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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

April 01, 2001; Volume 297,Issue 1

2001 ASPET OTTO KRAYER AWARD LECTURE

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    Molecular Targets for Antiviral Agents
    Erik De Clercq
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 1-10;

PERSPECTIVES IN PHARMACOLOGY

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    Unifying Perspectives of the Mechanisms Underlying the Development of Tolerance and Physical Dependence to Opioids
    David A. Taylor and William W. Fleming
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 11-18;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Probenecid-Associated Alterations in Valproate Glucuronide Hepatobiliary Disposition: Mechanistic Assessment Using Mathematical Modeling
    E. Stacy Ward, Gary M. Pollack and Kim L. R. Brouwer
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 141-147;
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    Regulation of Hepatic Cytochrome P450 2C11 via cAMP: Implications for Down-Regulation in Diabetes, Fasting, and Inflammation
    Heinrich Iber, Tong Li-Masters, Qi Chen, Sheng Yu and Edward T. Morgan
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 174-180;
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    Transcriptional and Post-Translational Regulation of CYP1A1 by Primaquine
    Veronica Werlinder, Maria Backlund, Andrei Zhukov and Magnus Ingelman-Sundberg
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 206-214;
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    Application of the Relative Activity Factor Approach in Scaling from Heterologously Expressed Cytochromes P450 to Human Liver Microsomes: Studies on Amitriptyline as a Model Substrate
    Karthik Venkatakrishnan, Lisa L. von Moltke and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 326-337;
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    Metabolism of levo-α-Acetylmethadol (LAAM) by Human Liver Cytochrome P450: Involvement of CYP3A4 Characterized by Atypical Kinetics with Two Binding Sites
    Yutaka Oda and Evan D. Kharasch
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 410-422;
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    Futile Cycling of Estrone Sulfate and Estrone in the Recirculating Perfused Rat Liver Preparation
    Eugene Tan, Thanh Lu and K. Sandy Pang
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 423-436;

CARDIOVASCULAR

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    Characterization of the Serotonin Receptor Mediating Contraction in the Mouse Thoracic Aorta and Signal Pathway Coupling
    C. M. McKune and S. W. Watts
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 88-95;
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    Hydrogen Peroxide Modifies the Kinetics of HERG Channel Expressed in a Mammalian Cell Line
    Jocelyn Bérubé, David Caouette and Pascal Daleau
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 96-102;
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    Dexfenfluramine-Associated Changes in 5-Hydroxytryptamine Transporter Expression and Development of Hypoxic Pulmonary Hypertension in Rats
    Saadia Eddahibi, Serge Adnot, Eric Frisdal, Micheline Levame, Michel Hamon and Bernadette Raffestin
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 148-154;
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    Effects of Diaspirin Cross-Linked Hemoglobin (DCLHb) during and Post-CPR in Swine
    Moses S. S. Chow, Chengde Fan, Hieu Tran, Hong Zhao and Li Zhou
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 224-229;
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    Calcium Channel Blockade in Vascular Smooth Muscle Cells: Major Hypotensive Mechanism of S-Petasin, a Hypotensive Sesquiterpene from Petasites formosanus
    Guei-Jane Wang, Andrew Yau-Chik Shum, Yun-Lian Lin, Jyh-Fei Liao, Xi-Chen Wu, Jun Ren and Chieh-Fu Chen
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 240-246;
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    A Novel Sodium-Hydrogen Exchanger Isoform-1 Inhibitor, Zoniporide, Reduces Ischemic Myocardial Injury in Vitro and in Vivo
    Delvin R. Knight, Andrew H. Smith, David M. Flynn, Joseph T. MacAndrew, Suzanne S. Ellery, Jimmy X. Kong, Ravi B. Marala, Ronald T. Wester, Angel Guzman-Perez, Roger J. Hill, William P. Magee and W. Ross Tracey
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 254-259;
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    Structure-Activity Relationships and Electrophysiological Effects of Short-Acting Amiodarone Homologs in Guinea Pig Isolated Heart
    Timothy E. Morey, Christoph N. Seubert, M. J. Pekka Raatikainen, Anatoly E. Martynyuk, Pascal Druzgala, Peter Milner, Mario D. Gonzalez and Donn M. Dennis
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 260-266;
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    β3-Adrenoceptor Agonist-Induced Increases in Lipolysis, Metabolic Rate, Facial Flushing, and Reflex Tachycardia in Anesthetized Rhesus Monkeys
    Gary J. Hom, Michael J. Forrest, Thomas J. Bach, Edward Brady, Mari Rios Candelore, Margaret A. Cascieri, Donna J. Fletcher, Michael H. Fisher, Susan A. Iliff, Robert Mathvink, Joseph Metzger, Victor Pecore, Richard Saperstein, Thomas Shih, Ann E. Weber, Matthew Wyvratt, Peter Zafian and D. Euan MacIntyre
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 299-307;
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    The Nitroderivative of Aspirin, NCX 4016, Reduces Infarct Size Caused by Myocardial Ischemia-Reperfusion in the Anesthetized Rat
    Giuseppe Rossoni, Barbara Manfredi, Vito De Gennaro Colonna, Micaela Bernareggi and Ferruccio Berti
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 380-387;
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    Blockade of Currents by the Antimalarial Drug Chloroquine in Feline Ventricular Myocytes
    José A. Sánchez-Chapula, Eduardo Salinas-Stefanon, Julian Torres-Jácome, Dora E. Benavides-Haro and Ricardo A. Navarro-Polanco
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 437-445;

