Journal of Pharmacology and Experimental Therapeutics: 298 (1)

July 01, 2001; Volume 298,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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The Dopamine Transporter and Cocaine Medication Development: Drug Self-Administration in Nonhuman Primates
Leonard L. Howell and Kristin M. Wilcox

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 1-6;
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Mechanisms of Endocannabinoid Inactivation: Biochemistry and Pharmacology
Andrea Giuffrida, Massimiliano Beltramo and Daniele Piomelli

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 7-14;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Molecular Basis of Perinatal Changes in UDP-Glucuronosyltransferase Activity in Maternal Rat Liver
Marcelo G. Luquita, Viviana A. Catania, Enrique J. Sánchez Pozzi, Luis M. Veggi, Tim Hoffman, José M. Pellegrino, Shin-ichi Ikushiro, Yoshikazu Emi, Takashi Iyanagi, Mary Vore and Aldo D. Mottino

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 49-56;
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In Vivo Pharmacokinetics of Selective μ-Opioid Peptide Agonists
Hazel H. Szeto, Jerry L. Lovelace, Genevieve Fridland, Yi Soong, Joseph Fasolo, Dunli Wu, Dominic M. Desiderio and Peter W. Schiller

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 57-61;
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Comparison of “Type I” and “Type II” Organic Cation Transport by Organic Cation Transporters and Organic Anion-Transporting Polypeptides
Jessica E. van Montfoort, Michael Müller, Geny M. M. Groothuis, Dirk K. F. Meijer, Hermann Koepsell and Peter J. Meier

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 110-115;
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Arsenic Induces Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) Gene in Primary Rat and Human Hepatocytes
Laurent Vernhet, Marie-Pascale Séité, Nathalie Allain, André Guillouzo and Olivier Fardel

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 234-239;
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Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier
Daisuke Sugiyama, Hiroyuki Kusuhara, Yoshihisa Shitara, Takaaki Abe, Peter J. Meier, Takashi Sekine, Hitoshi Endou, Hiroshi Suzuki and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 316-322;
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P-glycoprotein-Mediated Efflux of Indinavir Metabolites in Caco-2 Cells Expressing Cytochrome P450 3A4
Jerome H. Hochman, Masato Chiba, Masayo Yamazaki, Cuyue Tang and Jiunn H. Lin

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 323-330;
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Stereoselective Pharmacokinetics and Pharmacodynamics of Organic Nitrates in Rats
Tomomi Hatanaka, Kayoko Ihara, Masaaki Kodera, Kazunori Katayama and Tamotsu Koizumi

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 346-353;

CARDIOVASCULAR

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Administration of a Potent Antagonist of Protease-Activated Receptor-1 (PAR-1) Attenuates Vascular Restenosis Following Balloon Angioplasty in Rats
Patricia Andrade-Gordon, Claudia K. Derian, Bruce E. Maryanoff, Han-Cheng Zhang, Michael F. Addo, Wai-man Cheung, Bruce P. Damiano, Michael R. D'Andrea, Andrew L. Darrow, Lawrence de Garavilla, Annette J. Eckardt, Edward C. Giardino, Barbara J. Haertlein and David F. McComsey

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 34-42;
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Multiple Pathways of Angiotensin I Conversion and Their Functional Role in the Canine Penile Corpus Cavernosum
Yusaku Iwamoto, Keifu Song, Shinji Takai, Mayumi Yamada, Denan Jin, Masato Sakaguchi, Haruhiko Ueda, Yoji Katsuoka and Mizuo Miyazaki

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 43-48;
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AT₁ Receptor Antagonist Telmisartan Administered Peripherally Inhibits Central Responses to Angiotensin II in Conscious Rats
P. Gohlke, S. Weiss, A. Jansen, W. Wienen, J. Stangier, W. Rascher, J. Culman and T. Unger

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 62-70;
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Histamine Increases Interstitial Adenosine Concentration via Activation of Ecto-5′-nucleotidase in Rat Hearts in Vivo
Toshio Obata, Shunichiro Kubota and Yasumitsu Yamanaka

