Journal of Pharmacology and Experimental Therapeutics: 296 (1)

January 01, 2001; Volume 296,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Cellular Thiols and Reactive Oxygen Species in Drug-Induced Apoptosis
Warren Davis, Ze'ev Ronai and Kenneth D. Tew

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 1-6;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Modulation of Intestinal Permeability by Nitric Oxide Donors: Implications in Intestinal Delivery of Poorly Absorbable Drugs
Akira Yamamoto, Hiroyuki Tatsumi, Masato Maruyama, Tomomi Uchiyama, Naoki Okada and Takuya Fujita

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 84-90;
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Hepatic Uptake of Synthetic Chlorogenic Acid Derivatives by the Organic Anion Transport Proteins
Dietmar Schwab, Andreas W. Herling, Horst Hemmerle, Gerrit Schubert, Bruno Hagenbuch and Hans-Joerg Burger

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 91-98;
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Scopolamine Bioavailability in Combined Oral and Transdermal Delivery
Zohar Nachum, Baruch Shahal, Avi Shupak, Orna Spitzer, Adi Gonen, Itzchak Beiran, Haim Lavon, Mirit Eynan, Shlomit Dachir and Aharon Levy

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 121-123;
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Enhanced Delivery of Doxorubicin into the Brain via a Peptide-Vector-Mediated Strategy: Saturation Kinetics and Specificity
Christophe Rousselle, Maria Smirnova, Philippe Clair, Jeanne-Marie Lefauconnier, Alain Chavanieu, Bernard Calas, Jean-Michel Scherrmann and Jamal Temsamani

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 124-131;
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A Novel Zidovudine Uptake System in Microglia
MeeRa Hong, Lyanne Schlichter and Reina Bendayan

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 141-149;
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Interactions between Cimetidine, Nitrofurantoin, and Probenecid Active Transport into Rat Milk
Phillip M. Gerk, Cheah Y. Oo, Earl W. Paxton, Jeffrey A. Moscow and Patrick J. McNamara

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 175-180;
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Effects of Benzyl Isothiocyanate on Rat and Human Cytochromes P450: Identification of Metabolites Formed by P450 2B1
Theunis C. Goosen, Danielle E. Mills and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 198-206;

CARDIOVASCULAR

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A Metabolic Fragment of Bradykinin, Arg-Pro-Pro-Gly-Phe, Protects against the Deleterious Effects of Lipopolysaccharide in Rats
Thomas A. Morinelli, Jerry G. Webb, Ayad A. Jaffa, Philip J. Privitera and Harry S. Margolius

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 71-76;
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Chronic Type IV Phosphodiesterase Inhibition Protects Glomerular Filtration Rate and Renal and Mesenteric Blood Flow in a Zymosan-Induced Model of Multiple Organ Dysfunction Syndrome Treated with Norepinephrine
Neal J. Thomas, Joseph A. Carcillo, William A. Herzer, Zaichuan Mi and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 168-174;

CELLULAR AND MOLECULAR

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Different Binding Modes of Amphibian and Human Corticotropin-Releasing Factor Type 1 and Type 2 Receptors: Evidence for Evolutionary Differences
Frank M. Dautzenberg, Gabrielle Py-Lang, Jacqueline Higelin, Christophe Fischer, Matthew B. Wright and Gerda Huber

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 113-120;
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In Vivo Demonstration of α_1A-Adrenoceptor Subtype Selectivity of KMD-3213 in Rat Tissues
Shizuo Yamada, Takashi Okura and Ryohei Kimura

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 160-167;
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α₂-Adrenoceptor Agonists Inhibit Vitreal Glutamate and Aspartate Accumulation and Preserve Retinal Function after Transient Ischemia
John E. Donello, Edwin U. Padillo, Michelle L. Webster, Larry A. Wheeler and Daniel W. Gil

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 216-223;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Pyrrolo-1,5-benzoxazepines Induce Apoptosis in Chronic Myelogenous Leukemia (CML) Cells by Bypassing the Apoptotic Suppressor Bcr-Abl
Margaret M. Mc Gee, Giuseppe Campiani, Anna Ramunno, Caterina Fattorusso, Vito Nacci, Mark Lawler, D. Clive Williams and Daniela M. Zisterer

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 31-40;

ENDOCRINE AND REPRODUCTIVE

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A New Hypoglycemic Agent, JTT-608, Evokes Protein Kinase A-Mediated Ca²⁺ Signaling in Rat Islet β-Cells: Strict Regulation by Glucose, Link to Insulin Release, and Cooperation with Glucagon-Like Peptide-1(7-36)amide and Pituitary Adenylate Cyclase-Activating Polypeptide
Suzuko Hashiguchi, Toshihiko Yada and Terukatsu Arima