CELLULAR AND MOLECULAR

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    Bradykinin B2 Receptor Endocytosis, Recycling, and Down-Regulation Assessed Using Green Fluorescent Protein Conjugates
    Dimcho R. Bachvarov, Steeve Houle, Magdalena Bachvarova, Johanne Bouthillier, Albert Adam and François Marceau
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 19-26;
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    Rebamipide Suppresses Formyl-methionyl-leucyl-phenylalanine (fMLP)-Induced Superoxide Production by Inhibiting fMLP-Receptor Binding in Human Neutrophils
    Chifumi Nagano, Atsushi Azuma, Hironobu Ishiyama, Kazuo Sekiguchi, Kenichi Imagawa and Mikio Kikuchi
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 388-394;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Discovery of a Novel Antitumor Benzolactone Enamide Class That Selectively Inhibits Mammalian Vacuolar-Type (H+)-ATPases
    Michael R. Boyd, Carlo Farina, Pietro Belfiore, Stefania Gagliardi, Jin Woo Kim, Yoichi Hayakawa, John A. Beutler, Tawnya C. McKee, Barry J. Bowman and Emma Jean Bowman
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 114-120;
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    Inducible Nitric Oxide Synthase Neutralizes Carbamoylating Potential of 1,3-Bis(2-chloroethyl)-1-nitrosourea in C6 Glioma Cells
    Jiu-Haw Yin, Ding-I Yang, Henry Chou, Ellen M. Thompson, Jan Xu and Chung Y. Hsu
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 308-315;
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    Biological Characterization of Eugeniin as an Anti-Herpes Simplex Virus Type 1 Compound in Vitro and in Vivo
    Masahiko Kurokawa, Toyoharu Hozumi, Minako Tsurita, Shigetoshi Kadota, Tsuneo Namba and Kimiyasu Shiraki
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 372-379;

