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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2001; Volume 296,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    The Biochemical and Neurologic Basis for the Treatment of Male Erectile Dysfunction
    Robert B. Moreland, Gin Hsieh, Masaki Nakane and Jorge D. Brioni
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 225-234;

CELLULAR AND MOLECULAR

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    Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates
    James E. Dunford, Keith Thompson, Fraser P. Coxon, Steven P. Luckman, Frederick M. Hahn, C. Dale Poulter, Frank H. Ebetino and Michael J. Rogers
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 235-242;
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    The Binding-Site Crevice of the D4 Dopamine Receptor Is Coupled to Three Distinct Sites of Allosteric Modulation
    John A. Schetz and David R. Sibley
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 359-363;
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    Regulation of Ornithine Decarboxylase Activity and Polyamine Transport by Agmatine in Rat Pulmonary Artery Endothelial Cells
    Pavel Babál, Mykhaylo Ruchko, Clayton C. Campbell, Susan P. Gilmour, John L. Mitchell, Jack W. Olson and Mark N. Gillespie
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 372-377;
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    Differential Sensitivity of Kv1.4, Kv1.2, and Their Tandem Channel to Acidic pH: Involvement of a Histidine Residue in High Sensitivity to Acidic pH
    Kuniaki Ishii, Kazuo Nunoki, Toshio Yamagishi, Hitoshi Okada and Norio Taira
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 405-411;
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    In Vitro and in Vivo Pharmacological Characterization of JTE-907, a Novel Selective Ligand for Cannabinoid CB2 Receptor
    Hiroyuki Iwamura, Hidekazu Suzuki, Yoshifumi Ueda, Tetsudo Kaya and Takashi Inaba
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 420-425;
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    The Thromboxane A2 Receptor Activates Mitogen-Activated Protein Kinase via Protein Kinase C-Dependent Gi Coupling and Src-Dependent Phosphorylation of the Epidermal Growth Factor Receptor
    Yunling Gao, Shaoqing Tang, Sharon Zhou and J. Anthony Ware
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 426-433;
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    A Common Mechanism for Cystic Fibrosis Transmembrane Conductance Regulator Protein Activation by Genistein and Benzimidazolone Analogs
    Layla Al-Nakkash, Shenghui Hu, Min Li and Tzyh-Chang Hwang
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 464-472;
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    Regulation of Thromboxane Receptor (TP) Phosphorylation by Protein Phosphatase 1 (PP1) and PP2A
    Robert F. Spurney
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 592-599;

TOXICOLOGY

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    Biochemical and Functional Characteristics of Cultured Renal Epithelial Cells from Uninephrectomized Rats: Factors Influencing Nephrotoxicity
    Lawrence H. Lash, David A. Putt and Rudolfs K. Zalups
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 243-251;
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    Metabolic Capabilities of CYP2F2 with Various Pulmonary Toxicants and Its Relative Abundance in Mouse Lung Subcompartments
    Michael A. Shultz, Dexter Morin, Ai-Min Chang and Alan Buckpitt
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 510-519;

CARDIOVASCULAR

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    Evidence for Inducible Nitric-Oxide Synthase Expression and Activity in Vascular Smooth Muscle of Streptozotocin-Diabetic Rats
    Andrea L. Bardell and Kathleen M. MacLeod
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 252-259;
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    Regional Differences in Anandamide- and Methanandamide-Induced Membrane Potential Changes in Rat Mesenteric Arteries
    Bert Vanheel and Johan Van de Voorde
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 322-328;
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    Effects of Salt Intake and Angiotensin II on Vascular Reactivity to Endothelin-1
    Jennifer R. Ballew, Stephanie W. Watts and Gregory D. Fink
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 345-350;
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    Signaling Mechanisms for the Selective Vasoconstrictor Effect of Norbormide on the Rat Small Arteries
    S. Bova, L. Trevisi, L. Cima, S. Luciani, V. Golovina and G. Cargnelli
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 458-463;
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    Vascular Endothelial Growth Factor-Mediated Endothelium-Dependent Relaxation Is Blunted in Spontaneously Hypertensive Rats
    Ming-Hui Liu, Hong-Kui Jin, H. Storm Floten, Qin Yang, Anthony P. C. Yim, Anthony Furnary, Thomas F. Zioncheck, Stuart Bunting and Guo-Wei He
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 473-477;
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    Differential Localization of P2 Receptor Subtypes in Mesenteric Arteries and Veins of Normotensive and Hypertensive Rats
    James J. Galligan, Margaret C. Hess, Sara B. Miller and Gregory D. Fink
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 478-485;
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    A Novel Synthetic Inhibitor of Factor Xa Decreases Early Reocclusion and Improves 24-h Patency after Coronary Fibrinolysis in Dogs
    Dana R. Abendschein, Pamela K. Baum, Peter Verhallen, Paul R. Eisenberg, Mark E. Sullivan and David R. Light
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 567-572;
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    Effects of Bupivacaine and a Novel Local Anesthetic, IQB-9302, on Human Cardiac K+ Channels
    Teresa González, Mónica Longobardo, Ricardo Caballero, Eva Delpón, Juan Tamargo and Carmen Valenzuela
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 573-583;
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    Differential Activation of Extracellular Signal Regulated Kinase Isoforms in Preconditioning and Opioid-Induced Cardioprotection
    Ryan M. Fryer, Phillip F. Pratt, Anna K. Hsu and Garrett J. Gross
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 642-649;