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 22-30;
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Stimulatory Effect of Clofibrate and Gemfibrozil Administration on the Formation of Fatty Acid Esters of Estradiol by Rat Liver Microsomes
Shiyao Xu, Bao Ting Zhu and Allan H. Conney

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 188-197;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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FR167653, a p38 Mitogen-Activated Protein Kinase Inhibitor, Prevents Helicobacter pylori-Induced Gastritis in Mongolian Gerbils
Satoru Takahashi, Yoshihiro Keto, Takuya Fujita, Tomomi Uchiyama and Akira Yamamoto

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 48-56;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Antianalgesic Action of Nociceptin Originating in the Brain Is Mediated by Spinal Prostaglandin E₂ in Mice
Jodie J. Rady, William B. Campbell and James M. Fujimoto

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 7-14;
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Adenosine Kinase Inhibitor GP515 Improves Experimental Colitis in Mice
Britta Siegmund, Florian Rieder, Stefan Albrich, Katrin Wolf, Christoph Bidlingmaier, Gary S. Firestein, David Boyle, Hans-Anton Lehr, Florian Loher, Gunther Hartmann, Stefan Endres and Andreas Eigler

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 99-105;
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S-Adenosyl-l-homocysteine Hydrolase Inhibitor Mediates Immunosuppressive Effects in Vivo: Suppression of Delayed Type Hypersensitivity Ear Swelling and Peptidoglycan Polysaccharide-Induced Arthritis
Yoshihisa Saso, Elaine M. Conner, Bradley R. Teegarden and Chong-Sheng Yuan

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 106-112;
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Luteolin Inhibits an Endotoxin-Stimulated Phosphorylation Cascade and Proinflammatory Cytokine Production in Macrophages
Angeliki Xagorari, Andreas Papapetropoulos, Antonis Mauromatis, Michalis Economou, Theodore Fotsis and Charis Roussos

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 181-187;
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Acute Effects of 3,4-Methylenedioxymethamphetamine Alone and in Combination with Ethanol on the Immune System in Humans
Roberta Pacifici, Piergiorgio Zuccaro, Candido Hernández López, Simona Pichini, Simonetta Di Carlo, Magi Farré, Pere Nolasc Roset, Jordi Ortuño, Jordi Segura and Rafael de La Torre

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 207-215;

NEUROPHARMACOLOGY

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Adrenal Tyrosine Hydroxylase Activity and Gene Expression Are Increased by Intraventricular Administration of Nicotine
Carol R. Sterling and A. William Tank

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 15-21;
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mGluR5 Antagonists 2-Methyl-6-(phenylethynyl)-pyridine and (E)-2-Methyl-6-(2-phenylethenyl)-pyridine Reduce Traumatic Neuronal Injury In Vitro and In Vivo by AntagonizingN-Methyl-d-aspartate Receptors
Vilen A. Movsesyan, Deirdre M. O'Leary, Lei Fan, Weili Bao, Paul G. M. Mullins, Susan M. Knoblach and Alan I. Faden

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 41-47;
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A Peptide Derived from Activity-Dependent Neuroprotective Protein (ADNP) Ameliorates Injury Response in Closed Head Injury in Mice
Liana Beni-Adani, Illana Gozes, Yoram Cohen, Yaniv Assaf, Ruth A. Steingart, Douglas E. Brenneman, Oded Eizenberg, Victoria Trembolver and Esther Shohami

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 57-63;
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Correlation between the Release of the Sympathetic Neurotransmitter ATP and Soluble Nucleotidases from the Guinea Pig Vas Deferens
Svetlana Mihaylova-Todorova, Latchezar D. Todorov and David P. Westfall

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 64-70;
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Ethanol Potentiation of Glycine-Induced Responses in Dissociated Neurons of Rat Ventral Tegmental Area
Jiang Hong Ye, Liang Tao, Jun Ren, Rebecca Schaefer, Kresimir Krnjević, Philip L. Liu, Dolores A. Schiller and Joseph J. McArdle

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 77-83;
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Influence of Gender and Sex Hormones on Nicotine Acute Pharmacological Effects in Mice
M. Imad Damaj

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 132-140;
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Use of Trifluoroperazine Isolates a [³H]Ifenprodil Binding Site in Rat Brain Membranes with the Pharmacology of the Voltage-Independent Ifenprodil Site onN-Methyl-d-aspartate Receptors Containing NR2B Subunits
Linda L. Coughenour and Bridget M. Barr

Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 150-159;

Erratum

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Journal of Pharmacology and Experimental Therapeutics January 2001, 296 (1) 224;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

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