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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2000; Volume 295,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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    Review of Mammalian DNA Repair and Translational Implications
    W. Kent Hansen and Mark R. Kelley
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 1-9;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Nonsteroidal Anti-Inflammatory Drugs Efficiently Reduce the Transport and Cytotoxicity of Adefovir Mediated by the Human Renal Organic Anion Transporter 1
    Andrew S. Mulato, Edmund S. Ho and Tomas Cihlar
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 10-15;
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    Hepatic Disposition of the Acyl Glucuronide 1-O-Gemfibrozil-β-d-glucuronide: Effects of Clofibric Acid, Acetaminophen, and Acetaminophen Glucuronide
    Lucia Sabordo, Benedetta C. Sallustio, Allan M. Evans and Roger L. Nation
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 44-50;
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    Limited Distribution of New Quinolone Antibacterial Agents into Brain Caused by Multiple Efflux Transporters at the Blood-Brain Barrier
    Ikumi Tamai, Junko Yamashita, Yasuto Kido, Aki Ohnari, Yoshimichi Sai, Yuichiro Shima, Kazumasa Naruhashi, Shoichi Koizumi and Akira Tsuji
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 146-152;
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    Novel Method of Greatly Enhanced Delivery of Liposomes to Lymph Nodes
    William T. Phillips, Robert Klipper and Beth Goins
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 309-313;
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    Secretory Mechanisms of Grepafloxacin and Levofloxacin in the Human Intestinal Cell Line Caco-2
    Hiroaki Yamaguchi, Ikuko Yano, Yukiya Hashimoto and Ken-Ichi Inui
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 360-366;

CARDIOVASCULAR

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    Wortmannin, a Potent Antineutrophil Agent, Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion
    Lindon H. Young, Yasuhiko Ikeda, Rosario Scalia and Allan M. Lefer
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 37-43;
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    Nonpeptide Factor Xa Inhibitors II. Antithrombotic Evaluation in a Rabbit Model of Electrically Induced Carotid Artery Thrombosis
    Pancras C. Wong, Earl J. Crain, Robert M. Knabb, Raymond P. Meade, Mimi L. Quan, Carol A. Watson, Ruth R. Wexler, Matthew R. Wright and Andrew M. Slee
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 212-218;
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    Vascular Contraction and Relaxation to Thrombin and Trypsin: Thrombomodulin Preferentially Attenuates Thrombin-Induced Contraction
    Anindya Bhattacharya and Marlene L. Cohen
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 284-290;
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    Mibefradil Block of Cloned T-Type Calcium Channels
    Ruth L. Martin, Jung-Ha Lee, Leanne L. Cribbs, Edward Perez-Reyes and Dorothy A. Hanck
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 302-308;

CELLULAR AND MOLECULAR

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    Preglomerular Microcirculation Expresses the cAMP-Adenosine Pathway
    Edwin K. Jackson and Zaichuan Mi
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 23-28;
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    Polychlorinated Biphenyl-Stimulation of Ca2+Oscillations in Developing Neocortical Cells: A Role for Excitatory Transmitters and L-Type Voltage-Sensitive Ca2+Channels
    Jon R. Inglefield and Timothy J. Shafer
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 105-113;
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    Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
    Elisabeth Buchdunger, Catherine L. Cioffi, Norman Law, David Stover, Sayuri Ohno-Jones, Brian J. Druker and Nicholas B. Lydon
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 139-145;
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    Gz Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization
    Prudence H. Tso and Yung H. Wong
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 168-176;
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    Modifications in the Phosphoinositide Signaling Pathway by Adrenal Glucocorticoids in Rat Brain: Focus on Phosphoinositide-Specific Phospholipase C and Inositol 1,4,5-Trisphosphate
    Yogesh Dwivedi, Hooriyah S. Rizavi, Jagadeesh S. Rao and Ghanshyam N. Pandey
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 244-254;
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    G-Protein Sensitivity of Ligand Binding to Human Dopamine D2 and D3 Receptors Expressed inEscherichia coli: Clues for a Constrained D3Receptor Structure
    Jurgen F. M. Vanhauwe, Katty Josson, Walter H. M. L. Luyten, Arnold J. Driessen and Josée E. Leysen
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 274-283;
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    Cellular Uptake and Efficacy of Antisense Oligonucleotides against RNAs of Two Na+ Channel Isoforms
    Hans Keller, Bernhard Schu, Reinhardt Rüdel and Heinrich Brinkmeier
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 367-372;
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    Identification of the Sites of Asparagine-Linked Glycosylation on the Human Thyrotropin Receptor and Studies on Their Role in Receptor Function and Expression
    Yuji Nagayama, Eijun Nishihara, Hiroyuki Namba, Shunichi Yamashita and Masami Niwa
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 404-409;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Inhibition of Volume-Regulated and Calcium-Activated Chloride Channels by the Antimalarial Mefloquine
    Chantal Maertens, Lin Wei, Guy Droogmans and Bernd Nilius
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 29-36;
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    A Pharmacodynamic Analysis of Erythropoietin-Stimulated Reticulocyte Response in Phlebotomized Sheep
    Sunny Hong Chapel, Peter Veng-Pedersen, Robert L. Schmidt and John A. Widness
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 346-351;

