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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

June 01, 2001; Volume 297,Issue 3

2001 TORALD SOLLMANN AWARD LECTURE

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    Looking Toward the Future, Using Lessons from the Past
    Benedict R. Lucchesi
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 829-836;

PERSPECTIVES IN PHARMACOLOGY

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    Regulator of G Protein Signaling Proteins: Novel Multifunctional Drug Targets
    Huailing Zhong and Richard R. Neubig
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 837-845;
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    3,4-Methylenedioxymethamphetamine (MDMA) as a Unique Model of Serotonin Receptor Function and Serotonin-Dopamine Interactions
    Michael G. Bankson and Kathryn A. Cunningham
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 846-852;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Hepatic Uptake and Gene Expression Mechanisms following Intravenous Administration of Plasmid DNA by Conventional and Hydrodynamics-Based Procedures
    Naoki Kobayashi, Takeshi Kuramoto, Kiyoshi Yamaoka, Mitsuru Hashida and Yoshinobu Takakura
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 853-860;
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    Effect of Capillary Efflux Transport Inhibition on the Determination of Probe Recovery During in Vivo Microdialysis in the Brain
    Haiying Sun, Peter M. Bungay and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 991-1000;
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    Inhibition of Biliary Excretion of Methotrexate by Probenecid in Rats: Quantitative Prediction of Interaction from in Vitro Data
    Kaoru Ueda, Yukio Kato, Kanji Komatsu and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1036-1043;
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    Identification of the Human Cytochromes P450 Responsible for in Vitro Formation of R- and S-Norfluoxetine
    Barbara J. Ring, James A. Eckstein, Jennifer S. Gillespie, Shelly N. Binkley, Mark VandenBranden and Steven A. Wrighton
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1044-1050;
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    Improved Pharmacokinetic Properties of a Polyethylene Glycol-Modified Form of Interferon-β-1a with Preserved in Vitro Bioactivity
    R. Blake Pepinsky, Doreen J. LePage, Alan Gill, Abhijit Chakraborty, Sujata Vaidyanathan, Marie Green, Darren P. Baker, Eric Whalley, Paula S. Hochman and Pauline Martin
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1059-1066;
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    Delivery across the Blood-Brain Barrier of Antisense Directed against Amyloid β: Reversal of Learning and Memory Deficits in Mice Overexpressing Amyloid Precursor Protein
    William A. Banks, Susan A. Farr, Waseem Butt, Vijaya B. Kumar, Mark W. Franko and John E. Morley
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1113-1121;
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    Expression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene
    Mizuho Tanabe, Ichiro Ieiri, Naoki Nagata, Kazuko Inoue, Soichiro Ito, Yasunobu Kanamori, Masakuni Takahashi, Yasuo Kurata, Junzo Kigawa, Shun Higuchi, Naoki Terakawa and Kenji Otsubo
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1137-1143;
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    Effects of 5-Fluorouracil on the Drug-Metabolizing Enzymes of the Small Intestine and the Consequent Drug Interaction with Nifedipine in Rats
    Kunihiro Yoshisue, Sekio Nagayama, Takashi Shindo and Yasuro Kawaguchi
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1166-1175;
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    Pulmonary Bioactivation of 1,1-Dichloroethylene Is Associated with CYP2E1 Levels in A/J, CD-1, and C57BL/6 Mice
    Poh-Gek Forkert, Stephanie M. Boyd and Judith B. Ulreich
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1193-1200;

