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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

December 01, 2000; Volume 295,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Improving the Treatment of Schizophrenia: Focus on Serotonin (5-HT)1A Receptors
    Mark J. Millan
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 853-861;
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    P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential
    Geoffrey Burnstock and Michael Williams
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 862-869;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Metabolism of Vitamin A and Its Active Metabolite All-trans-retinoic Acid in Small Intestinal Enterocytes
    Alfonso Lampen, Silke Meyer, Thomas Arnhold and Heinz Nau
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 979-985;
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    Sequence Analyses of CYP2B Genes and Catalytic Profiles for P450s in Qdj:Sprague-Dawley Rats That Lack Response to the Phenobarbital-Mediated Induction of CYP2B2
    Hideyuki Yamada, Hiromi Matsunaga, Kazuhiro Tsuji, Sanae Matsumoto, Midori Yamamoto, Yuji Ishii, Curtis J. Omiecinski and Kazuta Oguri
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 986-993;
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    Influence of Antipsychotic, Antiemetic, and Ca2+Channel Blocker Drugs on the Cellular Accumulation of the Anticancer Drug Daunorubicin: P-glycoprotein Modulation
    Safaa Ibrahim, James Peggins, Alan Knapton, Thomas Licht and Adorjan Aszalos
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1276-1283;

CARDIOVASCULAR

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    Role of Mitochondrial Cytochrome c in Cocaine-Induced Apoptosis in Coronary Artery Endothelial Cells
    Jiale He, Yuhui Xiao, Carlos A. Casiano and Lubo Zhang
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 896-903;
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    Pharmacological Profile of Recombinant, Human Activated Protein C (LY203638) in a Canine Model of Coronary Artery Thrombosis
    Charles V. Jackson, Blanche D. Bailey and Timothy J. Shetler
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 967-971;
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    Pharmacological Characterization of a New Ca2+Sensitizer
    Paola Dorigo, Maura Floreani, Giovanni Santostasi, Ildebrando Maragno, Daniela Danieli-Betto, Elena Germinario, Sebastiano Marciani Magno, Gianpaolo Primofiore, Anna Maria Marini and Federico Da Settimo
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 994-1004;
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    Effects of Carvedilol and Its Analog BM-910228 on Mitochondrial Function and Oxidative Stress
    Rui M. V. Abreu, Dario J. S. L. Santos and António J. M. Moreno
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1022-1030;
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    Inhibitory Effect of TAS-301, a New Synthesized Constrictive Remodeling Regulator, on Renarrowing after Balloon Overstretch Injury of Porcine Coronary Artery
    Eiji Sasaki, Yasutaka Tanahashi, Yasundo Yamasaki, Nobuyuki Oda, Yoshihisa Nozawa, Hiroshi Terakawa, Kazuhisa Miyoshi, Yoshiyuki Muranaka, Hidekazu Miyake and Naosuke Matsuura
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1043-1050;
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    Different Effect of the Ca2+ Sensitizers EMD 57033 and CGP 48506 on Cross-Bridge Cycling in Human Myocardium
    Klara Brixius, Uwe Mehlhorn, Wilhelm Bloch and Robert H. G. Schwinger
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1284-1290;

CELLULAR AND MOLECULAR

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    Fibroblast Growth Factor Protects Nitric Oxide-Induced Apoptosis in Neuronal SHSY-5Y Cells
    Asavari Wagle and Jai Pal Singh
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 889-895;
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    Regulation of c-Jun N-Terminal Kinase by the ORL1Receptor through Multiple G Proteins
    Anthony S. L. Chan and Yung H. Wong
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1094-1100;
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    Protein Kinase C Mediates Lipopolysaccharide- and Phorbol-Induced Nitric-Oxide Synthase Activity and Cellular Injury in the Rat Colon
    Barry L. Tepperman, Qing Chang and Brian D. Soper
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1249-1257;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Roles of Nuclear Factor-κB, p53, and p21/WAF1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis
    Anne-Cécile Hellin, Mohamed Bentires-Alj, Myriam Verlaet, Valérie Benoit, Jacques Gielen, Vincent Bours and Marie-Paule Merville
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 870-878;
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    Lack of In Vitro Cytotoxicity, Associated to Increased G2-M Cell Fraction and Inhibition of Matrigel Invasion, May Predict In Vivo-Selective Antimetastasis Activity of Ruthenium Complexes
    Sonia Zorzet, Alberta Bergamo, Moreno Cocchietto, Alenka Sorc, Barbara Gava, Enzo Alessio, Elisabetta Iengo and Gianni Sava
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 927-933;

ENDOCRINE AND REPRODUCTIVE

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    Antidiuretic Effects of a Nonpeptide Vasopressin V2-Receptor Agonist, OPC-51803, Administered Orally to Rats
    Shigeki Nakamura, Takahiro Hirano, Kenji Tsujimae, Masashi Aoyama, Kazumi Kondo, Yoshitaka Yamamura, Toyoki Mori and Michiaki Tominaga
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1005-1011;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Pharmacological and Molecular Characterization of Muscarinic Receptor Subtypes in Human Esophageal Smooth Muscle
    Harold G. Preiksaitis, Pawel S. Krysiak, Tom Chrones, Vaishnav Rajgopal and Lisanne G. Laurier
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 879-888;
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    Treatment of Allergic Asthma by Targeting Janus Kinase 3-Dependent Leukotriene Synthesis in Mast Cells with 4-(3′,5′-Dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)
    Ravi Malaviya, Chun-Lin Chen, Christopher Navara, Rama Malaviya, Xing-Ping Liu, Margaret Keenan, Barbara Waurzyniak and Fatih M. Uckun
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 912-926;
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    Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: I. Region-Specific Enzyme Activity
    Renee C. Paige, Fred H. Royce, Charles G. Plopper and Alan R. Buckpitt
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 934-941;
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    Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: II. Quantitative Histopathology
    Renee C. Paige, Viviana Wong and Charles G. Plopper
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 942-950;
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    Effect of a Novel Anti-Inflammatory Compound, YM976, on Antigen-Induced Eosinophil Infiltration into the Lungs in Rats, Mice, and Ferrets
    Motonori Aoki, Masahiro Fukunaga, Minetake Kitagawa, Kazumi Hayashi, Tatsuaki Morokata, Go Ishikawa, Satoshi Kubo and Toshimitsu Yamada
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1149-1155;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Modulation of Human Monocyte Activities by Tranilast, SB 252218, a Compound Demonstrating Efficacy in Restenosis
    Elizabeth A. Capper, Amy K. Roshak, Brian J. Bolognese, Patricia L. Podolin, Timothy Smith, David L. Dewitt, Karen M. Anderson and Lisa A. Marshall
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1061-1069;
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    ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties: I. In Vitro Characterization and Acute Antinociceptive Effects in the Mouse
    Michael F. Jarvis, Haixia Yu, Kathy Kohlhaas, Karen Alexander, Chih-Hung Lee, Mequin Jiang, Shripad S. Bhagwat, Michael Williams and Elizabeth A. Kowaluk
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1156-1164;
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    ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties. II. In Vivo Characterization in the Rat
    Elizabeth A. Kowaluk, Joe Mikusa, Carol T. Wismer, Chang Z. Zhu, Edmund Schweitzer, James J. Lynch, Chih-Hung Lee, Meiqun Jiang, Shripad S. Bhagwat, Arthur Gomtsyan, Jeff McKie, Bryan F. Cox, James Polakowski, Glenn Reinhart, Michael Williams and Michael F. Jarvis
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1165-1174;

