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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2000; Volume 294,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Phospholipase A2s in Cell Injury and Death
    Brian S. Cummings, Jane McHowat and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 793-799;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Efflux of Dietary Flavonoid Quercetin 4′-β-Glucoside across Human Intestinal Caco-2 Cell Monolayers by Apical Multidrug Resistance-Associated Protein-2
    Richard A. Walgren, Karl J. Karnaky, George E. Lindenmayer and Thomas Walle
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 830-836;
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    Cellular Uptake of Dietary Flavonoid Quercetin 4′-β-Glucoside by Sodium-Dependent Glucose Transporter SGLT1
    Richard A. Walgren, Jiann-Trzuo Lin, Rolf K.-H. Kinne and Thomas Walle
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 837-843;
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    Rat Multispecific Organic Anion Transporter 1 (rOAT1) Transports Zidovudine, Acyclovir, and Other Antiviral Nucleoside Analogs
    Saiko Wada, Minoru Tsuda, Takashi Sekine, Seok Ho Cha, Miyako Kimura, Yoshikatsu Kanai and Hitoshi Endou
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 844-849;
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    Pharmacokinetics and Metabolism of the Methotrexate Metabolite 2,4-Diamino-N 10-methylpteroic Acid
    Brigitte C. Widemann, Edward Sung, Lawrence Anderson, Wanda L. Salzer, Frank M. Balis, Karen S. Monitjo, Cynthia McCully, Mary Hawkins and Peter C. Adamson
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 894-901;
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    Activation of Cytochrome P450 Gene Expression in the Rat Brain by Phenobarbital-Like Inducers
    Benoît Schilter, Mark R. Andersen, Chetana Acharya and Curtis J. Omiecinski
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 916-922;
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    Vesicular Transport of Newly Synthesized Cytochromes P4501A to the Outside of Rat Hepatocyte Plasma Membranes
    Marie-Anne Robin, Véronique Descatoire, Marie Le Roy, Alain Berson, François-Pierre Lebreton, Michel Maratrat, François Ballet, Jacqueline Loeper and Dominique Pessayre
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1063-1069;
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    CYP1A2 and CYP2D6 4-Hydroxylate Propranolol and Both Reactions Exhibit Racial Differences
    Julie A. Johnson, Vanessa L. Herring, Michael S. Wolfe and Mary V. Relling
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1099-1105;
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    Recombinant Cytochrome P450 2D18 Metabolism of Dopamine and Arachidonic Acid
    Chad M. Thompson, Jorge H. Capdevila and Henry W. Strobel
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1120-1130;

CARDIOVASCULAR

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    Potentiation of Penile Tumescence by T-1032, a New Potent and Specific Phosphodiesterase Type V Inhibitor, in Dogs
    Tsunehisa Noto, Hirotaka Inoue, Tomihiro Ikeo and Kohei Kikkawa
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 870-875;
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    Nephroprotective Effect of Treatment with Calcium Channel Blockers in Spontaneously Hypertensive Rats
    Maurizio Sabbatini, Lucia Vitaioli, Emilia Baldoni and Francesco Amenta
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 948-954;
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    Stereoselective Interactions of the Enantiomers of Chromanol 293B with Human Voltage-Gated Potassium Channels
    Iris C.-H. Yang, Michael W. Scherz, Anthony Bahinski, Paul B. Bennett and Katherine T. Murray
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 955-962;
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    Influence of Purinoceptor Antagonism on Diadenosine Pentaphosphate-Induced Hypotension in Anesthetized Rats
    Martin Steinmetz, Truc Van Le, Peter Hollah, Gert Gabriëls, Helge Hohage, Karl Heinz Rahn and Eberhard Schlatter
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 963-968;
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    EndothelinA Receptor Subtype Mediates Endothelin-Induced Contractility in Left Ventricular Cardiomyocytes Isolated from Rabbit Myocardium
    Elizabeth J. Kelso, Barbara J. McDermott, Bernard Silke and J. Paul Spiers
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1047-1052;
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    Diadenosine Polyphosphates Cause Contraction and Relaxation in Isolated Rat Resistance Arteries
    Martin Steinmetz, Eberhard Schlatter, Harry Alexander Jozef Struijker Boudier, Karl Heinz Rahn and Jozef Gabriel Rita De Mey
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1175-1181;
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    Heterogenous Vascular Effects of AP5A in Different Rat Resistance Arteries Are Due to Heterogenous Distribution of P2X and P2Y1 Purinoceptors
    Martin Steinmetz, Stefan Bierer, Peter Hollah, Karl Heinz Rahn and Eberhard Schlatter
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1182-1187;
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    Consequence of Exercise on the Cardiovascular Effects of l-Propranolol in Spontaneously Hypertensive Rats
    Lena Brynne, Lennart K. Paalzow and Mats O. Karlsson
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1201-1208;

