Journal of Pharmacology and Experimental Therapeutics: 295 (1)

October 01, 2000; Volume 295,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Review of Mammalian DNA Repair and Translational Implications
W. Kent Hansen and Mark R. Kelley

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 1-9;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Nonsteroidal Anti-Inflammatory Drugs Efficiently Reduce the Transport and Cytotoxicity of Adefovir Mediated by the Human Renal Organic Anion Transporter 1
Andrew S. Mulato, Edmund S. Ho and Tomas Cihlar

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 10-15;
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Hepatic Disposition of the Acyl Glucuronide 1-O-Gemfibrozil-β-d-glucuronide: Effects of Clofibric Acid, Acetaminophen, and Acetaminophen Glucuronide
Lucia Sabordo, Benedetta C. Sallustio, Allan M. Evans and Roger L. Nation

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 44-50;
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Limited Distribution of New Quinolone Antibacterial Agents into Brain Caused by Multiple Efflux Transporters at the Blood-Brain Barrier
Ikumi Tamai, Junko Yamashita, Yasuto Kido, Aki Ohnari, Yoshimichi Sai, Yuichiro Shima, Kazumasa Naruhashi, Shoichi Koizumi and Akira Tsuji

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 146-152;
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Novel Method of Greatly Enhanced Delivery of Liposomes to Lymph Nodes
William T. Phillips, Robert Klipper and Beth Goins

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 309-313;
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Secretory Mechanisms of Grepafloxacin and Levofloxacin in the Human Intestinal Cell Line Caco-2
Hiroaki Yamaguchi, Ikuko Yano, Yukiya Hashimoto and Ken-Ichi Inui

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 360-366;

CARDIOVASCULAR

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Wortmannin, a Potent Antineutrophil Agent, Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion
Lindon H. Young, Yasuhiko Ikeda, Rosario Scalia and Allan M. Lefer

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 37-43;
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Nonpeptide Factor Xa Inhibitors II. Antithrombotic Evaluation in a Rabbit Model of Electrically Induced Carotid Artery Thrombosis
Pancras C. Wong, Earl J. Crain, Robert M. Knabb, Raymond P. Meade, Mimi L. Quan, Carol A. Watson, Ruth R. Wexler, Matthew R. Wright and Andrew M. Slee

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 212-218;
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Vascular Contraction and Relaxation to Thrombin and Trypsin: Thrombomodulin Preferentially Attenuates Thrombin-Induced Contraction
Anindya Bhattacharya and Marlene L. Cohen

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 284-290;
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Mibefradil Block of Cloned T-Type Calcium Channels
Ruth L. Martin, Jung-Ha Lee, Leanne L. Cribbs, Edward Perez-Reyes and Dorothy A. Hanck

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 302-308;

CELLULAR AND MOLECULAR

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Preglomerular Microcirculation Expresses the cAMP-Adenosine Pathway
Edwin K. Jackson and Zaichuan Mi

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 23-28;
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Polychlorinated Biphenyl-Stimulation of Ca²⁺Oscillations in Developing Neocortical Cells: A Role for Excitatory Transmitters and L-Type Voltage-Sensitive Ca²⁺Channels
Jon R. Inglefield and Timothy J. Shafer

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 105-113;
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Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
Elisabeth Buchdunger, Catherine L. Cioffi, Norman Law, David Stover, Sayuri Ohno-Jones, Brian J. Druker and Nicholas B. Lydon

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 139-145;
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G_z Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization
Prudence H. Tso and Yung H. Wong

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 168-176;
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Modifications in the Phosphoinositide Signaling Pathway by Adrenal Glucocorticoids in Rat Brain: Focus on Phosphoinositide-Specific Phospholipase C and Inositol 1,4,5-Trisphosphate
Yogesh Dwivedi, Hooriyah S. Rizavi, Jagadeesh S. Rao and Ghanshyam N. Pandey

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 244-254;
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G-Protein Sensitivity of Ligand Binding to Human Dopamine D₂ and D₃ Receptors Expressed inEscherichia coli: Clues for a Constrained D₃Receptor Structure
Jurgen F. M. Vanhauwe, Katty Josson, Walter H. M. L. Luyten, Arnold J. Driessen and Josée E. Leysen

