Journal of Pharmacology and Experimental Therapeutics: 297 (1)

April 01, 2001; Volume 297,Issue 1

2001 ASPET OTTO KRAYER AWARD LECTURE

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Molecular Targets for Antiviral Agents
Erik De Clercq

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 1-10;

PERSPECTIVES IN PHARMACOLOGY

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Unifying Perspectives of the Mechanisms Underlying the Development of Tolerance and Physical Dependence to Opioids
David A. Taylor and William W. Fleming

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 11-18;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Probenecid-Associated Alterations in Valproate Glucuronide Hepatobiliary Disposition: Mechanistic Assessment Using Mathematical Modeling
E. Stacy Ward, Gary M. Pollack and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 141-147;
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Regulation of Hepatic Cytochrome P450 2C11 via cAMP: Implications for Down-Regulation in Diabetes, Fasting, and Inflammation
Heinrich Iber, Tong Li-Masters, Qi Chen, Sheng Yu and Edward T. Morgan

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 174-180;
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Transcriptional and Post-Translational Regulation of CYP1A1 by Primaquine
Veronica Werlinder, Maria Backlund, Andrei Zhukov and Magnus Ingelman-Sundberg

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 206-214;
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Application of the Relative Activity Factor Approach in Scaling from Heterologously Expressed Cytochromes P450 to Human Liver Microsomes: Studies on Amitriptyline as a Model Substrate
Karthik Venkatakrishnan, Lisa L. von Moltke and David J. Greenblatt

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 326-337;
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Metabolism of levo-α-Acetylmethadol (LAAM) by Human Liver Cytochrome P450: Involvement of CYP3A4 Characterized by Atypical Kinetics with Two Binding Sites
Yutaka Oda and Evan D. Kharasch

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 410-422;
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Futile Cycling of Estrone Sulfate and Estrone in the Recirculating Perfused Rat Liver Preparation
Eugene Tan, Thanh Lu and K. Sandy Pang

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 423-436;

CARDIOVASCULAR

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Characterization of the Serotonin Receptor Mediating Contraction in the Mouse Thoracic Aorta and Signal Pathway Coupling
C. M. McKune and S. W. Watts

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 88-95;
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Hydrogen Peroxide Modifies the Kinetics of HERG Channel Expressed in a Mammalian Cell Line
Jocelyn Bérubé, David Caouette and Pascal Daleau

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 96-102;
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Dexfenfluramine-Associated Changes in 5-Hydroxytryptamine Transporter Expression and Development of Hypoxic Pulmonary Hypertension in Rats
Saadia Eddahibi, Serge Adnot, Eric Frisdal, Micheline Levame, Michel Hamon and Bernadette Raffestin

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 148-154;
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Effects of Diaspirin Cross-Linked Hemoglobin (DCLHb) during and Post-CPR in Swine
Moses S. S. Chow, Chengde Fan, Hieu Tran, Hong Zhao and Li Zhou

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 224-229;
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Calcium Channel Blockade in Vascular Smooth Muscle Cells: Major Hypotensive Mechanism of S-Petasin, a Hypotensive Sesquiterpene from Petasites formosanus
Guei-Jane Wang, Andrew Yau-Chik Shum, Yun-Lian Lin, Jyh-Fei Liao, Xi-Chen Wu, Jun Ren and Chieh-Fu Chen

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 240-246;
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A Novel Sodium-Hydrogen Exchanger Isoform-1 Inhibitor, Zoniporide, Reduces Ischemic Myocardial Injury in Vitro and in Vivo
Delvin R. Knight, Andrew H. Smith, David M. Flynn, Joseph T. MacAndrew, Suzanne S. Ellery, Jimmy X. Kong, Ravi B. Marala, Ronald T. Wester, Angel Guzman-Perez, Roger J. Hill, William P. Magee and W. Ross Tracey

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 254-259;
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Structure-Activity Relationships and Electrophysiological Effects of Short-Acting Amiodarone Homologs in Guinea Pig Isolated Heart
Timothy E. Morey, Christoph N. Seubert, M. J. Pekka Raatikainen, Anatoly E. Martynyuk, Pascal Druzgala, Peter Milner, Mario D. Gonzalez and Donn M. Dennis

