Table of Contents

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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  Hepatic Uptake and Gene Expression Mechanisms following Intravenous Administration of Plasmid DNA by Conventional and Hydrodynamics-Based Procedures

  Naoki Kobayashi, Takeshi Kuramoto, Kiyoshi Yamaoka, Mitsuru Hashida and Yoshinobu Takakura

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 853-860;
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  Effect of Capillary Efflux Transport Inhibition on the Determination of Probe Recovery During in Vivo Microdialysis in the Brain

  Haiying Sun, Peter M. Bungay and William F. Elmquist

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 991-1000;
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  Inhibition of Biliary Excretion of Methotrexate by Probenecid in Rats: Quantitative Prediction of Interaction from in Vitro Data

  Kaoru Ueda, Yukio Kato, Kanji Komatsu and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1036-1043;
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  Identification of the Human Cytochromes P450 Responsible for in Vitro Formation of R- and S-Norfluoxetine

  Barbara J. Ring, James A. Eckstein, Jennifer S. Gillespie, Shelly N. Binkley, Mark VandenBranden and Steven A. Wrighton

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1044-1050;
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  Improved Pharmacokinetic Properties of a Polyethylene Glycol-Modified Form of Interferon-β-1a with Preserved in Vitro Bioactivity

  R. Blake Pepinsky, Doreen J. LePage, Alan Gill, Abhijit Chakraborty, Sujata Vaidyanathan, Marie Green, Darren P. Baker, Eric Whalley, Paula S. Hochman and Pauline Martin

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1059-1066;
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  Delivery across the Blood-Brain Barrier of Antisense Directed against Amyloid β: Reversal of Learning and Memory Deficits in Mice Overexpressing Amyloid Precursor Protein

  William A. Banks, Susan A. Farr, Waseem Butt, Vijaya B. Kumar, Mark W. Franko and John E. Morley

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1113-1121;
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  Expression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene

  Mizuho Tanabe, Ichiro Ieiri, Naoki Nagata, Kazuko Inoue, Soichiro Ito, Yasunobu Kanamori, Masakuni Takahashi, Yasuo Kurata, Junzo Kigawa, Shun Higuchi, Naoki Terakawa and Kenji Otsubo

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1137-1143;
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  Effects of 5-Fluorouracil on the Drug-Metabolizing Enzymes of the Small Intestine and the Consequent Drug Interaction with Nifedipine in Rats

  Kunihiro Yoshisue, Sekio Nagayama, Takashi Shindo and Yasuro Kawaguchi

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1166-1175;
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  Pulmonary Bioactivation of 1,1-Dichloroethylene Is Associated with CYP2E1 Levels in A/J, CD-1, and C57BL/6 Mice

  Poh-Gek Forkert, Stephanie M. Boyd and Judith B. Ulreich

  Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1193-1200;