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 274-283;
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Cellular Uptake and Efficacy of Antisense Oligonucleotides against RNAs of Two Na⁺ Channel Isoforms
Hans Keller, Bernhard Schu, Reinhardt Rüdel and Heinrich Brinkmeier

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 367-372;
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Identification of the Sites of Asparagine-Linked Glycosylation on the Human Thyrotropin Receptor and Studies on Their Role in Receptor Function and Expression
Yuji Nagayama, Eijun Nishihara, Hiroyuki Namba, Shunichi Yamashita and Masami Niwa

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 404-409;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Inhibition of Volume-Regulated and Calcium-Activated Chloride Channels by the Antimalarial Mefloquine
Chantal Maertens, Lin Wei, Guy Droogmans and Bernd Nilius

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 29-36;
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A Pharmacodynamic Analysis of Erythropoietin-Stimulated Reticulocyte Response in Phlebotomized Sheep
Sunny Hong Chapel, Peter Veng-Pedersen, Robert L. Schmidt and John A. Widness

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 346-351;

ENDOCRINE AND REPRODUCTIVE

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Estrogen Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator-Mediated Chloride Secretion
Ashvani K. Singh, Bruce D. Schultz, John A. Katzenellenbogen, Elmer M. Price, Robert J. Bridges and Neil A. Bradbury

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 195-204;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Long-Term Aquaretic Efficacy of a Selective Nonpeptide V₂-Vasopressin Receptor Antagonist, SR121463, in Cirrhotic Rats
Wladimiro Jiménez, Claudine Serradeil-Le Gal, Josefa Ros, Carmen Cano, Pilar Cejudo, Manuel Morales-Ruiz, Vicente Arroyo, Marc Pascal, Francisca Rivera, Jean-Pierre Maffrand and Juan Rodés

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 83-90;
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Effect of Hydroxyeicosatetraenoic Acids on Furosemide-Sensitive Chloride Secretion in Rat Distal Colon
Markus Wegmann, Antje Kämpen, Susanne Weber, Hannsjörg W. Seyberth and Arnold Köckerling

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 133-138;
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Inhibition of Thromboxane A₂-Induced Cl⁻Secretion by Antidiarrhea Drug Loperamide in Isolated Rat Colon
Tomoyuki Suzuki, Hideki Sakai, Akira Ikari and Noriaki Takeguchi

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 233-238;
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Interaction and Transport of Thiazide Diuretics, Loop Diuretics, and Acetazolamide via Rat Renal Organic Anion Transporter rOAT1
Yuichi Uwai, Hideyuki Saito, Yukiya Hashimoto and Ken-Ichi Inui

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 261-265;
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Intestinal Type 2 Proteinase-Activated Receptors: Expression in Opioid-Sensitive Secretomotor Neural Circuits That Mediate Epithelial Ion Transport
Benedict T. Green, Nigel W. Bunnett, Anjali Kulkarni-Narla, Martin Steinhoff and David R. Brown

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 410-416;
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Evidence for Peroxynitrite Formation in Renal Ischemia-Reperfusion Injury: Studies with the Inducible Nitric Oxide Synthase Inhibitorl-N ⁶-(1-Iminoethyl)lysine
Lisa M. Walker, Patrick D. Walker, Syed Z. Imam, Syed F. Ali and Philip R. Mayeux

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 417-422;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Amelioration of Murine Experimental Colitis by Inhibition of Mucosal Addressin Cell Adhesion Molecule-1
Shingo Kato, Ryota Hokari, Koji Matsuzaki, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Toru Miyahara, Kazuro Itoh, Hiromasa Ishii and Soichiro Miura

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 183-189;
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Anti-Inflammatory and Antinociceptive Properties of BP 2-94, a Histamine H₃-Receptor Agonist Prodrug
Agnès Rouleau, Holger Stark, Walter Schunack and Jean-Charles Schwartz

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 219-225;
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A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little Emetogenic Activity
Motonori Aoki, Miki Kobayashi, Jun Ishikawa, Yuji Saita, Yoshiya Terai, Kazuhisa Takayama, Keiji Miyata and Toshimitsu Yamada

