Journal of Pharmacology and Experimental Therapeutics: 296 (3)

March 01, 2001; Volume 296,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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The Role of Time as a Quantifiable Variable of Toxicity and the Experimental Conditions When Haber's c ×t Product Can Be Observed: Implications for Therapeutics
Karl K. Rozman and John Doull

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 663-668;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results
Masayo Yamazaki, William E. Neway, Tomoyuki Ohe, I-Wu Chen, Janice F. Rowe, Jerome H. Hochman, Masato Chiba and Jiunn H. Lin

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 723-735;
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Rescue from Enhanced Alkylator-Induced Cell Death with Low Molecular Weight Sulfur-Containing Chemoprotectants
Leslie L. Muldoon, Shannan L. Walker-Rosenfeld, Christopher Hale, Shawna E. Purcell, Lisa C. Bennett and Edward A. Neuwelt

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 797-805;
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Pharmacokinetic Properties of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats
Richard S. Geary, Tanya A. Watanabe, LoAnne Truong, Sue Freier, Elena A. Lesnik, Namir B. Sioufi, Henri Sasmor, Muthiah Manoharan and Arthur A. Levin

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 890-897;
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Absolute Bioavailability of 2′-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides following Intraduodenal Instillation in Rats
Richard S. Geary, Oleg Khatsenko, Keith Bunker, Rosanne Crooke, Max Moore, Todd Burckin, LoAnne Truong, Henri Sasmor and Arthur A. Levin

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 898-904;
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Drug-Induced Hemodynamic Perturbations Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water
Tom C. Krejcie, Zhao Wang and Michael J. Avram

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 922-930;

CARDIOVASCULAR

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Comparative Specificity of Platelet α_IIbβ₃ Integrin Antagonists
Gaétan Thibault, Patrick Tardif and Geneviève Lapalme

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 690-696;
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Gender Differences in the Effect of Age on Electrical Field Stimulation (EFS)-Induced Adrenergic Vasoconstriction in Rat Mesenteric Resistance Arteries
Jennifer C. Sullivan and Cathy A. Davison

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 782-788;
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Potassium Current Antagonist Properties and Proarrhythmic Consequences of Quinolone Antibiotics
Mark E. Anderson, Alexander Mazur, Tao Yang and Dan M. Roden

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 806-810;
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Low-Affinity M₂ Receptor Binding State Mediates Mouse Atrial Bradycardia: Comparative Effects of Carbamylcholine and the M₁ Receptor Agonists Sabcomeline and Xanomeline
Peter W. Stengel and Marlene L. Cohen

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 818-824;
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α_1D-Adrenoceptors Cause Endothelium-Dependent Vasodilatation in the Rat Mesenteric Vascular Bed
Sandra Filippi, Astrid Parenti, Sandra Donnini, Harris J. Granger, Alessandro Fazzini and Fabrizio Ledda

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 869-875;
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Differences between Peptide and Nonpeptide B₂Bradykinin Receptor Antagonists in Blocking Bronchoconstriction and Hypotension Induced by Bradykinin in Anesthetized Guinea Pigs
Manuela Tramontana, Alessandro Lecci, Stefania Meini, Xavier Montserrat, Jaume Pascual, Sandro Giuliani, Laura Quartara and Carlo Alberto Maggi

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1051-1057;
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Antiangiogenic Effect of KR31372 in Rat Sponge Implant Model
Chi Dae Kim, Hyung Hwan Kim, Yong Ki Kim, Yong Keun Kwak, Sun-Ok Kim, Sung-Eun Yoo and Ki Whan Hong

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1085-1090;

CELLULAR AND MOLECULAR

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Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells
Eugenia Bloch-Shilderman, Hao Jiang, Saleh Abu-Raya, Michal Linial and Philip Lazarovici

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 704-711;
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Cleavage of Intracellular Substrates of Botulinum Toxins A, C, and D in a Mammalian Target Tissue
Sarinee Kalandakanond and Julie A. Coffield

