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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2000; Volume 295,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Molecular Mechanisms of Selective Estrogen Receptor Modulator (SERM) Action
    Martin Dutertre and Carolyn L. Smith
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 431-437;
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    Multiple Central Nervous System Targets for Eliciting Beneficial Effects on Memory and Cognition
    Jerry J. Buccafusco and Alvin V. Terry
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 438-446;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Three-Dimensional Quantitative Structure Activity Relationship Computational Approaches for Prediction of Human In Vitro Intrinsic Clearance
    Sean Ekins and R. Scott Obach
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 463-473;
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    Altered Hepatobiliary Disposition of Acetaminophen Glucuronide in Isolated Perfused Livers from Multidrug Resistance-Associated Protein 2-Deficient TR− Rats
    Hao Xiong, Kenneth C. Turner, E. Stacy Ward, Peter L. M. Jansen and Kim L. R. Brouwer
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 512-518;
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    Tasosartan, Enoltasosartan, and Angiotensin II Receptor Blockade: The Confounding Role of Protein Binding
    Marc P. Maillard, Julien Rossat, Hans-R. Brunner and Michel Burnier
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 649-654;
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    Chronic Intragastric Infusion of Ethanol-Containing Diets Induces CYP3A9 While Decreasing CYP3A2 in Male Rats ,
    J. Craig Rowlands, Huamin Wang, Reza Hakkak, Martin J. J. Ronis, Henry W. Strobel and Thomas M. Badger
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 747-752;
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    Scaling Drug Biotransformation Data from cDNA-Expressed Cytochrome P-450 to Human Liver: A Comparison of Relative Activity Factors and Human Liver Abundance in Studies of Mirtazapine Metabolism
    Elke Störmer, Lisa L. von Moltke and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 793-801;
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    Right Heart Failure Impairs Hepatic Elimination of p-Nitrophenol without Inducing Changes in Content or Latency of Hepatic UDP-Glucuronosyltransferases
    Connie Y. Ng, Hany Ghabrial, Denis J. Morgan, Michael S. Ching, Richard A. Smallwood and Peter W. Angus
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 830-835;
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    Evaluation of Route of Input on the Hepatic Disposition of Diazepam
    Selma Sahin and Malcolm Rowland
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 836-843;
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    5-Hydroxylation of Omeprazole by Human Liver Microsomal Fractions from Chinese Populations Related to CYP2C19 Gene Dose and Individual Ethnicity
    Yan Shu, Lian-Sheng Wang, Zhen-Hua Xu, Nan He, Wei-Min Xiao, Wei Wang, Song-Lin Huang and Hong-Hao Zhou
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 844-851;

