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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2001; Volume 299,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Regulation of Adult Neurogenesis by Psychotropic Drugs and Stress
    Ronald S. Duman, Jessica Malberg and Shin Nakagawa
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 401-407;
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    Estrogenic Actions in the Brain: Estrogen, Phytoestrogens, and Rapid Intracellular Signaling Mechanisms
    Scott M. Belcher and Attila Zsarnovszky
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 408-414;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Mechanism of Pluronic Effect on P-Glycoprotein Efflux System in Blood-Brain Barrier: Contributions of Energy Depletion and Membrane Fluidization
    Elena V. Batrakova, Shu Li, Sergey V. Vinogradov, Valery Yu Alakhov, Donald W. Miller and Alexander V. Kabanov
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 483-493;
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    Intravenous Human Interleukin-1α Impairs Memory Processing in Mice: Dependence on Blood-Brain Barrier Transport into Posterior Division of the Septum
    William A. Banks, Susan A. Farr, Michael E. La Scola and John E. Morley
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 536-541;
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    Protein Kinase C Suppresses Rat Organic Anion Transporting Polypeptide 1- and 2-Mediated Uptake
    Grace L. Guo and Curtis D. Klaassen
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 551-557;
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    Nucleoside Phosphonate Interactions with Multiple Organic Anion Transporters in Renal Proximal Tubule
    David S. Miller
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 567-574;
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    Correlation between Epithelial Cell Permeability of Cephalexin and Expression of Intestinal Oligopeptide Transporter
    Xiao-Yan Chu, Gloria P. Sánchez-Castaño, Kazutaka Higaki, Doo-Man Oh, Cheng-Pang Hsu and Gordon L. Amidon
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 575-582;
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    Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery
    Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys, Liyue Huang, Jonathon B. Morgan, Lindsey O. Webster and Cosette S. Serabjit-Singh
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 620-628;
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    Regulation of Cyp1a1 Induction by Dioxin as a Function of Cell Cycle Phase
    Ronald P. Santini, Scott Myrand, Cornelis Elferink and John J. Reiners
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 718-728;

BEHAVIORAL PHARMACOLOGY

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    Studies of Tolerance and Dependence with the δ-Opioid Agonist SNC80 in Rhesus Monkeys Responding under a Schedule of Food Presentation
    Michael R. Brandt, M. Scott Furness, Kenner C. Rice, Bradford D. Fischer and S. Stevens Negus
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 629-637;

CARDIOVASCULAR

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    Dependence of δ1-Opioid Receptor-Induced Cardioprotection on a Tyrosine Kinase-Dependent but Not a Src-Dependent Pathway
    Ryan M. Fryer, Yigang Wang, Anna K. Hsu, Hiroshi Nagase and Garrett J. Gross
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 477-482;
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    A Growth Factor Mixture That Significantly Enhances Angiogenesis in Vivo
    Wilfried Roethy, Eduard Fiehn, Kotaro Suehiro, Anguo Gu, Geng Hua Yi, Juichiro Shimizu, Jie Wang, Geping Zhang, John Ranieri, Rama Akella, Sarah E. Funk, E. Helene Sage, James Benedict and Daniel Burkhoff
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 494-500;
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    Protein Kinase C-ε Is a Trigger of Delayed Cardioprotection against Myocardial Ischemia of κ-Opioid Receptor Stimulation in Rat Ventricular Myocytes
    Guan-Ying Wang, Jing Jun Zhou, Jian Shan and Tak-Ming Wong
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 603-610;
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    Vicinal Nitrohydroxyeicosatrienoic Acids: Vasodilator Lipids Formed by Reaction of Nitrogen Dioxide with Arachidonic Acid
    Michael Balazy, Takafumi Iesaki, James L. Park, Houli Jiang, Pawel M. Kaminski and Michael S. Wolin
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 611-619;
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    Functional Characterization of α1-Adrenoceptor Subtypes in Human Subcutaneous Resistance Arteries
    Yagna P. R. Jarajapu, Fiona Johnston, Colin Berry, Andrew Renwick, John C. McGrath, Allan MacDonald and Chris Hillier
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 729-734;
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    Propafenone Modulates Potassium Channel Activities of Vascular Smooth Muscle from Rat Portal Veins
    Angel L. Cogolludo, Francisco Pérez-Vizcaı́no, Gustavo López-López, Manuel Ibarra, Francisco Zaragozá-Arnáez and Juan Tamargo
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 801-810;