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 71-76;
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Presynaptic α₇-Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Nitric Oxidergic Neurogenic Vasodilation in Porcine Basilar Arteries
Min-Liang Si and Tony J. F. Lee

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 122-128;
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Cocaine-Mediated Apoptosis in Bovine Coronary Artery Endothelial Cells: Role of Nitric Oxide
Jiale He, Yuhui Xiao and Lubo Zhang

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 180-187;
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Enhanced Cardiac L-Type Calcium Current Response to β₂-Adrenergic Stimulation in Heart Failure
Zhu-Shan Zhang, Heng-Jie Cheng, Tomohiko Ukai, Hideo Tachibana and Che-Ping Cheng

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 188-196;
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Novel Short-Acting A_2A Adenosine Receptor Agonists for Coronary Vasodilation: Inverse Relationship between Affinity and Duration of Action of A_2A Agonists
Zhenhai Gao, Zhihe Li, Stephen P. Baker, Robert D. Lasley, Stephanie Meyer, Elfatih Elzein, Venkata Palle, Jeff A. Zablocki, Brent Blackburn and Luiz Belardinelli

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 209-218;

CELLULAR AND MOLECULAR

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Stimulation of Guanosine-5′-O-(3-[³⁵S]thio)triphosphate Binding in Digitonin-Permeabilized C6 Rat Glioma Cells: Evidence for an Organized Association of μ-Opioid Receptors and G Protein
Andrew Alt, Iain J. McFadyen, Charles D. Fan, James H. Woods and John R. Traynor

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 116-121;
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Geraniol, a Component of Plant Essential Oils, Inhibits Growth and Polyamine Biosynthesis in Human Colon Cancer Cells
S. Carnesecchi, Y. Schneider, J. Ceraline, B. Duranton, F. Gosse, N. Seiler and F. Raul

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 197-200;
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Rabbit α₂-Adrenoceptors: Both Platelets and Adipocytes Have α_2A-Pharmacology
Diane P. Naselsky, Daryl Ashton, Robert R. Ruffolo and J. Paul Hieble

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 219-225;
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Agonist Activity of the δ-Antagonists TIPP and TIPP-ψ in Cellular Models Expressing Endogenous or Transfected δ-Opioid Receptors
Nancy A. Martin, Maguerite T. Terruso and Paul L. Prather

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 240-248;
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Ca²⁺/Calmodulin-Dependent Protein Kinase II and Cytosolic Phospholipase A₂ Contribute to Mitogenic Signaling in Myeloblastic Leukemia U-937 Cells
Mubarack M. Muthalif, Farid Ljuca, J. Brent Roaten, Neelu Pentapaty, Mohammed R. Uddin and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 272-278;
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Cytosolic Phospholipase A₂ Activation by the p38 Kinase Inhibitor SB203580 in Rabbit Aortic Smooth Muscle Cells
S. Fatima, Z. Khandekar, J.-H. Parmentier and Kufait U. Malik

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 331-338;
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Pharmacologic or Genetic Manipulation of Glutathione S-Transferase P1–1 (GSTπ) Influences Cell Proliferation Pathways
Julie E. Ruscoe, Lilliam A. Rosario, Tieli Wang, Laurent Gaté, Pinar Arifoglu, C. Roland Wolf, Colin J. Henderson, Ze'ev Ronai and Kenneth D. Tew

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 339-345;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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D609 Inhibits Ionizing Radiation-Induced Oxidative Damage by Acting as a Potent Antioxidant
Daohong Zhou, Christopher M. Lauderback, Tao Yu, Stephen A. Brown, D. Allan Butterfield and John S. Thompson

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 103-109;
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Modulation of 1,3-Bis-(2-chloroethyl)-1-nitrosourea Resistance in Human Tumor Cells Using Hammerhead Ribozymes Designed to DegradeO ⁶-Methylguanine DNA Methyltransferase mRNA
Qiwei Zhang, David W. Ohannesian, Emiko L. Kreklau and Leonard C. Erickson

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 141-147;
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In Vivo Synergistic Interaction of Liposome-Coencapsulated Gentamicin and Ceftazidime
Raymond M. Schiffelers, Gert Storm, Marian T. ten Kate, Lorna E. T. Stearne-Cullen, Jan G. den Hollander, Henri A. Verbrugh and Irma A. J. M. Bakker-Woudenberg