CARDIOVASCULAR

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    Enhanced EndothelinA Receptor-Mediated Calcium Mobilization and Contraction in Organ Cultured Porcine Coronary Arteries
    Brent J. F. Hill, Laxmansa C. Katwa, Brian R. Wamhoff and Michael Sturek
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 484-491;
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    Prevention of Arterial Thrombosis by Intravenously Administered Platelet P2T Receptor Antagonist AR-C69931MX in a Canine Model
    Jinbao Huang, Edward M. Driscoll, Michael L. Gonzales, Andrew M. Park and Benedict R. Lucchesi
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 492-499;
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    Tamoxifen Acutely Relaxes Coronary Arteries by an Endothelium-, Nitric Oxide-, and Estrogen Receptor-Dependent Mechanism
    Gemma A. Figtree, Carolyn M. Webb and Peter Collins
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 519-523;
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    A Pyrroline Derivative of Mexiletine Offers Marked Protection against Ischemia/Reperfusion-Induced Myocardial Contractile Dysfunction
    Haiquan Li, Kai Y. Xu, Lan Zhou, Tamas Kalai, Jay L. Zweier, Kalman Hideg and Periannan Kuppusamy
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 563-571;
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    Endothelin Receptor Antagonism Does Not Prevent the Development of In Vivo Glyceryl Trinitrate Tolerance in the Rat
    Jodan D. Ratz, Amy B. Fraser, Karen J. Rees-Milton, Michael A. Adams and Brian M. Bennett
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 578-585;
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    Rationale for the Combination of PGE1 andS-Nitroso-glutathione to Induce Relaxation of Human Penile Smooth Muscle
    Javier Angulo, Pedro Cuevas, Ignacio Moncada, Antonio Martín-Morales, Antonio Allona, Argentina Fernández, Sonia Gabancho, Peter Ney and Iñigo Sáenz de Tejada
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 586-593;
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    Modulation of Nitric-Oxide Synthase by Nicotine
    Britt H. Tonnessen, Sandra R. Severson, Richard D. Hurt and Virginia M. Miller
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 601-606;
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    Interactions of the 5-Hydroxytryptamine 3 Antagonist Class of Antiemetic Drugs with Human Cardiac Ion Channels
    Yuri A. Kuryshev, Arthur M. Brown, Lin Wang, Claude R. Benedict and David Rampe
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 614-620;
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    Protective Effect of Omapatrilat, a Vasopeptidase Inhibitor, on the Metabolism of Bradykinin in Normal and Failing Human Hearts
    Charles Blais, David Fortin, Jean-Lucien Rouleau, Giuseppe Molinaro and Albert Adam
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 621-626;
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    An α1A/α1L-Adrenoceptor Mediates Contraction of Canine Subcutaneous Resistance Arteries
    Sally Anne Argyle and John Christie McGrath
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 627-633;
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    Endogenous Bradykinin and the Renin and Pressor Responses to Furosemide in Humans
    Laine J. Murphey, Sandeep Kumar and Nancy J. Brown
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 644-648;
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    Glycoprotein IIb/IIIa Receptor Number and Occupancy during Chronic Administration of an Oral Antagonist
    Martin J. Quinn, Dermot Cox, J. Brendan Foley and Desmond J. Fitzgerald
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 670-676;
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    Losartan Improves Recovery of Contraction and Inhibits Transient Inward Current in a Cellular Model of Cardiac Ischemia and Reperfusion
    William E. Louch, Gregory R. Ferrier and Susan E. Howlett
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 697-704;
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    Characterization of Mibefradil Block of the Human Heart Delayed Rectifier hKv1.5
    Loïc Perchenet and Odile Clément-Chomienne
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 771-778;
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    Potent and Reversible Effects of ATI-2001 on Atrial and Atrioventricular Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart
    M. J. Pekka Raatikainen, Timothy E. Morey, Pascal Druzgala, Peter Milner, Mario D. Gonzalez and Donn M. Dennis
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 779-785;
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    Nitric Oxide Stimulatory and Endothelial Protective Effects of Idoxifene, a Selective Estrogen Receptor Modulator, in the Splanchnic Artery of the Ovariectomized Rat
    Xin L. Ma, Feng Gao, Chen-Ling Yao, Jun Chen, Bernard L. Lopez, Theodore A. Christopher, Jyoti Disa, Juan-Li Gu, Eliot H. Ohlstein and Tian-Li Yue
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 786-792;
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    Functional Evidence of a Constitutively Active Population of α1D-Adrenoceptors in Rat Aorta
    Regina Gisbert, Maria Antonia Noguera, Maria Dolores Ivorra and Pilar D'Ocon
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 810-817;
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    Inhibition of Endothelial Cell Activation by Nitric Oxide Donors
    Antonella Zampolli, Giuseppina Basta, Guido Lazzerini, Martin Feelisch and Raffaele De Caterina
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 818-823;

