Journal of Pharmacology and Experimental Therapeutics: 295 (3)

December 01, 2000; Volume 295,Issue 3

PERSPECTIVES IN PHARMACOLOGY

You have access
Improving the Treatment of Schizophrenia: Focus on Serotonin (5-HT)_1A Receptors
Mark J. Millan

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 853-861;
You have access
P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential
Geoffrey Burnstock and Michael Williams

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 862-869;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

You have access
Metabolism of Vitamin A and Its Active Metabolite All-trans-retinoic Acid in Small Intestinal Enterocytes
Alfonso Lampen, Silke Meyer, Thomas Arnhold and Heinz Nau

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 979-985;
You have access
Sequence Analyses of CYP2B Genes and Catalytic Profiles for P450s in Qdj:Sprague-Dawley Rats That Lack Response to the Phenobarbital-Mediated Induction of CYP2B2
Hideyuki Yamada, Hiromi Matsunaga, Kazuhiro Tsuji, Sanae Matsumoto, Midori Yamamoto, Yuji Ishii, Curtis J. Omiecinski and Kazuta Oguri

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 986-993;
You have access
Influence of Antipsychotic, Antiemetic, and Ca²⁺Channel Blocker Drugs on the Cellular Accumulation of the Anticancer Drug Daunorubicin: P-glycoprotein Modulation
Safaa Ibrahim, James Peggins, Alan Knapton, Thomas Licht and Adorjan Aszalos

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1276-1283;

CARDIOVASCULAR

You have access
Role of Mitochondrial Cytochrome c in Cocaine-Induced Apoptosis in Coronary Artery Endothelial Cells
Jiale He, Yuhui Xiao, Carlos A. Casiano and Lubo Zhang

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 896-903;
You have access
Pharmacological Profile of Recombinant, Human Activated Protein C (LY203638) in a Canine Model of Coronary Artery Thrombosis
Charles V. Jackson, Blanche D. Bailey and Timothy J. Shetler

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 967-971;
You have access
Pharmacological Characterization of a New Ca²⁺Sensitizer
Paola Dorigo, Maura Floreani, Giovanni Santostasi, Ildebrando Maragno, Daniela Danieli-Betto, Elena Germinario, Sebastiano Marciani Magno, Gianpaolo Primofiore, Anna Maria Marini and Federico Da Settimo

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 994-1004;
You have access
Effects of Carvedilol and Its Analog BM-910228 on Mitochondrial Function and Oxidative Stress
Rui M. V. Abreu, Dario J. S. L. Santos and António J. M. Moreno

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1022-1030;
You have access
Inhibitory Effect of TAS-301, a New Synthesized Constrictive Remodeling Regulator, on Renarrowing after Balloon Overstretch Injury of Porcine Coronary Artery
Eiji Sasaki, Yasutaka Tanahashi, Yasundo Yamasaki, Nobuyuki Oda, Yoshihisa Nozawa, Hiroshi Terakawa, Kazuhisa Miyoshi, Yoshiyuki Muranaka, Hidekazu Miyake and Naosuke Matsuura

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1043-1050;
You have access
Different Effect of the Ca²⁺ Sensitizers EMD 57033 and CGP 48506 on Cross-Bridge Cycling in Human Myocardium
Klara Brixius, Uwe Mehlhorn, Wilhelm Bloch and Robert H. G. Schwinger

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1284-1290;

CELLULAR AND MOLECULAR

You have access
Fibroblast Growth Factor Protects Nitric Oxide-Induced Apoptosis in Neuronal SHSY-5Y Cells
Asavari Wagle and Jai Pal Singh

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 889-895;
You have access
Regulation of c-Jun N-Terminal Kinase by the ORL₁Receptor through Multiple G Proteins
Anthony S. L. Chan and Yung H. Wong

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1094-1100;
You have access
Protein Kinase C Mediates Lipopolysaccharide- and Phorbol-Induced Nitric-Oxide Synthase Activity and Cellular Injury in the Rat Colon
Barry L. Tepperman, Qing Chang and Brian D. Soper