NEUROPHARMACOLOGY

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    Evidence of a Functional α7-Neuronal Nicotinic Receptor Subtype Located on Motoneurons of the Dorsal Motor Nucleus of the Vagus
    Manuel Ferreira, Steven N. Ebert, David C. Perry, Robert P. Yasuda, Chandra M. Baker, Martha I. Dávila-García, Kenneth J. Kellar and Richard A. Gillis
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 260-269;
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    Gabapentin Antinociception in Mice with Acute Herpetic Pain Induced by Herpes Simplex Virus Infection
    Ichiro Takasaki, Tsugunobu Andoh, Hiroshi Nojima, Kimiyasu Shiraki and Yasushi Kuraishi
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 270-275;
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    Effective Plasma Concentration of a Novel Na+/Ca2+ Channel Blocker NS-7 for Its Cerebroprotective Actions in Rats with a Transient Middle Cerebral Artery Occlusion
    Yasuaki Aoki, Masaru Tamura, Yoshinori Itoh, Toshie Seto, Kiyoko Nonaka, Hideya Mukai and Yojiro Ukai
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 306-311;
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    SB 239063, a Second-Generation p38 Mitogen-Activated Protein Kinase Inhibitor, Reduces Brain Injury and Neurological Deficits in Cerebral Focal Ischemia
    F. C. Barone, E. A. Irving, A. M. Ray, J. C. Lee, S. Kassis, S. Kumar, A. M. Badger, R. F. White, M. J. McVey, J. J. Legos, J. A. Erhardt, A. H. Nelson, E. H. Ohlstein, A. J. Hunter, K. Ward, B. R. Smith, J. L. Adams and A. A. Parsons
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 312-321;
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    Dinapsoline: Characterization of a D1 Dopamine Receptor Agonist in a Rat Model of Parkinson's Disease
    Amit G. Gulwadi, Carolyn D. Korpinen, Richard B. Mailman, David E. Nichols, Sing-Yuen Sit and Matthew T. Taber
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 338-344;
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    Drug Interactions with the Dopamine Transporter in Cryopreserved Human Caudate
    Amy J. Eshleman, Katherine Wolfrum, Deborah C. Mash, Kevin Christensen and Aaron Janowsky
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 442-449;
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    Intravenous Nicotine and Caffeine: Subjective and Physiological Effects in Cocaine Abusers
    Bridgette E. Garrett and Roland R. Griffiths
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 486-494;
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    Long-Term Changes in Basal Ganglia Function after a Neurotoxic Regimen of Methamphetamine
    David E. Chapman, Glen R. Hanson, Raymond P. Kesner and Kristen A. Keefe
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 520-527;
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    Pharmacokinetic and Pharmacodynamic Evaluations of a Potent Analgesic, Dihydroetorphine, in Hairless Rat
    Satoshi Ohmori, Teruaki Hayashi, Masami Kawase, Setsuo Saito and Yasunori Morimoto
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 528-536;
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    Bradykinin Modulation of Tumor Vasculature: I. Activation of B2 Receptors Increases Delivery of Chemotherapeutic Agents into Solid Peripheral Tumors, Enhancing Their Efficacy
    Dwaine F. Emerich, Pamela Snodgrass, Reginald L. Dean, Denise Lafreniere, Mary Agostino, Tania Wiens, Hua Xiong, Brant Hasler, Joanne Marsh, Melissa Pink, Byong Su Kim and Raymond T. Bartus
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 623-631;
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    Bradykinin Modulation of Tumor Vasculature: II. Activation of Nitric Oxide and Phospholipase A2/Prostaglandin Signaling Pathways Synergistically Modifies Vascular Physiology and Morphology to Enhance Delivery of Chemotherapeutic Agents to Tumors
    Dwaine F. Emerich, Reginald L. Dean, Pamela Snodgrass, Denise Lafreniere, Mary Agostino, Tania Wiens, Hua Xiong, Brant Hasler, Joanne Marsh, Melissa Pink, Byong Su Kim, Brigido Perdomo and Raymond T. Bartus
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 632-641;
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    Pharmacological Properties of the Potent Epileptogenic Amino Acid Dysiherbaine, a Novel Glutamate Receptor Agonist Isolated from the Marine Sponge Dysidea herbacea
    Ryuichi Sakai, Geoffrey T. Swanson, Keiko Shimamoto, Tim Green, Anis Contractor, Andrea Ghetti, Yoshiko Tamura-Horikawa, Chie Oiwa and Hisao Kamiya
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 650-658;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Apoptotic Events in a Human Ovarian Cancer Cell Line Exposed to Anthracyclines
    Daniela Bellarosa, Alessandra Ciucci, Angela Bullo, Federica Nardelli, Stefano Manzini, Carlo Alberto Maggi and Cristina Goso