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 749-755;
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Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist
Nambi Aiyar, Robert A. Daines, Jyoti Disa, Pamela A. Chambers, Charles F. Sauermelch, Marie-J. Quiniou, Nassirah Khandoudi, Bernard Gout, Stephen A. Douglas and Robert N. Willette

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 768-775;
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Protein Tyrosine Kinase Inhibitors Alter Human Dopamine Transporter Activity in Xenopus Oocytes
Suzanne Doolen and Nancy R. Zahniser

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 931-938;
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Complexities of Measuring Antagonist Potency at P2X₇Receptor Orthologs
A. D. Hibell, K. M. Thompson, M. Xing, P. P. A. Humphrey and A. D. Michel

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 947-957;
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Cleavage of SNAP-25 by Botulinum Toxin Type A Requires Receptor-Mediated Endocytosis, pH-Dependent Translocation, and Zinc
Sarinee Kalandakanond and Julie A. Coffield

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 980-986;
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Cloning and Characterization of a Novel Human Histamine Receptor
Kelley L. Morse, Jiang Behan, Thomas M. Laz, Robert E. West, Scott A. Greenfeder, John C. Anthes, Shelby Umland, Yuntao Wan, R. William Hipkin, Waldemar Gonsiorek, Niu Shin, Eric L. Gustafson, Xudong Qiao, Suke Wang, Joseph A. Hedrick, Jonathan Greene, Marvin Bayne and Frederick J. Monsma

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1058-1066;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Both Extraneuronal Monoamine Transporter and O ⁶ -Methylguanine-DNA Methyltransferase Expression Influence the Antitumor Efficacy of 2-Chloroethyl-3-sarcosinamide- 1-nitrosourea in Human Tumor Xenografts
Zhong-Ping Chen, Zhi-Min Wang, Christopher A. Carter, Michael C. Alley, Gérard Mohr and Lawrence C. Panasci

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 712-715;
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Protection of Mammalian Cells against Chemotherapeutic Agents Thiotepa, 1,3-N,N′-Bis(2-chloroethyl)-N-nitrosourea, and Mafosfamide Using the DNA Base Excision Repair Genes Fpg and α-hOgg1: Implications for Protective Gene Therapy Applications
Yi Xu, W. Kent Hansen, Thomas A. Rosenquist, David A. Williams, Melissa Limp-Foster and Mark R. Kelley

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 825-831;
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Design of a Chimeric 3-Methyl-1,2,3-triazene with Mixed Receptor Tyrosine Kinase and DNA Damaging Properties: A Novel Tumor Targeting Strategy
Stephanie L. Matheson, James McNamee and Bertrand J. Jean-Claude

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 832-840;
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Inactivation of HumanO ⁶-Alkylguanine-DNA Alkyltransferase by Modified Oligodeoxyribonucleotides Containing O ⁶-Benzylguanine
Anthony E. Pegg, Karina Goodtzova, Natalia A. Loktionova, Sreenivas Kanugula, Gary T. Pauly and Robert C. Moschel

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 958-965;
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Enhancement of Paclitaxel Delivery to Solid Tumors by Apoptosis-Inducing Pretreatment: Effect of Treatment Schedule
Seong Hoon Jang, M. Guillaume Wientjes and Jessie L.-S. Au

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1035-1042;

ENDOCRINE AND REPRODUCTIVE

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Hormonal Regulation of the Contractile Response Induced by Okadaic Acid in the Rat Uterus
Mar Trujillo, Luz Candenas, Cristina G. Cintado, Josefina Magraner, Javier Fernandez, Julio D. Martín and Francisco M. Pinto

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 841-848;
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Effects of Cocaine on Luteinizing Hormone in Women during the Follicular and Luteal Phases of the Menstrual Cycle and in Men
Jack H. Mendelson, Michelle B. Sholar, Arthur J. Siegel and Nancy K. Mello