CELLULAR AND MOLECULAR

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    Differential Effects of 4-Chloro-m-cresol and Caffeine on Skinned Fibers from Rat Fast and Slow Skeletal Muscles
    Stéphanie Choisy, Corinne Huchet-Cadiou and Claude Léoty
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 884-893;
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    Aryloxypropanolamine and Catecholamine Ligand Interactions with the β1-Adrenergic Receptor: Evidence for Interaction with Distinct Conformations of β1-Adrenergic Receptors
    Anish A. Konkar, Zhengxian Zhu and James G. Granneman
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 923-932;
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    G1 Phase Growth Arrest and Induction of p21 Waf1/Cip1/Sdi1 in IB3-1 Cells Treated with 4-Sodium Phenylbutyrate
    Sharon A. McGrath-Morrow and Jennifer L. Stahl
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 941-947;
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    Alterations in G-Proteins and β-Adrenergic Responsive Adenylyl Cyclase in Rat Urinary Bladder during Aging
    Ithaar H. Derweesh, Marcia A. Wheeler and Robert M. Weiss
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 969-974;
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    Interaction of p-Fluorofentanyl on Cloned Human Opioid Receptors and Exploration of the Role of Trp-318 and His-319 in μ-Opioid Receptor Selectivity
    Chris Ulens, Maurits Van Boven, Paul Daenens and Jan Tytgat
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1024-1033;
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    Two Amino Acids in the Sixth Transmembrane Segment of the Mouse Gastrin-Releasing Peptide Receptor Are Important for Receptor Activation
    Yuhmei Lin, Xiaoying Jian, Zolan Lin, Glenn S. Kroog, Samuel Mantey, Robert T. Jensen, James Battey and John Northup
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1053-1062;
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    Synergistic Stimulation of Airway Smooth Muscle Cell Mitogenesis
    Tracy L. Ediger and Myron L. Toews
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1076-1082;
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    Inhibition of [3H]Thymidine Transport Is a Nonspecific Effect of PDMP in Primary Cultures of Mouse Epidermal Keratinocytes
    Richard D. Griner and Wendy B. Bollag
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1219-1224;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Antitumor Imidazolyl Disulfide IV-2 Causes Irreversible G2/M Cell Cycle Arrest without Hyperphosphorylation of Cyclin-Dependent Kinase Cdk1
    Andreas Vogt, Kenji Tamura, Shawndra Watson and John S. Lazo
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1070-1075;

