Walter G. Smith
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 577-582; DOI: https://doi.org/10.1124/jpet.300.2.577
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    Pharmacological Characterization of SC-57461A (3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid HCl), a Potent and Selective Inhibitor of Leukotriene A4Hydrolase II: In Vivo Studies
    James F. Kachur, Leslie J. Askonas, Doreen Villani-Price, Nayereh Ghoreishi-Haack, Suzanne Won-Kim, Chi-Dean D. Liang, Mark A. Russell and Walter G. Smith
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 583-587; DOI: https://doi.org/10.1124/jpet.300.2.583
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    Depressant Effect of Ambroxol on Stimulated Functional Responses and Cell Death in Rat Alveolar Macrophages Exposed to Silica in Vitro
    Young Ki Kim, Yoon Young Jang, Eun Sook Han and Chung Soo Lee
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 629-637; DOI: https://doi.org/10.1124/jpet.300.2.629
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    A Novel Class of Endotoxin Receptor Agonists with Simplified Structure, Toll-Like Receptor 4-Dependent Immunostimulatory Action, and Adjuvant Activity
    Lynn D. Hawkins, Sally T. Ishizaka, Pamela McGuinness, Huiming Zhang, Wendy Gavin, Bruce DeCosta, Zhaoyang Meng, Hu Yang, Maureen Mullarkey, Donna W. Young, Hua Yang, Daniel P. Rossignol, Anneliese Nault, Jeffrey Rose, Melinda Przetak, Jesse C. Chow and Fabian Gusovsky
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 655-661; DOI: https://doi.org/10.1124/jpet.300.2.655
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    Tenidap, an Anti-Inflammatory Agent, Inhibits DNA and Collagen Syntheses, Depresses Cell Proliferation, and Lowers Intracellular pH in Cultured Human Gingival Fibroblasts
    Hiroko Matsumoto and Akira Fujii
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 668-672; DOI: https://doi.org/10.1124/jpet.300.2.668
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    Inhibition of Lipopolysaccharide-Induced Apoptosis by Cilostazol in Human Umbilical Vein Endothelial Cells
    Ki Young Kim, Hwa Kyoung Shin, Jae Moon Choi and Ki Whan Hong
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 709-715; DOI: https://doi.org/10.1124/jpet.300.2.709

