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Research ArticleCARDIOVASCULAR

An Up-Regulation of Renal α2A-Adrenoceptors Is Associated with Resistance to Salt-Induced Hypertension in Sabra Rats

Mostafa Khalid, Yves Giudicelli and Jean-Pierre Dausse
Journal of Pharmacology and Experimental Therapeutics December 2001, 299 (3) 928-933;
Mostafa Khalid
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Yves Giudicelli
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Jean-Pierre Dausse
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Abstract

This study investigates the incidence of high-salt diet in blood pressures, renal α2-adrenoceptor subtypes distribution, and gene expression in salt-sensitive (SBH) and salt-resistant (SBN) Sabra rats. Comparisons have been made between SBH and SBN rats submitted to a normal or a high-salt diet for 6 weeks. Only α2B-adrenoceptors are detected in kidneys of SBH rats, whatever the diet. In contrast, mRNA corresponding to α2A- and α2B-subtypes are found in this substrain. In these rats, high-salt diet increases blood pressures and up-regulates gene expression and density of only α2B-adrenoceptors. Inversely, α2A- and α2B-adrenoceptors and corresponding mRNA are found in kidneys of SBN rats. In these rats, a high-salt diet does not affect blood pressures but increases gene expression and densities of both α2A- and α2B-adrenoceptors. If the up-regulation of renal α2B-adrenoceptor subtypes is indicative of the hypertensive phenotype, the present study shows that this mechanism is also present in normotensive salt-resistant Sabra rats. In fact, the absence of α2A-adrenoceptors in SBH could be responsible for the lack of adequate receptor-mediated renal functions predisposing to salt-sensitivity and consequently the development of hypertension. Conversely, the presence of this receptor in SBN rats and its up-regulation could be protective change against the increase of α2B-adrenoceptors induced by the salt overload and could consequently be responsible for the resistance to salt-induced hypertension.

Footnotes

  • Supported by grants from INSERM and the University RenéDescartes.

  • Abbreviations:
    SBH
    salt-sensitive Sabra rats
    SBN
    salt-resistant Sabra rats
    RT-PCR
    reverse transcription-polymerase chain reaction
    PCR
    polymerase chain reaction
    bp
    base pair(s)
    • Received May 17, 2001.
    • Accepted August 10, 2001.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 299 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 299, Issue 3
1 Dec 2001
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Research ArticleCARDIOVASCULAR

An Up-Regulation of Renal α2A-Adrenoceptors Is Associated with Resistance to Salt-Induced Hypertension in Sabra Rats

Mostafa Khalid, Yves Giudicelli and Jean-Pierre Dausse
Journal of Pharmacology and Experimental Therapeutics December 1, 2001, 299 (3) 928-933;

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Research ArticleCARDIOVASCULAR

An Up-Regulation of Renal α2A-Adrenoceptors Is Associated with Resistance to Salt-Induced Hypertension in Sabra Rats

Mostafa Khalid, Yves Giudicelli and Jean-Pierre Dausse
Journal of Pharmacology and Experimental Therapeutics December 1, 2001, 299 (3) 928-933;
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