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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2001; Volume 298,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Drug Synergism: Its Detection and Applications
    Ronald J. Tallarida
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 865-872;
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    Growth Factor Signaling in Cell Survival: Implications for Cancer Treatment
    Sunit Talapatra and Craig B. Thompson
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 873-878;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Pharmacokinetics and Tissue Distribution of SB-251353, a Novel Human CXC Chemokine, after Intravenous Administration to Mice
    Timothy W. Hepburn, Timothy K. Hart, Vicki L. Horton, Teresa S. Sellers, LeeAnn P. Tobia, James J. Urbanski, Wei Shi and Charles B. Davis
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 886-893;
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    Transport Characteristics of the Anti-human Immunodeficiency Virus Nucleoside Analog, Abacavir, into Brain and Cerebrospinal Fluid
    S. A. Thomas, A. Bye and M. B. Segal
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 947-953;
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    Functional Characterization of Rat Organic Anion Transporter 2 in LLC-PK1 Cells
    Naomi Morita, Hiroyuki Kusuhara, Takashi Sekine, Hitoshi Endou and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1179-1184;
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    Multidrug Resistance-Associated Protein-1 Functional Activity in Calu-3 Cells
    Karen O. Hamilton, Elizabeth Topp, Irwan Makagiansar, Teruna Siahaan, Mehran Yazdanian and Kenneth L. Audus
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1199-1205;
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    Liposomal and Nonliposomal Drug Pharmacokinetics after Administration of Liposome-Encapsulated Vincristine and Their Contribution to Drug Tissue Distribution Properties
    Rajesh Krishna, Murray S. Webb, Ginette St. Onge and Lawrence D. Mayer
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1206-1212;
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    Kinetics of P-Glycoprotein-Mediated Efflux of Paclitaxel
    Seong Hoon Jang, M. Guillaume Wientjes and Jessie L.-S. Au
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1236-1242;
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    P-Glycoprotein Efflux at the Blood-Brain Barrier Mediates Differences in Brain Disposition and Pharmacodynamics between Two Structurally Related Neurokinin-1 Receptor Antagonists
    Bill J. Smith, Angela C. Doran, Stafford McLean, F. David Tingley, Brian T. O'Neill and Shama M. Kajiji
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1252-1259;

CARDIOVASCULAR

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    Oxidative Inactivation of Nitric Oxide and Endothelial Dysfunction in Stroke-Prone Spontaneous Hypertensive Rats
    Xin-Liang Ma, Feng Gao, Allen H. Nelson, Bernard L. Lopez, Theodore A. Christopher, Tian-Li Yue and Frank C. Barone
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 879-885;
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    Protein Kinase A-Dependent and -Independent Effects of Isoproterenol in Rat Isolated Mesenteric Artery: Interactions with Levcromakalim
    Richard White, Fiona E. Bottrill, Derrick Siau and C. Robin Hiley
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 917-924;
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    In Contrast to Forskolin and 3-Isobutyl-1-methylxanthine, Amrinone Stimulates the Cardiac Voltage-Sensitive Release Mechanism without Increasing Calcium-Induced Calcium Release
    Wei Xiong, Heidi M. Moore, Susan E. Howlett and Gregory R. Ferrier
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 954-963;
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    Inhibitors of Bradykinin-Inactivating Enzymes Decrease Myocardial Ischemia/Reperfusion Injury following 3 and 7 Days of Reperfusion
    J. A. Schriefer, E. P. Broudy and A. H. Hassen
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 970-975;
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    Metabolism of Methadone andlevo-α-Acetylmethadol (LAAM) by Human Intestinal Cytochrome P450 3A4 (CYP3A4): Potential Contribution of Intestinal Metabolism to Presystemic Clearance and Bioactivation
    Yutaka Oda and Evan D. Kharasch
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1021-1032;
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    Decrease in Ca2+-Sensitizing Effect of UD-CG 212 Cl, a Metabolite of Pimobendan, under Acidotic Condition in Canine Ventricular Myocardium
    Reiko Takahashi, Yasuhisa Shimazaki and Masao Endoh
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1060-1066;
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    Effects of Anorexinogen Agents on Cloned Voltage-Gated K+ Channel hKv1.5
    Loı̈c Perchenet, Laurence Hilfiger, Jacques Mizrahi and Odile Clément-Chomienne
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1108-1119;
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    Selective Renal Vasodilation and Active Renal Artery Perfusion Improve Renal Function in Dogs with Acute Heart Failure
    Kotaro Suehiro, Juichiro Shimizu, Geng-Hua Yi, Anguo Gu, Jie Wang, Gad Keren and Daniel Burkhoff
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1154-1160;
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    Lusitropic Effect of MCC-135 Is Associated with Improvement of Sarcoplasmic Reticulum Function in Ventricular Muscles of Rats with Diabetic Cardiomyopathy
    Naoya Satoh, Taku Sato, Mayumi Shimada, Kumi Yamada and Yoshimi Kitada
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1161-1166;
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    Efficacy of the Novel Selective Platelet-Derived Growth Factor Receptor Antagonist CT52923 on Cellular Proliferation, Migration, and Suppression of Neointima following Vascular Injury
    Jin-Chen Yu, Nathalie A. Lokker, Stanley Hollenbach, Mutiah Apatira, Jason Li, Andreas Betz, David Sedlock, Shoji Oda, Yuji Nomoto, Kenji Matsuno, Shin-ichi Ide, Eiji Tsukuda and Neill A. Giese
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1172-1178;

