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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Mechanisms of Induction of Persistent Nociception by Dynorphin

Tinna M. Laughlin, Alice A. Larson and George L. Wilcox
Journal of Pharmacology and Experimental Therapeutics October 2001, 299 (1) 6-11;
Tinna M. Laughlin
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Alice A. Larson
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George L. Wilcox
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Abstract

The opioid peptide dynorphin has been demonstrated to be both nociceptive and antinociceptive. This article will review the potential mechanisms through which dynorphin contributes to spinally mediated nociception. Specifically, we will examine the interaction of dynorphin with multiple sites on the NMDA receptor complex. Dynorphin-induced opioid activity is generally inhibitory, with a tendency to impede nociceptive signals and serve in a neuroprotective capacity. In contrast, dynorphin's interaction with multiple sites on the NMDA receptor complex produces excitatory responses resulting in nociceptive and even toxic effects. Thus, it is hypothesized that dynorphin has both physiological and pathological roles in acute and chronic pain states.

Footnotes

  • Abbreviations:
    CFA
    complete Freund's adjuvant
    NMDA
    N-methyl-d-aspartate
    nNOS
    neuronal nitric-oxide synthase
    iNOS
    inducible NOS
    IL
    interleukin
    • Received December 26, 2000.
    • Accepted May 11, 2001.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 299 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 299, Issue 1
1 Oct 2001
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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Mechanisms of Induction of Persistent Nociception by Dynorphin

Tinna M. Laughlin, Alice A. Larson and George L. Wilcox
Journal of Pharmacology and Experimental Therapeutics October 1, 2001, 299 (1) 6-11;

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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Mechanisms of Induction of Persistent Nociception by Dynorphin

Tinna M. Laughlin, Alice A. Larson and George L. Wilcox
Journal of Pharmacology and Experimental Therapeutics October 1, 2001, 299 (1) 6-11;
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  • Article
    • Abstract
    • Background
    • Involvement of NMDA Receptors in Dynorphin Nociception
    • Binding Studies
    • Electrophysiological Studies
    • Other Nociceptive Mechanisms of Dynorphin
    • Presynaptic or Postsynaptic Mechanism of Dynorphin Action
    • Dynorphin at NMDA Receptor Sites Is Toxic; Dynorphin at Opioid Receptors Protects
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