ENDOCRINE AND REPRODUCTIVE

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    Estrogen Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator-Mediated Chloride Secretion
    Ashvani K. Singh, Bruce D. Schultz, John A. Katzenellenbogen, Elmer M. Price, Robert J. Bridges and Neil A. Bradbury
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 195-204;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Long-Term Aquaretic Efficacy of a Selective Nonpeptide V2-Vasopressin Receptor Antagonist, SR121463, in Cirrhotic Rats
    Wladimiro Jiménez, Claudine Serradeil-Le Gal, Josefa Ros, Carmen Cano, Pilar Cejudo, Manuel Morales-Ruiz, Vicente Arroyo, Marc Pascal, Francisca Rivera, Jean-Pierre Maffrand and Juan Rodés
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 83-90;
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    Effect of Hydroxyeicosatetraenoic Acids on Furosemide-Sensitive Chloride Secretion in Rat Distal Colon
    Markus Wegmann, Antje Kämpen, Susanne Weber, Hannsjörg W. Seyberth and Arnold Köckerling
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 133-138;
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    Inhibition of Thromboxane A2-Induced Cl−Secretion by Antidiarrhea Drug Loperamide in Isolated Rat Colon
    Tomoyuki Suzuki, Hideki Sakai, Akira Ikari and Noriaki Takeguchi
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 233-238;
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    Interaction and Transport of Thiazide Diuretics, Loop Diuretics, and Acetazolamide via Rat Renal Organic Anion Transporter rOAT1
    Yuichi Uwai, Hideyuki Saito, Yukiya Hashimoto and Ken-Ichi Inui
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 261-265;
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    Intestinal Type 2 Proteinase-Activated Receptors: Expression in Opioid-Sensitive Secretomotor Neural Circuits That Mediate Epithelial Ion Transport
    Benedict T. Green, Nigel W. Bunnett, Anjali Kulkarni-Narla, Martin Steinhoff and David R. Brown
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 410-416;
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    Evidence for Peroxynitrite Formation in Renal Ischemia-Reperfusion Injury: Studies with the Inducible Nitric Oxide Synthase Inhibitorl-N 6-(1-Iminoethyl)lysine
    Lisa M. Walker, Patrick D. Walker, Syed Z. Imam, Syed F. Ali and Philip R. Mayeux
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 417-422;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Amelioration of Murine Experimental Colitis by Inhibition of Mucosal Addressin Cell Adhesion Molecule-1
    Shingo Kato, Ryota Hokari, Koji Matsuzaki, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Toru Miyahara, Kazuro Itoh, Hiromasa Ishii and Soichiro Miura
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 183-189;
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    Anti-Inflammatory and Antinociceptive Properties of BP 2-94, a Histamine H3-Receptor Agonist Prodrug
    Agnès Rouleau, Holger Stark, Walter Schunack and Jean-Charles Schwartz
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 219-225;
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    A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little Emetogenic Activity
    Motonori Aoki, Miki Kobayashi, Jun Ishikawa, Yuji Saita, Yoshiya Terai, Kazuhisa Takayama, Keiji Miyata and Toshimitsu Yamada
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 255-260;

