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Research ArticleNEUROPHARMACOLOGY

Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior in Mice

Rebecca J. Ralph, Martin P. Paulus and Mark A. Geyer
Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 148-155;
Rebecca J. Ralph
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Martin P. Paulus
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Mark A. Geyer
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Abstract

Several reports describe substantive behavioral differences between strains of mice both at baseline and in response to pharmacological manipulations. For example, mouse strain differences have been reported in prepulse inhibition (PPI) and patterns of locomotor activity, two behavioral processes that are altered by dopamine (DA) agonists such as amphetamine. Here, we characterized acoustic and tactile startle reactivity, acoustic PPI, and both the amounts and spatial patterns of locomotor activity in C57BL/6J, 129SvEv (129S6), and 129SvJ (129X1) mice at baseline and in amphetamine dose-response studies. Because hearing loss is common in numerous strains of mice, we also assessed cross-modal PPI using a light prepulse with an airpuff startle stimulus. The results establish that these three inbred strains of mice display both intra- and cross-modal PPI, and that amphetamine decreases PPI and startle reactivity in a dose-, sensory modality-, and strain-specific manner. Furthermore, the amount of locomotor activity and the spatial pattern of motor sequences are altered differentially after treatment with amphetamine in C57BL/6J and 129X1 mice, but not in 129S6 mice. Given that amphetamine releases presynaptic DA, these findings are consistent with the role of DA in the modulation of PPI and motor patterns in mice. These findings highlight the importance of selecting appropriate strains of mice for behavioral, pharmacological, and genetic studies.

Footnotes

  • These studies were supported by the Veterans Affairs VISN 22 Mental Illness Research, Education, and Clinical Center, and grants from the National Institute on Drug Abuse (DA02925 and DA11277) and the National Institute of Mental Health (F31-MH12806, MH61326, and MH42228). M. A. Geyer holds an equity interest in San Diego Instruments.

  • Abbreviations:
    PPI
    prepulse inhibition
    DA
    dopamine
    VT
    video-tracker
    ANOVA
    analysis of variance
    • Received December 5, 2000.
    • Accepted March 21, 2001.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 298 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 298, Issue 1
1 Jul 2001
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Research ArticleNEUROPHARMACOLOGY

Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior in Mice

Rebecca J. Ralph, Martin P. Paulus and Mark A. Geyer
Journal of Pharmacology and Experimental Therapeutics July 1, 2001, 298 (1) 148-155;

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Research ArticleNEUROPHARMACOLOGY

Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior in Mice

Rebecca J. Ralph, Martin P. Paulus and Mark A. Geyer
Journal of Pharmacology and Experimental Therapeutics July 1, 2001, 298 (1) 148-155;
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