Journal of Pharmacology and Experimental Therapeutics: 298 (3)

September 01, 2001; Volume 298,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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Drug Synergism: Its Detection and Applications
Ronald J. Tallarida

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 865-872;
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Growth Factor Signaling in Cell Survival: Implications for Cancer Treatment
Sunit Talapatra and Craig B. Thompson

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 873-878;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Pharmacokinetics and Tissue Distribution of SB-251353, a Novel Human CXC Chemokine, after Intravenous Administration to Mice
Timothy W. Hepburn, Timothy K. Hart, Vicki L. Horton, Teresa S. Sellers, LeeAnn P. Tobia, James J. Urbanski, Wei Shi and Charles B. Davis

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 886-893;
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Transport Characteristics of the Anti-human Immunodeficiency Virus Nucleoside Analog, Abacavir, into Brain and Cerebrospinal Fluid
S. A. Thomas, A. Bye and M. B. Segal

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 947-953;
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Functional Characterization of Rat Organic Anion Transporter 2 in LLC-PK1 Cells
Naomi Morita, Hiroyuki Kusuhara, Takashi Sekine, Hitoshi Endou and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1179-1184;
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Multidrug Resistance-Associated Protein-1 Functional Activity in Calu-3 Cells
Karen O. Hamilton, Elizabeth Topp, Irwan Makagiansar, Teruna Siahaan, Mehran Yazdanian and Kenneth L. Audus

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1199-1205;
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Liposomal and Nonliposomal Drug Pharmacokinetics after Administration of Liposome-Encapsulated Vincristine and Their Contribution to Drug Tissue Distribution Properties
Rajesh Krishna, Murray S. Webb, Ginette St. Onge and Lawrence D. Mayer

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1206-1212;
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Kinetics of P-Glycoprotein-Mediated Efflux of Paclitaxel
Seong Hoon Jang, M. Guillaume Wientjes and Jessie L.-S. Au

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1236-1242;
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P-Glycoprotein Efflux at the Blood-Brain Barrier Mediates Differences in Brain Disposition and Pharmacodynamics between Two Structurally Related Neurokinin-1 Receptor Antagonists
Bill J. Smith, Angela C. Doran, Stafford McLean, F. David Tingley, Brian T. O'Neill and Shama M. Kajiji

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1252-1259;

CARDIOVASCULAR

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Oxidative Inactivation of Nitric Oxide and Endothelial Dysfunction in Stroke-Prone Spontaneous Hypertensive Rats
Xin-Liang Ma, Feng Gao, Allen H. Nelson, Bernard L. Lopez, Theodore A. Christopher, Tian-Li Yue and Frank C. Barone

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 879-885;
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Protein Kinase A-Dependent and -Independent Effects of Isoproterenol in Rat Isolated Mesenteric Artery: Interactions with Levcromakalim
Richard White, Fiona E. Bottrill, Derrick Siau and C. Robin Hiley

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 917-924;
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In Contrast to Forskolin and 3-Isobutyl-1-methylxanthine, Amrinone Stimulates the Cardiac Voltage-Sensitive Release Mechanism without Increasing Calcium-Induced Calcium Release
Wei Xiong, Heidi M. Moore, Susan E. Howlett and Gregory R. Ferrier

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 954-963;
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Inhibitors of Bradykinin-Inactivating Enzymes Decrease Myocardial Ischemia/Reperfusion Injury following 3 and 7 Days of Reperfusion
J. A. Schriefer, E. P. Broudy and A. H. Hassen

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 970-975;
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Metabolism of Methadone andlevo-α-Acetylmethadol (LAAM) by Human Intestinal Cytochrome P450 3A4 (CYP3A4): Potential Contribution of Intestinal Metabolism to Presystemic Clearance and Bioactivation
Yutaka Oda and Evan D. Kharasch

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1021-1032;
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Decrease in Ca²⁺-Sensitizing Effect of UD-CG 212 Cl, a Metabolite of Pimobendan, under Acidotic Condition in Canine Ventricular Myocardium
Reiko Takahashi, Yasuhisa Shimazaki and Masao Endoh