CARDIOVASCULAR

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    Phytoestrogens Restore Nitric Oxide-Mediated Relaxation in Isolated Pulmonary Arteries from Chronically Hypoxic Rats
    M. R. Karamsetty, J. R. Klinger and N. S. Hill
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 968-974;
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    Protective Effect of Melanocortin Peptides in Rat Myocardial Ischemia
    Carla Bazzani, Salvatore Guarini, Annibale R. Botticelli, Davide Zaffe, Aldo Tomasi, Anna Bini, Maria Michela Cainazzo, Giuseppe Ferrazza, Chiara Mioni and Alfio Bertolini
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1082-1087;
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    Acute Cardiovascular Effects of Magnesium and Their Relationship to Systemic and Myocardial Magnesium Concentrations after Short Infusion in Awake Sheep
    D. Zheng, R. N. Upton, G. L. Ludbrook and A. Martinez
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1176-1183;
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    Pharmacologic Characterization of BMS-191095, a Mitochondrial KATP Opener with No Peripheral Vasodilator or Cardiac Action Potential Shortening Activity
    Gary J. Grover, Albert J. D'Alonzo, Keith D. Garlid, Robert Bajgar, Nicholas J. Lodge, Paul G. Sleph, Raymond B. Darbenzio, Thomas A. Hess, Mark A. Smith, Petr Paucek and Karnail S. Atwal
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1184-1192;

CELLULAR AND MOLECULAR

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    Human Liver-Specific Organic Anion Transporter, LST-1, Mediates Uptake of Pravastatin by Human Hepatocytes
    Daisuke Nakai, Rie Nakagomi, Yoshitake Furuta, Taro Tokui, Takaaki Abe, Toshihiko Ikeda and Kenji Nishimura
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 861-867;
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    Involvement of Protein Kinase C-ε in Signal Transduction of Thrombopoietin in Enhancement of Interleukin-3-Dependent Proliferation of Primitive Hematopoietic Progenitors
    Noriyuki Shiroshita, Manabu Musashi, Keisuke Sakurada, Kazuhiro Kimura, Yuzo Tsuda, Shuichi Ota, Hiroshi Iwasaki, Tamotsu Miyazaki, Takashi Kato, Hiroshi Miyazaki, Akihiro Shimosaka and Masahiro Asaka
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 868-875;
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    Mechanisms of Regulation of Agonist Efficacy at the 5-HT1A Receptor by Phospholipid-Derived Signaling Components
    Kenda L. J. Evans, Jodie D. Cropper, Kelly A. Berg and William P. Clarke
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1025-1035;
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    Tumor Necrosis Factor-α Induces Cyclooxygenase-2 Expression and Prostaglandin Release in Brain Microvessel Endothelial Cells
    Karen S. Mark, William J. Trickler and Donald W. Miller
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1051-1058;
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    Heterologous Sensitization of Recombinant Adenylate Cyclases by Activation of D2 Dopamine Receptors
    Medhane G. Cumbay and Val J. Watts
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1201-1209;
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    Functional Differences between Full and Partial Agonists: Evidence for Ligand-Specific Receptor Conformations
    Roland Seifert, Katharina Wenzel-Seifert, Ulrik Gether and Brian K. Kobilka
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1218-1226;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Intracellular Localization of the Radiation Enhancer Motexafin Gadolinium Using Interferometric Fourier Fluorescence Microscopy
    Kathryn W. Woodburn
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 888-894;
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    Binding of the Aminothiol WR-1065 to Transcription Factors Influences Cellular Response to Anticancer Drugs
    Hongxie Shen, Zhijian J. Chen, Jack T. Zilfou, Elizabeth Hopper, Maureen Murphy and Kenneth D. Tew
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1067-1073;
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    Extravascular Transport of the DNA Intercalator and Topoisomerase PoisonN-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): Diffusion and Metabolism in Multicellular Layers of Tumor Cells
    Kevin O. Hicks, Frederik B. Pruijn, Bruce C. Baguley and William R. Wilson
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1088-1098;
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    Aromatase Inhibition by an 11,13-Dihydroderivative of a Sesquiterpene Lactone
    Javier G. Blanco, Roberto R. Gil, José L. Bocco, Tamara L. Meragelman, Susana Genti-Raimondi and Alfredo Flury
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1099-1105;
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    Low in Vivo Toxicity of a Novel Cisplatin-Ursodeoxycholic Derivative (Bamet-UD2) with Enhanced Cytostatic Activity versus Liver Tumors
    Maria F. Dominguez, Rocio I. R. Macias, Irantzu Izco-Basurko, Antonio de la Fuente, Maria J. Pascual, Jose M. Criado, Maria J. Monte, Javier Yajeya and Jose J. G. Marin
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1106-1112;