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 369-375;

ENDOCRINE AND REPRODUCTIVE

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Riboflavin Uptake in Human Trophoblast-Derived BeWo Cell Monolayers: Cellular Translocation and Regulatory Mechanisms
Se-Ne Huang and Peter W. Swaan

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 264-271;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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In Vivo Inhibition of Fas Ligand-Mediated Killing by TR6, a Fas Ligand Decoy Receptor
Kevin Connolly, Yun Hee Cho, Roxanne Duan, James Fikes, Theresa Gregorio, David W. LaFleur, Zebedee Okoye, Theodora W. Salcedo, Gemma Santiago, Stephen Ullrich, Ping Wei, Kathleen Windle, Eling Wong, Xiao-Tao Yao, Ya-Qin Zhang, Grace Zheng and Paul A. Moore

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 25-33;
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Chronic Lipopolysaccharide Exposure on Airway Function, Cell Infiltration, and Nitric Oxide Generation in Conscious Guinea Pigs: Effect of Rolipram and Dexamethasone
Toby J. Toward and Kenneth J. Broadley

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 298-306;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Bradykinin B1 Receptor Up-Regulation by Interleukin-1β and B1 Agonist Occurs through Independent and Synergistic Intracellular Signaling Mechanisms in Human Lung Fibroblasts
Stephen B. Phagoo, Krisanavane Reddi, Kathryn D. Anderson, L. M. Fredrik Leeb-Lundberg and David Warburton

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 77-85;
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Pharmacokinetics, Pharmacodynamics, and Platelet Binding of an Anti-Glycoprotein IIb/IIIa Monoclonal Antibody (7E3) in the Rat: A Quantitative Rat Model of Immune Thrombocytopenic Purpura
Ryan J. Hansen and Joseph P. Balthasar

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 165-171;
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Phosphatidylcholine Association Increases the Anti-Inflammatory and Analgesic Activity of Ibuprofen in Acute and Chronic Rodent Models of Joint Inflammation: Relationship to Alterations in Bioavailability and Cyclooxygenase-Inhibitory Potency
Lenard M. Lichtenberger, Jimmy J. Romero, Winanda M. J. de Ruijter, Fariba Behbod, Rebecca Darling, Anis Q. Ashraf and Sudershan K. Sanduja

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 279-287;
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Early Augmentation of Interleukin (IL)-12 Level in the Airway of Mice Administered Orally with Clarithromycin or Intranasally with IL-12 Results in Alleviation of Influenza Infection
Minako Tsurita, Masahiko Kurokawa, Masami Imakita, Yoshiko Fukuda, Yukio Watanabe and Kimiyasu Shiraki

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 362-368;
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BMS-229724 Is a Tight-Binding Inhibitor of Cytosolic Phospholipase A₂ That Acts at the Lipid/Water Interface and Possesses Anti-Inflammatory Activity in Skin Inflammation Models
James R. Burke, Lynda B. Davern, Paul L. Stanley, Kurt R. Gregor, Jacques Banville, Roger Remillard, John W. Russell, Patrick J. Brassil, Mark R. Witmer, Graham Johnson, Jeffrey A. Tredup and Kenneth M. Tramposch

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 376-385;

NEUROPHARMACOLOGY

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The Anticonvulsant, Antihyperalgesic Agent Gabapentin Is an Agonist at Brain γ-Aminobutyric Acid Type B Receptors Negatively Coupled to Voltage-Dependent Calcium Channels
Sandrine Bertrand, Gordon Y. K. Ng, Maya Gadhvi Purisai, Shannyn E. Wolfe, Mathew W. Severidt, Dominique Nouel, Richard Robitaille, Malcolm J. Low, Gary P. O'Neill, Kathleen Metters, Jean-Claude Lacaille, Bibie M. Chronwall and Stephen J. Morris

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 15-24;
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Positive Modulation of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) Receptors in Prefrontal Cortical Pyramidal Neurons by a Novel Allosteric Potentiator
Polly J. Baumbarger, Mark Muhlhauser, Jin Zhai, Charles R. Yang and Eric S. Nisenbaum

