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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

July 01, 2001; Volume 298,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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    The Dopamine Transporter and Cocaine Medication Development: Drug Self-Administration in Nonhuman Primates
    Leonard L. Howell and Kristin M. Wilcox
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 1-6;
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    Mechanisms of Endocannabinoid Inactivation: Biochemistry and Pharmacology
    Andrea Giuffrida, Massimiliano Beltramo and Daniele Piomelli
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 7-14;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Molecular Basis of Perinatal Changes in UDP-Glucuronosyltransferase Activity in Maternal Rat Liver
    Marcelo G. Luquita, Viviana A. Catania, Enrique J. Sánchez Pozzi, Luis M. Veggi, Tim Hoffman, José M. Pellegrino, Shin-ichi Ikushiro, Yoshikazu Emi, Takashi Iyanagi, Mary Vore and Aldo D. Mottino
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 49-56;
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    In Vivo Pharmacokinetics of Selective μ-Opioid Peptide Agonists
    Hazel H. Szeto, Jerry L. Lovelace, Genevieve Fridland, Yi Soong, Joseph Fasolo, Dunli Wu, Dominic M. Desiderio and Peter W. Schiller
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 57-61;
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    Comparison of “Type I” and “Type II” Organic Cation Transport by Organic Cation Transporters and Organic Anion-Transporting Polypeptides
    Jessica E. van Montfoort, Michael Müller, Geny M. M. Groothuis, Dirk K. F. Meijer, Hermann Koepsell and Peter J. Meier
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 110-115;
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    Arsenic Induces Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) Gene in Primary Rat and Human Hepatocytes
    Laurent Vernhet, Marie-Pascale Séité, Nathalie Allain, André Guillouzo and Olivier Fardel
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 234-239;
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    Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier
    Daisuke Sugiyama, Hiroyuki Kusuhara, Yoshihisa Shitara, Takaaki Abe, Peter J. Meier, Takashi Sekine, Hitoshi Endou, Hiroshi Suzuki and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 316-322;
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    P-glycoprotein-Mediated Efflux of Indinavir Metabolites in Caco-2 Cells Expressing Cytochrome P450 3A4
    Jerome H. Hochman, Masato Chiba, Masayo Yamazaki, Cuyue Tang and Jiunn H. Lin
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 323-330;
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    Stereoselective Pharmacokinetics and Pharmacodynamics of Organic Nitrates in Rats
    Tomomi Hatanaka, Kayoko Ihara, Masaaki Kodera, Kazunori Katayama and Tamotsu Koizumi
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 346-353;

CARDIOVASCULAR

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    Administration of a Potent Antagonist of Protease-Activated Receptor-1 (PAR-1) Attenuates Vascular Restenosis Following Balloon Angioplasty in Rats
    Patricia Andrade-Gordon, Claudia K. Derian, Bruce E. Maryanoff, Han-Cheng Zhang, Michael F. Addo, Wai-man Cheung, Bruce P. Damiano, Michael R. D'Andrea, Andrew L. Darrow, Lawrence de Garavilla, Annette J. Eckardt, Edward C. Giardino, Barbara J. Haertlein and David F. McComsey
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 34-42;
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    Multiple Pathways of Angiotensin I Conversion and Their Functional Role in the Canine Penile Corpus Cavernosum
    Yusaku Iwamoto, Keifu Song, Shinji Takai, Mayumi Yamada, Denan Jin, Masato Sakaguchi, Haruhiko Ueda, Yoji Katsuoka and Mizuo Miyazaki
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 43-48;
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    AT1 Receptor Antagonist Telmisartan Administered Peripherally Inhibits Central Responses to Angiotensin II in Conscious Rats
    P. Gohlke, S. Weiss, A. Jansen, W. Wienen, J. Stangier, W. Rascher, J. Culman and T. Unger
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 62-70;
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    Histamine Increases Interstitial Adenosine Concentration via Activation of Ecto-5′-nucleotidase in Rat Hearts in Vivo
    Toshio Obata, Shunichiro Kubota and Yasumitsu Yamanaka
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 71-76;
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    Presynaptic α7-Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Nitric Oxidergic Neurogenic Vasodilation in Porcine Basilar Arteries
    Min-Liang Si and Tony J. F. Lee
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 122-128;
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    Cocaine-Mediated Apoptosis in Bovine Coronary Artery Endothelial Cells: Role of Nitric Oxide
    Jiale He, Yuhui Xiao and Lubo Zhang
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 180-187;
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    Enhanced Cardiac L-Type Calcium Current Response to β2-Adrenergic Stimulation in Heart Failure
    Zhu-Shan Zhang, Heng-Jie Cheng, Tomohiko Ukai, Hideo Tachibana and Che-Ping Cheng
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 188-196;
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    Novel Short-Acting A2A Adenosine Receptor Agonists for Coronary Vasodilation: Inverse Relationship between Affinity and Duration of Action of A2A Agonists
    Zhenhai Gao, Zhihe Li, Stephen P. Baker, Robert D. Lasley, Stephanie Meyer, Elfatih Elzein, Venkata Palle, Jeff A. Zablocki, Brent Blackburn and Luiz Belardinelli
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 209-218;