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 972-979;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Functional Implication of Spare ATP-Sensitive K⁺Channels in Bladder Smooth Muscle Cells
Char-Chang Shieh, Jianlin Feng, Steven A. Buckner, Jorge D. Brioni, Michael J. Coghlan, James P. Sullivan and Murali Gopalakrishnan

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 669-675;
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Pharmacological Effect of Tamsulosin in Relation to Dog Plasma and Tissue Concentrations: Prostatic and Urethral Retention Possibly Contributes to Uroselectivity of Tamsulosin
Shuichi Sato, Akiyoshi Ohtake, Hiroshi Matsushima, Chikashi Saitoh, Shinji Usuda and Keiji Miyata

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 697-703;
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Inhibition of Na⁺/K⁺-ATPase by Endothelin-1 in Human Nonpigmented Ciliary Epithelial Cells
Ganesh Prasanna, Adnan Dibas, Christina Hulet and Thomas Yorio

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 966-971;
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Polyinosinic Acid and Polycationic Liposomes Attenuate the Hepatic Clearance of Circulating Plasmid DNA
Rodney F. Minchin, Denise Carpenter and Rebecca J. Orr

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1006-1012;
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Effects of Diaspirin Cross-linked Hemoglobin on Motor Function of the Duodenum and Biliary System in the Australian Brush-Tailed Possum in Vivo
Hiroyuki Konomi, Charmaine M. Woods, Adrian C. B. Meedeniya, Lynne C. Giles, James Toouli and Gino T. P. Saccone

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1067-1073;
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Nuclear Localization of Biliverdin Reductase in the Rat Kidney: Response to Nephrotoxins That Induce Heme Oxygenase-1
Mahin D. Maines, James F. Ewing, Tian J. Huang and Nariman Panahian

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1091-1097;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Lacidipine Modulates the Secretion of Matrix Metalloproteinase-9 by Human Macrophages
Stefano Bellosta, Monica Canavesi, Elda Favari, Luciano Cominacini, Giovanni Gaviraghi, Remo Fumagalli, Rodolfo Paoletti and Franco Bernini

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 736-743;
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Antiflammin-2 Prevents HL-60 Adhesion to Endothelial Cells and Prostanoid Production Induced by Lipopolysaccharides
Juan J. Moreno

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 884-889;
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Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium
John J. E. Haddad, Bared Safieh-Garabedian, Nayef E. Saadé and Stephen C. Land

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 996-1005;

NEUROPHARMACOLOGY

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Evidence for Involvement of Central 5-HT₄ Receptors in Cholinergic Function Associated with Cognitive Processes: Behavioral, Electrophysiological, and Neurochemical Studies
Machiko Matsumoto, Hiroko Togashi, Kiyoshi Mori, Ken-ichi Ueno, Satoshi Ohashi, Taku Kojima and Mitsuhiro Yoshioka

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 676-682;
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Modulation of Recombinant Small-Conductance Ca²⁺-Activated K⁺ Channels by the Muscle Relaxant Chlorzoxazone and Structurally Related Compounds
Ying-Jun Cao, John C. Dreixler, Jeffrey D. Roizen, Michael T. Roberts and Khaled M. Houamed

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 683-689;
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Correlation between Molecular Volume and Effects of n-Alcohols on Human Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
Elizabeth L. Godden, R. Adron Harris and Thomas V. Dunwiddie

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 716-722;
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Influence of Maternal Milk on Functional Activation of δ-Opioid Receptors in Postnatal Rats
Robin James Goody and Ian Kitchen

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 744-748;
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Coadministration of Intrathecal Strychnine and Bicuculline Effects Synergistic Allodynia in the Rat: An Isobolographic Analysis
Christopher W. Loomis, Hemal Khandwala, Geraldine Osmond and Michael P. Hefferan

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 756-761;
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Regulation of the Vesicular Monoamine Transporter-2: A Novel Mechanism for Cocaine and Other Psychostimulants
Jeffrey M. Brown, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 762-767;
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Opioid-Mediated Facilitation of Long-Term Depression in Rat Hippocampus
John J. Wagner, Lida R. Etemad and Angela M. Thompson