ENDOCRINE AND REPRODUCTIVE

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    A Novel Enhancer of Insulinotrophic Action by High Glucose (JTT-608) Stimulates Insulin Secretion from Pancreatic β-Cells via a New Cellular Mechanism
    Naoki Itabashi, Koji Okada, Shigeaki Muto, Nobuya Fujita, Takeshi Ohta, Jun-ichi Miyazaki, Yasushi Asano and Toshikazu Saito
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 953-960;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Colon Epithelial Cell Death in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis Is Associated with Increased Inducible Nitric-Oxide Synthase Expression and Peroxynitrite Production
    Gang Yue, Pi-Shiang Lai, Kingsley Yin, Frank F. Sun, Robert G. Nagele, Xiao Liu, Kersti K. Linask, Congli Wang, King-Teh Lin and Patrick Y-K. Wong
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 915-925;
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    Central Muscarinic Mechanisms Regulating Voiding in Rats
    Yoshiyuki Ishiura, Mitsuharu Yoshiyama, Osamu Yokoyama, Mikio Namiki and William C. de Groat
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 933-939;
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    Cholera Toxin Induces Prostaglandin Synthesis via Post-Transcriptional Activation of Cyclooxygenase-2 in the Rat Jejunum
    Eckhard Beubler, Rufina Schuligoi, Ashok K. Chopra, Deborah A. Ribardo and Bernhard A. Peskar
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 940-945;
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    Effects of Carbocysteine on Antigen-Induced Increases in Cough Sensitivity and Bronchial Responsiveness in Guinea Pigs
    Nobuyuki Katayama, Masaki Fujimura, Akihito Ueda, Toshiyuki Kita, Miki Abo, Hideki Tachibana, Shigeharu Myou and Kazuyoshi Kurashima
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 975-980;
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    Supraspinal δ- and μ-Opioid Receptors Mediate Gastric Mucosal Protection in the Rat
    K. Gyires and A. Z. Rónai
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1010-1015;
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    Characterization and Autoradiographic Localization of Neurotensin Binding Sites in Human Sigmoid Colon
    Yael Azriel and Elizabeth Burcher
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1074-1081;
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    A High-Capacity Quantitative Mouse Model of Drug-Mediated Immunosuppression Based on Rejection of an Allogeneic Subcutaneous Tumor
    Denise Hammond-McKibben, Philip Lake, Jin Zhang, Nicole Tart-Risher, Ronald Hugo and Marla Weetall
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1144-1151;
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    Acetylcholine-Induced Desensitization of the Contractile Response to Histamine in Guinea Pig Ileum Is Prevented by Either Pertussis Toxin Treatment or by Selective Inactivation of Muscarinic M3Receptors
    Darakhshanda Shehnaz, Khurram Z. Ansari and Frederick J. Ehlert
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1152-1159;
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    Adaptive Gastric Cytoprotection Is Mediated by Prostaglandin EP1 Receptors: A Study Using Rats and Knockout Mice
    Koji Takeuchi, Hideo Araki, Masakazu Umeda, Yusaku Komoike and Keizo Suzuki
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1160-1165;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Amelioration of Immune-Mediated Experimental Colitis: Tolerance Induction in the Presence of Preexisting Immunity and Surrogate Antigen Bystander Effect
    Israel Gotsman, Amir Shlomai, Ruslana Alper, Elazar Rabbani, Dean Engelhardt and Yaron Ilan
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 926-932;
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    An Oral Drug Delivery System Targeting Immune-Regulating Cells Ameliorates Mucosal Injury in Trinitrobenzene Sulfonic Acid-Induced Colitis
    Hiroshi Nakase, Kazuichi Okazaki, Yasuhiko Tabata, Suguru Uose, Masaya Ohana, Kazushige Uchida, Toshiki Nishi, Andra's Debreceni, Toshiyuki Itoh, Chiharu Kawanami, Masao Iwano, Yoshito Ikada and Tsutomu Chiba
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1122-1128;
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    In Vivo Delivery of Antisense Oligonucleotides in pH-Sensitive Liposomes Inhibits Lipopolysaccharide-Induced Production of Tumor Necrosis Factor-α in Rats
    Biddanda C. Ponnappa, Indranil Dey, Guang-chou Tu, Feng Zhou, Maria Aini, Qing-na Cao and Yedy Israel
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1129-1136;