ENDOCRINE AND REPRODUCTIVE

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    Stimulatory Effect of Clofibrate on the Action of Estradiol in the Mammary Gland but Not in the Uterus of Rats
    Shiyao Xu, Bao Ting Zhu, May Xiaoxin Cai and Allan H. Conney
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 50-56;
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    Comparison of the Modulatory Effects of Human and Rat Liver Microsomal Metabolism on the Estrogenicity of Bisphenol A: Implications for Extrapolation to Humans
    Robert Elsby, James L. Maggs, John Ashby and B. Kevin Park
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 103-113;
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    Natriuretic Peptide-Induced Relaxation of Myometrium from the Pregnant Guinea Pig Is Not Mediated by Guanylate Cyclase Activation
    Jorge A. Carvajal, Kripamoy Aguan, Loren P. Thompson, Irina A. Buhimschi and Carl P. Weiner
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 181-188;
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    Effect of Ovarian Hormones and Estrous Cycle on Stimulation of the Hypothalamo-Pituitary-Adrenal Axis by Cocaine
    Q. David Walker, Reynold Francis, Jose Cabassa and Cynthia M. Kuhn
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 291-298;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor β (TGF-β) Overexpression, and Collagen Accumulation in Irradiated Rat Intestine
    Junru Wang, Huaien Zheng and Martin Hauer-Jensen
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 35-42;
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    Cloning and Functional Characterization of Two Murine Uridine Nucleotide Receptors Reveal a Potential Target for Correcting Ion Transport Deficiency in Cystic Fibrosis Gallbladder
    Eduardo R. Lazarowski, Lori G. Rochelle, Wanda K. O'Neal, Carla M. P. Ribeiro, Barbara R. Grubb, Vivian Zhang, T. Kendall Harden and Richard C. Boucher
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 43-49;
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    Characterization of Opioid Receptors Modulating Neurogenic Contractions of Circular Muscle from Porcine Ileum and Evidence That δ- and κ-Opioid Receptors Are Coexpressed in Myenteric Neurons
    Sutthasinee Poonyachoti, Philip S. Portoghese and David R. Brown
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 69-77;
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    Intravasal Peroxynitrite Generation Causes Dysfunction in the Isolated Perfused Rat Lung via Endothelin
    Katja Eichert, Jürg Hamacher, Michael Andreas Wunder and Albrecht Wendel
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 128-132;
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    Antiasthmatic Effect of YM976, a Novel PDE4 Inhibitor, in Guinea Pigs
    Motonori Aoki, Satoshi Yamamoto, Miki Kobayashi, Keiko Ohga, Hiroyuki Kanoh, Keiji Miyata, Kazuo Honda and Toshimitsu Yamada
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 165-173;
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    In Vitro and in Vivo Pharmacological Characterization of BIIL 284, a Novel and Potent Leukotriene B4 Receptor Antagonist
    F. W. Birke, C. J. Meade, R. Anderskewitz, G. A. Speck and H.-M. Jennewein
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 458-466;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Matrix Metalloproteinase Inhibitors Cause Cell Cycle Arrest and Apoptosis in Glomerular Mesangial Cells
    Catherine Daniel, Jeremy Duffield, Thomas Brunner, Karin Steinmann-Niggli, Nadège Lods and Hans-Peter Marti
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 57-68;
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    Pharmacokinetic/Pharmacodynamic Modeling of Antipyretic and Anti-Inflammatory Effects of Naproxen in the Rat
    Mariona Josa, JoséPérez Urizar, Javier Rapado, Carmen Dios-Viéitez, Gilberto Castañeda-Hernández, Francisco Flores-Murrieta, María Jesús Renedo and Iñaki F. Trocóniz
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 198-205;
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    Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro
    Armin Hatzelmann and Christian Schudt
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 267-279;
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    In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor
    Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig, Lutz Wollin, Armin Hatzelmann and Rolf Beume
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 280-290;