NEUROPHARMACOLOGY

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    Regulation of the Human Norepinephrine Transporter by Cocaine and Amphetamine
    Meng-Yang Zhu, Susan Shamburger, Jing Li and Gregory A. Ordway
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 951-959;
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    Tetrapeptide Derivatives of [d-Pen2,d-Pen5]-Enkephalin (DPDPE) Lacking an N-Terminal Tyrosine Residue Are Agonists at the μ-Opioid Receptor
    Iain J. McFadyen, Katarzyna Sobczyk-Kojiro, Michael J. Schaefer, Jeffrey C. Ho, John R. Omnaas, Henry I. Mosberg and John R. Traynor
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 960-966;
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    Insulin Enhancement of Opioid Peptide Transport across the Blood-Brain Barrier and Assessment of Analgesic Effect
    Ken A. Witt, Jason D. Huber, Richard D. Egleton and Thomas P. Davis
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 972-978;
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    Attenuation of μ-Opioid Tolerance and Cross-Tolerance by the Competitive N-Methyl-d-aspartate Receptor Antagonist LY235959 Is Related to Tolerance and Cross-Tolerance Magnitude
    Richard M. Allen and Linda A. Dykstra
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1012-1021;
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    Dose- and Time-Dependent Bimodal Effects of κ-Opioid Agonists on Locomotor Activity in Mice
    Alexander Kuzmin, Johan Sandin, Lars Terenius and Sven-Ove Ögren
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1031-1042;
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    Anticonvulsant and Adverse Effects of Avermectin Analogs in Mice Are Mediated through the γ-Aminobutyric AcidA Receptor
    Gerard R. Dawson, Keith A. Wafford, Alison Smith, George R. Marshall, Peter J. Bayley, James M. Schaeffer, Peter T. Meinke and R. M. McKernan
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1051-1060;
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    Opioid Receptor Imaging with Positron Emission Tomography and [18F]Cyclofoxy in Long-Term, Methadone-Treated Former Heroin Addicts
    Mitchel A. Kling, Richard E. Carson, Lisa Borg, Alan Zametkin, John A. Matochik, James Schluger, Peter Herscovitch, Kenner C. Rice, Ann Ho, William C. Eckelman and Mary Jeanne Kreek
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1070-1076;
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    Methamphetamine-Induced Rapid Decrease in Dopamine Transporter Function: Role of Dopamine and Hyperthermia ,
    Ryan R. Metzger, Heather M. Haughey, Diana G. Wilkins, James W. Gibb, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1077-1085;
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    Stimulus-Dependent Modulation of [3H]Norepinephrine Release from Rat Neocortical Slices by Gabapentin and Pregabalin
    David J. Dooley, Cindy M. Donovan and Thomas A. Pugsley
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1086-1093;
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    Changes in the Ambulatory Activity and Discriminative Stimulus Effects of Psychostimulant Drugs in Rats Chronically Exposed to Caffeine: Effect of Caffeine Dose
    Maciej Gasior, Maria Jaszyna, Jamie Peters and Steven R. Goldberg
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1101-1111;
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    Comparison of [3H]Glyburide Binding with Opiate Analgesia, Tolerance, and Dependence in ICR and Swiss-Webster Mice
    Vera C. Campbell, William L. Dewey and Sandra P. Welch
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1112-1119;
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    Antidepressant-Like Behavioral Effects Mediated by 5-Hydroxytryptamine2C Receptors
    John F. Cryan and Irwin Lucki
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1120-1126;
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    Natural and Artificial Enzymes Against Cocaine. I. Monoclonal Antibody 15A10 and the Reinforcing Effects of Cocaine in Rats ,
    Theodore J. Baird, Shi-Xian Deng, Donald W. Landry, Gail Winger and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1127-1134;
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    Supraspinal Antinociceptive Response to [d-Pen2,5]-Enkephalin (DPDPE) Is Pharmacologically Distinct from That to Other δ-Agonists in the Rat
    Graeme L. Fraser, Amynah A. Pradhan, Paul B. S. Clarke and Claes Wahlestedt
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1135-1141;