NEUROPHARMACOLOGY

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    Opioid Receptor Types Selectively Cointernalize with G Protein-Coupled Receptor Kinases 2 and 3
    Rüdiger Schulz, Andrea Wehmeyer and Karin Schulz
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 376-384; DOI: https://doi.org/10.1124/jpet.300.2.376
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    Pharmacological Protection of Synaptic Function, Spatial Learning, and Memory from Transient Hypoxia in Rats
    Miao-Kun Sun, Hui Xu and Daniel L. Alkon
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 408-416; DOI: https://doi.org/10.1124/jpet.300.2.408
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    Altered Glutamate Receptor Function during Recovery of Bladder Detrusor-External Urethral Sphincter Coordination in a Rat Model of Spinal Cord Injury
    Victor Pikov and Jean R. Wrathall
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 421-427; DOI: https://doi.org/10.1124/jpet.300.2.421
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    Dextromethorphan Potentiates the Antinociceptive Effects of Morphine and the δ-Opioid Agonist SNC80 in Squirrel Monkeys
    Richard M. Allen, Arthur L. Granger and Linda A. Dykstra
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 435-441; DOI: https://doi.org/10.1124/jpet.300.2.435
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    Acute Neurochemical and Behavioral Effects of Stereoisomers of 4-Methylaminorex in Relation to Brain Drug Concentrations
    Aino Kankaanpää, Satu Ellermaa, Esa Meririnne, Paula Hirsjärvi and Timo Seppälä
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 450-459; DOI: https://doi.org/10.1124/jpet.300.2.450
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    Preclinical Pharmacology of Fiduxosin, a Novel α1-Adrenoceptor Antagonist with Uroselective Properties
    Arthur A. Hancock, Steven A. Buckner, Michael E. Brune, Timothy A. Esbenshade, Lynne M. Ireland, Sweta Katwala, Ivan Milicic, Michael D. Meyer, James F. Kerwin and Michael Williams
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 478-486; DOI: https://doi.org/10.1124/jpet.300.2.478
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    Effect of Fiduxosin, an Antagonist Selective for α1A- and α1D-Adrenoceptors, on Intraurethral and Arterial Pressure Responses in Conscious Dogs
    Michael E. Brune, Sweta P. Katwala, Ivan Milicic, David G. Witte, James F. Kerwin, Michael D. Meyer, Arthur A. Hancock and Michael Williams
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 487-494; DOI: https://doi.org/10.1124/jpet.300.2.487
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    Modeling of Relationships between Pharmacokinetics and Blockade of Agonist-Induced Elevation of Intraurethral Pressure and Mean Arterial Pressure in Conscious Dogs Treated with α1-Adrenoceptor Antagonists
    David G. Witte, Michael E. Brune, Sweta P. Katwala, Ivan Milicic, Deanne Stolarik, Yu-Hua Hui, Kennan C. Marsh, James F. Kerwin, Michael D. Meyer and Arthur A. Hancock
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 495-504; DOI: https://doi.org/10.1124/jpet.300.2.495
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    Plasticity in Excitatory Amino Acid Receptor-Mediated Descending Pain Modulation after Inflammation
    Yun Guan, Ryuji Terayama, Ronald Dubner and Ke Ren
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 513-520; DOI: https://doi.org/10.1124/jpet.300.2.513
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    α1A-Adrenoceptors Mediate Sympathetically Evoked Pupillary Dilation in Rats
    Yongxin Yu and Michael C. Koss
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 521-525; DOI: https://doi.org/10.1124/jpet.300.2.521
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    Transgenic Expression of a Mutant Glycine Receptor Decreases Alcohol Sensitivity of Mice
    G. S. Findlay, M. J. Wick, M. P. Mascia, D. Wallace, G. W. Miller, R. A. Harris and Y. A. Blednov
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 526-534; DOI: https://doi.org/10.1124/jpet.300.2.526
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    Paradoxical Effects of the Opioid Antagonist Naltrexone on Morphine Analgesia, Tolerance, and Reward in Rats
    Kelly J. Powell, Noura S. Abul-Husn, Asha Jhamandas, Mary C. Olmstead, Richard J. Beninger and Khem Jhamandas
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 588-596; DOI: https://doi.org/10.1124/jpet.300.2.588
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    Acute and Chronic Effects of Methamphetamine on Tele-Methylhistamine Levels in Mouse Brain: Selective Involvement of the D2 and not D3Receptor
    S. Morisset, C. Pilon, J. Tardivel-Lacombe, D. Weinstein, W. Rostene, C. Betancur, P. Sokoloff, J.-C. Schwartz and J.-M. Arrang
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 621-628; DOI: https://doi.org/10.1124/jpet.300.2.621
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    Roles of Endogenous Opioid Peptides in Modulation of Nocifensive Response to Formalin
    Hsiang-en Wu, Kuei-chun Hung, Hirokazu Mizoguchi, Hiroshi Nagase and Leon F. Tseng
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 647-654; DOI: https://doi.org/10.1124/jpet.300.2.647
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    Effect of 2-(Phosphono-methyl)-pentanedioic Acid on Allodynia and Afferent Ectopic Discharges in a Rat Model of Neuropathic Pain
    Shao-Rui Chen, Krystyna M. Wozniak, Barbara S. Slusher and Hui-Lin Pan
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 662-667; DOI: https://doi.org/10.1124/jpet.300.2.662
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    Role of Steroids in Sex Differences in Morphine-Induced Analgesia: Activational and Organizational Effects
    Theodore J. Cicero, Bruce Nock, Lynn O'Connor and Edward R. Meyer
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 695-701; DOI: https://doi.org/10.1124/jpet.300.2.695

TOXICOLOGY

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    Underlying Endotoxemia Augments Toxic Responses to Chlorpromazine: Is There a Relationship to Drug Idiosyncrasy?
    John P. Buchweitz, Patricia E. Ganey, Steven J. Bursian and Robert A. Roth
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 460-467; DOI: https://doi.org/10.1124/jpet.300.2.460

Erratum

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    Correction to “Liver Targeting of Interferon-β with a Liver-Affinity Polysaccharide Based on Metal Coordination in Mice”
    Journal of Pharmacology and Experimental Therapeutics February 2002, 300 (2) 716;
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Journal of Pharmacology and Experimental Therapeutics: 300 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 300, Issue 2
1 Feb 2002
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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