Journal of Pharmacology and Experimental Therapeutics: 295 (2)

November 01, 2000; Volume 295,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Molecular Mechanisms of Selective Estrogen Receptor Modulator (SERM) Action
Martin Dutertre and Carolyn L. Smith

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 431-437;
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Multiple Central Nervous System Targets for Eliciting Beneficial Effects on Memory and Cognition
Jerry J. Buccafusco and Alvin V. Terry

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 438-446;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Three-Dimensional Quantitative Structure Activity Relationship Computational Approaches for Prediction of Human In Vitro Intrinsic Clearance
Sean Ekins and R. Scott Obach

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 463-473;
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Altered Hepatobiliary Disposition of Acetaminophen Glucuronide in Isolated Perfused Livers from Multidrug Resistance-Associated Protein 2-Deficient TR⁻ Rats
Hao Xiong, Kenneth C. Turner, E. Stacy Ward, Peter L. M. Jansen and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 512-518;
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Tasosartan, Enoltasosartan, and Angiotensin II Receptor Blockade: The Confounding Role of Protein Binding
Marc P. Maillard, Julien Rossat, Hans-R. Brunner and Michel Burnier

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 649-654;
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Chronic Intragastric Infusion of Ethanol-Containing Diets Induces CYP3A9 While Decreasing CYP3A2 in Male Rats ,
J. Craig Rowlands, Huamin Wang, Reza Hakkak, Martin J. J. Ronis, Henry W. Strobel and Thomas M. Badger

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 747-752;
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Scaling Drug Biotransformation Data from cDNA-Expressed Cytochrome P-450 to Human Liver: A Comparison of Relative Activity Factors and Human Liver Abundance in Studies of Mirtazapine Metabolism
Elke Störmer, Lisa L. von Moltke and David J. Greenblatt

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 793-801;
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Right Heart Failure Impairs Hepatic Elimination of p-Nitrophenol without Inducing Changes in Content or Latency of Hepatic UDP-Glucuronosyltransferases
Connie Y. Ng, Hany Ghabrial, Denis J. Morgan, Michael S. Ching, Richard A. Smallwood and Peter W. Angus

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 830-835;
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Evaluation of Route of Input on the Hepatic Disposition of Diazepam
Selma Sahin and Malcolm Rowland

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 836-843;
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5-Hydroxylation of Omeprazole by Human Liver Microsomal Fractions from Chinese Populations Related to CYP2C19 Gene Dose and Individual Ethnicity
Yan Shu, Lian-Sheng Wang, Zhen-Hua Xu, Nan He, Wei-Min Xiao, Wei Wang, Song-Lin Huang and Hong-Hao Zhou

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 844-851;

CARDIOVASCULAR

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Enhanced Endothelin_A Receptor-Mediated Calcium Mobilization and Contraction in Organ Cultured Porcine Coronary Arteries
Brent J. F. Hill, Laxmansa C. Katwa, Brian R. Wamhoff and Michael Sturek

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 484-491;
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Prevention of Arterial Thrombosis by Intravenously Administered Platelet P2T Receptor Antagonist AR-C69931MX in a Canine Model
Jinbao Huang, Edward M. Driscoll, Michael L. Gonzales, Andrew M. Park and Benedict R. Lucchesi

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 492-499;
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Tamoxifen Acutely Relaxes Coronary Arteries by an Endothelium-, Nitric Oxide-, and Estrogen Receptor-Dependent Mechanism
Gemma A. Figtree, Carolyn M. Webb and Peter Collins

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 519-523;
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A Pyrroline Derivative of Mexiletine Offers Marked Protection against Ischemia/Reperfusion-Induced Myocardial Contractile Dysfunction
Haiquan Li, Kai Y. Xu, Lan Zhou, Tamas Kalai, Jay L. Zweier, Kalman Hideg and Periannan Kuppusamy