CELLULAR AND MOLECULAR

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    Cyclic GMP-Dependent Protein Kinase Activation and Induction by Exisulind and CP461 in Colon Tumor Cells
    Li Liu, Han Li, Tashandra Underwood, Marti Lloyd, Mary David, Gerhard Sperl, Rifat Pamukcu and W. Joseph Thompson
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 583-592;
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    Differences in Rapid Desensitization of 5-Hydroxytryptamine2A and 5-Hydroxytryptamine2C Receptor-Mediated Phospholipase C Activation
    Kelly A. Berg, Brian D. Stout, Saul Maayani and William P. Clarke
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 593-602;
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    Regions in Rat and Human Parathyroid Hormone (PTH) 2 Receptors Controlling Receptor Interaction with PTH and with Antagonist Ligands
    Carleton P. Goold, Ted B. Usdin and Sam R. J. Hoare
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 678-690;
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    Purine Nucleoside-Dependent Inhibition of Cellular Proliferation in 1321N1 Human Astrocytoma Cells
    Karri K. Bradley and Michael E. Bradley
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 748-752;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Nontoxic Doses of Suramin Enhance Activity of Doxorubicin in Prostate Tumors
    Yilong Zhang, SaeHeum Song, Fan Yang, Jessie L.-S. Au and M. Guillaume Wientjes
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 426-433;
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    cDNA Microarray Analysis of Multidrug Resistance: Doxorubicin Selection Produces Multiple Defects in Apoptosis Signaling Pathways
    George S. Watts, Bernard W. Futscher, Robert Isett, Mary Gleason-Guzman, Mark W. Kunkel and Sydney E. Salmon
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 434-441;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Preventing Gut Leakiness by Oats Supplementation Ameliorates Alcohol-Induced Liver Damage in Rats
    Ali Keshavarzian, Sandeep Choudhary, Earle W. Holmes, Sherri Yong, Ali Banan, Shriram Jakate and Jeremy Z. Fields
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 442-448;
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    Characterization of Novel Kidney-Specific Delivery System Using an Alkylglucoside Vector
    Kazuhiko Shirota, Yukio Kato, Koukichi Suzuki and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 459-467;
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    Interaction of 2,3-Dimercapto-1-propane Sulfonate with the Human Organic Anion Transporter hOAT1
    Florian Islinger, Michael Gekle and Stephen H. Wright
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 741-747;
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    Colitis-Induced Alterations in Adrenergic Control of Circular Smooth Muscle in Vitro in Rats
    Aiping Zhao, Carol Bossone, Victor Piñeiro-Carrero and Terez Shea-Donohue
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 768-774;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Prodigiosin Blocks T Cell Activation by Inhibiting Interleukin-2Rα Expression and Delays Progression of Autoimmune Diabetes and Collagen-Induced Arthritis
    Sang Bae Han, Se Hyung Park, Young Jin Jeon, Young Kook Kim, Hwan Mook Kim and Kyu Hwan Yang
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 415-425;
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    Functional Characterization of Cyclooxygenase-2 Polymorphisms
    Ellen Fritsche, Seung Joon Baek, Lorraine M. King, Darryl C. Zeldin, Thomas E. Eling and Douglas A. Bell
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 468-476;
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    FR167653, a Cytokine Synthesis Inhibitor, Exhibits Anti-Inflammatory Effects Early in Rat Carrageenin-Induced Pleurisy but No Effect Later
    Ko Hatanaka, Michiko Kawamura, Naoki Murai, Michiko Ogino, Masataka Majima, Keiko Ogino and Yoshiteru Harada
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 519-527;
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    Immunoglobulin Treatment Prevents Congestive Heart Failure in Murine Encephalomyocarditis Viral Myocarditis Associated with Reduction of Inflammatory Cytokines
    Chiharu Kishimoto, Hitoshi Takada, Hiroshi Kawamata, Miho Umatake and Hiroshi Ochiai
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 645-651;
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    Effect of Peroxisome Proliferator-Activated Receptor α Activation on Leukotriene B4 Metabolism in Isolated Rat Hepatocytes
    Jessica Fiedler, Francis R. Simon, Mieko Iwahashi and Robert C. Murphy
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 691-697;
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    Phosphodiesterase 4 Inhibitors Prevent Cytokine Secretion by T Lymphocytes by Inhibiting Nuclear Factor-κB and Nuclear Factor of Activated T Cells Activation
    José Luis Jimenez, Carmen Punzón, Joaquı́n Navarro, M. Angeles Muñoz-Fernández and Manuel Fresno
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 753-759;
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    Biodegradable Nanoparticles for Targeted Drug Delivery in Treatment of Inflammatory Bowel Disease
    Alf Lamprecht, Nathalie Ubrich, Hiromitsu Yamamoto, Ulrich Schäfer, Hirofumi Takeuchi, Philippe Maincent, Yoshiaki Kawashima and Claus-Michael Lehr
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 775-781;