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1249-1257;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

You have access
Roles of Nuclear Factor-κB, p53, and p21/WAF1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis
Anne-Cécile Hellin, Mohamed Bentires-Alj, Myriam Verlaet, Valérie Benoit, Jacques Gielen, Vincent Bours and Marie-Paule Merville

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 870-878;
You have access
Lack of In Vitro Cytotoxicity, Associated to Increased G₂-M Cell Fraction and Inhibition of Matrigel Invasion, May Predict In Vivo-Selective Antimetastasis Activity of Ruthenium Complexes
Sonia Zorzet, Alberta Bergamo, Moreno Cocchietto, Alenka Sorc, Barbara Gava, Enzo Alessio, Elisabetta Iengo and Gianni Sava

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 927-933;

ENDOCRINE AND REPRODUCTIVE

You have access
Antidiuretic Effects of a Nonpeptide Vasopressin V₂-Receptor Agonist, OPC-51803, Administered Orally to Rats
Shigeki Nakamura, Takahiro Hirano, Kenji Tsujimae, Masashi Aoyama, Kazumi Kondo, Yoshitaka Yamamura, Toyoki Mori and Michiaki Tominaga

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1005-1011;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

You have access
Pharmacological and Molecular Characterization of Muscarinic Receptor Subtypes in Human Esophageal Smooth Muscle
Harold G. Preiksaitis, Pawel S. Krysiak, Tom Chrones, Vaishnav Rajgopal and Lisanne G. Laurier

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 879-888;
You have access
Treatment of Allergic Asthma by Targeting Janus Kinase 3-Dependent Leukotriene Synthesis in Mast Cells with 4-(3′,5′-Dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)
Ravi Malaviya, Chun-Lin Chen, Christopher Navara, Rama Malaviya, Xing-Ping Liu, Margaret Keenan, Barbara Waurzyniak and Fatih M. Uckun

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 912-926;
You have access
Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: I. Region-Specific Enzyme Activity
Renee C. Paige, Fred H. Royce, Charles G. Plopper and Alan R. Buckpitt

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 934-941;
You have access
Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: II. Quantitative Histopathology
Renee C. Paige, Viviana Wong and Charles G. Plopper

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 942-950;
You have access
Effect of a Novel Anti-Inflammatory Compound, YM976, on Antigen-Induced Eosinophil Infiltration into the Lungs in Rats, Mice, and Ferrets
Motonori Aoki, Masahiro Fukunaga, Minetake Kitagawa, Kazumi Hayashi, Tatsuaki Morokata, Go Ishikawa, Satoshi Kubo and Toshimitsu Yamada

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1149-1155;

INFLAMMATION AND IMMUNOPHARMACOLOGY

You have access
Modulation of Human Monocyte Activities by Tranilast, SB 252218, a Compound Demonstrating Efficacy in Restenosis
Elizabeth A. Capper, Amy K. Roshak, Brian J. Bolognese, Patricia L. Podolin, Timothy Smith, David L. Dewitt, Karen M. Anderson and Lisa A. Marshall

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1061-1069;
You have access
ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties: I. In Vitro Characterization and Acute Antinociceptive Effects in the Mouse
Michael F. Jarvis, Haixia Yu, Kathy Kohlhaas, Karen Alexander, Chih-Hung Lee, Mequin Jiang, Shripad S. Bhagwat, Michael Williams and Elizabeth A. Kowaluk

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1156-1164;
You have access
ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties. II. In Vivo Characterization in the Rat
Elizabeth A. Kowaluk, Joe Mikusa, Carol T. Wismer, Chang Z. Zhu, Edmund Schweitzer, James J. Lynch, Chih-Hung Lee, Meiqun Jiang, Shripad S. Bhagwat, Arthur Gomtsyan, Jeff McKie, Bryan F. Cox, James Polakowski, Glenn Reinhart, Michael Williams and Michael F. Jarvis

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1165-1174;

NEUROPHARMACOLOGY

You have access
Regulation of the Human Norepinephrine Transporter by Cocaine and Amphetamine
Meng-Yang Zhu, Susan Shamburger, Jing Li and Gregory A. Ordway

