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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2001; Volume 297,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Transgenic Studies of Pain and Analgesia: Mutation or Background Genotype?
    William R. Lariviere, Elissa J. Chesler and Jeffrey S. Mogil
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 467-473;
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    Critical Role for Nitric Oxide Signaling in Cardiac and Neuronal Ischemic Preconditioning and Tolerance
    Krishnadas Nandagopal, Ted M. Dawson and Valina L. Dawson
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 474-478;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Contribution of P-glycoprotein to the Enhancing Effects of Dimethyl-β-cyclodextrin on Oral Bioavailability of Tacrolimus
    Hidetoshi Arima, Kiyokazu Yunomae, Fumitoshi Hirayama and Kaneto Uekama
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 547-555;
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    Pharmacokinetics of Cocaine in Maternal and Fetal Rhesus Monkeys at Mid-Gestation
    Ming Zhou, Zan-Min Song and Michael S. Lidow
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 556-562;
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    Pharmacokinetics of Celecoxib after Oral Administration in Dogs and Humans: Effect of Food and Site of Absorption
    Susan K. Paulson, Margaret B. Vaughn, Susan M. Jessen, Yvette Lawal, Christopher J. Gresk, Bo Yan, Timothy J. Maziasz, Chyung S. Cook and Aziz Karim
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 638-645;
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    Structure-Hepatic Disposition Relationships for Cationic Drugs in Isolated Perfused Rat Livers: Transmembrane Exchange and Cytoplasmic Binding Process
    Daniel Y. Hung, Ping Chang, Michael Weiss and Michael S. Roberts
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 780-789;

CARDIOVASCULAR

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    Cytochrome P450 Metabolites of Arachidonic Acid but Not Cyclooxygenase-2 Metabolites Contribute to the Pulmonary Vascular Hyporeactivity in Rats with Acute Pseudomonas Pneumonia
    Asma Yaghi, Christopher D. Webb, Jeremy A. Scott, Sanjay Mehta, John R. Bend and David G. McCormack
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 479-488;
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    Occupancy of the Internal and External Pools of Glycoprotein IIb/IIIa following Abciximab Bolus and Infusion
    Martin J. Quinn, Ross T. Murphy, Michelle Dooley, J. Brendan Foley and Desmond J. Fitzgerald
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 496-500;
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    Effect of LY287045, a Thrombin/Trypsin Inhibitor, on Thrombin and Trypsin-Induced Aortic Contraction and Relaxation
    Anindya Bhattacharya, Gerald F. Smith and Marlene L. Cohen
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 573-581;
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    RXP 407, a Selective Inhibitor of the N-Domain of Angiotensin I-Converting Enzyme, Blocks in Vivo the Degradation of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro with No Effect on Angiotensin I Hydrolysis
    Christophe Junot, Marie-Francoise Gonzales, Eric Ezan, Joel Cotton, Gilles Vazeux, Annie Michaud, Michel Azizi, Stamatia Vassiliou, Athanasios Yiotakis, Pierre Corvol and Vincent Dive
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 606-611;
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    Blockade of Delta Opioid Receptors in the Ventrolateral Periaqueductal Gray Region Inhibits the Fall in Arterial Pressure Evoked by Hemorrhage
    Sinan Cavun, Garth E. Resch, Adam D. Evec, Michelle M. Rapacon-Baker and William R. Millington
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 612-619;
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    Regional Vascular Selectivity of Angiotensin II
    Edwin K. Jackson and William A. Herzer
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 736-745;
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    High-Affinity Blockade of Human Ether-A-Go-Go-Related Gene Human Cardiac Potassium Channels by the Novel Antiarrhythmic Drug BRL-32872
    Dierk Thomas, Gunnar Wendt-Nordahl, Katja Röckl, Eckhard Ficker, Arthur M. Brown and Johann Kiehn
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 753-761;
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    Cyclosporine and FK506 Differentially Regulate the Sarcolemmal Na+-K+ Pump
    Mahidi Mardini, Anastasia S. Mihailidou, Angela Wong and Helge H. Rasmussen
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 804-810;
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    Effects of Cannabinoids on Sympathetic and Parasympathetic Neuroeffector Transmission in the Rabbit Heart
    Bela Szabo, Ulrich Nordheim and Nathalie Niederhoffer
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 819-826;