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 260-266;
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β₃-Adrenoceptor Agonist-Induced Increases in Lipolysis, Metabolic Rate, Facial Flushing, and Reflex Tachycardia in Anesthetized Rhesus Monkeys
Gary J. Hom, Michael J. Forrest, Thomas J. Bach, Edward Brady, Mari Rios Candelore, Margaret A. Cascieri, Donna J. Fletcher, Michael H. Fisher, Susan A. Iliff, Robert Mathvink, Joseph Metzger, Victor Pecore, Richard Saperstein, Thomas Shih, Ann E. Weber, Matthew Wyvratt, Peter Zafian and D. Euan MacIntyre

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 299-307;
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The Nitroderivative of Aspirin, NCX 4016, Reduces Infarct Size Caused by Myocardial Ischemia-Reperfusion in the Anesthetized Rat
Giuseppe Rossoni, Barbara Manfredi, Vito De Gennaro Colonna, Micaela Bernareggi and Ferruccio Berti

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 380-387;
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Blockade of Currents by the Antimalarial Drug Chloroquine in Feline Ventricular Myocytes
José A. Sánchez-Chapula, Eduardo Salinas-Stefanon, Julian Torres-Jácome, Dora E. Benavides-Haro and Ricardo A. Navarro-Polanco

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 437-445;

CELLULAR AND MOLECULAR

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Bradykinin B₂ Receptor Endocytosis, Recycling, and Down-Regulation Assessed Using Green Fluorescent Protein Conjugates
Dimcho R. Bachvarov, Steeve Houle, Magdalena Bachvarova, Johanne Bouthillier, Albert Adam and François Marceau

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 19-26;
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Rebamipide Suppresses Formyl-methionyl-leucyl-phenylalanine (fMLP)-Induced Superoxide Production by Inhibiting fMLP-Receptor Binding in Human Neutrophils
Chifumi Nagano, Atsushi Azuma, Hironobu Ishiyama, Kazuo Sekiguchi, Kenichi Imagawa and Mikio Kikuchi

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 388-394;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Discovery of a Novel Antitumor Benzolactone Enamide Class That Selectively Inhibits Mammalian Vacuolar-Type (H⁺)-ATPases
Michael R. Boyd, Carlo Farina, Pietro Belfiore, Stefania Gagliardi, Jin Woo Kim, Yoichi Hayakawa, John A. Beutler, Tawnya C. McKee, Barry J. Bowman and Emma Jean Bowman

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 114-120;
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Inducible Nitric Oxide Synthase Neutralizes Carbamoylating Potential of 1,3-Bis(2-chloroethyl)-1-nitrosourea in C6 Glioma Cells
Jiu-Haw Yin, Ding-I Yang, Henry Chou, Ellen M. Thompson, Jan Xu and Chung Y. Hsu

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 308-315;
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Biological Characterization of Eugeniin as an Anti-Herpes Simplex Virus Type 1 Compound in Vitro and in Vivo
Masahiko Kurokawa, Toyoharu Hozumi, Minako Tsurita, Shigetoshi Kadota, Tsuneo Namba and Kimiyasu Shiraki

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 372-379;

ENDOCRINE AND REPRODUCTIVE

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Stimulatory Effect of Clofibrate on the Action of Estradiol in the Mammary Gland but Not in the Uterus of Rats
Shiyao Xu, Bao Ting Zhu, May Xiaoxin Cai and Allan H. Conney

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 50-56;
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Comparison of the Modulatory Effects of Human and Rat Liver Microsomal Metabolism on the Estrogenicity of Bisphenol A: Implications for Extrapolation to Humans
Robert Elsby, James L. Maggs, John Ashby and B. Kevin Park

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 103-113;
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Natriuretic Peptide-Induced Relaxation of Myometrium from the Pregnant Guinea Pig Is Not Mediated by Guanylate Cyclase Activation
Jorge A. Carvajal, Kripamoy Aguan, Loren P. Thompson, Irina A. Buhimschi and Carl P. Weiner