CELLULAR AND MOLECULAR

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    The Catalytic DNA Topoisomerase II Inhibitor Dexrazoxane (ICRF-187) Induces Endopolyploidy in Chinese Hamster Ovary Cells
    Brian B. Hasinoff, Michael E. Abram, Gaik-Lean Chee, Erwin Huebner, Edward H. Byard, Norman Barnabé, Victor J. Ferrans, Zu-Xi Yu and Jack C. Yalowich
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 474-483;
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    δ-Opioid Receptors Are More Efficiently Coupled to Adenylyl Cyclase Than to L-Type Ca2+ Channels in Transfected Rat Pituitary Cells
    Paul L. Prather, Lei Song, Elemer T. Piros, Ping Y. Law and Tim G. Hales
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 552-562;
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    Cross-Chimeric Analysis of Selectivity of Secretin and VPAC1 Receptor Activation
    Chan-Guk Park, Subhas C. Ganguli, Delia I. Pinon, Elizabeth M. Hadac and Laurence J. Miller
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 682-688;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Efficacy of LGD1069 (Targretin), a Retinoid X Receptor-Selective Ligand, for Treatment of Uterine Leiomyoma
    Shantini D. Gamage, Eric D. Bischoff, Kevin D. Burroughs, William W. Lamph, Marco M. Gottardis, Cheryl L. Walker and Robin Fuchs-Young
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 677-681;
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    Sensitivity of Myelomonocytic Leukemia Cells to Arsenite-Induced Cell Cycle Disruption, Apoptosis, and Enhanced Differentiation Is Dependent on the Inter-Relationship between Arsenic Concentration, Duration of Treatment, and Cell Cycle Phase
    Michael J. McCabe, Kameshwar P. Singh, Srikar A. Reddy, Bhadrani Chelladurai, Joel G. Pounds, John J. Reiners and J. Christopher States
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 724-733;
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    Semiphysiological Model for the Time Course of Leukocytes after Varying Schedules of 5-Fluorouracil in Rats
    Lena E. Friberg, Agneta Freijs, Marie Sandström and Mats O. Karlsson
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 734-740;

ENDOCRINE AND REPRODUCTIVE

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    Hypoglycemic Effect of Insulin-Transferrin Conjugate in Streptozotocin-Induced Diabetic Rats
    Cindy Q. Xia, Jeff Wang and Wei-Chiang Shen
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 594-600;
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    Beneficial Insulin-Sensitizing and Vascular Effects of S15261 in the Insulin-Resistant JCR:LA-cp Rat
    James C. Russell, Denis Ravel, Jean-Paul Pégorier, Pascal Delrat, Roeline Jochemsen, Sheila F. O'Brien, Sandra E. Kelly, Sandra T. Davidge and David N. Brindley
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 753-760;
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    Tuberoinfundibular Peptide (7-39) [TIP(7-39)], a Novel, Selective, High-Affinity Antagonist for the Parathyroid Hormone-1 Receptor with No Detectable Agonist Activity
    Sam R. J. Hoare and Ted B. Usdin
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 761-770;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Induction of Cyclooxygenase-2 in Rat Gastric Mucosa by Rebamipide, a Mucoprotective Agent
    Wei-Hao Sun, Shingo Tsuji, Masahiko Tsujii, Edhi S. Gunawan, Naoki Kawai, Arata Kimura, Yoshimi Kakiuchi, Masakazu Yasumaru, Hideki Iijima, Yoshiko Okuda, Yutaka Sasaki, Masatsugu Hori and Sunao Kawano
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 447-452;
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    Role of Inducible Nitric-Oxide Synthase in Regulation of Whole-Cell Current in Lung Epithelial Cells
    Beata Kamosinska, Anna Radomski, Shu Fu Paul Man, Marek W. Radomski and Marek Duszyk
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 500-505;
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    Excitatory and Inhibitory Actions of Isoprostanes in Human and Canine Airway Smooth Muscle
    Luke J. Janssen, Mahmood Premji, Stuart Netherton, Adrianna Catalli, Gerard Cox, Shaf Keshavjee and Denis J. Crankshaw
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 506-511;
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    Signaling Mechanisms Coupled to Presynaptic A1- and H3-Receptors in the Inhibition of Cholinergic Contractile Responses of the Guinea Pig Ileum
    John J. Lee and Michael E. Parsons
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 607-613;
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    A Turnover Model of Irreversible Inhibition of Gastric Acid Secretion by Omeprazole in the Dog
    Angela Äbelö, Ulf G. Eriksson, Mats O. Karlsson, Håkan Larsson and Johan Gabrielsson
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 662-669;
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    Polarized Efflux of Mono- and Diacid Metabolites of ME3229, an Ester-Type Prodrug of a Glycoprotein IIb/IIIa Receptor Antagonist, in Rat Small Intestine
    Noriko Okudaira, Izumi Komiya and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 717-723;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Identification of R146225 as a Novel, Orally Active Inhibitor of Interleukin-5 Biosynthesis
    Jean Van Wauwe, Frans Aerts, Marina Cools, Frederik Deroose, Eddy Freyne, Jan Goossens, Bart Hermans, Jean Lacrampe, Heidi Van Genechten, Frans Van Gerven and Greta Van Nyen
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 655-661;
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    Cyclooxygenase-2-Mediated Angiogenesis in Carrageenin-Induced Granulation Tissue in Rats
    Ajoy Kumar Ghosh, Noriyasu Hirasawa, Hisae Niki and Kazuo Ohuchi
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 802-809;