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 276-283;
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    Antimitotic Actions of a Novel Analog of the Fungal Metabolite Palmarumycin CP1
    John S. Lazo, Kenji Tamura, Andreas Vogt, Jae-Kyu Jung, Sonia Rodriguez, Raghavan Balachandran, Billy W. Day and Peter Wipf
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 364-371;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Trimellitic Anhydride-Induced Allergic Response in the Guinea Pig Lung Involves Antibody-Dependent and -Independent Complement System Activation
    Christen P. Larsen, Ronald R. Regal and Jean F. Regal
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 284-292;
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    Intestinal Inflammation Enhances the Inhibitory Effects of Opioids on Intestinal Permeability in Mice
    Lluı́s Valle, Olga Pol and Margarita M. Puig
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 378-387;
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    RETRACTION: Pre- or Post-Ischemic Treatment with a Novel Na+/Ca2+ Exchange Inhibitor, KB-R7943, Shows Renal Protective Effects in Rats with Ischemic Acute Renal Failure
    Junji Yamashita, Makoto Itoh, Toshihiko Kuro, Yutaka Kobayashi, Masaya Ogata, Masanori Takaoka and Yasuo Matsumura
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 412-419;
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    Effects of Isoprostanes and Prostanoids on Porcine Small Intestine
    Martin Andreas Unmack, Patangi K. Rangachari and Erik Skadhauge
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 434-441;
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    Benzimidazolone Activators of Chloride Secretion: Potential Therapeutics for Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
    Sangeeta Singh, Colin A. Syme, Ashvani K. Singh, Daniel C. Devor and Robert J. Bridges
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 600-611;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Synthesis of 5-Oxo-6,8,11,14-eicosatetraenoic Acid and Identification of Novel ω-Oxidized Metabolites in the Mouse Macrophage
    John M. Hevko, Rebecca C. Bowers and Robert C. Murphy
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 293-305;
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    Modulation of P450 CYP3A4-Dependent Metabolism by P-glycoprotein: Implications for P450 Phenotyping
    Jens M. Baron, Lay Beng Goh, Denggao Yao, C. Roland Wolf and Thomas Friedberg
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 351-358;
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    Pharmacokinetics and Pharmacodynamics of an Antisense Phosphorothioate Oligonucleotide Targeting Fas mRNA in Mice
    Rosie Z. Yu, Hong Zhang, Richard S. Geary, Mark Graham, Lilit Masarjian, Kristina Lemonidis, Rosanne Crooke, Nicholas M. Dean and Arthur A. Levin
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 388-395;
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    Characterization of a Novel Cationic Drug Transporter in Human Retinal Pigment Epithelial Cells
    Yong-Hae Han, Douglas H. Sweet, Dan-Ning Hu and John B. Pritchard
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 450-457;
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    Human CYP1B1 and Anticancer Agent Metabolism: Mechanism for Tumor-Specific Drug Inactivation?
    Bertrand Rochat, Janine M. Morsman, Graeme I. Murray, William D. Figg and Howard L. McLeod
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 537-541;
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    Molecular Cloning and Regulation of Expression of Two Novel Mouse CYP4F Genes: Expression in Peroxisome Proliferator-Activated Receptor α-Deficient Mice upon Lipopolysaccharide and Clofibrate Challenges
    Xiaoming Cui, Hidenori Kawashima, Thomas B. Barclay, Jeffrey M. Peters, Frank J. Gonzalez, Edward T. Morgan and Henry W. Strobel
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 542-550;
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    Pluronic P85 Enhances the Delivery of Digoxin to the Brain: In Vitro and in Vivo Studies
    Elena V. Batrakova, Donald W. Miller, Shu Li, Valery Yu Alakhov, Alexander V. Kabanov and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 551-557;
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    Kinetic Profiling of P-glycoprotein-Mediated Drug Efflux in Rat and Human Intestinal Epithelia
    R. H. Stephens, C. A. O'Neill, A. Warhurst, G. L. Carlson, M. Rowland and G. Warhurst
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 584-591;
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    Kinetics of Monochloroacetic Acid in Adult Male Rats after Intravenous Injection of a Subtoxic and a Toxic Dose
    Shakil A. Saghir, Kristian Fried and Karl K. Rozman
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 612-622;

