Journal of Pharmacology and Experimental Therapeutics: 300 (1)

January 01, 2002; Volume 300,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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A New Benzodiazepine Pharmacology
H. Möhler, J. M. Fritschy and U. Rudolph

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 2-8; DOI: https://doi.org/10.1124/jpet.300.1.2

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Transplacental Transfer and Metabolism of Buprenorphine
Tatiana Nanovskaya, Sujal Deshmukh, Monica Brooks and Mahmoud S. Ahmed

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 26-33; DOI: https://doi.org/10.1124/jpet.300.1.26
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O-Dealkylation of Fluoxetine in Relation toCYP2C19 Gene Dose and Involvement of CYP3A4 in Human Liver Microsomes
Zhao-Qian Liu, Bing Zhu, Yun-Fu Tan, Zhi-Rong Tan, Lian-Sheng Wang, Song-Lin Huang, Yan Shu and Hong-Hao Zhou

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 105-111; DOI: https://doi.org/10.1124/jpet.300.1.105
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Induction Profile of Rat Organic Anion Transporting Polypeptide 2 (oatp2) by Prototypical Drug-Metabolizing Enzyme Inducers That Activate Gene Expression through Ligand-Activated Transcription Factor Pathways
Grace L. Guo, Supratim Choudhuri and Curtis D. Klaassen

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 206-212; DOI: https://doi.org/10.1124/jpet.300.1.206
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Involvement of CYP2J2 and CYP4F12 in the Metabolism of Ebastine in Human Intestinal Microsomes
Takanori Hashizume, Susumu Imaoka, Masashi Mise, Yoshiaki Terauchi, Toshihiko Fujii, Hisashi Miyazaki, Tetsuya Kamataki and Yoshihiko Funae

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 298-304; DOI: https://doi.org/10.1124/jpet.300.1.298
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Pharmacokinetics of Murine Anti-Human CD3 Antibodies in Man Are Determined by the Disappearance of Target Antigen
R. T. Meijer, R. P. Koopmans, I. J. M. ten Berge and P. T. A. Schellekens

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 346-353; DOI: https://doi.org/10.1124/jpet.300.1.346

ANNOUNCEMENT

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On-Line Submission and Review
S. J. Enna

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 1; DOI: https://doi.org/10.1124/jpet.300.1.1

CARDIOVASCULAR

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Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal α₂-Adrenoceptor Subtypes
Mostafa Khalid, Norelyaquine Ilhami, Yves Giudicelli and Jean-Pierre Dausse

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 43-49; DOI: https://doi.org/10.1124/jpet.300.1.43
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Nociceptin Inhibits γ-Aminobutyric Acidergic Inputs to Cardiac Parasympathetic Neurons in the Nucleus Ambiguus
Priya Venkatesan, Jijiang Wang, Cory Evans, Mustapha Irnaten and David Mendelowitz

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 78-82; DOI: https://doi.org/10.1124/jpet.300.1.78
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Effects of the Anticholinesterase Edrophonium on Spectral Analysis of Heart Rate and Blood Pressure Variability in Humans
Alain Deschamps, Steven B. Backman, Vera Novak, Gilles Plourde, Pierre Fiset and Daniel Chartrand

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 112-117; DOI: https://doi.org/10.1124/jpet.300.1.112
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Interactions between Cocaine and Dopamine Agonists on Cardiovascular Function in Squirrel Monkeys
C. W. Schindler, J. P. Gilman, J. Bergman, N. K. Mello, R. L. Woosley and S. R. Goldberg

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 180-187; DOI: https://doi.org/10.1124/jpet.300.1.180
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Regulation of Cyclooxygenase by the Heme-Heme Oxygenase System in Microvessel Endothelial Cells
Asifa Haider, Rafal Olszanecki, Richard Gryglewski, Michal L. Schwartzman, Elias Lianos, Attallah Kappas, Alberto Nasjletti and Nader G. Abraham

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 188-194; DOI: https://doi.org/10.1124/jpet.300.1.188
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Angiotensin Peptides Modulate Bradykinin Levels in the Interstitium of the Dog Heart in Vivo
Chih-Chang Wei, Carlos M. Ferrario, K. Bridget Brosnihan, Diane M. Farrell, Wayne E. Bradley, Ayad A. Jaffa and Louis J. Dell'Italia

