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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2000; Volume 294,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Stoichiometry and Compartmentation in G Protein-Coupled Receptor Signaling: Implications for Therapeutic Interventions Involving Gs
    Rennolds S. Ostrom, Steven R. Post and Paul A. Insel
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 407-412;
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    Placental Transporters Relevant to Drug Distribution across the Maternal-Fetal Interface
    Vadivel Ganapathy, Puttur D. Prasad, Malliga E. Ganapathy and Frederick H. Leibach
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 413-420;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Basis for Dosing Time-Dependent Changes in the Antiviral Activity of Interferon-α in Mice
    Shigehiro Ohdo, De-Sheng Wang, Satoru Koyanagi, Hiroshi Takane, Kouichi Inoue, Hironori Aramaki, Eiji Yukawa and Shun Higuchi
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 488-493;
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    Functional Evidence for Presence of PEPT2 in Rat Choroid Plexus: Studies with Glycylsarcosine
    Nathan S. Teuscher, Alexander Novotny, Richard F. Keep and David E. Smith
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 494-499;
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    A Study of the Intestinal Absorption of an Ester-Type Prodrug, ME3229, in Rats: Active Efflux Transport as a Cause of Poor Bioavailability of the Active Drug
    Noriko Okudaira, Tomoko Tatebayashi, Graham C. Speirs, Izumi Komiya and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 580-587;
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    Mahogany (1377–1428) Enters Brain by a Saturable Transport System
    Abba J. Kastin and Victoria Akerstrom
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 633-636;
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    Pharmacokinetics of Sodium Tungstate in Rat and Dog: A Population Approach
    Sophie Le Lamer, Patrick Poucheret, Gérard Cros, Renaud Kiesgen de Richter, Pierre-Antoine Bonnet and Françoise Bressolle
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 714-721;
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    Disposition of Glutathione Conjugates in Rats by a Novel Glutamic Acid Pathway: Characterization of Unique Peptide Conjugates by Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/NMR
    Abdul E. Mutlib, John Shockcor, Robert Espina, Nilsa Graciani, Alicia Du and Liang-Shang Gan
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 735-745;
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    Bioactivation of Selenocysteine Se-Conjugates by a Highly Purified Rat Renal Cysteine Conjugate β-Lyase/Glutamine Transaminase K
    Jan N. M. Commandeur, Ioanna Andreadou, Martijn Rooseboom, Marcel Out, Laurens J. de Leur, Ed Groot and Nico P. E. Vermeulen
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 753-761;
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    Evaluation of the Kinetics of β-Elimination Reactions of Selenocysteine Se-Conjugates in Human Renal Cytosol: Possible Implications for the Use as Kidney Selective Prodrugs
    Martijn Rooseboom, Nico P. E. Vermeulen, Ioanna Andreadou and Jan N. M. Commandeur
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 762-769;

CARDIOVASCULAR

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    Opioid-Induced Cardioprotection against Myocardial Infarction and Arrhythmias: Mitochondrial versus Sarcolemmal ATP-Sensitive Potassium Channels
    Ryan M. Fryer, Anna K. Hsu, Hiroshi Nagase and Garrett J. Gross
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 451-457;
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    Comparison of L-Type Calcium Channel Blockade by Nifedipine and/or Cadmium in Guinea Pig Ventricular Myocytes
    Jian-Bing Shen, Bin Jiang and Achilles J. Pappano
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 562-570;
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    Vascular Reactivity of Isolated Thoracic Aorta of the C57BL/6J Mouse
    Amber Russell and Stephanie Watts
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 598-604;
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    Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion
    Jörg Knapp, Peter Bokník, Bettina Linck, Hartmut Lüss, Frank U. Müller, Lars Petertönjes, Wilhelm Schmitz and Joachim Neumann
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 620-626;
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    Functional Properties of Transgenic Mouse Hearts Overexpressing Both Calsequestrin and the Na+-Ca2+Exchanger
    Bettina Linck, Peter Bokník, Sabine Huke, Uwe Kirchhefer, Jörg Knapp, Hartmut Lüss, Frank U. Müller, Joachim Neumann, Zahide Tanriseven, Ute Vahlensieck, Hideo A. Baba, Larry R. Jones, Kenneth D. Philipson and Wilhelm Schmitz
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 648-657;
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    Cannabinoids Cause Central Sympathoexcitation and Bradycardia in Rabbits
    Nathalie Niederhoffer and Bela Szabo
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 707-713;
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    Protection against Myocardial Dysfunction Induced by Global Ischemia-Reperfusion by Antisense-Oligodeoxynucleotides Directed at β1-Adrenoceptor mRNA
    Hongjiang Chen, Yuan Clare Zhang, Dayuan Li, M. Ian Phillips, Paullete Mehta, Min Shi and Jawahar L. Mehta
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 722-727;
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    Inhibition of α1-Adrenergic-Mediated Responses in Rat Ventricular Myocytes by Adenosine A1 Receptor Activation: Role of the KATP Channel
    Nina Hoque, Michael A. Cook and Morris Karmazyn
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 770-777;
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    Effect of Cyclosporine on HMG-CoA Reductase, Cholesterol 7α-Hydroxylase, LDL Receptor, HDL Receptor, VLDL Receptor, and Lipoprotein Lipase Expressions
    Nosratola D. Vaziri, Kaihui Liang and Habib Azad
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 778-783;