ENDOCRINE AND REPRODUCTIVE

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    Assessment of the Effects of Metabolism on the Estrogenic Activity of Xenoestrogens: A Two-Stage Approach Coupling Human Liver Microsomes and a Yeast Estrogenicity Assay
    Robert Elsby, James L. Maggs, John Ashby, David Paton, John P. Sumpter and B. Kevin Park
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 329-337;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Pharmacokinetics and Immunological Effects of Exogenously Administered Recombinant Human B Lymphocyte Stimulator (BLyS) in Mice
    Tom J. Parry, Todd A. Riccobene, Steven J. Strawn, Rita Williams, Rami Daoud, Jeffrey Carrell, Svetlana Sosnovtseva, Renée C. Miceli, Carol M. Poortman, Les Sekut, Yuling Li, James Fikes and Cynthia Sung
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 396-404;
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    Anti-Inflammatory Effects of ABT-702, a Novel Non-Nucleoside Adenosine Kinase Inhibitor, in Rat Adjuvant Arthritis
    David L. Boyle, Elizabeth A. Kowaluk, Michael F. Jarvis, Chih-Hung Lee, Shripad S. Bhagwat, Michael Williams and Gary S. Firestein
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 495-500;
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    Effects of A-134974, a Novel Adenosine Kinase Inhibitor, on Carrageenan-Induced Inflammatory Hyperalgesia and Locomotor Activity in Rats: Evaluation of the Sites of Action
    Steve McGaraughty, Katharine L. Chu, Carol T. Wismer, Joe Mikusa, Chang Z. Zhu, Marlon Cowart, Elizabeth A. Kowaluk and Michael F. Jarvis
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 501-509;
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    Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2
    D. Riendeau, M. D. Percival, C. Brideau, S. Charleson, D. Dubé, D. Ethier, J.-P. Falgueyret, R. W. Friesen, R. Gordon, G. Greig, J. Guay, J. Mancini, M. Ouellet, E. Wong, L. Xu, S. Boyce, D. Visco, Y. Girard, P. Prasit, R. Zamboni, I. W. Rodger, M. Gresser, A. W. Ford-Hutchinson, R. N. Young and C.-C. Chan
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 558-566;

ASPET MEETING REPORT

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    Glutamate 2000: Old Dog, New Tricks
    Robert Schwarcz
    Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 659-667;
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Journal of Pharmacology and Experimental Therapeutics: 296 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 296, Issue 2
1 Feb 2001
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  • PERSPECTIVES IN PHARMACOLOGY
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  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • ENDOCRINE AND REPRODUCTIVE
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • ASPET MEETING REPORT
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