CELLULAR AND MOLECULAR

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    Stimulation of Guanosine-5′-O-(3-[35S]thio)triphosphate Binding in Digitonin-Permeabilized C6 Rat Glioma Cells: Evidence for an Organized Association of μ-Opioid Receptors and G Protein
    Andrew Alt, Iain J. McFadyen, Charles D. Fan, James H. Woods and John R. Traynor
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 116-121;
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    Geraniol, a Component of Plant Essential Oils, Inhibits Growth and Polyamine Biosynthesis in Human Colon Cancer Cells
    S. Carnesecchi, Y. Schneider, J. Ceraline, B. Duranton, F. Gosse, N. Seiler and F. Raul
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 197-200;
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    Rabbit α2-Adrenoceptors: Both Platelets and Adipocytes Have α2A-Pharmacology
    Diane P. Naselsky, Daryl Ashton, Robert R. Ruffolo and J. Paul Hieble
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 219-225;
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    Agonist Activity of the δ-Antagonists TIPP and TIPP-ψ in Cellular Models Expressing Endogenous or Transfected δ-Opioid Receptors
    Nancy A. Martin, Maguerite T. Terruso and Paul L. Prather
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 240-248;
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    Ca2+/Calmodulin-Dependent Protein Kinase II and Cytosolic Phospholipase A2 Contribute to Mitogenic Signaling in Myeloblastic Leukemia U-937 Cells
    Mubarack M. Muthalif, Farid Ljuca, J. Brent Roaten, Neelu Pentapaty, Mohammed R. Uddin and Kafait U. Malik
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 272-278;
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    Cytosolic Phospholipase A2 Activation by the p38 Kinase Inhibitor SB203580 in Rabbit Aortic Smooth Muscle Cells
    S. Fatima, Z. Khandekar, J.-H. Parmentier and Kufait U. Malik
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 331-338;
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    Pharmacologic or Genetic Manipulation of Glutathione S-Transferase P1–1 (GSTπ) Influences Cell Proliferation Pathways
    Julie E. Ruscoe, Lilliam A. Rosario, Tieli Wang, Laurent Gaté, Pinar Arifoglu, C. Roland Wolf, Colin J. Henderson, Ze'ev Ronai and Kenneth D. Tew
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 339-345;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    D609 Inhibits Ionizing Radiation-Induced Oxidative Damage by Acting as a Potent Antioxidant
    Daohong Zhou, Christopher M. Lauderback, Tao Yu, Stephen A. Brown, D. Allan Butterfield and John S. Thompson
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 103-109;
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    Modulation of 1,3-Bis-(2-chloroethyl)-1-nitrosourea Resistance in Human Tumor Cells Using Hammerhead Ribozymes Designed to DegradeO 6-Methylguanine DNA Methyltransferase mRNA
    Qiwei Zhang, David W. Ohannesian, Emiko L. Kreklau and Leonard C. Erickson
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 141-147;
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    In Vivo Synergistic Interaction of Liposome-Coencapsulated Gentamicin and Ceftazidime
    Raymond M. Schiffelers, Gert Storm, Marian T. ten Kate, Lorna E. T. Stearne-Cullen, Jan G. den Hollander, Henri A. Verbrugh and Irma A. J. M. Bakker-Woudenberg
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 369-375;

