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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Phospholipase A2s in Cell Injury and Death

Brian S. Cummings, Jane McHowat and Rick G. Schnellmann
Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 793-799;
Brian S. Cummings
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Jane McHowat
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Rick G. Schnellmann
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Abstract

Phospholipase A2s (PLA2s) represent a family of esterases that hydrolyze the sn-2 ester bond in phospholipids, releasing free fatty acids and lysophospholipids. PLA2s are important in the signaling of several cellular processes and are known to play a significant role in inflammation. Studies also show that PLA2s are modulators of drug-, chemical-, and ischemia/reperfusion-induced cellular injury. The role of PLA2s in apoptosis and oncosis depends upon the PLA2 isoform, the cell type, and the stimulus of injury. The purpose of this review is to discuss the functions of iPLA2, cPLA2 and sPLA2 isoforms in oncosis and apoptosis, including oxidant-induced and receptor-mediated cell death. In addition, the measurement and modulation of PLA2 is discussed.

Footnotes

  • Send reprint requests to: Dr. Rick G. Schnellmann, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 Markham St., Slot 638, Little Rock, AR 72205-7199. E-mail: rschnell{at}biomed.uams.edu

  • Abbreviations:
    PLA2
    phospholipase A2
    AACOCF3
    arachidonyl trifluoromethyl ketone
    BEL
    bromoenol lactone
    TNFα
    tumor necrosis factor α
    PKC
    protein kinase C
    PKA
    protein kinase A
    MAPK
    mitogen-activated protein kinase
    • Received January 3, 2000.
    • Accepted March 15, 2000.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 294 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 294, Issue 3
1 Sep 2000
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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Phospholipase A2s in Cell Injury and Death

Brian S. Cummings, Jane McHowat and Rick G. Schnellmann
Journal of Pharmacology and Experimental Therapeutics September 1, 2000, 294 (3) 793-799;

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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Phospholipase A2s in Cell Injury and Death

Brian S. Cummings, Jane McHowat and Rick G. Schnellmann
Journal of Pharmacology and Experimental Therapeutics September 1, 2000, 294 (3) 793-799;
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