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1060-1066;
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Effects of Anorexinogen Agents on Cloned Voltage-Gated K⁺ Channel hKv1.5
Loı̈c Perchenet, Laurence Hilfiger, Jacques Mizrahi and Odile Clément-Chomienne

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1108-1119;
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Selective Renal Vasodilation and Active Renal Artery Perfusion Improve Renal Function in Dogs with Acute Heart Failure
Kotaro Suehiro, Juichiro Shimizu, Geng-Hua Yi, Anguo Gu, Jie Wang, Gad Keren and Daniel Burkhoff

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1154-1160;
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Lusitropic Effect of MCC-135 Is Associated with Improvement of Sarcoplasmic Reticulum Function in Ventricular Muscles of Rats with Diabetic Cardiomyopathy
Naoya Satoh, Taku Sato, Mayumi Shimada, Kumi Yamada and Yoshimi Kitada

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1161-1166;
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Efficacy of the Novel Selective Platelet-Derived Growth Factor Receptor Antagonist CT52923 on Cellular Proliferation, Migration, and Suppression of Neointima following Vascular Injury
Jin-Chen Yu, Nathalie A. Lokker, Stanley Hollenbach, Mutiah Apatira, Jason Li, Andreas Betz, David Sedlock, Shoji Oda, Yuji Nomoto, Kenji Matsuno, Shin-ichi Ide, Eiji Tsukuda and Neill A. Giese

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1172-1178;

CELLULAR AND MOLECULAR

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Cell Cycle Effects of Nonsteroidal Anti-Inflammatory Drugs and Enhanced Growth Inhibition in Combination with Gemcitabine in Pancreatic Carcinoma Cells
Michele T. Yip-Schneider, Christopher J. Sweeney, Sin-Ho Jung, Pamela L. Crowell and Mark S. Marshall

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 976-985;
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Fenamates: A Novel Class of Reversible Gap Junction Blockers
Erik G. A. Harks, Albert D. G. de Roos, Peter H. J. Peters, Laura H. de Haan, Abraham Brouwer, Dirk L. Ypey, Everardus J. J. van Zoelen and Alexander P. R. Theuvenet

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1033-1041;
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Voltage-Dependent Antagonist/Agonist Actions of Taurine on Ca²⁺-Activated Potassium Channels of Rat Skeletal Muscle Fibers
Domenico Tricarico, Mariagrazia Barbieri and Diana Conte Camerino

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1167-1171;
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Phosphorylation and Desensitization of the Human Thromboxane Receptor-α by G Protein-Coupled Receptor Kinases
Huiping Zhou, Fengxiang Yan and Hsin-Hsiung Tai

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1243-1251;
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Synthesis and Pharmacological Evaluation of Dimeric Muscarinic Acetylcholine Receptor Agonists
Arthur Christopoulos, Marianne K. O. Grant, Negar Ayoubzadeh, Ok Nyu Kim, Per Sauerberg, Lone Jeppesen and Esam E. El-Fakahany

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1260-1268;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Antitumor Activity of Antisense Clusterin Oligonucleotides Is Improved in Vitro and in Vivo by Incorporation of 2′-O-(2-Methoxy)Ethyl Chemistry
Tobias Zellweger, Hideaki Miyake, Scott Cooper, Kim Chi, Boyd S. Conklin, Brett P. Monia and Martin E. Gleave

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 934-940;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Prevention of Neutrophil-Mediated Hepatic Ischemia/Reperfusion Injury by Superoxide Dismutase and Catalase Derivatives
Yoshiyuki Yabe, Naoki Kobayashi, Tsuyoshi Nishihashi, Rei Takahashi, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 894-899;
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Dopamine Inhibits Vasopressin Action in the Rat Inner Medullary Collecting Duct via α₂-Adrenoceptors
Richard M. Edwards and David P. Brooks

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1001-1006;
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Effect of Steviol on para-Aminohippurate Transport by Isolated Perfused Rabbit Renal Proximal Tubule
Varanuj Chatsudthipong and Promsuk Jutabha