NEUROPHARMACOLOGY

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    N-Acetylated α-Linked Acidic Dipeptidase Converts N-Acetylaspartylglutamate from a Neuroprotectant to a Neurotoxin
    Ajit G. Thomas, James J. Vornov, Jennifer L. Olkowski, Aviva T. Merion and Barbara S. Slusher
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 16-22;
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    Comparison between Intraperitoneal and Oral Methylphenidate Administration: A Microdialysis and Locomotor Activity Study
    Madina R. Gerasimov, Maja Franceschi, Nora D. Volkow, Andrew Gifford, Samuel J. Gatley, Douglas Marsteller, Patricia E. Molina and Stephen L. Dewey
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 51-57;
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    Nicotinic Modulation of Mesoprefrontal Dopamine Neurons: Pharmacologic and Neuroanatomic Characterization
    Tony P. George, Christopher D. Verrico, Marina R. Picciotto and Robert H. Roth
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 58-66;
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    Effects of Acute and Subchronic Administration of Typical and Atypical Antipsychotic Drugs on the Neurotensin System of the Rat Brain
    Becky Kinkead, Shanna Shahid, Michael J. Owens and Charles B. Nemeroff
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 67-73;
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    Incomplete, Asymmetric, and Route-Dependent Cross-Tolerance between Oxycodone and Morphine in the Dark Agouti Rat
    Carsten K. Nielsen, Fraser B. Ross and Maree T. Smith
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 91-99;
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    Effects of Microdialyzed Oxotremorine, Carbachol, Epibatidine, and Scopolamine on Intraspinal Release of Acetylcholine in the Rat
    A. Urban Höglund, Charlotte Hamilton and Lars Lindblom
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 100-104;
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    Effects of Agonist-Antagonist Opioids in Humans Trained in a Hydromorphone/Not Hydromorphone Discrimination
    Kenzie L. Preston and George E. Bigelow
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 114-124;
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    Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide
    Bin Liu, Jian-Wei Jiang, Belinda C. Wilson, Lina Du, San-Nan Yang, Jiz-Yuh Wang, Gen-Cheng Wu, Xiao-Ding Cao and Jau-Shyong Hong
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 125-132;
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    Chlormethiazole: Effectiveness against Toxic Effects of Cocaine in Mice
    Maciej Gasior, Jesse T. Ungard and Jeffrey M. Witkin
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 153-161;
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    Antinociceptive Effect of Pregabalin in Septic Shock-Induced Rectal Hypersensitivity in Rats
    Helene Eutamene, Anne-Marie Coelho, Vassilia Theodorou, Magali Toulouse, Maria Chovet, Annette Doherty, Jean Fioramonti and Lionel Bueno
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 162-167;
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    Gastric Effects of Cholecystokinin and Its Interaction with Leptin on Brainstem Neuronal Activity in Neonatal Rats
    Chun-Su Yuan, Anoja S. Attele, Lucy Dey and Jing-Tian Xie
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 177-182;
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    Retro-Inverso Prosaptide Peptides Retain Bioactivity, Are Stable In Vivo, and Are Blood-Brain Barrier Permeable
    Eve M. Taylor, Deborah A. Otero, William A. Banks and John S. O'Brien
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 190-194;
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    Sex- and Estrous Cycle-Related Differences in the Effects of Acute Antipsychotic Drug Administration on Neurotensin-Containing Neurons in the Rat Brain
    Becky Kinkead, Steven M. Lorch, Michael J. Owens and Charles B. Nemeroff
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 205-211;
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    Inverse Agonist Activity of Atypical Antipsychotic Drugs at Human 5-Hydroxytryptamine2C Receptors
    Katharine Herrick-Davis, Ellinor Grinde and Milt Teitler
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 226-232;
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    Antisense-Mediated Down-Regulation of the Human Huntingtin Gene
    Ruben J. Boado, Aleksey Kazantsev, Barbara L. Apostol, Leslie M. Thompson and William M. Pardridge
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 239-243;
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    Serotonergic Modulation of Rat Pineal Gland Activity: In Vivo Evidence for a 5-Hydroxytryptamine2C Receptor Involvement