CELLULAR AND MOLECULAR

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    Cell Cycle Effects of Nonsteroidal Anti-Inflammatory Drugs and Enhanced Growth Inhibition in Combination with Gemcitabine in Pancreatic Carcinoma Cells
    Michele T. Yip-Schneider, Christopher J. Sweeney, Sin-Ho Jung, Pamela L. Crowell and Mark S. Marshall
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 976-985;
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    Fenamates: A Novel Class of Reversible Gap Junction Blockers
    Erik G. A. Harks, Albert D. G. de Roos, Peter H. J. Peters, Laura H. de Haan, Abraham Brouwer, Dirk L. Ypey, Everardus J. J. van Zoelen and Alexander P. R. Theuvenet
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1033-1041;
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    Voltage-Dependent Antagonist/Agonist Actions of Taurine on Ca2+-Activated Potassium Channels of Rat Skeletal Muscle Fibers
    Domenico Tricarico, Mariagrazia Barbieri and Diana Conte Camerino
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1167-1171;
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    Phosphorylation and Desensitization of the Human Thromboxane Receptor-α by G Protein-Coupled Receptor Kinases
    Huiping Zhou, Fengxiang Yan and Hsin-Hsiung Tai
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1243-1251;
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    Synthesis and Pharmacological Evaluation of Dimeric Muscarinic Acetylcholine Receptor Agonists
    Arthur Christopoulos, Marianne K. O. Grant, Negar Ayoubzadeh, Ok Nyu Kim, Per Sauerberg, Lone Jeppesen and Esam E. El-Fakahany
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1260-1268;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Antitumor Activity of Antisense Clusterin Oligonucleotides Is Improved in Vitro and in Vivo by Incorporation of 2′-O-(2-Methoxy)Ethyl Chemistry
    Tobias Zellweger, Hideaki Miyake, Scott Cooper, Kim Chi, Boyd S. Conklin, Brett P. Monia and Martin E. Gleave
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 934-940;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Prevention of Neutrophil-Mediated Hepatic Ischemia/Reperfusion Injury by Superoxide Dismutase and Catalase Derivatives
    Yoshiyuki Yabe, Naoki Kobayashi, Tsuyoshi Nishihashi, Rei Takahashi, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 894-899;
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    Dopamine Inhibits Vasopressin Action in the Rat Inner Medullary Collecting Duct via α2-Adrenoceptors
    Richard M. Edwards and David P. Brooks
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1001-1006;
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    Effect of Steviol on para-Aminohippurate Transport by Isolated Perfused Rabbit Renal Proximal Tubule
    Varanuj Chatsudthipong and Promsuk Jutabha
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1120-1127;
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    Suppression of Acute Experimental Colitis by a Highly Selective Inducible Nitric-Oxide Synthase Inhibitor,N-[3-(Aminomethyl)benzyl]acetamidine
    Esko Kankuri, Kirsi Vaali, Richard G. Knowles, Mari Lähde, Riitta Korpela, Heikki Vapaatalo and Eeva Moilanen
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1128-1132;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Inhibition of Tumor Necrosis Factor-α (TNF-α) Production and Arthritis in the Rat by GW3333, a Dual Inhibitor of TNF-α-Converting Enzyme and Matrix Metalloproteinases
    James G. Conway, Robert C. Andrews, Beth Beaudet, D. Mark Bickett, Virginia Boncek, Thomas A. Brodie, Richard L. Clark, R. Christian Crumrine, Michael A. Leenitzer, Darryl L. McDougald, Bajin Han, Kevin Hedeen, Peiyuan Lin, Marcos Milla, Marcia Moss, Heather Pink, Michael H. Rabinowitz, Timothy Tippin, Phillip W. Scates, Jeffrey Selph, Stephen A. Stimpson, Janet Warner and J. David Becherer
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 900-908;
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    Mistletoe Lectin-1 Increases Tumor Necrosis Factor-α Release in Lipopolysaccharide-Stimulated Whole Blood via Inhibition of Interleukin-10 Production
    Eva-Maria Boneberg and Thomas Hartung
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 996-1000;
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    Studies on Mechanisms of Low Emetogenicity of YM976, a Novel Phosphodiesterase Type 4 Inhibitor
    Motonori Aoki, Masahiro Fukunaga, Tohru Sugimoto, Yasuno Hirano, Miki Kobayashi, Kazuo Honda and Toshimitsu Yamada
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1142-1149;
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    Immune Stimulation by a CpG-Containing Oligodeoxynucleotide Is Enhanced When Encapsulated and Delivered in Lipid Particles
    Barbara Mui, Sameersingh G. Raney, Sean C. Semple and Michael J. Hope
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1185-1192;
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    Immunosuppression by δ-Opioid Antagonist Naltrindole: δ- and Triple μ/δ/κ-Opioid Receptor Knockout Mice Reveal a Nonopioid Activity
    Claire Gavériaux-Ruff, Dominique Filliol, Frédéric Simonin, Hans W. D. Matthes and Brigitte L. Kieffer
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1193-1198;
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    Limited Efficacy of Thalidomide in the Treatment of Febrile Attacks of the Hyper-IgD and Periodic Fever Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
    Joost P. H. Drenth, Alieke G. Vonk, Anna Simon, Richard Powell and Jos W. M. van der Meer
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1221-1226;

