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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2002; Volume 300,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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    A New Benzodiazepine Pharmacology
    H. Möhler, J. M. Fritschy and U. Rudolph
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 2-8; DOI: https://doi.org/10.1124/jpet.300.1.2

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Transplacental Transfer and Metabolism of Buprenorphine
    Tatiana Nanovskaya, Sujal Deshmukh, Monica Brooks and Mahmoud S. Ahmed
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 26-33; DOI: https://doi.org/10.1124/jpet.300.1.26
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    O-Dealkylation of Fluoxetine in Relation toCYP2C19 Gene Dose and Involvement of CYP3A4 in Human Liver Microsomes
    Zhao-Qian Liu, Bing Zhu, Yun-Fu Tan, Zhi-Rong Tan, Lian-Sheng Wang, Song-Lin Huang, Yan Shu and Hong-Hao Zhou
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 105-111; DOI: https://doi.org/10.1124/jpet.300.1.105
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    Induction Profile of Rat Organic Anion Transporting Polypeptide 2 (oatp2) by Prototypical Drug-Metabolizing Enzyme Inducers That Activate Gene Expression through Ligand-Activated Transcription Factor Pathways
    Grace L. Guo, Supratim Choudhuri and Curtis D. Klaassen
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 206-212; DOI: https://doi.org/10.1124/jpet.300.1.206
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    Involvement of CYP2J2 and CYP4F12 in the Metabolism of Ebastine in Human Intestinal Microsomes
    Takanori Hashizume, Susumu Imaoka, Masashi Mise, Yoshiaki Terauchi, Toshihiko Fujii, Hisashi Miyazaki, Tetsuya Kamataki and Yoshihiko Funae
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 298-304; DOI: https://doi.org/10.1124/jpet.300.1.298
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    Pharmacokinetics of Murine Anti-Human CD3 Antibodies in Man Are Determined by the Disappearance of Target Antigen
    R. T. Meijer, R. P. Koopmans, I. J. M. ten Berge and P. T. A. Schellekens
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 346-353; DOI: https://doi.org/10.1124/jpet.300.1.346

ANNOUNCEMENT

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    On-Line Submission and Review
    S. J. Enna
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 1; DOI: https://doi.org/10.1124/jpet.300.1.1

CARDIOVASCULAR

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    Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal α2-Adrenoceptor Subtypes
    Mostafa Khalid, Norelyaquine Ilhami, Yves Giudicelli and Jean-Pierre Dausse
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 43-49; DOI: https://doi.org/10.1124/jpet.300.1.43
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    Nociceptin Inhibits γ-Aminobutyric Acidergic Inputs to Cardiac Parasympathetic Neurons in the Nucleus Ambiguus
    Priya Venkatesan, Jijiang Wang, Cory Evans, Mustapha Irnaten and David Mendelowitz
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 78-82; DOI: https://doi.org/10.1124/jpet.300.1.78
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    Effects of the Anticholinesterase Edrophonium on Spectral Analysis of Heart Rate and Blood Pressure Variability in Humans
    Alain Deschamps, Steven B. Backman, Vera Novak, Gilles Plourde, Pierre Fiset and Daniel Chartrand
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 112-117; DOI: https://doi.org/10.1124/jpet.300.1.112
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    Interactions between Cocaine and Dopamine Agonists on Cardiovascular Function in Squirrel Monkeys
    C. W. Schindler, J. P. Gilman, J. Bergman, N. K. Mello, R. L. Woosley and S. R. Goldberg
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 180-187; DOI: https://doi.org/10.1124/jpet.300.1.180
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    Regulation of Cyclooxygenase by the Heme-Heme Oxygenase System in Microvessel Endothelial Cells
    Asifa Haider, Rafal Olszanecki, Richard Gryglewski, Michal L. Schwartzman, Elias Lianos, Attallah Kappas, Alberto Nasjletti and Nader G. Abraham
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 188-194; DOI: https://doi.org/10.1124/jpet.300.1.188
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    Angiotensin Peptides Modulate Bradykinin Levels in the Interstitium of the Dog Heart in Vivo
    Chih-Chang Wei, Carlos M. Ferrario, K. Bridget Brosnihan, Diane M. Farrell, Wayne E. Bradley, Ayad A. Jaffa and Louis J. Dell'Italia
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 324-329; DOI: https://doi.org/10.1124/jpet.300.1.324

