In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor

	Abstract	Full	Pdf
Mar 2001	89	29	118
Apr 2001	22	71	78
May 2001	16	68	57
Jun 2001	11	58	62
Jul 2001	5	39	39
Aug 2001	12	68	69
Sep 2001	7	58	63
Oct 2001	4	65	36
Nov 2001	5	57	52
Dec 2001	5	29	42
Jan 2002	4	31	36
Feb 2002	5	52	39
Mar 2002	6	39	54
Apr 2002	3	46	72
May 2002	24	59	71
Jun 2002	1	42	62
Jul 2002	6	42	55
Aug 2002	1	44	49
Sep 2002	3	46	60
Oct 2002	1	58	68
Nov 2002	2	56	77
Dec 2002	6	61	60
Jan 2003	5	49	56
Feb 2003	0	38	51
Mar 2003	2	36	56
Apr 2003	5	64	72
May 2003	0	49	53
Jun 2003	1	47	62
Jul 2003	23	73	56
Aug 2003	33	66	57
Sep 2003	29	79	46
Oct 2003	26	98	98
Nov 2003	30	70	55
Dec 2003	27	76	60
Jan 2004	39	100	80
Feb 2004	39	94	55
Mar 2004	48	133	79
Apr 2004	37	124	57
May 2004	52	137	50
Jun 2004	34	131	97
Jul 2004	29	116	81
Aug 2004	27	101	76
Sep 2004	36	123	83
Oct 2004	25	135	70
Nov 2004	16	148	94
Dec 2004	22	148	74
Jan 2005	50	169	45
Feb 2005	23	126	73
Mar 2005	21	99	54
Apr 2005	6	53	38
May 2005	26	85	67
Jun 2005	31	72	31
Jul 2005	26	66	49
Aug 2005	32	78	65
Sep 2005	36	83	50
Oct 2005	27	101	41
Nov 2005	23	78	66
Dec 2005	13	45	21
Jan 2006	14	71	24
Feb 2006	16	64	29
Mar 2006	7	57	29
Apr 2006	9	61	23
May 2006	9	64	53
Jun 2006	9	54	33
Jul 2006	9	42	26
Aug 2006	11	50	45
Sep 2006	11	34	33
Oct 2006	7	40	37
Nov 2006	17	49	40
Dec 2006	11	39	32
Jan 2007	12	22	23
Feb 2007	15	27	27
Mar 2007	10	32	34
Apr 2007	17	43	49
May 2007	14	29	22
Jun 2007	7	33	27
Jul 2007	10	36	29
Aug 2007	17	46	32
Sep 2007	18	32	27
Oct 2007	19	63	39
Nov 2007	10	38	19
Dec 2007	5	32	20
Jan 2008	11	46	48
Feb 2008	10	26	20
Mar 2008	12	38	27
Apr 2008	14	22	17
May 2008	14	15	10
Jun 2008	12	23	19
Jul 2008	12	14	19
Aug 2008	26	35	25
Sep 2008	49	38	21
Oct 2008	43	28	25
Nov 2008	24	24	19
Dec 2008	22	24	4
Jan 2009	21	29	25
Feb 2009	17	12	18
Mar 2009	25	28	35
Apr 2009	19	31	25
May 2009	20	29	26
Jun 2009	18	22	24
Jul 2009	9	24	18
Aug 2009	13	20	19
Sep 2009	32	25	21
Oct 2009	20	24	23
Nov 2009	17	34	25
Dec 2009	30	23	30
Jan 2010	23	24	20
Feb 2010	28	35	35
Mar 2010	39	65	46
Apr 2010	24	58	35
May 2010	10	25	17
Jun 2010	13	50	38
Jul 2010	13	54	45
Aug 2010	21	30	19
Sep 2010	13	34	32
Oct 2010	18	35	29
Nov 2010	17	32	26
Dec 2010	9	28	18
Jan 2011	16	24	20
Feb 2011	6	33	21
Mar 2011	30	56	36
Apr 2011	14	39	36
May 2011	18	29	33
Jun 2011	35	23	36
Jul 2011	42	35	47
Aug 2011	55	22	38
Sep 2011	61	41	58