ENDOCRINE AND REPRODUCTIVE

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    The Effects of Cocaine on Basal and Human Chorionic Gonadotropin-Stimulated Ovarian Steroid Hormones in Female Rhesus Monkeys
    Nancy K. Mello, Jack H. Mendelson, Maureen Kelly and Carrie A. Bowen
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1137-1145;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    The Effect of Berberine Chloride on Experimental Colitis in Rats In Vivo and In Vitro
    Haiyan Zhou and Satoru Mineshita
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 822-829;
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    Phorbol-Stimulated Ca2+ Mobilization and Contraction in Dispersed Intestinal Smooth Muscle Cells
    Karnam S. Murthy, Yuen San Yee, John R. Grider and Gabriel M. Makhlouf
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 991-996;
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    Influence of Heme Oxygenase Inhibitors on the Basal Tissue Enzymatic Activity and Smooth Muscle Relaxation of Internal Anal Sphincter
    Satish Rattan and Sushanta Chakder
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1009-1016;
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    Adenosine and Selective A2A Receptor Agonists Reduce Ischemia/Reperfusion Injury of Rat Liver Mainly by Inhibiting Leukocyte Activation
    Naoaki Harada, Kenji Okajima, Kazunori Murakami, Sadaharu Usune, Chiemi Sato, Koichi Ohshima and Takeshi Katsuragi
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1034-1042;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Cloning and Cellular Localization of the Rat Mast Cell 78-kDa Protein Phosphorylated in Response to the Mast Cell “Stabilizer” Cromolyn
    Theoharis C. Theoharides, Linghua Wang, Xinzhu Pang, Richard Letourneau, Kerry E. Culm, Subimal Basu, Ying Wang and Ivan Correia
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 810-821;
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    Rebamipide Inhibits Neutrophil Adhesion to Hypoxia/Reoxygenation-Stimulated Endothelial Cells via Nuclear Factor-κB-Dependent Pathway
    Chi Dae Kim, Yong Ki Kim, So Hyun Lee and Ki Whan Hong
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 864-869;
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    Dose-Dependent Effects of Recombinant Human Interleukin-11 on Contractile Properties in Rabbit 2,4,6-Trinitrobenzene Sulfonic Acid Colitis
    Inge Depoortere, Theo Thijs, Gert Van Assche, James C. Keith and Theo L. Peeters
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 983-990;
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    Cerivastatin Improves Survival of Mice with Lipopolysaccharide-Induced Sepsis
    Hitoshi Ando, Toshinari Takamura, Tsuguhito Ota, Yukihiro Nagai and Ken-ichi Kobayashi
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1043-1046;
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    The Importance of the Hypothalamo-Hypophyseal-Adrenal Axis to the Anti-Inflammatory Actions of the κ-Opioid Agonist PNU-50,488H in Rats with Adjuvant Arthritis
    Jodie L. Wilson, John J. Carmody and Judith S. Walker
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1131-1136;
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    Potential Clinical Use of Butyric Acid Derivatives to Induce Antigen-Specific T Cell Inactivation
    Kathleen M. Gilbert, Rahnuma Wahid, Nuria Portabella Fecher, James P. Freeman and E. Kim Fifer
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1146-1153;
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    Inhibition of Extracellular Signal-Regulated Kinase Suppresses Endotoxin-Induced Nitric Oxide Synthesis in Mouse Macrophages and in Human Colon Epithelial Cells
    Aleksi Lahti, Mari Lähde, Hannu Kankaanranta and Eeva Moilanen
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1188-1194;