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 951-959;
You have access
Tetrapeptide Derivatives of [d-Pen²,d-Pen⁵]-Enkephalin (DPDPE) Lacking an N-Terminal Tyrosine Residue Are Agonists at the μ-Opioid Receptor
Iain J. McFadyen, Katarzyna Sobczyk-Kojiro, Michael J. Schaefer, Jeffrey C. Ho, John R. Omnaas, Henry I. Mosberg and John R. Traynor

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 960-966;
You have access
Insulin Enhancement of Opioid Peptide Transport across the Blood-Brain Barrier and Assessment of Analgesic Effect
Ken A. Witt, Jason D. Huber, Richard D. Egleton and Thomas P. Davis

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 972-978;
You have access
Attenuation of μ-Opioid Tolerance and Cross-Tolerance by the Competitive N-Methyl-d-aspartate Receptor Antagonist LY235959 Is Related to Tolerance and Cross-Tolerance Magnitude
Richard M. Allen and Linda A. Dykstra

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1012-1021;
You have access
Dose- and Time-Dependent Bimodal Effects of κ-Opioid Agonists on Locomotor Activity in Mice
Alexander Kuzmin, Johan Sandin, Lars Terenius and Sven-Ove Ögren

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1031-1042;
You have access
Anticonvulsant and Adverse Effects of Avermectin Analogs in Mice Are Mediated through the γ-Aminobutyric Acid_A Receptor
Gerard R. Dawson, Keith A. Wafford, Alison Smith, George R. Marshall, Peter J. Bayley, James M. Schaeffer, Peter T. Meinke and R. M. McKernan

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1051-1060;
You have access
Opioid Receptor Imaging with Positron Emission Tomography and [¹⁸F]Cyclofoxy in Long-Term, Methadone-Treated Former Heroin Addicts
Mitchel A. Kling, Richard E. Carson, Lisa Borg, Alan Zametkin, John A. Matochik, James Schluger, Peter Herscovitch, Kenner C. Rice, Ann Ho, William C. Eckelman and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1070-1076;
You have access
Methamphetamine-Induced Rapid Decrease in Dopamine Transporter Function: Role of Dopamine and Hyperthermia ,
Ryan R. Metzger, Heather M. Haughey, Diana G. Wilkins, James W. Gibb, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1077-1085;
You have access
Stimulus-Dependent Modulation of [³H]Norepinephrine Release from Rat Neocortical Slices by Gabapentin and Pregabalin
David J. Dooley, Cindy M. Donovan and Thomas A. Pugsley

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1086-1093;
You have access
Changes in the Ambulatory Activity and Discriminative Stimulus Effects of Psychostimulant Drugs in Rats Chronically Exposed to Caffeine: Effect of Caffeine Dose
Maciej Gasior, Maria Jaszyna, Jamie Peters and Steven R. Goldberg

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1101-1111;
You have access
Comparison of [³H]Glyburide Binding with Opiate Analgesia, Tolerance, and Dependence in ICR and Swiss-Webster Mice
Vera C. Campbell, William L. Dewey and Sandra P. Welch

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1112-1119;
You have access
Antidepressant-Like Behavioral Effects Mediated by 5-Hydroxytryptamine_2C Receptors
John F. Cryan and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1120-1126;
You have access
Natural and Artificial Enzymes Against Cocaine. I. Monoclonal Antibody 15A10 and the Reinforcing Effects of Cocaine in Rats ,
Theodore J. Baird, Shi-Xian Deng, Donald W. Landry, Gail Winger and James H. Woods

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1127-1134;
You have access
Supraspinal Antinociceptive Response to [d-Pen^2,5]-Enkephalin (DPDPE) Is Pharmacologically Distinct from That to Other δ-Agonists in the Rat
Graeme L. Fraser, Amynah A. Pradhan, Paul B. S. Clarke and Claes Wahlestedt