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 86-102;
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Dopamine D1 and D2 Receptors Influence Dopamine Transporter Synthesis and Degradation in the Rat
Heather L. Kimmel, Andrew R. Joyce, F. Ivy Carroll and Michael J. Kuhar

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 129-140;
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Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior in Mice
Rebecca J. Ralph, Martin P. Paulus and Mark A. Geyer

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 148-155;
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Acute Opioid Pretreatment Potentiates Naltrexone-Induced Drinking Suppression in Water-Deprived Rats
David A. White and Stephen G. Holtzman

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 156-164;
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Lobeline Attenuates d-Methamphetamine Self-Administration in Rats
Steven B. Harrod, Linda P. Dwoskin, Peter A. Crooks, Jennifer E. Klebaur and Michael T. Bardo

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 172-179;
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Coadministered Nitrous Oxide Enhances the Effect of Isoflurane on GABAergic Transmission by an Increase in Open-Channel Block
Gerhard Hapfelmeier, Rainer Haseneder, Eberhard Kochs, Michaela Beyerle and Walter Zieglgänsberger

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 201-208;
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Dopamine-Independent Locomotion Following Blockade of N-Methyl-d-aspartate Receptors in the Ventral Tegmental Area
Jennifer L. Cornish, Mistu Nakamura and Peter W. Kalivas

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 226-233;
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SEA0400, a Novel and Selective Inhibitor of the Na⁺-Ca²⁺ Exchanger, Attenuates Reperfusion Injury in the in Vitro and in Vivo Cerebral Ischemic Models
Toshio Matsuda, Naohisa Arakawa, Kazuhiro Takuma, Yoko Kishida, Yasushi Kawasaki, Masaki Sakaue, Kenzo Takahashi, Teisuke Takahashi, Taizo Suzuki, Tomomi Ota, Akiko Hamano-Takahashi, Michihito Onishi, Yu Tanaka, Kazuya Kameo and Akemichi Baba

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 249-256;
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Blockade of Opioid Receptors in Rostral Ventral Medulla Prevents Antihyperalgesia Produced by Transcutaneous Electrical Nerve Stimulation (TENS)
A. Kalra, M. O. Urban and K. A. Sluka

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 257-263;
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N-Methyl-d-Aspartate Receptor Antagonists Potentiate the Antinociceptive Effects of Morphine in Squirrel Monkeys
Richard M. Allen and Linda A. Dykstra

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 288-297;
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Pharmacological Characterization of ZD6021: A Novel, Orally Active Antagonist of the Tachykinin Receptors
William L. Rumsey, David Aharony, Russell A. Bialecki, Brian M. Abbott, Herbert G. Barthlow, Robert Caccese, Smita Ghanekar, David Lengel, Michelle McCarthy, Barbara Wenrich, Bradley Undem, Cyrus Ohnmacht, Ashok Shenvi, Jeffrey S. Albert, Fred Brown, Peter R. Bernstein and Keith Russell

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 307-315;
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Effects of T-588, a Cognitive Enhancer Compound, on Synaptic Plasticity in the Dentate Gyrus of Freely Moving Rats
Hidetoshi Yamaguchi, Ryoi Tamura, Jun-Ichi Kuriwaki, Satoshi Eifuku and Taketoshi Ono

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 354-361;
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Effects of JL13, a Pyridobenzoxazepine with Potential Atypical Antipsychotic Activity, in Animal Models for Schizophrenia
Bart A. Ellenbroek, Jean-François Liégeois, Jacques Bruhwyler and Alexander R. Cools

Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 386-391;

Errata

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Correction to “Contribution of P-glycoprotein to the enhancing effects of dimethyl-β-cyclodextrin on oral bioavailability of tacrolimus”
Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 392;
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Correction to “Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum”
Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 393;
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Correction to “Effect of capillary efflux transport inhibition on the determination of probe recovery during in vivo microdialysis in the brain”
Journal of Pharmacology and Experimental Therapeutics July 2001, 298 (1) 393;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

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