CELLULAR AND MOLECULAR

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    Simultaneous Intracellular Calcium and Sodium Flux Imaging in Human Vanilloid Receptor 1 (VR1)-Transfected Human Embryonic Kidney Cells: A Method to Resolve Ionic Dependence of VR1-Mediated Cell Death
    Elfrida R. Grant, Adrienne E. Dubin, Sui-Po Zhang, Robert A. Zivin and Zhong Zhong
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 9-17; DOI: https://doi.org/10.1124/jpet.300.1.9
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    Unique Ability of Troglitazone to Up-Regulate Peroxisome Proliferator-Activated Receptor-γ Expression in Hepatocytes
    Gerald F. Davies, Pamela J. McFie, Ramji L. Khandelwal and William J. Roesler
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 72-77; DOI: https://doi.org/10.1124/jpet.300.1.72
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    α1B- and α1D-Adrenergic Receptors Exhibit Different Requirements for Agonist and Mitogen-Activated Protein Kinase Activation to Regulate Growth Responses in Rat 1 Fibroblasts
    Bruce A. Waldrop, Diana Mastalerz, Michael T. Piascik and Ginell R. Post
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 83-90; DOI: https://doi.org/10.1124/jpet.300.1.83
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    Regulatory Properties of α1B-Adrenergic Receptors Defective in Coupling to Phosphoinositide Hydrolysis
    Jiefa Wang, Lei Wang, Jodi L. Anderson, Nancy A. Schulte and Myron L. Toews
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 134-141; DOI: https://doi.org/10.1124/jpet.300.1.134
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    Relationship between Rate and Extent of G Protein Activation: Comparison between Full and Partial Opioid Agonists
    John R. Traynor, Mary J. Clark and Ann E. Remmers
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 157-161; DOI: https://doi.org/10.1124/jpet.300.1.157
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    Characterization of a Novel, Broad-Based Fungicidal Activity for the Antiarrhythmic Drug Amiodarone
    William E. Courchesne
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 195-199; DOI: https://doi.org/10.1124/jpet.300.1.195
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    Nonpeptide Tachykinin Receptor Antagonists. III. SB 235375, a Low Central Nervous System-Penetrant, Potent and Selective Neurokinin-3 Receptor Antagonist, Inhibits Citric Acid-Induced Cough and Airways Hyper-reactivity in Guinea Pigs
    Douglas W. P. Hay, Giuseppe A. M. Giardina, Don E. Griswold, David C. Underwood, Charles J. Kotzer, Brian Bush, William Potts, Punam Sandhu, Dave Lundberg, James J. Foley, Dulcie B. Schmidt, Lenox D. Martin, David Kilian, Jeffrey J. Legos, Frank C. Barone, Mark A. Luttmann, Mario Grugni, Luca F. Raveglia and Henry M. Sarau
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 314-323; DOI: https://doi.org/10.1124/jpet.300.1.314
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    Extracellular Signal-Regulated Kinases and G Protein-Coupled Receptors in Megakaryocytic Human Erythroleukemia Cells: Selective Activation, Differential Regulation, and Dissociation from Mitogenesis
    Hung Wu, Huang-Wei Shen, Tin-Feng Wu, Lawrence F. Brass and Kuo-Chun Sung
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 339-345; DOI: https://doi.org/10.1124/jpet.300.1.339

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    In Vivo Selection of Antifolate-Resistant Transgenic Hematopoietic Stem Cells in a Murine Bone Marrow Transplant Model
    Christopher A. Warlick, Michaeleen D. Diers, John E. Wagner and R. Scott McIvor
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 50-56; DOI: https://doi.org/10.1124/jpet.300.1.50
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    Nonpeptidomimetic Farnesyltransferase Inhibitor RPR-115135 Increases Cytotoxicity of 5-Fluorouracil: Role of p53
    Patrizia Russo, Cristina Ottoboni, Davide Malacarne, Alessandra Crippa, Jean-Francois Riou and Patrick M. O'Connor
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 220-226; DOI: https://doi.org/10.1124/jpet.300.1.220