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1135-1141;
You have access
Inhibition of Morphine Tolerance Development by a Substance P-Opioid Peptide Chimera
Stacy E. Foran, Daniel B. Carr, Andrzej W. Lipkowski, Iwona Maszczynska, James E. Marchand, Aleksandra Misicka, Martin Beinborn, Alan S. Kopin and Richard M. Kream

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1142-1148;
You have access
Studies to Investigate the Role of 5-HT_2C Receptors on Cocaine- and Food-Maintained Behavior
Andrew J. Grottick, Paul J. Fletcher and Guy A. Higgins

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1183-1191;
You have access
S18616, a Highly Potent, Spiroimidazoline Agonist at α₂-Adrenoceptors: I. Receptor Profile, Antinociceptive and Hypothermic Actions in Comparison with Dexmedetomidine and Clonidine
Mark J. Millan, Anne Dekeyne, Adrian Newman-Tancredi, Didier Cussac, Valérie Audinot, Graeme Milligan, Delphine Duqueyroix, Sylvie Girardon, Jimmy Mullot, Jean A. Boutin, Jean-Paul Nicolas, Anne Renouard-Try, Jean-Michel Lacoste and Alex Cordi

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1192-1205;
You have access
S18616, a Highly Potent Spiroimidazoline Agonist at α₂-Adrenoceptors: II. Influence on Monoaminergic Transmission, Motor Function, and Anxiety in Comparison with Dexmedetomidine and Clonidine
Mark J. Millan, Françoise Lejeune, Alain Gobert, Mauricette Brocco, Agnés Auclair, Catherine Bosc, Jean-Michel Rivet, Jean-Michel Lacoste, Alex Cordi and Anne Dekeyne

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1206-1222;
You have access
Quantitative Autoradiographic Mapping of Rat Brain Dopamine D3 Binding with [¹²⁵I]7-OH-PIPAT: Evidence for the Presence of D3 Receptors on Dopaminergic and Nondopaminergic Cell Bodies and Terminals
Gregg D. Stanwood, Roman P. Artymyshyn, Mei-Ping Kung, Hank F. Kung, Irwin Lucki and Paul McGonigle

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1223-1231;
You have access
Differential Regulation of Dopamine D2 and D3 Receptors by Chronic Drug Treatments
Gregg D. Stanwood, Irwin Lucki and Paul McGonigle

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1232-1240;
You have access
Chronic Treatment with the Neuroactive Steroid Ganaxolone in the Rat Induces Anticonvulsant Tolerance to Diazepam but Not to Itself
Doodipala S. Reddy and Michael A. Rogawski

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1241-1248;
You have access
Alterations in Neuronal γ-Aminobutyric Acid_AReceptor Responsiveness in Genetic Models of Seizure Susceptibility with Different Expression Patterns
Lance R. Molnar, William W. Fleming and David A. Taylor

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1258-1266;
You have access
Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents
Will P. J. M. Spooren, Annick Vassout, Hans C. Neijt, Rainer Kuhn, Fabrizio Gasparini, Silvain Roux, Roger D. Porsolt and Conrad Gentsch

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1267-1275;

TOXICOLOGY

You have access
Protective Effect of S-Nitrosylated α₁-Protease Inhibitor on Hepatic Ischemia-Reperfusion Injury
Norisato Ikebe, Takaaki Akaike, Yoichi Miyamoto, Kazuyuki Hayashida, Jun Yoshitake, Michio Ogawa and Hiroshi Maeda

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 904-911;
You have access
Repression of Activity-Dependent c-fos and Brain-Derived Neurotrophic Factor mRNA Expression by Pyrethroid Insecticides Accompanying a Decrease in Ca²⁺ Influx into Neurons
Lisa Imamura, Hiroshi Hasegawa, Kaori Kurashina, Ayako Hamanishi, Akiko Tabuchi and Masaaki Tsuda

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1175-1182;

ASPET MEETING REPORT

You have access
Meeting Report of the ASPET Colloquium: Functional Genomics
Anthony R. Porcari and Ronald J. Shebuski

Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1291-1295;

Main menu

User menu

Search

Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

ASPET MEETING REPORT

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals