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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Review of Mammalian DNA Repair and Translational Implications

W. Kent Hansen and Mark R. Kelley
Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 1-9;
W. Kent Hansen
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Mark R. Kelley
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Abstract

The area of mammalian DNA repair and its relationship to cancer and therapeutic approaches is rapidly growing, both through the studies of basic mechanisms and in the use of this knowledge for translational applications. We have attempted to briefly and succinctly cover the four pathways of mammalian DNA repair, which are: direct reversal, mismatch, nucleotide excision, and base excision repair. We have also tried to identify and reference results in the literature relating the various repair pathways to cellular resistance following chemotherapeutic treatments and to provide some potential direction whereby laboratory results may be applicable to clinical therapeutics, particularly for cancer treatments.

Footnotes

  • Send reprint requests to: Mark R. Kelley, Ph.D., Department of Pediatrics (Hematology/Oncology), Herman B. Wells Center for Pediatric Research, 702 Barnhill Dr., Rm. 2600, Indianapolis, IN 46202. E-mail: mkelley{at}iupui.edu

  • ↵1 The authors were supported by National Institutes of Health/National Cancer Institute Program Project Grant PO1-CA75426 and by NIH Grants CA76643, ES07815, NS38506, Army CDMRP OC990085, and the Gynecologic Oncology Group (GOG) Ovarian Cancer Research Fund. We also apologize to all those investigators whose references we had to leave out due to the limitation of references allowed.

  • Abbreviations:
    MMR
    mismatch repair
    BER
    base excision repair
    NER
    nucleotide excision repair
    MMS
    methyl methanesulfonate
    MGMT/AGT
    O6-methylguanine-DNA methyltransferase
    BCNU
    1,3-bis(2-chloroethyl)-1-nitrosourea
    HNPCC
    hereditary nonpolyposis colon cancer
    XP
    xeroderma pigmentosum
    RPA
    replication protein A
    TFIIH
    transcription factor IIH (XPB, XPD, p62, p52, p44, p44)
    ERCC1
    excision repair cross-complementing 1
    FEN
    flap endonuclease
    PCNA
    proliferating cell nuclear antigen
    RFC
    replication factor C
    O6-meG
    O6-methylguanine
    XRCC1
    X-ray cross-species complementing 1
    8-oxoG
    7,8-dihydro-8-oxoguanine
    Fpg
    formamidopyrimidine glycosylase
    3-meA
    3-methyladenine
    • Received March 10, 2000.
    • Accepted April 17, 2000.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 295 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 295, Issue 1
1 Oct 2000
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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Review of Mammalian DNA Repair and Translational Implications

W. Kent Hansen and Mark R. Kelley
Journal of Pharmacology and Experimental Therapeutics October 1, 2000, 295 (1) 1-9;

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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Review of Mammalian DNA Repair and Translational Implications

W. Kent Hansen and Mark R. Kelley
Journal of Pharmacology and Experimental Therapeutics October 1, 2000, 295 (1) 1-9;
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    • Mismatch Repair
    • Nucleotide Excision Repair
    • Direct Repair: O6-Methylguanine-DNA Methyltransferase
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