    Luca Steardo, Palmiero Monteleone, Luigia Trabace, Carla Cannizzaro, Mario Maj and Vincenzo Cuomo
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 266-273;
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    Discovery of “Self-Synergistic” Spinal/Supraspinal Antinociception Produced by Acetaminophen (Paracetamol)
    Robert B. Raffa, Dennis J. Stone and Ronald J. Tallarida
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 291-294;
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    Effect of Phenylalanine and Its Metabolites on the Proliferation and Viability of Neuronal and Astroglial Cells: Possible Relevance in Maternal Phenylketonuria
    Jan Oberdoerster, Marina Guizzetti and Lucio G. Costa
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 295-301;
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    Nitric Oxide Is Involved in Acetylcholinesterase Inhibitor-Induced Myopathy in Rats
    Gayathri Jeyarasasingam, Michael Yeluashvili and Maryka Quik
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 314-320;
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    Bupropion Is a Nicotinic Antagonist
    Jennifer E. Slemmer, Billy R. Martin and M. Imad Damaj
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 321-327;
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    Cannabinoid Agonist Signal Transduction in Rat Brain: Comparison of Cannabinoid Agonists in Receptor Binding, G-Protein Activation, and Adenylyl Cyclase Inhibition
    Christopher S. Breivogel and Steven R. Childers
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 328-336;
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    Characterization of the Anxiolytic Properties of a Novel Neuroactive Steroid, Co 2-6749 (GMA-839; WAY-141839; 3α, 21-Dihydroxy-3β-trifluoromethyl-19-nor-5β-pregnan-20-one), a Selective Modulator of γ-Aminobutyric AcidA Receptors
    Kimberly E. Vanover, Sharon Rosenzweig-Lipson, Jon E. Hawkinson, Nancy C. Lan, James D. Belluzzi, Larry Stein, James E. Barrett, Paul L. Wood and Richard B. Carter
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 337-345;
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    Modeling of the In Vivo Antinociceptive Interaction between an Opioid Agonist, (+)-O-Desmethyltramadol, and a Monoamine Reuptake Inhibitor, (−)-O-Desmethyltramadol, in Rats
    María J. Garrido, Marta Valle, Miguel A. Campanero, Rosario Calvo and Iñaki F. Trocóniz
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 352-359;
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    Nonpeptide Tachykinin Receptor Antagonists. II. Pharmacological and Pharmacokinetic Profile of SB-222200, a Central Nervous System Penetrant, Potent and Selective NK-3 Receptor Antagonist
    Henry M. Sarau, Don E. Griswold, Brian Bush, William Potts, Punam Sandhu, Dave Lundberg, James J. Foley, Dulcie B. Schmidt, Edward F. Webb, Lenox D. Martin, Jeffrey J. Legos, Robert G. Whitmore, Frank C. Barone, Andrew D. Medhurst, Mark A. Luttmann, Giuseppe A. M. Giardina and Douglas W. P. Hay
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 373-381;
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    Pharmacological Characterization of the Discriminative Stimulus Effects of the Potassium Channel Blocker 4-Aminopyridine in Rats
    Roxanne Brandsgaard, James E. Barrett and Sharon Rosenzweig-Lipson
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 382-391;
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    Transport of N-Acetylaspartate by the Na+-Dependent High-Affinity Dicarboxylate Transporter NaDC3 and Its Relevance to the Expression of the Transporter in the Brain
    Wei Huang, Haiping Wang, Ramesh Kekuda, You-Jun Fei, Anne Friedrich, Jian Wang, Simon J. Conway, Richard S. Cameron, Frederick H. Leibach and Vadivel Ganapathy
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 392-403;
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    Effects of Chronic Ethanol Treatment on γ-Aminobutyric AcidA and Glycine Receptors in Mouse Glycinergic Spinal Neurons
    Brigitte van Zundert, Felipe A. Albarran and Luis G. Aguayo
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 423-429;

TOXICOLOGY

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    Temporal Changes in Metallothionein Gene Transcription in Rat Kidney and Liver: Relationship to Content of Mercury and Metallothionein Protein
    Rudolfs K. Zalups and James Koropatnick
    Journal of Pharmacology and Experimental Therapeutics October 2000, 295 (1) 74-82;
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Journal of Pharmacology and Experimental Therapeutics: 295 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 295, Issue 1
1 Oct 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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