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 563-571;
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Endothelin Receptor Antagonism Does Not Prevent the Development of In Vivo Glyceryl Trinitrate Tolerance in the Rat
Jodan D. Ratz, Amy B. Fraser, Karen J. Rees-Milton, Michael A. Adams and Brian M. Bennett

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 578-585;
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Rationale for the Combination of PGE₁ andS-Nitroso-glutathione to Induce Relaxation of Human Penile Smooth Muscle
Javier Angulo, Pedro Cuevas, Ignacio Moncada, Antonio Martín-Morales, Antonio Allona, Argentina Fernández, Sonia Gabancho, Peter Ney and Iñigo Sáenz de Tejada

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 586-593;
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Modulation of Nitric-Oxide Synthase by Nicotine
Britt H. Tonnessen, Sandra R. Severson, Richard D. Hurt and Virginia M. Miller

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 601-606;
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Interactions of the 5-Hydroxytryptamine 3 Antagonist Class of Antiemetic Drugs with Human Cardiac Ion Channels
Yuri A. Kuryshev, Arthur M. Brown, Lin Wang, Claude R. Benedict and David Rampe

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 614-620;
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Protective Effect of Omapatrilat, a Vasopeptidase Inhibitor, on the Metabolism of Bradykinin in Normal and Failing Human Hearts
Charles Blais, David Fortin, Jean-Lucien Rouleau, Giuseppe Molinaro and Albert Adam

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 621-626;
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An α_1A/α_1L-Adrenoceptor Mediates Contraction of Canine Subcutaneous Resistance Arteries
Sally Anne Argyle and John Christie McGrath

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 627-633;
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Endogenous Bradykinin and the Renin and Pressor Responses to Furosemide in Humans
Laine J. Murphey, Sandeep Kumar and Nancy J. Brown

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 644-648;
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Glycoprotein IIb/IIIa Receptor Number and Occupancy during Chronic Administration of an Oral Antagonist
Martin J. Quinn, Dermot Cox, J. Brendan Foley and Desmond J. Fitzgerald

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 670-676;
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Losartan Improves Recovery of Contraction and Inhibits Transient Inward Current in a Cellular Model of Cardiac Ischemia and Reperfusion
William E. Louch, Gregory R. Ferrier and Susan E. Howlett

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 697-704;
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Characterization of Mibefradil Block of the Human Heart Delayed Rectifier hKv1.5
Loïc Perchenet and Odile Clément-Chomienne

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 771-778;
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Potent and Reversible Effects of ATI-2001 on Atrial and Atrioventricular Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart
M. J. Pekka Raatikainen, Timothy E. Morey, Pascal Druzgala, Peter Milner, Mario D. Gonzalez and Donn M. Dennis

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 779-785;
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Nitric Oxide Stimulatory and Endothelial Protective Effects of Idoxifene, a Selective Estrogen Receptor Modulator, in the Splanchnic Artery of the Ovariectomized Rat
Xin L. Ma, Feng Gao, Chen-Ling Yao, Jun Chen, Bernard L. Lopez, Theodore A. Christopher, Jyoti Disa, Juan-Li Gu, Eliot H. Ohlstein and Tian-Li Yue

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 786-792;
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Functional Evidence of a Constitutively Active Population of α_1D-Adrenoceptors in Rat Aorta
Regina Gisbert, Maria Antonia Noguera, Maria Dolores Ivorra and Pilar D'Ocon

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 810-817;
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Inhibition of Endothelial Cell Activation by Nitric Oxide Donors
Antonella Zampolli, Giuseppina Basta, Guido Lazzerini, Martin Feelisch and Raffaele De Caterina

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 818-823;

CELLULAR AND MOLECULAR

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The Catalytic DNA Topoisomerase II Inhibitor Dexrazoxane (ICRF-187) Induces Endopolyploidy in Chinese Hamster Ovary Cells
Brian B. Hasinoff, Michael E. Abram, Gaik-Lean Chee, Erwin Huebner, Edward H. Byard, Norman Barnabé, Victor J. Ferrans, Zu-Xi Yu and Jack C. Yalowich