NEUROPHARMACOLOGY

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    Cellular Depolarization of Neurons in the Locus Ceruleus Region of the Guinea Pig Associated with the Development of Tolerance to Opioids
    J.-Q. Kong, J. Meng, P. S. Biser, W. W. Fleming and D. A. Taylor
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 909-916;
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    Differential Sensitivity of Mesencephalic Neurons to Inhibition of Phosphatase 2A
    Gail D. Zeevalk, Laura P. Bernard, Lawrence Manzino and Patricia K. Sonsalla
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 925-933;
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    Biphasic Alterations of cAMP Levels and Inhibition of Norepinephrine Release in Iris-Ciliary Body by Bremazocine
    Karen R. M. Russell and David E. Potter
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 941-946;
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    Dosing Time-Dependent Tolerance of Catalepsy by Repetitive Administration of Haloperidol in Mice
    Jarupa Viyoch, Shigehiro Ohdo, Eiji Yukawa and Shun Higuchi
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 964-969;
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    Pentylenetetrazole-Induced Inhibition of Recombinant γ-Aminobutyric Acid Type A (GABAA) Receptors: Mechanism and Site of Action
    Ren-Qi Huang, Cathy L. Bell-Horner, Mohammed I. Dibas, Douglas F. Covey, John A. Drewe and Glenn H. Dillon
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 986-995;
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    Opioid and Cannabinoid Modulation of Precipitated Withdrawal in Δ9-Tetrahydrocannabinol and Morphine-Dependent Mice
    A. H. Lichtman, S. M. Sheikh, H. H. Loh and B. R. Martin
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1007-1014;
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    Agonist-, Antagonist-, and Inverse Agonist-Regulated Trafficking of the δ-Opioid Receptor Correlates with, but Does Not Require, G Protein Activation
    Paulette A. Zaki, Duane E. Keith, James B. Thomas, F. I. Carroll and Christopher J. Evans
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1015-1020;
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    α1 and β2 Adrenoreceptor Agonists Inhibit Pentylenetetrazole-Induced Seizures in Mice Lacking Norepinephrine
    David Weinshenker, Patricia Szot, Nicole S. Miller and Richard D. Palmiter
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1042-1048;
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    GR89,696: A Potent κ-Opioid Agonist with Subtype Selectivity in Rhesus Monkeys
    Eduardo R. Butelman, M. C. Holden Ko, John R. Traynor, Jeffrey A. Vivian, Mary-Jeanne Kreek and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1049-1059;
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    Genetic Regulation of Extracellular Serotonin by 5-Hydroxytryptamine1A and 5-Hydroxytryptamine1BAutoreceptors in Different Brain Regions of the Mouse
    Deborah A. Knobelman, René Hen and Irwin Lucki
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1083-1091;
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    Regional Patterns of Compensation following Genetic Deletion of Either 5-Hydroxytryptamine1A or 5-Hydroxytryptamine1B Receptor in the Mouse