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 181-188;
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Effect of Ovarian Hormones and Estrous Cycle on Stimulation of the Hypothalamo-Pituitary-Adrenal Axis by Cocaine
Q. David Walker, Reynold Francis, Jose Cabassa and Cynthia M. Kuhn

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 291-298;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor β (TGF-β) Overexpression, and Collagen Accumulation in Irradiated Rat Intestine
Junru Wang, Huaien Zheng and Martin Hauer-Jensen

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 35-42;
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Cloning and Functional Characterization of Two Murine Uridine Nucleotide Receptors Reveal a Potential Target for Correcting Ion Transport Deficiency in Cystic Fibrosis Gallbladder
Eduardo R. Lazarowski, Lori G. Rochelle, Wanda K. O'Neal, Carla M. P. Ribeiro, Barbara R. Grubb, Vivian Zhang, T. Kendall Harden and Richard C. Boucher

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 43-49;
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Characterization of Opioid Receptors Modulating Neurogenic Contractions of Circular Muscle from Porcine Ileum and Evidence That δ- and κ-Opioid Receptors Are Coexpressed in Myenteric Neurons
Sutthasinee Poonyachoti, Philip S. Portoghese and David R. Brown

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 69-77;
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Intravasal Peroxynitrite Generation Causes Dysfunction in the Isolated Perfused Rat Lung via Endothelin
Katja Eichert, Jürg Hamacher, Michael Andreas Wunder and Albrecht Wendel

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 128-132;
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Antiasthmatic Effect of YM976, a Novel PDE4 Inhibitor, in Guinea Pigs
Motonori Aoki, Satoshi Yamamoto, Miki Kobayashi, Keiko Ohga, Hiroyuki Kanoh, Keiji Miyata, Kazuo Honda and Toshimitsu Yamada

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 165-173;
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In Vitro and in Vivo Pharmacological Characterization of BIIL 284, a Novel and Potent Leukotriene B₄ Receptor Antagonist
F. W. Birke, C. J. Meade, R. Anderskewitz, G. A. Speck and H.-M. Jennewein

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 458-466;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Matrix Metalloproteinase Inhibitors Cause Cell Cycle Arrest and Apoptosis in Glomerular Mesangial Cells
Catherine Daniel, Jeremy Duffield, Thomas Brunner, Karin Steinmann-Niggli, Nadège Lods and Hans-Peter Marti

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 57-68;
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Pharmacokinetic/Pharmacodynamic Modeling of Antipyretic and Anti-Inflammatory Effects of Naproxen in the Rat
Mariona Josa, JoséPérez Urizar, Javier Rapado, Carmen Dios-Viéitez, Gilberto Castañeda-Hernández, Francisco Flores-Murrieta, María Jesús Renedo and Iñaki F. Trocóniz

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 198-205;
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Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro
Armin Hatzelmann and Christian Schudt

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 267-279;
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In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor
Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig, Lutz Wollin, Armin Hatzelmann and Rolf Beume

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 280-290;

NEUROPHARMACOLOGY

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Effect of Acute Ethanol on Striatal Dopamine Neurotransmission in Ambulatory Rats
Evgeny A. Budygin, Paul E. M. Phillips, Donita L. Robinson, Andrew P. Kennedy, Raul R. Gainetdinov and R. Mark Wightman

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 27-34;
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Prostaglandin A₁ Protects Striatal Neurons against Excitotoxic Injury in Rat Striatum
Zheng-Hong Qin, Yumei Wang, Ren-Wu Chen, Xiaoxia Wang, Ming Ren, De-Maw Chuang and Thomas N. Chase

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 78-87;
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Changes in Opioid and Cannabinoid Receptor Protein following Short-Term Combination Treatment with Δ⁹-Tetrahydrocannabinol and Morphine
Diana L. Cichewicz, Victoria L. Haller and Sandra P. Welch