NEUROPHARMACOLOGY

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    Effect of Acute Ethanol on Striatal Dopamine Neurotransmission in Ambulatory Rats
    Evgeny A. Budygin, Paul E. M. Phillips, Donita L. Robinson, Andrew P. Kennedy, Raul R. Gainetdinov and R. Mark Wightman
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 27-34;
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    Prostaglandin A1 Protects Striatal Neurons against Excitotoxic Injury in Rat Striatum
    Zheng-Hong Qin, Yumei Wang, Ren-Wu Chen, Xiaoxia Wang, Ming Ren, De-Maw Chuang and Thomas N. Chase
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 78-87;
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    Changes in Opioid and Cannabinoid Receptor Protein following Short-Term Combination Treatment with Δ9-Tetrahydrocannabinol and Morphine
    Diana L. Cichewicz, Victoria L. Haller and Sandra P. Welch
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 121-127;
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    Dynamic Dopamine-Antagonist Interactions at Recombinant Human Dopamine D2short Receptor: Dopamine-Bound versus Antagonist-Bound Receptor States
    Petrus J. Pauwels, Fréderic Finana, Stéphanie Tardif, Thierry Wurch and Francis C. Colpaert
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 133-140;
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    Zebra Finch CB1 Cannabinoid Receptor: Pharmacology and in Vivo and in Vitro Effects of Activation
    Ken Soderstrom and Frank Johnson
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 189-197;
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    Enadoline Discrimination in Squirrel Monkeys: Effects of Opioid Agonists and Antagonists
    Galen J. Carey and Jack Bergman
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 215-223;
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    A-85380 and Epibatidine Each Interact with Disparate Spinal Nicotinic Receptor Subtypes to Achieve Analgesia and Nociception
    Imran M. Khan, Shanaka Stanislaus, Limin Zhang, Palmer Taylor and Tony L. Yaksh
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 230-239;
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    Zolpidem, Triazolam, and Diazepam Decrease Distress Vocalizations in Mouse Pups: Differential Antagonism by Flumazenil and β-Carboline-3-carboxylate-t-butyl ester (β-CCt)
    James K. Rowlett, Walter Tornatzky, James M. Cook, Chunrong Ma and Klaus A. Miczek
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 247-253;
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    Serotonergic Manipulations Both Potentiate and Reduce Brain Stimulation Reward in Rats: Involvement of Serotonin-1A Receptors
    Amanda A. Harrison and Athina Markou
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 316-325;
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    General Anesthetic Potencies of a Series of Propofol Analogs Correlate with Potency for Potentiation of γ-Aminobutyric Acid (GABA) Current at the GABAA Receptor but Not with Lipid Solubility
    Matthew D. Krasowski, Andrew Jenkins, Pamela Flood, Amiinah Y. Kung, Anton J. Hopfinger and Neil L. Harrison
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 338-351;
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    Neurometer Measurement of Current Stimulus Threshold in Rats
    Tetsuo Kiso, Yukinori Nagakura, Takashi Toya, Naoyuki Matsumoto, Seiji Tamura, Hiroyuki Ito, Masamichi Okada and Tokio Yamaguchi
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 352-356;
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    Antagonism of 5-Hydroxytryptamine2A Receptors Attenuates the Behavioral Effects of Cocaine in Rats
    Lance R. McMahon and Kathryn A. Cunningham
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 357-363;
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    Antinociceptive and Respiratory Effects of Intrathecal H-Tyr-d-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1]DALDA
    Megumi Shimoyama, Naohito Shimoyama, Guo-Min Zhao, Peter W. Schiller and Hazel H. Szeto
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 364-371;
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    A 5-HT7 Receptor-Mediated Depolarization in the Anterodorsal Thalamus. I. Pharmacological Characterization
    Esther M. Chapin and Rodrigo Andrade
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 395-402;
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    A 5-HT7 Receptor-Mediated Depolarization in the Anterodorsal Thalamus. II. Involvement of the Hyperpolarization-Activated Current Ih
    Esther M. Chapin and Rodrigo Andrade
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 403-409;
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    Sex-Related Differences in Antinociception and Tolerance Development following Chronic Intravenous Infusion of Morphine in the Rat: Modulatory Role of Testosterone via Morphine Clearance
    Samantha M. South, Andrew W. E. Wright, Michael Lau, Laurence E. Mather and Maree T. Smith
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 446-457;

TOXICOLOGY

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    Renal and Hepatic Toxicity of Trichloroethylene and Its Glutathione-Derived Metabolites in Rats and Mice: Sex-, Species-, and Tissue-Dependent Differences
    Lawrence H. Lash, Wei Qian, David A. Putt, Sarah E. Hueni, Adnan A. Elfarra, Renee J. Krause and Jean C. Parker
    Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 155-164;
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Journal of Pharmacology and Experimental Therapeutics: 297 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 297, Issue 1
1 Apr 2001
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  • 2001 ASPET OTTO KRAYER AWARD LECTURE
  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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