NEUROPHARMACOLOGY

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    Antiparkinsonian Agent Piribedil Displays Antagonist Properties at Native, Rat, and Cloned, Human α2 -Adrenoceptors: Cellular and Functional Characterization
    Mark J. Millan, Didier Cussac, Graeme Milligan, Craig Carr, Valérie Audinot, Alain Gobert, Franćoise Lejeune, Jean-Michel Rivet, Mauricette Brocco, Delphine Duqueyroix, Jean-Paul Nicolas, Jean A. Boutin and Adrian Newman-Tancredi
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 876-887;
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    Structural Modifications to anN-Methyl-d-aspartate Receptor Antagonist Result in Large Differences in Trapping Block
    G. A. R. Mealing, T. H. Lanthorn, D. L. Small, R. J. Murray, K. C. Mattes, T. M. Comas and P. Morley
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 906-914;
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    Pharmacological Enhancement of Synaptic Efficacy, Spatial Learning, and Memory through Carbonic Anhydrase Activation in Rats
    Miao-Kun Sun and Daniel L. Alkon
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 961-967;
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    Differential Sensitivity of Expressed L-Type Calcium Channels and Muscarinic M1 Receptors to Volatile Anesthetics inXenopus Oocytes
    Ganesan L. Kamatchi, Marcel E. Durieux and Carl Lynch
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 981-990;
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    Effects of Fluvoxamine on Ethanol-Reinforced Behavior in the Rat
    R. J. Lamb and T. U. C. Järbe
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1001-1009;
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    Protein Kinase C and Intracellular Calcium Are Required for Amphetamine-Mediated Dopamine Release via the Norepinephrine Transporter in Undifferentiated PC12 Cells
    Lana Kantor, G. H. Keikilani Hewlett, Yang Hae Park, Sarah M. Richardson-Burns, Mathew J. Mellon and Margaret E. Gnegy
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1016-1024;
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    Propentofylline, a Glial Modulating Agent, Exhibits Antiallodynic Properties in a Rat Model of Neuropathic Pain
    S. M. Sweitzer, P. Schubert and J. A. DeLeo
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1210-1217;

TOXICOLOGY

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    Unique Gene Expression Patterns in Liver and Kidney Associated with Exposure to Chemical Toxicants
    Matthew J. Bartosiewicz, David Jenkins, Sharron Penn, Jennifer Emery and Alan Buckpitt
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 895-905;
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    Protective Effect of Polyethylene Glycol against Prolonged Cold Ischemia and Reperfusion Injury: Study in the Isolated Perfused Rat Kidney
    Thierry Hauet, Denis Mothes, Jean-Michel Goujon, Michel Carretier and Michel Eugene
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 946-952;

Erratum

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    Correction to “Molecular targets for antiviral agents”
    Journal of Pharmacology and Experimental Therapeutics June 2001, 297 (3) 1227;
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Journal of Pharmacology and Experimental Therapeutics: 297 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 297, Issue 3
1 Jun 2001
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  • 2001 TORALD SOLLMANN AWARD LECTURE
  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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