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 121-127;
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Dynamic Dopamine-Antagonist Interactions at Recombinant Human Dopamine D_2short Receptor: Dopamine-Bound versus Antagonist-Bound Receptor States
Petrus J. Pauwels, Fréderic Finana, Stéphanie Tardif, Thierry Wurch and Francis C. Colpaert

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 133-140;
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Zebra Finch CB1 Cannabinoid Receptor: Pharmacology and in Vivo and in Vitro Effects of Activation
Ken Soderstrom and Frank Johnson

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 189-197;
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Enadoline Discrimination in Squirrel Monkeys: Effects of Opioid Agonists and Antagonists
Galen J. Carey and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 215-223;
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A-85380 and Epibatidine Each Interact with Disparate Spinal Nicotinic Receptor Subtypes to Achieve Analgesia and Nociception
Imran M. Khan, Shanaka Stanislaus, Limin Zhang, Palmer Taylor and Tony L. Yaksh

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 230-239;
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Zolpidem, Triazolam, and Diazepam Decrease Distress Vocalizations in Mouse Pups: Differential Antagonism by Flumazenil and β-Carboline-3-carboxylate-t-butyl ester (β-CCt)
James K. Rowlett, Walter Tornatzky, James M. Cook, Chunrong Ma and Klaus A. Miczek

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 247-253;
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Serotonergic Manipulations Both Potentiate and Reduce Brain Stimulation Reward in Rats: Involvement of Serotonin-1A Receptors
Amanda A. Harrison and Athina Markou

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 316-325;
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General Anesthetic Potencies of a Series of Propofol Analogs Correlate with Potency for Potentiation of γ-Aminobutyric Acid (GABA) Current at the GABA_A Receptor but Not with Lipid Solubility
Matthew D. Krasowski, Andrew Jenkins, Pamela Flood, Amiinah Y. Kung, Anton J. Hopfinger and Neil L. Harrison

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 338-351;
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Neurometer Measurement of Current Stimulus Threshold in Rats
Tetsuo Kiso, Yukinori Nagakura, Takashi Toya, Naoyuki Matsumoto, Seiji Tamura, Hiroyuki Ito, Masamichi Okada and Tokio Yamaguchi

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 352-356;
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Antagonism of 5-Hydroxytryptamine_2A Receptors Attenuates the Behavioral Effects of Cocaine in Rats
Lance R. McMahon and Kathryn A. Cunningham

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 357-363;
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Antinociceptive and Respiratory Effects of Intrathecal H-Tyr-d-Arg-Phe-Lys-NH₂ (DALDA) and [Dmt¹]DALDA
Megumi Shimoyama, Naohito Shimoyama, Guo-Min Zhao, Peter W. Schiller and Hazel H. Szeto

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 364-371;
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A 5-HT₇ Receptor-Mediated Depolarization in the Anterodorsal Thalamus. I. Pharmacological Characterization
Esther M. Chapin and Rodrigo Andrade

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 395-402;
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A 5-HT₇ Receptor-Mediated Depolarization in the Anterodorsal Thalamus. II. Involvement of the Hyperpolarization-Activated Current I_h
Esther M. Chapin and Rodrigo Andrade

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 403-409;
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Sex-Related Differences in Antinociception and Tolerance Development following Chronic Intravenous Infusion of Morphine in the Rat: Modulatory Role of Testosterone via Morphine Clearance
Samantha M. South, Andrew W. E. Wright, Michael Lau, Laurence E. Mather and Maree T. Smith

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 446-457;

TOXICOLOGY

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Renal and Hepatic Toxicity of Trichloroethylene and Its Glutathione-Derived Metabolites in Rats and Mice: Sex-, Species-, and Tissue-Dependent Differences
Lawrence H. Lash, Wei Qian, David A. Putt, Sarah E. Hueni, Adnan A. Elfarra, Renee J. Krause and Jean C. Parker

Journal of Pharmacology and Experimental Therapeutics April 2001, 297 (1) 155-164;

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Table of Contents

2001 ASPET OTTO KRAYER AWARD LECTURE

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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