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 324-329; DOI: https://doi.org/10.1124/jpet.300.1.324

CELLULAR AND MOLECULAR

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Simultaneous Intracellular Calcium and Sodium Flux Imaging in Human Vanilloid Receptor 1 (VR1)-Transfected Human Embryonic Kidney Cells: A Method to Resolve Ionic Dependence of VR1-Mediated Cell Death
Elfrida R. Grant, Adrienne E. Dubin, Sui-Po Zhang, Robert A. Zivin and Zhong Zhong

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 9-17; DOI: https://doi.org/10.1124/jpet.300.1.9
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Unique Ability of Troglitazone to Up-Regulate Peroxisome Proliferator-Activated Receptor-γ Expression in Hepatocytes
Gerald F. Davies, Pamela J. McFie, Ramji L. Khandelwal and William J. Roesler

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 72-77; DOI: https://doi.org/10.1124/jpet.300.1.72
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α_1B- and α_1D-Adrenergic Receptors Exhibit Different Requirements for Agonist and Mitogen-Activated Protein Kinase Activation to Regulate Growth Responses in Rat 1 Fibroblasts
Bruce A. Waldrop, Diana Mastalerz, Michael T. Piascik and Ginell R. Post

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 83-90; DOI: https://doi.org/10.1124/jpet.300.1.83
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Regulatory Properties of α_1B-Adrenergic Receptors Defective in Coupling to Phosphoinositide Hydrolysis
Jiefa Wang, Lei Wang, Jodi L. Anderson, Nancy A. Schulte and Myron L. Toews

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 134-141; DOI: https://doi.org/10.1124/jpet.300.1.134
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Relationship between Rate and Extent of G Protein Activation: Comparison between Full and Partial Opioid Agonists
John R. Traynor, Mary J. Clark and Ann E. Remmers

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 157-161; DOI: https://doi.org/10.1124/jpet.300.1.157
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Characterization of a Novel, Broad-Based Fungicidal Activity for the Antiarrhythmic Drug Amiodarone
William E. Courchesne

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 195-199; DOI: https://doi.org/10.1124/jpet.300.1.195
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Nonpeptide Tachykinin Receptor Antagonists. III. SB 235375, a Low Central Nervous System-Penetrant, Potent and Selective Neurokinin-3 Receptor Antagonist, Inhibits Citric Acid-Induced Cough and Airways Hyper-reactivity in Guinea Pigs
Douglas W. P. Hay, Giuseppe A. M. Giardina, Don E. Griswold, David C. Underwood, Charles J. Kotzer, Brian Bush, William Potts, Punam Sandhu, Dave Lundberg, James J. Foley, Dulcie B. Schmidt, Lenox D. Martin, David Kilian, Jeffrey J. Legos, Frank C. Barone, Mark A. Luttmann, Mario Grugni, Luca F. Raveglia and Henry M. Sarau

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 314-323; DOI: https://doi.org/10.1124/jpet.300.1.314
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Extracellular Signal-Regulated Kinases and G Protein-Coupled Receptors in Megakaryocytic Human Erythroleukemia Cells: Selective Activation, Differential Regulation, and Dissociation from Mitogenesis
Hung Wu, Huang-Wei Shen, Tin-Feng Wu, Lawrence F. Brass and Kuo-Chun Sung

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 339-345; DOI: https://doi.org/10.1124/jpet.300.1.339

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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In Vivo Selection of Antifolate-Resistant Transgenic Hematopoietic Stem Cells in a Murine Bone Marrow Transplant Model
Christopher A. Warlick, Michaeleen D. Diers, John E. Wagner and R. Scott McIvor

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 50-56; DOI: https://doi.org/10.1124/jpet.300.1.50
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Nonpeptidomimetic Farnesyltransferase Inhibitor RPR-115135 Increases Cytotoxicity of 5-Fluorouracil: Role of p53
Patrizia Russo, Cristina Ottoboni, Davide Malacarne, Alessandra Crippa, Jean-Francois Riou and Patrick M. O'Connor

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 220-226; DOI: https://doi.org/10.1124/jpet.300.1.220

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Group I Metabotropic Glutamate Receptor Antagonists Block Secondary Thermal Hyperalgesia in Rats with Knee Joint Inflammation
Liping Zhang, Ying Lu, Ying Chen and Karin N. Westlund