NEUROPHARMACOLOGY

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    Selective Blockade of Neurokinin-2 Receptors Produces Antidepressant-Like Effects Associated with Reduced Corticotropin-Releasing Factor Function
    Régis Steinberg, Richard Alonso, Guy Griebel, Lionel Bert, Mireille Jung, Florence Oury-Donat, Martine Poncelet, Christiane Gueudet, Christophe Desvignes, Gérard Le Fur and Philippe Soubrié
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 449-458;
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    Modulation of N-Type Ca2+ Currents by A1-Adenosine Receptor Activation in Male Rat Pelvic Ganglion Neurons
    Kyu-Sang Park, Seong-Woo Jeong, Seung-Kyu Cha, Boo-Soo Lee, In Deok Kong, Stephen R. Ikeda and Joong-Woo Lee
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 501-508;
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    Differential Effects of D1- and D2-Like Compounds on Cocaine Self-Administration in Lewis and Fischer 344 Inbred Rats
    Colin N. Haile and Therese A. Kosten
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 509-518;
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    A Novel Thienylhydrazone, (2-Thienylidene)3,4-methylenedioxybenzoylhydrazine, Increases Inotropism and Decreases Fatigue of Skeletal Muscle
    Hugo Gonzalez-Serratos, Ruzhang Chang, Edna F. R. Pereira, Newton G. Castro, Yasco Aracava, Paulo A. Melo, Patrı́cia C. Lima, Carlos A. M. Fraga, Eliezer J. Barreiro and Edson X. Albuquerque
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 558-566;
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    OPC-28326, a Selective Femoral Vasodilator, Is an α2C-Adrenoceptor-Selective Antagonist
    Bing Sun, Simon Lockyer, Jess Li, Ruoyan Chen, Masuhiro Yoshitake and Jun-Ichi Kambayashi
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 652-658;
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    Confluence of Antianalgesic Action of Diverse Agents through Brain Interleukin1β in Mice
    Jodie J. Rady and James M. Fujimoto
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 659-665;
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    Trafficking-Dependent and -Independent Pathways of Neurotransmitter Transporter Regulation Differentially Involving p38 Mitogen-Activated Protein Kinase Revealed in Studies of Insulin Modulation of Norepinephrine Transport in SK-N-SH Cells
    Subbu Apparsundaram, Uhna Sung, Raymond D. Price and Randy D. Blakely
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 666-677;
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    Neurotensin Levels in Specific Brain Regions and Hypnotic Sensitivity to Ethanol and Pentobarbital as a Function of Time after Haloperidol Administration in Selectively Bred Rat Lines
    V. Gene Erwin, Richard Radcliffe and Richard A. Deitrich
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 698-704;
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    Lithium Increases Potency of Lidocaine-Induced Block of Voltage-Gated Na+ Currents in Rat Sensory Neurons in Vitro
    Michael S. Gold and Paul D. Thut
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 705-711;
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    Use of the β-Imager for Rapid ex Vivo Autoradiography Exemplified with Central Nervous System Penetrating Neurokinin 3 Antagonists
    Xavier Langlois, Paula te Riele, Cindy Wintmolders, Josée E. Leysen and Mirek Jurzak
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 712-717;
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    Differential Kinetics of Transport of 2′,3′-Dideoxyinosine and Adenosine via Concentrative Na+ Nucleoside Transporter CNT2 Cloned from Rat Blood-Brain Barrier
    Jian Yi Li, Ruben J. Boado and William M. Pardridge
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 735-740;
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    Discriminative Stimulus Effects of Intravenous Heroin and Its Metabolites in Rhesus Monkeys: Opioid and Dopaminergic Mechanisms
    Donna M. Platt, James K. Rowlett and Roger D. Spealman
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 760-767;
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    The Muscarinic Receptor Agonist Xanomeline Has an Antipsychotic-Like Profile in the Rat
    K. J. Stanhope, N. R. Mirza, M. J. Bickerdike, J. L. Bright, N. R. Harrington, M. B. Hesselink, G. A. Kennett, S. Lightowler, M. J. Sheardown, R. Syed, R. L. Upton, G. Wadsworth, S. M. Weiss and A. Wyatt
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 782-792;

TOXICOLOGY

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    Evidence for Nonacetylcholinesterase Targets of Organophosphorus Nerve Agent: Supersensitivity of Acetylcholinesterase Knockout Mouse to VX Lethality
    Ellen G. Duysen, Bin Li, Weihua Xie, Lawrence M. Schopfer, Robert S. Anderson, Clarence A. Broomfield and Oksana Lockridge
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 528-535;
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    Low Doses of Nicotine and Ethanol Induce CYP2E1 and Chlorzoxazone Metabolism in Rat Liver
    Lisa A. Howard, Alina L. Micu, Edward M. Sellers and Rachel F. Tyndale
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 542-550;
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    Dietary Saturated Fatty Acids Reverse Inflammatory and Fibrotic Changes in Rat Liver Despite Continued Ethanol Administration
    Amin A. Nanji, Kalle Jokelainen, George L. Tipoe, Amir Rahemtulla and Andrew J. Dannenberg
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 638-644;
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    Toxicity of Alpidem, a Peripheral Benzodiazepine Receptor Ligand, but Not Zolpidem, in Rat Hepatocytes: Role of Mitochondrial Permeability Transition and Metabolic Activation
    Alain Berson, Véronique Descatoire, Angela Sutton, Daniel Fau, Béatrice Maulny, Nathalie Vadrot, Gérard Feldmann, Brigitte Berthon, Thierry Tordjmann and Dominique Pessayre
    Journal of Pharmacology and Experimental Therapeutics November 2001, 299 (2) 793-800;
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Journal of Pharmacology and Experimental Therapeutics: 299 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 299, Issue 2
1 Nov 2001
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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