CELLULAR AND MOLECULAR

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    Semicarbazide-Sensitive Amine Oxidase Substrates Stimulate Glucose Transport and Inhibit Lipolysis in Human Adipocytes
    Nathalie Morin, Jose-Miguel Lizcano, Emi Fontana, Luc Marti, Fatima Smih, Philippe Rouet, Danielle Prévot, Antonio Zorzano, Mercedes Unzeta and Christian Carpéné
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 563-572;
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    Up-Regulation of Cell Surface Sodium Channels by Cyclosporin A, FK506, and Rapamycin in Adrenal Chromaffin Cells
    Seiji Shiraishi, Toshihiko Yanagita, Hideyuki Kobayashi, Yasuhito Uezono, Hiroki Yokoo, Shin-Ichi Minami, Mayumi Takasaki and Akihiko Wada
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 657-665;
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    Inositol 1,4,5-Triphosphate Receptor-Sensitive Ca2+Release, Store-Operated Ca2+ Entry, and cAMP Responsive Element Binding Protein Phosphorylation in Developing Cortical Cells following Exposure to Polychlorinated Biphenyls
    Jon R. Inglefield, William R. Mundy and Timothy J. Shafer
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 762-773;
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    Force Spectroscopy between Acetylcholine and Single Acetylcholinesterase Molecules and the Effects of Inhibitors and Reactivators Studied by Atomic Force Microscopy
    Zhang Yingge, Bai Chunli, Wang Chen and Zhao Delu
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 798-803;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Effect of Stavudine on Mitochondrial Genome and Fatty Acid Oxidation in Lean and Obese Mice
    Isabelle Gaou, Miriam Malliti, Marie-Christine Guimont, Philippe Lettéron, Christine Demeilliers, Gilles Peytavin, Claude Degott, Dominique Pessayre and Bernard Fromenty
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 516-523;
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    Comparison of Single- Versus Double-Bolus Treatments of O 6-Benzylguanine for Depletion ofO 6-Methylguanine DNA Methyltransferase (MGMT) Activity in Vivo: Development of a Novel Fluorometric Oligonucleotide Assay for Measurement of Mgmt Activity
    Emiko L. Kreklau, Naili Liu, Zhaohua Li, Kenneth Cornetta and Leonard C. Erickson
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 524-530;
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    Selective Interactions of the Human Immunodeficiency Virus-Inactivating Protein Cyanovirin-N with High-Mannose Oligosaccharides on gp120 and Other Glycoproteins
    Shilpa R. Shenoy, Barry R. O'Keefe, Anders J. Bolmstedt, Laura K. Cartner and Michael R. Boyd
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 704-710;

ENDOCRINE AND REPRODUCTIVE

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    Pharmacological Characterization of KUR-1246, a Selective Uterine Relaxant
    Mamoru Kobayashi, Keiko Takeda, Satoshi Murata, Masami Kojima, Masuo Akahane, Yoshihito Inoue, Kenji Kitamura and Tatsuhiko Kawarabayashi
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 666-671;
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    Prevention of Fetal Demise and Growth Restriction in a Mouse Model of Fetal Alcohol Syndrome
    Catherine Y. Spong, Daniel T. Abebe, Illana Gozes, Douglas E. Brenneman and Joanna M. Hill
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 774-779;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Pharmacological Evidence for a 7-Benzylidenenaltrexone-Preferring Opioid Receptor Mediating the Inhibitory Actions of Peptidic δ- and μ-Opioid Agonists on Neurogenic Ion Transport in Porcine Ileal Mucosa
    Sutthasinee Poonyachoti, Philip S. Portoghese and David R. Brown
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 672-679;