ENDOCRINE AND REPRODUCTIVE

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    Riboflavin Uptake in Human Trophoblast-Derived BeWo Cell Monolayers: Cellular Translocation and Regulatory Mechanisms
    Se-Ne Huang and Peter W. Swaan
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 264-271;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    In Vivo Inhibition of Fas Ligand-Mediated Killing by TR6, a Fas Ligand Decoy Receptor
    Kevin Connolly, Yun Hee Cho, Roxanne Duan, James Fikes, Theresa Gregorio, David W. LaFleur, Zebedee Okoye, Theodora W. Salcedo, Gemma Santiago, Stephen Ullrich, Ping Wei, Kathleen Windle, Eling Wong, Xiao-Tao Yao, Ya-Qin Zhang, Grace Zheng and Paul A. Moore
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 25-33;
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    Chronic Lipopolysaccharide Exposure on Airway Function, Cell Infiltration, and Nitric Oxide Generation in Conscious Guinea Pigs: Effect of Rolipram and Dexamethasone
    Toby J. Toward and Kenneth J. Broadley
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 298-306;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Bradykinin B1 Receptor Up-Regulation by Interleukin-1β and B1 Agonist Occurs through Independent and Synergistic Intracellular Signaling Mechanisms in Human Lung Fibroblasts
    Stephen B. Phagoo, Krisanavane Reddi, Kathryn D. Anderson, L. M. Fredrik Leeb-Lundberg and David Warburton
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 77-85;
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    Pharmacokinetics, Pharmacodynamics, and Platelet Binding of an Anti-Glycoprotein IIb/IIIa Monoclonal Antibody (7E3) in the Rat: A Quantitative Rat Model of Immune Thrombocytopenic Purpura
    Ryan J. Hansen and Joseph P. Balthasar
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 165-171;
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    Phosphatidylcholine Association Increases the Anti-Inflammatory and Analgesic Activity of Ibuprofen in Acute and Chronic Rodent Models of Joint Inflammation: Relationship to Alterations in Bioavailability and Cyclooxygenase-Inhibitory Potency
    Lenard M. Lichtenberger, Jimmy J. Romero, Winanda M. J. de Ruijter, Fariba Behbod, Rebecca Darling, Anis Q. Ashraf and Sudershan K. Sanduja
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 279-287;
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    Early Augmentation of Interleukin (IL)-12 Level in the Airway of Mice Administered Orally with Clarithromycin or Intranasally with IL-12 Results in Alleviation of Influenza Infection
    Minako Tsurita, Masahiko Kurokawa, Masami Imakita, Yoshiko Fukuda, Yukio Watanabe and Kimiyasu Shiraki
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 362-368;
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    BMS-229724 Is a Tight-Binding Inhibitor of Cytosolic Phospholipase A2 That Acts at the Lipid/Water Interface and Possesses Anti-Inflammatory Activity in Skin Inflammation Models
    James R. Burke, Lynda B. Davern, Paul L. Stanley, Kurt R. Gregor, Jacques Banville, Roger Remillard, John W. Russell, Patrick J. Brassil, Mark R. Witmer, Graham Johnson, Jeffrey A. Tredup and Kenneth M. Tramposch
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 376-385;