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 149-156; DOI: https://doi.org/10.1124/jpet.300.1.149
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KF24345, an Adenosine Uptake Inhibitor, Suppresses Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production and Leukopenia via Endogenous Adenosine in Mice
Tohru Noji, Makoto Takayama, Mirai Mizutani, Yuko Okamura, Haruki Takai, Akira Karasawa and Hideaki Kusaka

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 200-205; DOI: https://doi.org/10.1124/jpet.300.1.200
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Histamine Regulation of Interleukin-18-Initiating Cytokine Cascade Is Associated with Down-Regulation of Intercellular Adhesion Molecule-1 Expression in Human Peripheral Blood Mononuclear Cells
Hideo Kohka Takahashi, Atsushi Yoshida, Hiromi Iwagaki, Tadashi Yoshino, Hideyuki Itoh, Toshihiko Morichika, Minori Yokoyama, Tadaatsu Akagi, Noriaki Tanaka, Shuji Mori and Masahiro Nishibori

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 227-235; DOI: https://doi.org/10.1124/jpet.300.1.227
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Pharmacodynamics and Pharmacogenomics of Methylprednisolone during 7-Day Infusions in Rats
Rohini Ramakrishnan, Debra C. DuBois, Richard R. Almon, Nancy A. Pyszczynski and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 245-256; DOI: https://doi.org/10.1124/jpet.300.1.245

NEUROPHARMACOLOGY

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The Potent Emetogenic Effects of the Endocannabinoid, 2-AG (2-Arachidonoylglycerol) Are Blocked by Δ⁹-Tetrahydrocannabinol and Other Cannnabinoids
Nissar A. Darmani

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 34-42; DOI: https://doi.org/10.1124/jpet.300.1.34
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[Arg¹⁴,Lys¹⁵]Nociceptin, a Highly Potent Agonist of the Nociceptin/Orphanin FQ Receptor: in Vitro and in Vivo Studies
Daniela Rizzi, Anna Rizzi, Raffaella Bigoni, Valeria Camarda, Giuliano Marzola, Remo Guerrini, Carmela De Risi, Domenico Regoli and Girolamo Calo'

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 57-63; DOI: https://doi.org/10.1124/jpet.300.1.57
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Electrophysiologic Characterization of the Antipsychotic Drug Sertindole in a Rabbit Heart Model of Torsade de Pointes: Low Torsadogenic Potential Despite QT Prolongation
Lars Eckardt, Günter Breithardt and Wilhelm Haverkamp

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 64-71; DOI: https://doi.org/10.1124/jpet.300.1.64
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Effects of Subcutaneous Methylnaltrexone on Morphine-Induced Peripherally Mediated Side Effects: A Double-Blind Randomized Placebo-Controlled Trial
Chun-Su Yuan, Gang Wei, Joseph F. Foss, Michael O'Connor, Theodore Karrison and Joachim Osinski

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 118-123; DOI: https://doi.org/10.1124/jpet.300.1.118
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Group II Metabotropic Glutamate Receptors Modulate Extracellular Glutamate in the Nucleus Accumbens
Zheng-Xiong Xi, David A. Baker, Hui Shen, Daniel S. Carson and Peter W. Kalivas

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 162-171; DOI: https://doi.org/10.1124/jpet.300.1.162
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Multiple Specific Binding Targets for Inhaled Anesthetics in the Mammalian Brain
Maryellen Fazen Eckenhoff, Kin Chan and Roderic G. Eckenhoff

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 172-179; DOI: https://doi.org/10.1124/jpet.300.1.172
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Rapid Elevation of Plasma Interleukin-6 by Morphine Is Dependent on Autonomic Stimulation of Adrenal Gland
Richard A. Houghtling and Barbara M. Bayer

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 213-219; DOI: https://doi.org/10.1124/jpet.300.1.213
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3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics
Cándido Hernández-López, Magı́ Farré, Pere N. Roset, Esther Menoyo, Nieves Pizarro, Jordi Ortuño, Marta Torrens, Jordi Camı́ and Rafael de la Torre

