Journal of Pharmacology and Experimental Therapeutics: 297 (2)

May 01, 2001; Volume 297,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Transgenic Studies of Pain and Analgesia: Mutation or Background Genotype?
William R. Lariviere, Elissa J. Chesler and Jeffrey S. Mogil

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 467-473;
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Critical Role for Nitric Oxide Signaling in Cardiac and Neuronal Ischemic Preconditioning and Tolerance
Krishnadas Nandagopal, Ted M. Dawson and Valina L. Dawson

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 474-478;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Contribution of P-glycoprotein to the Enhancing Effects of Dimethyl-β-cyclodextrin on Oral Bioavailability of Tacrolimus
Hidetoshi Arima, Kiyokazu Yunomae, Fumitoshi Hirayama and Kaneto Uekama

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 547-555;
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Pharmacokinetics of Cocaine in Maternal and Fetal Rhesus Monkeys at Mid-Gestation
Ming Zhou, Zan-Min Song and Michael S. Lidow

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 556-562;
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Pharmacokinetics of Celecoxib after Oral Administration in Dogs and Humans: Effect of Food and Site of Absorption
Susan K. Paulson, Margaret B. Vaughn, Susan M. Jessen, Yvette Lawal, Christopher J. Gresk, Bo Yan, Timothy J. Maziasz, Chyung S. Cook and Aziz Karim

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 638-645;
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Structure-Hepatic Disposition Relationships for Cationic Drugs in Isolated Perfused Rat Livers: Transmembrane Exchange and Cytoplasmic Binding Process
Daniel Y. Hung, Ping Chang, Michael Weiss and Michael S. Roberts

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 780-789;

CARDIOVASCULAR

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Cytochrome P450 Metabolites of Arachidonic Acid but Not Cyclooxygenase-2 Metabolites Contribute to the Pulmonary Vascular Hyporeactivity in Rats with Acute Pseudomonas Pneumonia
Asma Yaghi, Christopher D. Webb, Jeremy A. Scott, Sanjay Mehta, John R. Bend and David G. McCormack

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 479-488;
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Occupancy of the Internal and External Pools of Glycoprotein IIb/IIIa following Abciximab Bolus and Infusion
Martin J. Quinn, Ross T. Murphy, Michelle Dooley, J. Brendan Foley and Desmond J. Fitzgerald

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 496-500;
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Effect of LY287045, a Thrombin/Trypsin Inhibitor, on Thrombin and Trypsin-Induced Aortic Contraction and Relaxation
Anindya Bhattacharya, Gerald F. Smith and Marlene L. Cohen

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 573-581;
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RXP 407, a Selective Inhibitor of the N-Domain of Angiotensin I-Converting Enzyme, Blocks in Vivo the Degradation of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro with No Effect on Angiotensin I Hydrolysis
Christophe Junot, Marie-Francoise Gonzales, Eric Ezan, Joel Cotton, Gilles Vazeux, Annie Michaud, Michel Azizi, Stamatia Vassiliou, Athanasios Yiotakis, Pierre Corvol and Vincent Dive

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 606-611;
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Blockade of Delta Opioid Receptors in the Ventrolateral Periaqueductal Gray Region Inhibits the Fall in Arterial Pressure Evoked by Hemorrhage
Sinan Cavun, Garth E. Resch, Adam D. Evec, Michelle M. Rapacon-Baker and William R. Millington

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 612-619;
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Regional Vascular Selectivity of Angiotensin II
Edwin K. Jackson and William A. Herzer

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 736-745;
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High-Affinity Blockade of Human Ether-A-Go-Go-Related Gene Human Cardiac Potassium Channels by the Novel Antiarrhythmic Drug BRL-32872
Dierk Thomas, Gunnar Wendt-Nordahl, Katja Röckl, Eckhard Ficker, Arthur M. Brown and Johann Kiehn

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 753-761;
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Cyclosporine and FK506 Differentially Regulate the Sarcolemmal Na⁺-K⁺ Pump
Mahidi Mardini, Anastasia S. Mihailidou, Angela Wong and Helge H. Rasmussen

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 804-810;
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Effects of Cannabinoids on Sympathetic and Parasympathetic Neuroeffector Transmission in the Rabbit Heart
Bela Szabo, Ulrich Nordheim and Nathalie Niederhoffer

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 819-826;

CELLULAR AND MOLECULAR

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Semicarbazide-Sensitive Amine Oxidase Substrates Stimulate Glucose Transport and Inhibit Lipolysis in Human Adipocytes
Nathalie Morin, Jose-Miguel Lizcano, Emi Fontana, Luc Marti, Fatima Smih, Philippe Rouet, Danielle Prévot, Antonio Zorzano, Mercedes Unzeta and Christian Carpéné

