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Research ArticleCELLULAR AND MOLECULAR

Dual Action of Octopamine on Glucose Transport into Adipocytes: Inhibition via β3-Adrenoceptor Activation and Stimulation via Oxidation by Amine Oxidases

Virgile Visentin, Nathalie Morin, Emi Fontana, Danielle Prévot, Jeremie Boucher, Isabelle Castan, Philippe Valet, Danica Grujic and Christian Carpéné
Journal of Pharmacology and Experimental Therapeutics October 2001, 299 (1) 96-104;
Virgile Visentin
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Nathalie Morin
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Emi Fontana
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Danielle Prévot
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Jeremie Boucher
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Isabelle Castan
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Philippe Valet
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Danica Grujic
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Christian Carpéné
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Abstract

Octopamine, which is closely related to norepinephrine, acts as a neurotransmitter in invertebrates and is a trace amine with undefined properties in vertebrates. The octopaminergic receptors identified in insects are targets of various pesticides but are absent in vertebrates. We have established that octopamine stimulates fat cell lipolysis in mammals via activation of β3-adrenoceptors (ARs), whereas this amine has been described elsewhere as an α2-AR agonist and as a substrate for monoamine oxidase (MAO) or semicarbazide-sensitive amine oxidase (SSAO). Because we have recently reported that amine oxidase substrates promote glucose transport in rat and human adipocytes, the in vitro octopamine effects on lipolysis and glucose uptake were reassessed by using adipocytes from β3-AR-deficient mice. The lipolytic effect and the counter-regulation of insulin action on glucose transport provoked by 0.1 to 1 mM octopamine or by 1 μM β3-AR agonists found in control animals disappeared in adipocytes from β3-AR-deficient mice. This revealed an insulin-like effect of octopamine on glucose uptake, which was dependent on its oxidation by MAO or SSAO, as was the case for tyramine and benzylamine, devoid of β3-adrenergic agonism. Similarly, octopamine promoted glucose transport in human adipocytes and exhibited a weaker lipolytic stimulation than in rodent adipocytes. These findings indicate that, besides its lipolytic activity, octopamine exerts, at millimolar dose, dual effect on glucose transport in adipocytes: counteracting insulin action via β3-AR activation and stimulating basal transport via its oxidation by MAO or SSAO.

Footnotes

  • This work was supported by European Union contract QLG7CT1999 00295. E.F. was partly financed by Communauté de Travail des Pyrénées and Actions Integrées PICASSO.

  • Abbreviations:
    AR
    adrenergic receptor
    MAO
    monoamine oxidase
    SSAO
    semicarbazide-sensitive amine oxidase
    2-DG
    2-deoxyglucose
    ADA
    adenosine deaminase
    INWAT
    intra-abdominal white adipose tissue
    SCWAT
    subcutaneous white adipose tissue
    WAT
    white adipose tissue
    • Received April 16, 2001.
    • Accepted July 9, 2001.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 299 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 299, Issue 1
1 Oct 2001
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Research ArticleCELLULAR AND MOLECULAR

Dual Action of Octopamine on Glucose Transport into Adipocytes: Inhibition via β3-Adrenoceptor Activation and Stimulation via Oxidation by Amine Oxidases

Virgile Visentin, Nathalie Morin, Emi Fontana, Danielle Prévot, Jeremie Boucher, Isabelle Castan, Philippe Valet, Danica Grujic and Christian Carpéné
Journal of Pharmacology and Experimental Therapeutics October 1, 2001, 299 (1) 96-104;

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Research ArticleCELLULAR AND MOLECULAR

Dual Action of Octopamine on Glucose Transport into Adipocytes: Inhibition via β3-Adrenoceptor Activation and Stimulation via Oxidation by Amine Oxidases

Virgile Visentin, Nathalie Morin, Emi Fontana, Danielle Prévot, Jeremie Boucher, Isabelle Castan, Philippe Valet, Danica Grujic and Christian Carpéné
Journal of Pharmacology and Experimental Therapeutics October 1, 2001, 299 (1) 96-104;
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