NEUROPHARMACOLOGY

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    Neuroprotective Effects of LY379268, a Selective mGlu2/3 Receptor Agonist: Investigations into Possible Mechanism of Action In Vivo
    Ann Bond, Nicole M. Jones, Caroline A. Hicks, Gary M. Whiffin, Mark A. Ward, Michael F. O'Neill, Ann E. Kingston, James A. Monn, Paul L. Ornstein, Darryle D. Schoepp, David Lodge and Michael J. O'Neill
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 800-809;
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    The Effects of High-Dose Methamphetamine in the Aging Rat: Differential Reinforcement of Low-Rate 72-s Schedule Behavior and Neurochemistry
    Karen E. Sabol, Jerry B. Richards and Kenneth Yung
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 850-863;
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    Actions of the Anticonvulsant Remacemide Metabolite AR-R12495AA on Afferent-Evoked Spinal Synaptic Transmission In Vitro and on Models of Acute and Chronic Inflammation in the Rat
    Aziz U. R. Asghar, Sibte S. Hasan and Anne E. King
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 876-883;
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    Antagonism of the Discriminative Stimulus Effects of Positive γ-Aminobutyric AcidA Modulators in Rhesus Monkeys Discriminating Midazolam
    Snjezana Lelas, Lisa R. Gerak and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 902-908;
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    Enhanced Anticonvulsant Activity of Ganaxolone after Neurosteroid Withdrawal in a Rat Model of Catamenial Epilepsy
    Doodipala S. Reddy and Michael A. Rogawski
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 909-915;
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    Methocinnamox Is a Potent, Long-Lasting, and Selective Antagonist of Morphine-Mediated Antinociception in the Mouse: Comparison with Clocinnamox, β-Funaltrexamine, and β-Chlornaltrexamine
    Jillian H. Broadbear, Tina L. Sumpter, Timothy F. Burke, Stephen M Husbands, John W. Lewis, James H. Woods and John R. Traynor
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 933-940;
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    Antagonism of δ2-Opioid Receptors by Naltrindole-5′-isothiocyanate Attenuates Heroin Self-Administration but Not Antinociception in Rats
    Thomas J. Martin, Susy A. Kim, David G. Cannon, Glen M. Sizemore, Di Bian, Frank Porreca and James E. Smith
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 975-982;
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    Muscarinic Cholinergic Modulation of Prepulse Inhibition of the Acoustic Startle Reflex
    Carrie K. Jones and Harlan E. Shannon
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1017-1023;
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    Uptake of Imipramine in Rat Liver Lysosomes In Vitro and Its Inhibition by Basic Drugs
    Junko Ishizaki, Koichi Yokogawa, Fujio Ichimura and Shoji Ohkuma
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1088-1098;
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    Differential Mechanisms Mediating Descending Pain Controls for Antinociception Induced by Supraspinally Administered Endomorphin-1 and Endomorphin-2 in the Mouse
    Masahiro Ohsawa, Hirokazu Mizoguchi, Minoru Narita, Mei Chu, Hiroshi Nagase and Leon F. Tseng
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1106-1111;
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    Evidence That Nicotinic α7 Receptors Are Not Involved in the Hyperlocomotor and Rewarding Effects of Nicotine
    Andrew J. Grottick, Gerhard Trube, William A. Corrigall, Joerg Huwyler, Parichehr Malherbe, Rene Wyler and Guy A. Higgins
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1112-1119;
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    Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A
    Charlie Reavill, Stephen G. Taylor, Martyn D. Wood, Tracey Ashmeade, Nigel E. Austin, Kim Y. Avenell, Izzy Boyfield, Clive L. Branch, Jackie Cilia, Martyn C. Coldwell, Michael S. Hadley, A. Jackie Hunter, Phil Jeffrey, Frances Jewitt, Christopher N. Johnson, Declan N. C. Jones, Andrew D. Medhurst, Derek N. Middlemiss, David J. Nash, Graham J. Riley, Carol Routledge, Geoff Stemp, Kevin M. Thewlis, Brenda Trail, Antonio K. K. Vong and Jim J. Hagan
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1154-1165;
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    Acute and Chronic Administration of the Selective D3Receptor Antagonist SB-277011-A Alters Activity of Midbrain Dopamine Neurons in Rats: An In Vivo Electrophysiological Study
    Charles R. Ashby, Yoshio Minabe, Geoff Stemp, Jim J. Hagan and Derek N. Middlemiss
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1166-1174;
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    BU48: A Novel Buprenorphine Analog That Exhibits δ-Opioid-Mediated Convulsions but Not δ-Opioid-Mediated Antinociception in Mice
    Daniel C. Broom, Li Guo, Andrew Coop, Stephen M. Husbands, John W. Lewis, James H. Woods and John R. Traynor
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1195-1200;
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    Cannabinoid Properties of Methylfluorophosphonate Analogs
    Billy R. Martin, Irina Beletskaya, Gray Patrick, Reneé Jefferson, Ramona Winckler, Dale G. Deutsch, Vincenzo Di Marzo, Olivier Dasse, Ann Mahadevan and Raj K. Razdan
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1209-1218;

TOXICOLOGY

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    Nitric Oxide and Its Metabolites Mediate Ethanol-Induced Microtubule Disruption and Intestinal Barrier Dysfunction
    Ali Banan, Jeremy Z. Fields, Heather Decker, Yang Zhang and Ali Keshavarzian
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 997-1008;
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    Efficacy of Novel Calpain Inhibitors in Preventing Renal Cell Death
    Jay F. Harriman, Shayla Waters-Williams, Der-Lun Chu, James C. Powers and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1083-1087;

Erratum

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    Journal of Pharmacology and Experimental Therapeutics September 2000, 294 (3) 1225;
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Journal of Pharmacology and Experimental Therapeutics: 294 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 294, Issue 3
1 Sep 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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