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Group I Metabotropic Glutamate Receptor Antagonists Block Secondary Thermal Hyperalgesia in Rats with Knee Joint Inflammation
    Liping Zhang, Ying Lu, Ying Chen and Karin N. Westlund
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 149-156; DOI: https://doi.org/10.1124/jpet.300.1.149
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    KF24345, an Adenosine Uptake Inhibitor, Suppresses Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production and Leukopenia via Endogenous Adenosine in Mice
    Tohru Noji, Makoto Takayama, Mirai Mizutani, Yuko Okamura, Haruki Takai, Akira Karasawa and Hideaki Kusaka
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 200-205; DOI: https://doi.org/10.1124/jpet.300.1.200
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    Histamine Regulation of Interleukin-18-Initiating Cytokine Cascade Is Associated with Down-Regulation of Intercellular Adhesion Molecule-1 Expression in Human Peripheral Blood Mononuclear Cells
    Hideo Kohka Takahashi, Atsushi Yoshida, Hiromi Iwagaki, Tadashi Yoshino, Hideyuki Itoh, Toshihiko Morichika, Minori Yokoyama, Tadaatsu Akagi, Noriaki Tanaka, Shuji Mori and Masahiro Nishibori
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 227-235; DOI: https://doi.org/10.1124/jpet.300.1.227
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    Pharmacodynamics and Pharmacogenomics of Methylprednisolone during 7-Day Infusions in Rats
    Rohini Ramakrishnan, Debra C. DuBois, Richard R. Almon, Nancy A. Pyszczynski and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 245-256; DOI: https://doi.org/10.1124/jpet.300.1.245

NEUROPHARMACOLOGY

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    The Potent Emetogenic Effects of the Endocannabinoid, 2-AG (2-Arachidonoylglycerol) Are Blocked by Δ9-Tetrahydrocannabinol and Other Cannnabinoids
    Nissar A. Darmani
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 34-42; DOI: https://doi.org/10.1124/jpet.300.1.34
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    [Arg14,Lys15]Nociceptin, a Highly Potent Agonist of the Nociceptin/Orphanin FQ Receptor: in Vitro and in Vivo Studies
    Daniela Rizzi, Anna Rizzi, Raffaella Bigoni, Valeria Camarda, Giuliano Marzola, Remo Guerrini, Carmela De Risi, Domenico Regoli and Girolamo Calo'
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 57-63; DOI: https://doi.org/10.1124/jpet.300.1.57
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    Electrophysiologic Characterization of the Antipsychotic Drug Sertindole in a Rabbit Heart Model of Torsade de Pointes: Low Torsadogenic Potential Despite QT Prolongation
    Lars Eckardt, Günter Breithardt and Wilhelm Haverkamp
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 64-71; DOI: https://doi.org/10.1124/jpet.300.1.64
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    Effects of Subcutaneous Methylnaltrexone on Morphine-Induced Peripherally Mediated Side Effects: A Double-Blind Randomized Placebo-Controlled Trial
    Chun-Su Yuan, Gang Wei, Joseph F. Foss, Michael O'Connor, Theodore Karrison and Joachim Osinski
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 118-123; DOI: https://doi.org/10.1124/jpet.300.1.118
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    Group II Metabotropic Glutamate Receptors Modulate Extracellular Glutamate in the Nucleus Accumbens
    Zheng-Xiong Xi, David A. Baker, Hui Shen, Daniel S. Carson and Peter W. Kalivas
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 162-171; DOI: https://doi.org/10.1124/jpet.300.1.162
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    Multiple Specific Binding Targets for Inhaled Anesthetics in the Mammalian Brain
    Maryellen Fazen Eckenhoff, Kin Chan and Roderic G. Eckenhoff
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 172-179; DOI: https://doi.org/10.1124/jpet.300.1.172
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    Rapid Elevation of Plasma Interleukin-6 by Morphine Is Dependent on Autonomic Stimulation of Adrenal Gland
    Richard A. Houghtling and Barbara M. Bayer
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 213-219; DOI: https://doi.org/10.1124/jpet.300.1.213
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    3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics
    Cándido Hernández-López, Magı́ Farré, Pere N. Roset, Esther Menoyo, Nieves Pizarro, Jordi Ortuño, Marta Torrens, Jordi Camı́ and Rafael de la Torre
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 236-244; DOI: https://doi.org/10.1124/jpet.300.1.236
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    Characterization of Rat Prepro-Orphanin FQ/Nociceptin(154–181): Nociceptive Processing in Supraspinal Sites
    Grace C. Rossi, Michael Pellegrino, Randi Shane, Catherine A. Abbadie, Jessica Dustman, Charles Jimenez, Richard J. Bodnar, Gavril W. Pasternak and Richard G. Allen
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 257-264; DOI: https://doi.org/10.1124/jpet.300.1.257
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    Morphine Tolerance in Spinal Cord Is Due to Interaction between μ- and δ-Receptors
    Pal Riba, Yong Ben, Andrew P. Smith, Susanna Furst and Nancy M. Lee
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 265-272; DOI: https://doi.org/10.1124/jpet.300.1.265
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    α2C-Adrenergic Receptors Mediate Spinal Analgesia and Adrenergic-Opioid Synergy
    Carolyn A. Fairbanks, Laura S. Stone, Kelley F. Kitto, H. Oanh Nguyen, Ivan J. Posthumus and George L. Wilcox
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 282-290; DOI: https://doi.org/10.1124/jpet.300.1.282
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    Effects of Diadenosine Polyphosphates on Tear Secretion in New Zealand White Rabbits
    J. Pintor, A. Peral, C. H. V. Hoyle, C. Redick, J. Douglass, I. Sims and B. Yerxa
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 291-297; DOI: https://doi.org/10.1124/jpet.300.1.291
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    The Effects of Deleting the Mouse Neurotensin Receptor NTR1 on Central and Peripheral Responses to Neurotensin
    Douglas J. Pettibone, J. Fred Hess, Patricia J. Hey, Marlene A. Jacobson, Michael Leviten, Edward V. Lis, Pierre J. Mallorga, Danette M. Pascarella, Melissa A. Snyder, Jacinta B. Williams and Zhizhen Zeng
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 305-313; DOI: https://doi.org/10.1124/jpet.300.1.305
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    A Competitive Interaction Model Predicts the Effect of WAY-100,635 on the Time Course of R -(+)-8-Hydroxy-2-(di-n-propylamino)tetralin-Induced Hypothermia
    Klaas P. Zuideveld, Nicoline Treijtel, Hugo J. Maas, Josy M. Gubbens-Stibbe, Lambertus A. Peletier, Piet H. van der Graaf and Meindert Danhof
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 330-338; DOI: https://doi.org/10.1124/jpet.300.1.330