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 236-244; DOI: https://doi.org/10.1124/jpet.300.1.236
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Characterization of Rat Prepro-Orphanin FQ/Nociceptin_(154–181): Nociceptive Processing in Supraspinal Sites
Grace C. Rossi, Michael Pellegrino, Randi Shane, Catherine A. Abbadie, Jessica Dustman, Charles Jimenez, Richard J. Bodnar, Gavril W. Pasternak and Richard G. Allen

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 257-264; DOI: https://doi.org/10.1124/jpet.300.1.257
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Morphine Tolerance in Spinal Cord Is Due to Interaction between μ- and δ-Receptors
Pal Riba, Yong Ben, Andrew P. Smith, Susanna Furst and Nancy M. Lee

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 265-272; DOI: https://doi.org/10.1124/jpet.300.1.265
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α_2C-Adrenergic Receptors Mediate Spinal Analgesia and Adrenergic-Opioid Synergy
Carolyn A. Fairbanks, Laura S. Stone, Kelley F. Kitto, H. Oanh Nguyen, Ivan J. Posthumus and George L. Wilcox

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 282-290; DOI: https://doi.org/10.1124/jpet.300.1.282
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Effects of Diadenosine Polyphosphates on Tear Secretion in New Zealand White Rabbits
J. Pintor, A. Peral, C. H. V. Hoyle, C. Redick, J. Douglass, I. Sims and B. Yerxa

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 291-297; DOI: https://doi.org/10.1124/jpet.300.1.291
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The Effects of Deleting the Mouse Neurotensin Receptor NTR1 on Central and Peripheral Responses to Neurotensin
Douglas J. Pettibone, J. Fred Hess, Patricia J. Hey, Marlene A. Jacobson, Michael Leviten, Edward V. Lis, Pierre J. Mallorga, Danette M. Pascarella, Melissa A. Snyder, Jacinta B. Williams and Zhizhen Zeng

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 305-313; DOI: https://doi.org/10.1124/jpet.300.1.305
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A Competitive Interaction Model Predicts the Effect of WAY-100,635 on the Time Course of R -(+)-8-Hydroxy-2-(di-n-propylamino)tetralin-Induced Hypothermia
Klaas P. Zuideveld, Nicoline Treijtel, Hugo J. Maas, Josy M. Gubbens-Stibbe, Lambertus A. Peletier, Piet H. van der Graaf and Meindert Danhof

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 330-338; DOI: https://doi.org/10.1124/jpet.300.1.330

TOXICOLOGY

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O ²-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate Protection Againstd-Galactosamine/Endotoxin-Induced Hepatotoxicity in Mice: Genomic Analysis Using Microarrays
Jie Liu, Joseph E. Saavedra, Tong Lu, Jian-Guo Song, James Clark, Michael P. Waalkes and Larry K. Keefer

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 18-25; DOI: https://doi.org/10.1124/jpet.300.1.18
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Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster
Robert G. Pendleton, Feroz Parvez, Marwa Sayed and Ralph Hillman

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 91-96; DOI: https://doi.org/10.1124/jpet.300.1.91
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Organ Distribution of Multidrug Resistance Proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and Hepatic Induction of Mrp3 by Constitutive Androstane Receptor Activators in Rats
Nathan J. Cherrington, Dylan P. Hartley, Ning Li, David R. Johnson and Curtis D. Klaassen

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 97-104; DOI: https://doi.org/10.1124/jpet.300.1.97
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Prenatal Nicotine Exposure Evokes Alterations of Cell Structure in Hippocampus and Somatosensory Cortex
Tara Sankar Roy, Frederic J. Seidler and Theodore A. Slotkin

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 124-133; DOI: https://doi.org/10.1124/jpet.300.1.124
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Inhibition of γ-Glutamyl Transpeptidase or CysteineS-Conjugate β-Lyase Activity Blocks the Nephrotoxicity of Cisplatin in Mice
Danyelle M. Townsend and Marie H. Hanigan

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 142-148; DOI: https://doi.org/10.1124/jpet.300.1.142
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Mechanisms of Circadian Rhythmicity of Carbon Tetrachloride Hepatotoxicity
James V. Bruckner, Raghupathy Ramanathan, K. Monica Lee and Srinivasa Muralidhara

Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 273-281; DOI: https://doi.org/10.1124/jpet.300.1.273

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

ANNOUNCEMENT

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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