Oct 2011	45	25	28
Nov 2011	46	28	59
Dec 2011	35	19	26
Jan 2012	31	30	34
Feb 2012	36	31	28
Mar 2012	60	36	45
Apr 2012	61	37	55
May 2012	46	24	47
Jun 2012	43	25	53
Jul 2012	28	28	41
Aug 2012	39	19	37
Sep 2012	35	21	51
Oct 2012	40	31	49
Nov 2012	37	18	51
Dec 2012	26	19	23
Jan 2013	42	17	40
Feb 2013	31	17	24
Mar 2013	20	15	28
Apr 2013	29	28	31
May 2013	27	26	32
Jun 2013	23	18	14
Jul 2013	33	13	24
Aug 2013	37	20	32
Sep 2013	11	11	20
Oct 2013	43	25	22
Nov 2013	33	15	13
Dec 2013	26	15	26
Jan 2014	38	21	23
Feb 2014	42	19	19
Mar 2014	22	17	25
Apr 2014	26	21	27
May 2014	18	14	22
Jun 2014	44	19	28
Jul 2014	37	19	17
Aug 2014	17	30	10
Sep 2014	28	15	22
Oct 2014	20	16	18
Nov 2014	14	17	18
Dec 2014	42	10	5
Jan 2015	27	26	19
Feb 2015	28	14	18
Mar 2015	62	19	13
Apr 2015	32	24	19
May 2015	20	20	16
Jun 2015	26	12	18
Jul 2015	101	20	26
Aug 2015	5	22	14
Sep 2015	24	7	16
Oct 2015	40	9	15
Nov 2015	26	13	22
Dec 2015	16	26	17
Jan 2016	18	9	16
Feb 2016	11	15	13
Mar 2016	23	15	31
Apr 2016	26	15	20
May 2016	30	14	30
Jun 2016	15	15	20
Jul 2016	13	16	16
Aug 2016	20	10	19
Sep 2016	20	7	13
Oct 2016	8	20	13
Nov 2016	6	13	15
Dec 2016	9	13	21
Jan 2017	14	14	19
Feb 2017	7	18	12
Mar 2017	3	11	10
Apr 2017	12	25	12
May 2017	8	22	22
Jun 2017	7	12	16
Jul 2017	7	12	13
Aug 2017	6	15	21
Sep 2017	2	16	14
Oct 2017	1	17	6
Nov 2017	5	23	14
Dec 2017	10	19	15
Jan 2018	12	21	8
Feb 2018	4	17	12
Mar 2018	13	36	5
Apr 2018	7	12	11
May 2018	4	13	17
Jun 2018	1	16	15
Jul 2018	7	19	14
Aug 2018	3	11	8
Sep 2018	26	15	10
Oct 2018	9	55	22
Nov 2018	3	74	18
Dec 2018	63	14	11
Jan 2019	44	3	2
Feb 2019	32	0	0
Mar 2019	14	2	3
Apr 2019	22	3	4
May 2019	14	4	3
Jun 2019	15	2	4
Jul 2019	25	3	3
Aug 2019	39	1	2
Sep 2019	36	0	0
Oct 2019	23	1	3
Nov 2019	45	4	2
Dec 2019	20	0	0
Jan 2020	13	1	0
Feb 2020	30	2	1
Mar 2020	35	2	1
Apr 2020	15	2	2
May 2020	32	2	2
Jun 2020	14	1	1
Jul 2020	15	1	1
Aug 2020	28	0	4
Sep 2020	15	2	0
Oct 2020	14	3	1
Nov 2020	11	5	0
Dec 2020	44	1	1
Jan 2021	36	14	1
Feb 2021	14	11	2
Mar 2021	29	5	3
Apr 2021	25	2	2
May 2021	28	11	3
Jun 2021	3	8	0
Jul 2021	16	2	1
Aug 2021	28	10	3
Sep 2021	11	3	2
Oct 2021	26	7	0
Nov 2021	27	1	0
Dec 2021	17	3	0
Jan 2022	20	1	2
Feb 2022	12	1	0
Mar 2022	23	4	4
Apr 2022	23	8	13
May 2022	28	2	1
Jun 2022	20	3	2
Jul 2022	32	1	0
Aug 2022	16	4	0
Sep 2022	27	3	2
Oct 2022	33	2	0
Nov 2022	21	6	2
Dec 2022	8	6	1
Jan 2023	32	6	1
Feb 2023	11	5	0
Mar 2023	26	4	2