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 255-260;

NEUROPHARMACOLOGY

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N-Acetylated α-Linked Acidic Dipeptidase Converts N-Acetylaspartylglutamate from a Neuroprotectant to a Neurotoxin
Ajit G. Thomas, James J. Vornov, Jennifer L. Olkowski, Aviva T. Merion and Barbara S. Slusher

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 16-22;
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Comparison between Intraperitoneal and Oral Methylphenidate Administration: A Microdialysis and Locomotor Activity Study
Madina R. Gerasimov, Maja Franceschi, Nora D. Volkow, Andrew Gifford, Samuel J. Gatley, Douglas Marsteller, Patricia E. Molina and Stephen L. Dewey

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 51-57;
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Nicotinic Modulation of Mesoprefrontal Dopamine Neurons: Pharmacologic and Neuroanatomic Characterization
Tony P. George, Christopher D. Verrico, Marina R. Picciotto and Robert H. Roth

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 58-66;
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Effects of Acute and Subchronic Administration of Typical and Atypical Antipsychotic Drugs on the Neurotensin System of the Rat Brain
Becky Kinkead, Shanna Shahid, Michael J. Owens and Charles B. Nemeroff

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 67-73;
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Incomplete, Asymmetric, and Route-Dependent Cross-Tolerance between Oxycodone and Morphine in the Dark Agouti Rat
Carsten K. Nielsen, Fraser B. Ross and Maree T. Smith

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 91-99;
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Effects of Microdialyzed Oxotremorine, Carbachol, Epibatidine, and Scopolamine on Intraspinal Release of Acetylcholine in the Rat
A. Urban Höglund, Charlotte Hamilton and Lars Lindblom

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 100-104;
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Effects of Agonist-Antagonist Opioids in Humans Trained in a Hydromorphone/Not Hydromorphone Discrimination
Kenzie L. Preston and George E. Bigelow

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 114-124;
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Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide
Bin Liu, Jian-Wei Jiang, Belinda C. Wilson, Lina Du, San-Nan Yang, Jiz-Yuh Wang, Gen-Cheng Wu, Xiao-Ding Cao and Jau-Shyong Hong

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 125-132;
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Chlormethiazole: Effectiveness against Toxic Effects of Cocaine in Mice
Maciej Gasior, Jesse T. Ungard and Jeffrey M. Witkin

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 153-161;
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Antinociceptive Effect of Pregabalin in Septic Shock-Induced Rectal Hypersensitivity in Rats
Helene Eutamene, Anne-Marie Coelho, Vassilia Theodorou, Magali Toulouse, Maria Chovet, Annette Doherty, Jean Fioramonti and Lionel Bueno

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 162-167;
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Gastric Effects of Cholecystokinin and Its Interaction with Leptin on Brainstem Neuronal Activity in Neonatal Rats
Chun-Su Yuan, Anoja S. Attele, Lucy Dey and Jing-Tian Xie

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 177-182;
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Retro-Inverso Prosaptide Peptides Retain Bioactivity, Are Stable In Vivo, and Are Blood-Brain Barrier Permeable
Eve M. Taylor, Deborah A. Otero, William A. Banks and John S. O'Brien

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 190-194;
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Sex- and Estrous Cycle-Related Differences in the Effects of Acute Antipsychotic Drug Administration on Neurotensin-Containing Neurons in the Rat Brain
Becky Kinkead, Steven M. Lorch, Michael J. Owens and Charles B. Nemeroff

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 205-211;
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Inverse Agonist Activity of Atypical Antipsychotic Drugs at Human 5-Hydroxytryptamine2C Receptors
Katharine Herrick-Davis, Ellinor Grinde and Milt Teitler

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 226-232;
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Antisense-Mediated Down-Regulation of the Human Huntingtin Gene
Ruben J. Boado, Aleksey Kazantsev, Barbara L. Apostol, Leslie M. Thompson and William M. Pardridge