NEUROPHARMACOLOGY

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    The Anticonvulsant, Antihyperalgesic Agent Gabapentin Is an Agonist at Brain γ-Aminobutyric Acid Type B Receptors Negatively Coupled to Voltage-Dependent Calcium Channels
    Sandrine Bertrand, Gordon Y. K. Ng, Maya Gadhvi Purisai, Shannyn E. Wolfe, Mathew W. Severidt, Dominique Nouel, Richard Robitaille, Malcolm J. Low, Gary P. O'Neill, Kathleen Metters, Jean-Claude Lacaille, Bibie M. Chronwall and Stephen J. Morris
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 15-24;
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    Positive Modulation of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) Receptors in Prefrontal Cortical Pyramidal Neurons by a Novel Allosteric Potentiator
    Polly J. Baumbarger, Mark Muhlhauser, Jin Zhai, Charles R. Yang and Eric S. Nisenbaum
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 86-102;
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    Dopamine D1 and D2 Receptors Influence Dopamine Transporter Synthesis and Degradation in the Rat
    Heather L. Kimmel, Andrew R. Joyce, F. Ivy Carroll and Michael J. Kuhar
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 129-140;
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    Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior in Mice
    Rebecca J. Ralph, Martin P. Paulus and Mark A. Geyer
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 148-155;
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    Acute Opioid Pretreatment Potentiates Naltrexone-Induced Drinking Suppression in Water-Deprived Rats
    David A. White and Stephen G. Holtzman
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 156-164;
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    Lobeline Attenuates d-Methamphetamine Self-Administration in Rats
    Steven B. Harrod, Linda P. Dwoskin, Peter A. Crooks, Jennifer E. Klebaur and Michael T. Bardo
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 172-179;
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    Coadministered Nitrous Oxide Enhances the Effect of Isoflurane on GABAergic Transmission by an Increase in Open-Channel Block
    Gerhard Hapfelmeier, Rainer Haseneder, Eberhard Kochs, Michaela Beyerle and Walter Zieglgänsberger
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 201-208;
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    Dopamine-Independent Locomotion Following Blockade of N-Methyl-d-aspartate Receptors in the Ventral Tegmental Area
    Jennifer L. Cornish, Mistu Nakamura and Peter W. Kalivas
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 226-233;
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    SEA0400, a Novel and Selective Inhibitor of the Na+-Ca2+ Exchanger, Attenuates Reperfusion Injury in the in Vitro and in Vivo Cerebral Ischemic Models
    Toshio Matsuda, Naohisa Arakawa, Kazuhiro Takuma, Yoko Kishida, Yasushi Kawasaki, Masaki Sakaue, Kenzo Takahashi, Teisuke Takahashi, Taizo Suzuki, Tomomi Ota, Akiko Hamano-Takahashi, Michihito Onishi, Yu Tanaka, Kazuya Kameo and Akemichi Baba
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 249-256;
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    Blockade of Opioid Receptors in Rostral Ventral Medulla Prevents Antihyperalgesia Produced by Transcutaneous Electrical Nerve Stimulation (TENS)
    A. Kalra, M. O. Urban and K. A. Sluka
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 257-263;
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    N-Methyl-d-Aspartate Receptor Antagonists Potentiate the Antinociceptive Effects of Morphine in Squirrel Monkeys
    Richard M. Allen and Linda A. Dykstra
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 288-297;
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    Pharmacological Characterization of ZD6021: A Novel, Orally Active Antagonist of the Tachykinin Receptors
    William L. Rumsey, David Aharony, Russell A. Bialecki, Brian M. Abbott, Herbert G. Barthlow, Robert Caccese, Smita Ghanekar, David Lengel, Michelle McCarthy, Barbara Wenrich, Bradley Undem, Cyrus Ohnmacht, Ashok Shenvi, Jeffrey S. Albert, Fred Brown, Peter R. Bernstein and Keith Russell
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 307-315;
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    Effects of T-588, a Cognitive Enhancer Compound, on Synaptic Plasticity in the Dentate Gyrus of Freely Moving Rats
    Hidetoshi Yamaguchi, Ryoi Tamura, Jun-Ichi Kuriwaki, Satoshi Eifuku and Taketoshi Ono
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 354-361;
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    Effects of JL13, a Pyridobenzoxazepine with Potential Atypical Antipsychotic Activity, in Animal Models for Schizophrenia
    Bart A. Ellenbroek, Jean-François Liégeois, Jacques Bruhwyler and Alexander R. Cools
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 386-391;

Errata

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    Correction to “Contribution of P-glycoprotein to the enhancing effects of dimethyl-β-cyclodextrin on oral bioavailability of tacrolimus”
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 392;
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    Correction to “Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum”
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 393;
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    Correction to “Effect of capillary efflux transport inhibition on the determination of probe recovery during in vivo microdialysis in the brain”
    Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 393;
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Journal of Pharmacology and Experimental Therapeutics: 298 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 298, Issue 1
1 Jul 2001
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
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  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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