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 563-572;
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Up-Regulation of Cell Surface Sodium Channels by Cyclosporin A, FK506, and Rapamycin in Adrenal Chromaffin Cells
Seiji Shiraishi, Toshihiko Yanagita, Hideyuki Kobayashi, Yasuhito Uezono, Hiroki Yokoo, Shin-Ichi Minami, Mayumi Takasaki and Akihiko Wada

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 657-665;
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Inositol 1,4,5-Triphosphate Receptor-Sensitive Ca²⁺Release, Store-Operated Ca²⁺ Entry, and cAMP Responsive Element Binding Protein Phosphorylation in Developing Cortical Cells following Exposure to Polychlorinated Biphenyls
Jon R. Inglefield, William R. Mundy and Timothy J. Shafer

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 762-773;
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Force Spectroscopy between Acetylcholine and Single Acetylcholinesterase Molecules and the Effects of Inhibitors and Reactivators Studied by Atomic Force Microscopy
Zhang Yingge, Bai Chunli, Wang Chen and Zhao Delu

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 798-803;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Effect of Stavudine on Mitochondrial Genome and Fatty Acid Oxidation in Lean and Obese Mice
Isabelle Gaou, Miriam Malliti, Marie-Christine Guimont, Philippe Lettéron, Christine Demeilliers, Gilles Peytavin, Claude Degott, Dominique Pessayre and Bernard Fromenty

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 516-523;
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Comparison of Single- Versus Double-Bolus Treatments of O ⁶-Benzylguanine for Depletion ofO ⁶-Methylguanine DNA Methyltransferase (MGMT) Activity in Vivo: Development of a Novel Fluorometric Oligonucleotide Assay for Measurement of Mgmt Activity
Emiko L. Kreklau, Naili Liu, Zhaohua Li, Kenneth Cornetta and Leonard C. Erickson

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 524-530;
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Selective Interactions of the Human Immunodeficiency Virus-Inactivating Protein Cyanovirin-N with High-Mannose Oligosaccharides on gp120 and Other Glycoproteins
Shilpa R. Shenoy, Barry R. O'Keefe, Anders J. Bolmstedt, Laura K. Cartner and Michael R. Boyd

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 704-710;

ENDOCRINE AND REPRODUCTIVE

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Pharmacological Characterization of KUR-1246, a Selective Uterine Relaxant
Mamoru Kobayashi, Keiko Takeda, Satoshi Murata, Masami Kojima, Masuo Akahane, Yoshihito Inoue, Kenji Kitamura and Tatsuhiko Kawarabayashi

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 666-671;
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Prevention of Fetal Demise and Growth Restriction in a Mouse Model of Fetal Alcohol Syndrome
Catherine Y. Spong, Daniel T. Abebe, Illana Gozes, Douglas E. Brenneman and Joanna M. Hill

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 774-779;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Pharmacological Evidence for a 7-Benzylidenenaltrexone-Preferring Opioid Receptor Mediating the Inhibitory Actions of Peptidic δ- and μ-Opioid Agonists on Neurogenic Ion Transport in Porcine Ileal Mucosa
Sutthasinee Poonyachoti, Philip S. Portoghese and David R. Brown

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 672-679;

NEUROPHARMACOLOGY

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Characterization of Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone
S. R. Engel, R. H. Purdy and K. A. Grant

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 489-495;
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Dopamine D1 Receptor Activation in the Medial Prefrontal Cortex Prevents the Expression of Cocaine Sensitization
Barbara A. Sorg, Na Li and Wei-Ran Wu

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 501-508;
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In Vivo Neurobiological Effects of Ibogaine and Its O-Desmethyl Metabolite, 12-Hydroxyibogamine (Noribogaine), in Rats
Michael H. Baumann, Richard B. Rothman, John P. Pablo and Deborah C. Mash

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 531-539;
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Reboxetine Modulates the Firing Pattern of Dopamine Cells in the Ventral Tegmental Area and Selectively Increases Dopamine Availability in the Prefrontal Cortex
Love Linnér, Hanna Endersz, Daniel Öhman, Finn Bengtsson, Martin Schalling and Torgny H. Svensson

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 540-546;
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Inverse Agonist Action of Leu-Enkephalin at δ₂-Opioid Receptors Mediates Spinal Antianalgesia
Jodie J. Rady, Blythe B. Holmes, Leon F. Tseng and James M. Fujimoto