TOXICOLOGY

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    O 2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate Protection Againstd-Galactosamine/Endotoxin-Induced Hepatotoxicity in Mice: Genomic Analysis Using Microarrays
    Jie Liu, Joseph E. Saavedra, Tong Lu, Jian-Guo Song, James Clark, Michael P. Waalkes and Larry K. Keefer
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 18-25; DOI: https://doi.org/10.1124/jpet.300.1.18
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    Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster
    Robert G. Pendleton, Feroz Parvez, Marwa Sayed and Ralph Hillman
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 91-96; DOI: https://doi.org/10.1124/jpet.300.1.91
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    Organ Distribution of Multidrug Resistance Proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and Hepatic Induction of Mrp3 by Constitutive Androstane Receptor Activators in Rats
    Nathan J. Cherrington, Dylan P. Hartley, Ning Li, David R. Johnson and Curtis D. Klaassen
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 97-104; DOI: https://doi.org/10.1124/jpet.300.1.97
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    Prenatal Nicotine Exposure Evokes Alterations of Cell Structure in Hippocampus and Somatosensory Cortex
    Tara Sankar Roy, Frederic J. Seidler and Theodore A. Slotkin
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 124-133; DOI: https://doi.org/10.1124/jpet.300.1.124
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    Inhibition of γ-Glutamyl Transpeptidase or CysteineS-Conjugate β-Lyase Activity Blocks the Nephrotoxicity of Cisplatin in Mice
    Danyelle M. Townsend and Marie H. Hanigan
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 142-148; DOI: https://doi.org/10.1124/jpet.300.1.142
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    Mechanisms of Circadian Rhythmicity of Carbon Tetrachloride Hepatotoxicity
    James V. Bruckner, Raghupathy Ramanathan, K. Monica Lee and Srinivasa Muralidhara
    Journal of Pharmacology and Experimental Therapeutics January 2002, 300 (1) 273-281; DOI: https://doi.org/10.1124/jpet.300.1.273
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Journal of Pharmacology and Experimental Therapeutics: 300 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 300, Issue 1
1 Jan 2002
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • ANNOUNCEMENT
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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