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1120-1127;
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Suppression of Acute Experimental Colitis by a Highly Selective Inducible Nitric-Oxide Synthase Inhibitor,N-[3-(Aminomethyl)benzyl]acetamidine
Esko Kankuri, Kirsi Vaali, Richard G. Knowles, Mari Lähde, Riitta Korpela, Heikki Vapaatalo and Eeva Moilanen

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1128-1132;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Inhibition of Tumor Necrosis Factor-α (TNF-α) Production and Arthritis in the Rat by GW3333, a Dual Inhibitor of TNF-α-Converting Enzyme and Matrix Metalloproteinases
James G. Conway, Robert C. Andrews, Beth Beaudet, D. Mark Bickett, Virginia Boncek, Thomas A. Brodie, Richard L. Clark, R. Christian Crumrine, Michael A. Leenitzer, Darryl L. McDougald, Bajin Han, Kevin Hedeen, Peiyuan Lin, Marcos Milla, Marcia Moss, Heather Pink, Michael H. Rabinowitz, Timothy Tippin, Phillip W. Scates, Jeffrey Selph, Stephen A. Stimpson, Janet Warner and J. David Becherer

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 900-908;
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Mistletoe Lectin-1 Increases Tumor Necrosis Factor-α Release in Lipopolysaccharide-Stimulated Whole Blood via Inhibition of Interleukin-10 Production
Eva-Maria Boneberg and Thomas Hartung

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 996-1000;
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Studies on Mechanisms of Low Emetogenicity of YM976, a Novel Phosphodiesterase Type 4 Inhibitor
Motonori Aoki, Masahiro Fukunaga, Tohru Sugimoto, Yasuno Hirano, Miki Kobayashi, Kazuo Honda and Toshimitsu Yamada

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1142-1149;
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Immune Stimulation by a CpG-Containing Oligodeoxynucleotide Is Enhanced When Encapsulated and Delivered in Lipid Particles
Barbara Mui, Sameersingh G. Raney, Sean C. Semple and Michael J. Hope

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1185-1192;
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Immunosuppression by δ-Opioid Antagonist Naltrindole: δ- and Triple μ/δ/κ-Opioid Receptor Knockout Mice Reveal a Nonopioid Activity
Claire Gavériaux-Ruff, Dominique Filliol, Frédéric Simonin, Hans W. D. Matthes and Brigitte L. Kieffer

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1193-1198;
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Limited Efficacy of Thalidomide in the Treatment of Febrile Attacks of the Hyper-IgD and Periodic Fever Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
Joost P. H. Drenth, Alieke G. Vonk, Anna Simon, Richard Powell and Jos W. M. van der Meer

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1221-1226;

NEUROPHARMACOLOGY

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Cellular Depolarization of Neurons in the Locus Ceruleus Region of the Guinea Pig Associated with the Development of Tolerance to Opioids
J.-Q. Kong, J. Meng, P. S. Biser, W. W. Fleming and D. A. Taylor

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 909-916;
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Differential Sensitivity of Mesencephalic Neurons to Inhibition of Phosphatase 2A
Gail D. Zeevalk, Laura P. Bernard, Lawrence Manzino and Patricia K. Sonsalla

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 925-933;
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Biphasic Alterations of cAMP Levels and Inhibition of Norepinephrine Release in Iris-Ciliary Body by Bremazocine
Karen R. M. Russell and David E. Potter

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 941-946;
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Dosing Time-Dependent Tolerance of Catalepsy by Repetitive Administration of Haloperidol in Mice
Jarupa Viyoch, Shigehiro Ohdo, Eiji Yukawa and Shun Higuchi

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 964-969;
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Pentylenetetrazole-Induced Inhibition of Recombinant γ-Aminobutyric Acid Type A (GABA_A) Receptors: Mechanism and Site of Action
Ren-Qi Huang, Cathy L. Bell-Horner, Mohammed I. Dibas, Douglas F. Covey, John A. Drewe and Glenn H. Dillon

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 986-995;
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Opioid and Cannabinoid Modulation of Precipitated Withdrawal in Δ⁹-Tetrahydrocannabinol and Morphine-Dependent Mice
A. H. Lichtman, S. M. Sheikh, H. H. Loh and B. R. Martin

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1007-1014;
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Agonist-, Antagonist-, and Inverse Agonist-Regulated Trafficking of the δ-Opioid Receptor Correlates with, but Does Not Require, G Protein Activation
Paulette A. Zaki, Duane E. Keith, James B. Thomas, F. I. Carroll and Christopher J. Evans

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1015-1020;
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α₁ and β₂ Adrenoreceptor Agonists Inhibit Pentylenetetrazole-Induced Seizures in Mice Lacking Norepinephrine
David Weinshenker, Patricia Szot, Nicole S. Miller and Richard D. Palmiter

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1042-1048;
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GR89,696: A Potent κ-Opioid Agonist with Subtype Selectivity in Rhesus Monkeys
Eduardo R. Butelman, M. C. Holden Ko, John R. Traynor, Jeffrey A. Vivian, Mary-Jeanne Kreek and James H. Woods

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1049-1059;
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Genetic Regulation of Extracellular Serotonin by 5-Hydroxytryptamine_1A and 5-Hydroxytryptamine_1BAutoreceptors in Different Brain Regions of the Mouse
Deborah A. Knobelman, René Hen and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1083-1091;
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Regional Patterns of Compensation following Genetic Deletion of Either 5-Hydroxytryptamine_1A or 5-Hydroxytryptamine_1B Receptor in the Mouse
Deborah A. Knobelman, René Hen, Julie A. Blendy and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1092-1100;
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Antidepressant-Like Behavioral Effects in 5-Hydroxytryptamine_1A and 5-Hydroxytryptamine_1B Receptor Mutant Mice
Arthur J. Mayorga, Ashutosh Dalvi, Michelle E. Page, Sarah Zimov-Levinson, René Hen and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1101-1107;
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Femtomolar Concentrations of Dynorphins Protect Rat Mesencephalic Dopaminergic Neurons against Inflammatory Damage
Bin Liu, Liya Qin, San-Nan Yang, Belinda C. Wilson, Yuxin Liu and Jau-Shyong Hong

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1133-1141;
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Cocaine-Induced Increases in Vesicular Dopamine Uptake: Role of Dopamine Receptors
Jeffrey M. Brown, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1150-1153;
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Ovarian Sex Steroid-Dependent Plasticity of Nociceptin/Orphanin FQ and Opioid Modulation of Spinal Dynorphin Release
Daya S. Gupta, Andrew B. Kelson, Willma E. Polgar, Lawrence Toll, Maria Szücs and Alan R. Gintzler

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1213-1220;
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Potency of Positive γ-Aminobutyric Acid_A Modulators to Substitute for a Midazolam Discriminative Stimulus in Untreated Monkeys Does Not Predict Potency to Attenuate a Flumazenil Discriminative Stimulus in Diazepam-Treated Monkeys
Lance R. McMahon, Lisa R. Gerak and Charles P. France

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1227-1235;
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The Antidepressant-Like Effect Induced by ς₁-Receptor Agonists and Neuroactive Steroids in Mice Submitted to the Forced Swimming Test
Alexandre Urani, François J. Roman, Vân-Ly Phan, Tsung-Ping Su and Tangui Maurice

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1269-1279;

TOXICOLOGY

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Actions of Pyrethroid Insecticides on Sodium Currents, Action Potentials, and Contractile Rhythm in Isolated Mammalian Ventricular Myocytes and Perfused Hearts
C. Ian Spencer, Kathryn H. Yuill, John J. Borg, Jules C. Hancox and Roland Z. Kozlowski

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1067-1082;
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Disruption of Mitochondrial Function and Cellular ATP Levels by Amiodarone and N-Desethylamiodarone in Initiation of Amiodarone-Induced Pulmonary Cytotoxicity
M. W. Bolt, J. W. Card, W. J. Racz, J. F. Brien and T. E. Massey

Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1280-1289;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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