NEUROPHARMACOLOGY

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    Characterization of Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone
    S. R. Engel, R. H. Purdy and K. A. Grant
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 489-495;
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    Dopamine D1 Receptor Activation in the Medial Prefrontal Cortex Prevents the Expression of Cocaine Sensitization
    Barbara A. Sorg, Na Li and Wei-Ran Wu
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 501-508;
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    In Vivo Neurobiological Effects of Ibogaine and Its O-Desmethyl Metabolite, 12-Hydroxyibogamine (Noribogaine), in Rats
    Michael H. Baumann, Richard B. Rothman, John P. Pablo and Deborah C. Mash
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 531-539;
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    Reboxetine Modulates the Firing Pattern of Dopamine Cells in the Ventral Tegmental Area and Selectively Increases Dopamine Availability in the Prefrontal Cortex
    Love Linnér, Hanna Endersz, Daniel Öhman, Finn Bengtsson, Martin Schalling and Torgny H. Svensson
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 540-546;
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    Inverse Agonist Action of Leu-Enkephalin at δ2-Opioid Receptors Mediates Spinal Antianalgesia
    Jodie J. Rady, Blythe B. Holmes, Leon F. Tseng and James M. Fujimoto
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 582-589;
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    β-Endorphin-Induced Feeding: Pharmacological Characterization Using Selective Opioid Antagonists and Antisense Probes in Rats
    Robert M. Silva, Maria M. Hadjimarkou, Grace C. Rossi, Gavril W. Pasternak and Richard J. Bodnar
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 590-596;
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    In Vivo Pharmacological Characterization of SoRI 9409, a Nonpeptidic Opioid μ-Agonist/δ-Antagonist That Produces Limited Antinociceptive Tolerance and Attenuates Morphine Physical Dependence
    Jennifer L. Wells, Jeffrey L. Bartlett, Subramaniam Ananthan and Edward J. Bilsky
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 597-605;
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    Effect of FK960, a Putative Cognitive Enhancer, on Synaptic Transmission in CA1 Neurons of Rat Hippocampus
    Joseph P. Hodgkiss and John S. Kelly
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 620-628;
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    Cannabinoid CB1 Receptor Agonists Produce Cerebellar Dysfunction in Mice
    Sachin Patel and Cecilia J. Hillard
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 629-637;
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    Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes
    Roger L. Papke, Paul R. Sanberg and R. Douglas Shytle
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 646-656;
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    Antidepressant Drug-Induced Alterations in Neuron-Localized Tumor Necrosis Factor-α mRNA and α2-Adrenergic Receptor Sensitivity
    Tracey J. Nickola, Tracey A. Ignatowski, Jessica L. Reynolds and Robert N. Spengler
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 680-687;
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    Comparison of Pharmacological Activities of Buprenorphine and Norbuprenorphine: Norbuprenorphine Is a Potent Opioid Agonist
    Peng Huang, George B. Kehner, Alan Cowan and Lee-Yuan Liu-Chen
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 688-695;
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    Electrophysiological Effects of Cocaethylene, Cocaine, and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area
    E. Bradshaw Bunney, Sarah B. Appel and Mark S. Brodie
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 696-703;
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    Long-Term Effects of Olanzapine, Risperidone, and Quetiapine on Dopamine Receptor Types in Regions of Rat Brain: Implications for Antipsychotic Drug Treatment
    Frank I. Tarazi, Kehong Zhang and Ross J. Baldessarini
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 711-717;
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    Molecular and Pharmacological Characterization of Muscarinic Receptor Subtypes in a Rat Parotid Gland Cell Line: Comparison with Native Parotid Gland
    Charles S. Bockman, Michael E. Bradley, Herbert K. Dang, Wanyun Zeng, Margaret A. Scofield and Frank J. Dowd
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 718-726;
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    Differential Effect of Gabapentin on Neuronal and Muscle Calcium Currents
    Kris J. Alden and Jesús Garcı́a
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 727-735;
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    Amphetamine Normalizes the Electrical Activity of Dopamine Neurons in the Ventral Tegmental Area following Prenatal Ethanol Exposure
    Changqing Xu and Roh-Yu Shen
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 746-752;
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    Pharmacological Properties of (2R)-N-[1-(6-Aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2- hydroxy-2-phenylacetamide: A Novel Muscarinic Antagonist with M2-Sparing Antagonistic Activity
    Hiroyasu Hirose, Ikuo Aoki, Toshifumi Kimura, Toru Fujikawa, Tomoshige Numazawa, Kaori Sasaki, Akio Sato, Takuro Hasegawa, Masaru Nishikibe, Morihiro Mitsuya, Norikazu Ohtake, Toshiaki Mase and Kazuhito Noguchi
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 790-797;

TOXICOLOGY

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    Primaquine-Induced Hemolytic Anemia: Formation and Hemotoxicity of the Arylhydroxylamine Metabolite 6-Methoxy-8-hydroxylaminoquinoline
    Laura J. C. Bolchoz, Robert A. Budinsky, David C. McMillan and David J. Jollow
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 509-515;
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    Characterization of the Caspase Inhibitor IDN-1965 in a Model of Apoptosis-Associated Liver Injury
    Niel C. Hoglen, Brad P. Hirakawa, Craig D. Fisher, Suzanne Weeks, Anu Srinivasan, Angela M. Wong, Karen L. Valentino, Kevin J. Tomaselli, Xu Bai, Don S. Karanewsky and Patricia C. Contreras
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 811-818;

Errata

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    Correction to “Lalsoacidipine modulates the secretion of matrix metalloproteinase-9 by human macrophages”
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 827;
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    Correction to “Pharmacokinetics and immunological effects of exogenously administered recombinant human B lymphocyte stimulator (BLyS) in mice”
    Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 827;
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Journal of Pharmacology and Experimental Therapeutics: 297 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 297, Issue 2
1 May 2001
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Errata
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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