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 474-483;
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δ-Opioid Receptors Are More Efficiently Coupled to Adenylyl Cyclase Than to L-Type Ca²⁺ Channels in Transfected Rat Pituitary Cells
Paul L. Prather, Lei Song, Elemer T. Piros, Ping Y. Law and Tim G. Hales

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 552-562;
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Cross-Chimeric Analysis of Selectivity of Secretin and VPAC₁ Receptor Activation
Chan-Guk Park, Subhas C. Ganguli, Delia I. Pinon, Elizabeth M. Hadac and Laurence J. Miller

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 682-688;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Efficacy of LGD1069 (Targretin), a Retinoid X Receptor-Selective Ligand, for Treatment of Uterine Leiomyoma
Shantini D. Gamage, Eric D. Bischoff, Kevin D. Burroughs, William W. Lamph, Marco M. Gottardis, Cheryl L. Walker and Robin Fuchs-Young

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 677-681;
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Sensitivity of Myelomonocytic Leukemia Cells to Arsenite-Induced Cell Cycle Disruption, Apoptosis, and Enhanced Differentiation Is Dependent on the Inter-Relationship between Arsenic Concentration, Duration of Treatment, and Cell Cycle Phase
Michael J. McCabe, Kameshwar P. Singh, Srikar A. Reddy, Bhadrani Chelladurai, Joel G. Pounds, John J. Reiners and J. Christopher States

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 724-733;
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Semiphysiological Model for the Time Course of Leukocytes after Varying Schedules of 5-Fluorouracil in Rats
Lena E. Friberg, Agneta Freijs, Marie Sandström and Mats O. Karlsson

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 734-740;

ENDOCRINE AND REPRODUCTIVE

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Hypoglycemic Effect of Insulin-Transferrin Conjugate in Streptozotocin-Induced Diabetic Rats
Cindy Q. Xia, Jeff Wang and Wei-Chiang Shen

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 594-600;
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Beneficial Insulin-Sensitizing and Vascular Effects of S15261 in the Insulin-Resistant JCR:LA-cp Rat
James C. Russell, Denis Ravel, Jean-Paul Pégorier, Pascal Delrat, Roeline Jochemsen, Sheila F. O'Brien, Sandra E. Kelly, Sandra T. Davidge and David N. Brindley

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 753-760;
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Tuberoinfundibular Peptide (7-39) [TIP(7-39)], a Novel, Selective, High-Affinity Antagonist for the Parathyroid Hormone-1 Receptor with No Detectable Agonist Activity
Sam R. J. Hoare and Ted B. Usdin

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 761-770;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Induction of Cyclooxygenase-2 in Rat Gastric Mucosa by Rebamipide, a Mucoprotective Agent
Wei-Hao Sun, Shingo Tsuji, Masahiko Tsujii, Edhi S. Gunawan, Naoki Kawai, Arata Kimura, Yoshimi Kakiuchi, Masakazu Yasumaru, Hideki Iijima, Yoshiko Okuda, Yutaka Sasaki, Masatsugu Hori and Sunao Kawano

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 447-452;
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Role of Inducible Nitric-Oxide Synthase in Regulation of Whole-Cell Current in Lung Epithelial Cells
Beata Kamosinska, Anna Radomski, Shu Fu Paul Man, Marek W. Radomski and Marek Duszyk

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 500-505;
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Excitatory and Inhibitory Actions of Isoprostanes in Human and Canine Airway Smooth Muscle
Luke J. Janssen, Mahmood Premji, Stuart Netherton, Adrianna Catalli, Gerard Cox, Shaf Keshavjee and Denis J. Crankshaw

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 506-511;
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Signaling Mechanisms Coupled to Presynaptic A₁- and H₃-Receptors in the Inhibition of Cholinergic Contractile Responses of the Guinea Pig Ileum
John J. Lee and Michael E. Parsons

