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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Characterization of the NADPH-Dependent Metabolism of 17β-Estradiol to Multiple Metabolites by Human Liver Microsomes and Selectively Expressed Human Cytochrome P450 3A4 and 3A5

Anthony J. Lee, Joseph W. Kosh, Allan H. Conney and Bao Ting Zhu
Journal of Pharmacology and Experimental Therapeutics August 2001, 298 (2) 420-432;

Article Information

vol. 298 no. 2 420-432
PubMed 
11454902
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 9, 2001
  • Accepted April 17, 2001
  • Published online August 1, 2001.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anthony J. Lee1,
  2. Joseph W. Kosh1,
  3. Allan H. Conney1,2 and
  4. Bao Ting Zhu1
  1. 1Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina (A.J.L., J.W.K., B.T.Z.); and 2Department of Chemical Biology, College of Pharmacy, Rutgers—The State University of New Jersey, Piscataway, New Jersey (A.H.C.)
  1. Bao Ting Zhu, Ph.D., Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Coker Life Sciences Building, 700 Sumter St., Columbia, SC 29208. E-mail: BTZhu{at}cop.sc.edu
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Characterization of the NADPH-Dependent Metabolism of 17β-Estradiol to Multiple Metabolites by Human Liver Microsomes and Selectively Expressed Human Cytochrome P450 3A4 and 3A5

Anthony J. Lee, Joseph W. Kosh, Allan H. Conney and Bao Ting Zhu
Journal of Pharmacology and Experimental Therapeutics August 1, 2001, 298 (2) 420-432;
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