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 582-589;
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β-Endorphin-Induced Feeding: Pharmacological Characterization Using Selective Opioid Antagonists and Antisense Probes in Rats
Robert M. Silva, Maria M. Hadjimarkou, Grace C. Rossi, Gavril W. Pasternak and Richard J. Bodnar

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 590-596;
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In Vivo Pharmacological Characterization of SoRI 9409, a Nonpeptidic Opioid μ-Agonist/δ-Antagonist That Produces Limited Antinociceptive Tolerance and Attenuates Morphine Physical Dependence
Jennifer L. Wells, Jeffrey L. Bartlett, Subramaniam Ananthan and Edward J. Bilsky

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 597-605;
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Effect of FK960, a Putative Cognitive Enhancer, on Synaptic Transmission in CA1 Neurons of Rat Hippocampus
Joseph P. Hodgkiss and John S. Kelly

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 620-628;
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Cannabinoid CB₁ Receptor Agonists Produce Cerebellar Dysfunction in Mice
Sachin Patel and Cecilia J. Hillard

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 629-637;
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Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes
Roger L. Papke, Paul R. Sanberg and R. Douglas Shytle

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 646-656;
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Antidepressant Drug-Induced Alterations in Neuron-Localized Tumor Necrosis Factor-α mRNA and α₂-Adrenergic Receptor Sensitivity
Tracey J. Nickola, Tracey A. Ignatowski, Jessica L. Reynolds and Robert N. Spengler

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 680-687;
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Comparison of Pharmacological Activities of Buprenorphine and Norbuprenorphine: Norbuprenorphine Is a Potent Opioid Agonist
Peng Huang, George B. Kehner, Alan Cowan and Lee-Yuan Liu-Chen

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 688-695;
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Electrophysiological Effects of Cocaethylene, Cocaine, and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area
E. Bradshaw Bunney, Sarah B. Appel and Mark S. Brodie

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 696-703;
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Long-Term Effects of Olanzapine, Risperidone, and Quetiapine on Dopamine Receptor Types in Regions of Rat Brain: Implications for Antipsychotic Drug Treatment
Frank I. Tarazi, Kehong Zhang and Ross J. Baldessarini

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 711-717;
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Molecular and Pharmacological Characterization of Muscarinic Receptor Subtypes in a Rat Parotid Gland Cell Line: Comparison with Native Parotid Gland
Charles S. Bockman, Michael E. Bradley, Herbert K. Dang, Wanyun Zeng, Margaret A. Scofield and Frank J. Dowd

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 718-726;
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Differential Effect of Gabapentin on Neuronal and Muscle Calcium Currents
Kris J. Alden and Jesús Garcı́a

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 727-735;
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Amphetamine Normalizes the Electrical Activity of Dopamine Neurons in the Ventral Tegmental Area following Prenatal Ethanol Exposure
Changqing Xu and Roh-Yu Shen

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 746-752;
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Pharmacological Properties of (2R)-N-[1-(6-Aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2- hydroxy-2-phenylacetamide: A Novel Muscarinic Antagonist with M₂-Sparing Antagonistic Activity
Hiroyasu Hirose, Ikuo Aoki, Toshifumi Kimura, Toru Fujikawa, Tomoshige Numazawa, Kaori Sasaki, Akio Sato, Takuro Hasegawa, Masaru Nishikibe, Morihiro Mitsuya, Norikazu Ohtake, Toshiaki Mase and Kazuhito Noguchi

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 790-797;

TOXICOLOGY

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Primaquine-Induced Hemolytic Anemia: Formation and Hemotoxicity of the Arylhydroxylamine Metabolite 6-Methoxy-8-hydroxylaminoquinoline
Laura J. C. Bolchoz, Robert A. Budinsky, David C. McMillan and David J. Jollow

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 509-515;
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Characterization of the Caspase Inhibitor IDN-1965 in a Model of Apoptosis-Associated Liver Injury
Niel C. Hoglen, Brad P. Hirakawa, Craig D. Fisher, Suzanne Weeks, Anu Srinivasan, Angela M. Wong, Karen L. Valentino, Kevin J. Tomaselli, Xu Bai, Don S. Karanewsky and Patricia C. Contreras

Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 811-818;

Errata

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Correction to “Lalsoacidipine modulates the secretion of matrix metalloproteinase-9 by human macrophages”
Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 827;
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Correction to “Pharmacokinetics and immunological effects of exogenously administered recombinant human B lymphocyte stimulator (BLyS) in mice”
Journal of Pharmacology and Experimental Therapeutics May 2001, 297 (2) 827;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

NEUROPHARMACOLOGY

TOXICOLOGY

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