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 607-613;
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A Turnover Model of Irreversible Inhibition of Gastric Acid Secretion by Omeprazole in the Dog
Angela Äbelö, Ulf G. Eriksson, Mats O. Karlsson, Håkan Larsson and Johan Gabrielsson

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 662-669;
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Polarized Efflux of Mono- and Diacid Metabolites of ME3229, an Ester-Type Prodrug of a Glycoprotein IIb/IIIa Receptor Antagonist, in Rat Small Intestine
Noriko Okudaira, Izumi Komiya and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 717-723;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Identification of R146225 as a Novel, Orally Active Inhibitor of Interleukin-5 Biosynthesis
Jean Van Wauwe, Frans Aerts, Marina Cools, Frederik Deroose, Eddy Freyne, Jan Goossens, Bart Hermans, Jean Lacrampe, Heidi Van Genechten, Frans Van Gerven and Greta Van Nyen

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 655-661;
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Cyclooxygenase-2-Mediated Angiogenesis in Carrageenin-Induced Granulation Tissue in Rats
Ajoy Kumar Ghosh, Noriyasu Hirasawa, Hisae Niki and Kazuo Ohuchi

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 802-809;

NEUROPHARMACOLOGY

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Long-Lasting Facilitation of 4-Amino-n-[2,3-³H]butyric Acid ([³H]GABA) Release from Rat Hippocampal Slices by Nicotinic Receptor Activation
Attila Köfalvi, Beáta Sperlágh, Tibor Zelles and E. Sylvester Vizi

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 453-462;
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Effects of Tetraethylammonium Analogs on Apoptosis and Membrane Currents in Cultured Cortical Neurons
Xin Wang, Ai Ying Xiao, Tomomi Ichinose and Shan Ping Yu

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 524-530;
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Site of Action of Lubeluzole on Voltage-Sensitive Ca²⁺ Channels in Isolated Dorsal Root Ganglion Cells of the Rat: Influence of pH
Roger Marrannes and Erik De Prins

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 531-545;
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Analgesic Synergy between Topical Lidocaine and Topical Opioids
Yuri A. Kolesnikov, Igor Chereshnev and Gavril W. Pasternak

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 546-551;
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Alterations of N-Methyl-d-aspartate Receptor Properties after Chemical Ischemia
Elias Aizenman, Jeroo D. Sinor, Jessica C. Brimecombe and Greta Ann Herin

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 572-577;
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Oral Cocaine Pharmacokinetics and Pharmacodynamics in a Cumulative-Dose Regimen: Pharmacokinetic-Pharmacodynamic Modeling of Concurrent Operant and Spontaneous Behavior within an Operant Context
Chyan E. Lau, Lei Sun, Qiao Wang, Allan Simpao and John L. Falk

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 634-643;
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Down-Regulation of Benzodiazepine Binding to α5 Subunit-Containing γ-Aminobutyric Acid_A Receptors in Tolerant Rat Brain Indicates Particular Involvement of the Hippocampal CA1 Region
Ming Li, Andras Szabo and Howard C. Rosenberg

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 689-696;
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The In Vitro Ethanol Sensitivity of Hippocampal Synaptic γ-Aminobutyric Acid_A Responses Differs in Lines of Mice and Rats Genetically Selected for Behavioral Sensitivity or Insensitivity to Ethanol
Wolfgang Poelchen, William R. Proctor and Thomas V. Dunwiddie

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 741-746;

TOXICOLOGY

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Putative Link between Transcriptional Regulation of IgM Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Aryl Hydrocarbon Receptor/Dioxin-Responsive Enhancer Signaling Pathway
Courtney E. W. Sulentic, Michael P. Holsapple and Norbert E. Kaminski

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 705-716;
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Nitric Oxide and NK₁-Tachykinin Receptors in Cyclophosphamide-Induced Cystitis, in Rats
Anna B. Alfieri and Luigi X. Cubeddu

Journal of Pharmacology and Experimental Therapeutics November 2000, 295 (2) 824-829;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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