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 239-243;
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Serotonergic Modulation of Rat Pineal Gland Activity: In Vivo Evidence for a 5-Hydroxytryptamine_2C Receptor Involvement
Luca Steardo, Palmiero Monteleone, Luigia Trabace, Carla Cannizzaro, Mario Maj and Vincenzo Cuomo

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 266-273;
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Discovery of “Self-Synergistic” Spinal/Supraspinal Antinociception Produced by Acetaminophen (Paracetamol)
Robert B. Raffa, Dennis J. Stone and Ronald J. Tallarida

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 291-294;
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Effect of Phenylalanine and Its Metabolites on the Proliferation and Viability of Neuronal and Astroglial Cells: Possible Relevance in Maternal Phenylketonuria
Jan Oberdoerster, Marina Guizzetti and Lucio G. Costa

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 295-301;
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Nitric Oxide Is Involved in Acetylcholinesterase Inhibitor-Induced Myopathy in Rats
Gayathri Jeyarasasingam, Michael Yeluashvili and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 314-320;
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Bupropion Is a Nicotinic Antagonist
Jennifer E. Slemmer, Billy R. Martin and M. Imad Damaj

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 321-327;
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Cannabinoid Agonist Signal Transduction in Rat Brain: Comparison of Cannabinoid Agonists in Receptor Binding, G-Protein Activation, and Adenylyl Cyclase Inhibition
Christopher S. Breivogel and Steven R. Childers

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 328-336;
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Characterization of the Anxiolytic Properties of a Novel Neuroactive Steroid, Co 2-6749 (GMA-839; WAY-141839; 3α, 21-Dihydroxy-3β-trifluoromethyl-19-nor-5β-pregnan-20-one), a Selective Modulator of γ-Aminobutyric Acid_A Receptors
Kimberly E. Vanover, Sharon Rosenzweig-Lipson, Jon E. Hawkinson, Nancy C. Lan, James D. Belluzzi, Larry Stein, James E. Barrett, Paul L. Wood and Richard B. Carter

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 337-345;
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Modeling of the In Vivo Antinociceptive Interaction between an Opioid Agonist, (+)-O-Desmethyltramadol, and a Monoamine Reuptake Inhibitor, (−)-O-Desmethyltramadol, in Rats
María J. Garrido, Marta Valle, Miguel A. Campanero, Rosario Calvo and Iñaki F. Trocóniz

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 352-359;
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Nonpeptide Tachykinin Receptor Antagonists. II. Pharmacological and Pharmacokinetic Profile of SB-222200, a Central Nervous System Penetrant, Potent and Selective NK-3 Receptor Antagonist
Henry M. Sarau, Don E. Griswold, Brian Bush, William Potts, Punam Sandhu, Dave Lundberg, James J. Foley, Dulcie B. Schmidt, Edward F. Webb, Lenox D. Martin, Jeffrey J. Legos, Robert G. Whitmore, Frank C. Barone, Andrew D. Medhurst, Mark A. Luttmann, Giuseppe A. M. Giardina and Douglas W. P. Hay

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 373-381;
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Pharmacological Characterization of the Discriminative Stimulus Effects of the Potassium Channel Blocker 4-Aminopyridine in Rats
Roxanne Brandsgaard, James E. Barrett and Sharon Rosenzweig-Lipson

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 382-391;
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Transport of N-Acetylaspartate by the Na⁺-Dependent High-Affinity Dicarboxylate Transporter NaDC3 and Its Relevance to the Expression of the Transporter in the Brain
Wei Huang, Haiping Wang, Ramesh Kekuda, You-Jun Fei, Anne Friedrich, Jian Wang, Simon J. Conway, Richard S. Cameron, Frederick H. Leibach and Vadivel Ganapathy

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 392-403;
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Effects of Chronic Ethanol Treatment on γ-Aminobutyric Acid_A and Glycine Receptors in Mouse Glycinergic Spinal Neurons
Brigitte van Zundert, Felipe A. Albarran and Luis G. Aguayo

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 423-429;

TOXICOLOGY

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Temporal Changes in Metallothionein Gene Transcription in Rat Kidney and Liver: Relationship to Content of Mercury and Metallothionein Protein
Rudolfs K. Zalups and James Koropatnick

Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 74-82;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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