NEUROPHARMACOLOGY

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    Long-Lasting Facilitation of 4-Amino-n-[2,3-3H]butyric Acid ([3H]GABA) Release from Rat Hippocampal Slices by Nicotinic Receptor Activation
    Attila Köfalvi, Beáta Sperlágh, Tibor Zelles and E. Sylvester Vizi
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 453-462;
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    Effects of Tetraethylammonium Analogs on Apoptosis and Membrane Currents in Cultured Cortical Neurons
    Xin Wang, Ai Ying Xiao, Tomomi Ichinose and Shan Ping Yu
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 524-530;
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    Site of Action of Lubeluzole on Voltage-Sensitive Ca2+ Channels in Isolated Dorsal Root Ganglion Cells of the Rat: Influence of pH
    Roger Marrannes and Erik De Prins
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 531-545;
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    Analgesic Synergy between Topical Lidocaine and Topical Opioids
    Yuri A. Kolesnikov, Igor Chereshnev and Gavril W. Pasternak
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 546-551;
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    Alterations of N-Methyl-d-aspartate Receptor Properties after Chemical Ischemia
    Elias Aizenman, Jeroo D. Sinor, Jessica C. Brimecombe and Greta Ann Herin
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 572-577;
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    Oral Cocaine Pharmacokinetics and Pharmacodynamics in a Cumulative-Dose Regimen: Pharmacokinetic-Pharmacodynamic Modeling of Concurrent Operant and Spontaneous Behavior within an Operant Context
    Chyan E. Lau, Lei Sun, Qiao Wang, Allan Simpao and John L. Falk
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 634-643;
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    Down-Regulation of Benzodiazepine Binding to α5 Subunit-Containing γ-Aminobutyric AcidA Receptors in Tolerant Rat Brain Indicates Particular Involvement of the Hippocampal CA1 Region
    Ming Li, Andras Szabo and Howard C. Rosenberg
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 689-696;
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    The In Vitro Ethanol Sensitivity of Hippocampal Synaptic γ-Aminobutyric AcidA Responses Differs in Lines of Mice and Rats Genetically Selected for Behavioral Sensitivity or Insensitivity to Ethanol
    Wolfgang Poelchen, William R. Proctor and Thomas V. Dunwiddie
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 741-746;

TOXICOLOGY

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    Putative Link between Transcriptional Regulation of IgM Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Aryl Hydrocarbon Receptor/Dioxin-Responsive Enhancer Signaling Pathway
    Courtney E. W. Sulentic, Michael P. Holsapple and Norbert E. Kaminski
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 705-716;
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    Nitric Oxide and NK1-Tachykinin Receptors in Cyclophosphamide-Induced Cystitis, in Rats
    Anna B. Alfieri and Luigi X. Cubeddu
    Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 824-829;
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Journal of Pharmacology and Experimental Therapeutics: 295 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 295, Issue 2
1 Nov 2000
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  • PERSPECTIVES IN PHARMACOLOGY
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  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
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