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 776-781;
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Titer-Dependent Antagonism of Cocaine following Active Immunization in Rhesus Monkeys
Lee Koetzner, Shixian Deng, Tina L. Sumpter, Michael Weisslitz, Ronald T. Abner, Donald W. Landry and James H. Woods

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 789-796;
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Heterosynaptic Transformation of GABAergic Gating in the Hippocampus and Effects of Carbonic Anhydrase Inhibition
Miao-Kun Sun, Dennis Dahl and Daniel L. Alkon

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 811-817;
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Dissociation of Nicotine Tolerance from Tobacco Dependence in Humans
Kenneth A. Perkins, Debra Gerlach, Michelle Broge, James E. Grobe, Mark Sanders, Carolyn Fonte, Josh Vender, Christine Cherry and Annette Wilson

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 849-856;
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Effects of Chronic Ethanol Intake and Its Withdrawal on the Expression and Phosphorylation of the CREB Gene Transcription Factor in Rat Cortex
Subhash C. Pandey, Adip Roy and Navdha Mittal

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 857-868;
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Locomotor Effects of Acute and Repeated Threshold Doses of Amphetamine and Methylphenidate: Relative Roles of Dopamine and Norepinephrine
Ronald Kuczenski and David S. Segal

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 876-883;
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Pharmacological Characterization of Locomotor Sensitization Induced by Chronic Phencyclidine Administration
Melissa Phillips, Cheng Wang and Kenneth M. Johnson

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 905-913;
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Fipronil Modulation of γ-Aminobutyric Acid_AReceptors in Rat Dorsal Root Ganglion Neurons
Tomoko Ikeda, Xilong Zhao, Keiichi Nagata, Yoshiaki Kono, Toshio Shono, Jay Z. Yeh and Toshio Narahashi

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 914-921;
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Antinociceptive Effects of δ-Opioid Agonists in Rhesus Monkeys: Effects on Chemically Induced Thermal Hypersensitivity
Michael R. Brandt, M. Scott Furness, Nancy K. Mello, Kenner C. Rice and S. Stevens Negus

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 939-946;
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Modifications of the Serotonergic System in Mice Lacking Serotonin Transporters: An in Vivo Electrophysiological Study
Gabriella Gobbi, Dennis L. Murphy, Klaus-Peter Lesch and Pierre Blier

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 987-995;
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Novel Pyrazole Cannabinoids: Insights into CB₁Receptor Recognition and Activation
Jenny L. Wiley, Renée G. Jefferson, Mark C. Grier, Anu Mahadevan, Raj K. Razdan and Billy R. Martin

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1013-1022;
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Lobeline Inhibits the Neurochemical and Behavioral Effects of Amphetamine
Dennis K. Miller, Peter A. Crooks, Lihong Teng, Jeffrey M. Witkin, Patrik Munzar, Steven R. Goldberg, Jane B. Acri and Linda P. Dwoskin

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1023-1034;
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Coexpression of P2X₃ and P2X₂ Receptor Subunits in Varying Amounts Generates Heterogeneous Populations of P2X Receptors That Evoke a Spectrum of Agonist Responses Comparable to That Seen in Sensory Neurons
Min Liu, Brian F. King, Philip M. Dunn, Weifang Rong, Andrea Townsend-Nicholson and Geoffrey Burnstock

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1043-1050;
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Selective Dopamine Receptor Stimulation Differentially Affects [³H]Arachidonic Acid Incorporation, a Surrogate Marker for Phospholipase A₂-Mediated Neurotransmitter Signal Transduction, in a Rodent Model of Parkinson's Disease
Takanori Hayakawa, Michael C. J. Chang, Stanley I. Rapoport and Nathan M. Appel

Journal of Pharmacology and Experimental Therapeutics March 2001, 296 (3) 1074-1084;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

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