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    Inhibition of Morphine Tolerance Development by a Substance P-Opioid Peptide Chimera
    Stacy E. Foran, Daniel B. Carr, Andrzej W. Lipkowski, Iwona Maszczynska, James E. Marchand, Aleksandra Misicka, Martin Beinborn, Alan S. Kopin and Richard M. Kream
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1142-1148;
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    Studies to Investigate the Role of 5-HT2C Receptors on Cocaine- and Food-Maintained Behavior
    Andrew J. Grottick, Paul J. Fletcher and Guy A. Higgins
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1183-1191;
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    S18616, a Highly Potent, Spiroimidazoline Agonist at α2-Adrenoceptors: I. Receptor Profile, Antinociceptive and Hypothermic Actions in Comparison with Dexmedetomidine and Clonidine
    Mark J. Millan, Anne Dekeyne, Adrian Newman-Tancredi, Didier Cussac, Valérie Audinot, Graeme Milligan, Delphine Duqueyroix, Sylvie Girardon, Jimmy Mullot, Jean A. Boutin, Jean-Paul Nicolas, Anne Renouard-Try, Jean-Michel Lacoste and Alex Cordi
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1192-1205;
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    S18616, a Highly Potent Spiroimidazoline Agonist at α2-Adrenoceptors: II. Influence on Monoaminergic Transmission, Motor Function, and Anxiety in Comparison with Dexmedetomidine and Clonidine
    Mark J. Millan, Françoise Lejeune, Alain Gobert, Mauricette Brocco, Agnés Auclair, Catherine Bosc, Jean-Michel Rivet, Jean-Michel Lacoste, Alex Cordi and Anne Dekeyne
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1206-1222;
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    Quantitative Autoradiographic Mapping of Rat Brain Dopamine D3 Binding with [125I]7-OH-PIPAT: Evidence for the Presence of D3 Receptors on Dopaminergic and Nondopaminergic Cell Bodies and Terminals
    Gregg D. Stanwood, Roman P. Artymyshyn, Mei-Ping Kung, Hank F. Kung, Irwin Lucki and Paul McGonigle
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1223-1231;
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    Differential Regulation of Dopamine D2 and D3 Receptors by Chronic Drug Treatments
    Gregg D. Stanwood, Irwin Lucki and Paul McGonigle
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1232-1240;
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    Chronic Treatment with the Neuroactive Steroid Ganaxolone in the Rat Induces Anticonvulsant Tolerance to Diazepam but Not to Itself
    Doodipala S. Reddy and Michael A. Rogawski
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1241-1248;
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    Alterations in Neuronal γ-Aminobutyric AcidAReceptor Responsiveness in Genetic Models of Seizure Susceptibility with Different Expression Patterns
    Lance R. Molnar, William W. Fleming and David A. Taylor
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1258-1266;
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    Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents
    Will P. J. M. Spooren, Annick Vassout, Hans C. Neijt, Rainer Kuhn, Fabrizio Gasparini, Silvain Roux, Roger D. Porsolt and Conrad Gentsch
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1267-1275;

TOXICOLOGY

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    Protective Effect of S-Nitrosylated α1-Protease Inhibitor on Hepatic Ischemia-Reperfusion Injury
    Norisato Ikebe, Takaaki Akaike, Yoichi Miyamoto, Kazuyuki Hayashida, Jun Yoshitake, Michio Ogawa and Hiroshi Maeda
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 904-911;
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    Repression of Activity-Dependent c-fos and Brain-Derived Neurotrophic Factor mRNA Expression by Pyrethroid Insecticides Accompanying a Decrease in Ca2+ Influx into Neurons
    Lisa Imamura, Hiroshi Hasegawa, Kaori Kurashina, Ayako Hamanishi, Akiko Tabuchi and Masaaki Tsuda
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1175-1182;

ASPET MEETING REPORT

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    Meeting Report of the ASPET Colloquium: Functional Genomics
    Anthony R. Porcari and Ronald J. Shebuski
    Journal of Pharmacology and Experimental Therapeutics December 2000, 295 (3) 1291-1295;
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Journal of Pharmacology and Experimental Therapeutics: 295 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 295, Issue 3
1 Dec 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • ASPET MEETING REPORT
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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