    Deborah A. Knobelman, René Hen, Julie A. Blendy and Irwin Lucki
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1092-1100;
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    Antidepressant-Like Behavioral Effects in 5-Hydroxytryptamine1A and 5-Hydroxytryptamine1B Receptor Mutant Mice
    Arthur J. Mayorga, Ashutosh Dalvi, Michelle E. Page, Sarah Zimov-Levinson, René Hen and Irwin Lucki
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1101-1107;
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    Femtomolar Concentrations of Dynorphins Protect Rat Mesencephalic Dopaminergic Neurons against Inflammatory Damage
    Bin Liu, Liya Qin, San-Nan Yang, Belinda C. Wilson, Yuxin Liu and Jau-Shyong Hong
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1133-1141;
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    Cocaine-Induced Increases in Vesicular Dopamine Uptake: Role of Dopamine Receptors
    Jeffrey M. Brown, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1150-1153;
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    Ovarian Sex Steroid-Dependent Plasticity of Nociceptin/Orphanin FQ and Opioid Modulation of Spinal Dynorphin Release
    Daya S. Gupta, Andrew B. Kelson, Willma E. Polgar, Lawrence Toll, Maria Szücs and Alan R. Gintzler
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1213-1220;
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    Potency of Positive γ-Aminobutyric AcidA Modulators to Substitute for a Midazolam Discriminative Stimulus in Untreated Monkeys Does Not Predict Potency to Attenuate a Flumazenil Discriminative Stimulus in Diazepam-Treated Monkeys
    Lance R. McMahon, Lisa R. Gerak and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1227-1235;
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    The Antidepressant-Like Effect Induced by ς1-Receptor Agonists and Neuroactive Steroids in Mice Submitted to the Forced Swimming Test
    Alexandre Urani, François J. Roman, Vân-Ly Phan, Tsung-Ping Su and Tangui Maurice
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1269-1279;

TOXICOLOGY

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    Actions of Pyrethroid Insecticides on Sodium Currents, Action Potentials, and Contractile Rhythm in Isolated Mammalian Ventricular Myocytes and Perfused Hearts
    C. Ian Spencer, Kathryn H. Yuill, John J. Borg, Jules C. Hancox and Roland Z. Kozlowski
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1067-1082;
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    Disruption of Mitochondrial Function and Cellular ATP Levels by Amiodarone and N-Desethylamiodarone in Initiation of Amiodarone-Induced Pulmonary Cytotoxicity
    M. W. Bolt, J. W. Card, W. J. Racz, J. F. Brien and T. E. Massey
    Journal of Pharmacology and Experimental Therapeutics September 2001, 298 (3) 1280-1289;
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Journal of Pharmacology and Experimental Therapeutics: 298 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 298, Issue 3
1 Sep 2001
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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