CELLULAR AND MOLECULAR

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    Quantitative Imaging in Live Human Cells Reveals Intracellular α1-Adrenoceptor Ligand-Binding Sites
    Janet F. Mackenzie, Craig J. Daly, John D. Pediani and John C. McGrath
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 434-443;
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    Agonist-Directed Trafficking of Porcine α2A-Adrenergic Receptor Signaling in Chinese Hamster Ovary Cells: l-Isoproterenol Selectively Activates Gs
    Christiaan B. Brink, Susan M. Wade and Richard R. Neubig
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 539-547;
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    Protein Kinase C and Phosphatase Inhibitors Block the Ability of Angiotensin I-Converting Enzyme Inhibitors to Resensitize the Receptor to Bradykinin without Altering the Primary Effects of Bradykinin
    Branislav M. Marcic and Ervin G. Erdös
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 605-612;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Cytochalasin E, an Epoxide ContainingAspergillus-Derived Fungal Metabolite, Inhibits Angiogenesis and Tumor Growth
    Taturo Udagawa, Jenny Yuan, Dipak Panigrahy, Yie-Hwa Chang, Jamshed Shah and Robert J. D'Amato
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 421-427;
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    The Influence of Coordinate Overexpression of Glutathione Phase II Detoxification Gene Products on Drug Resistance
    Miechelle O'Brien, Gary D. Kruh and Kenneth D. Tew
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 480-487;
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    Attenuation of O 6-Methylguanine-DNA Methyltransferase Activity and mRNA Levels by Cisplatin and Temozolomide in Jurkat Cells
    Stefania D'Atri, Grazia Graziani, Pedro Miguel Lacal, Vittoria Nisticò, Sara Gilberti, Isabella Faraoni, Amanda J. Watson, Enzo Bonmassar and Geoffrey P. Margison
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 664-671;
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    Chronopharmacology of Antitumor Effect Induced by Interferon-β in Tumor-Bearing Mice
    Hiroshi Takane, Shigehiro Ohdo, Tomoko Yamada, Eiji Yukawa and Shun Higuchi
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 746-752;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    α2-Adrenergic Receptors Stimulate Oligopeptide Transport in a Human Intestinal Cell Line
    Françoise Berlioz, Jean-José Maoret, Hervé Paris, Marc Laburthe, Robert Farinotti and Claude Rozé
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 466-472;
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    Hydroxyprolylserine Derivatives JBP923 and JBP485 Exhibit the Antihepatitis Activities after Gastrointestinal Absorption in Rats
    Ke-Xin Liu, Yukio Kato, Tai-Ichi Kaku, Tomofumi Santa, Kazuhiro Imai, Akira Yagi, Takashi Ishizu and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 510-515;
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    Elevated Airway GSH Resynthesis Confers Protection to Clara Cells from Naphthalene Injury in Mice Made Tolerant by Repeated Exposures
    Jay A. A. West, Alan R. Buckpitt and Charles G. Plopper
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 516-523;
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    Histamine Suppresses A-Type Potassium Current in Myenteric Neurons from Guinea Pig Small Intestine
    Alexander M. Starodub and Jackie D. Wood
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 555-561;
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    Glucocorticoid-Induced Alterations of Renal Sulfate Transport
    Kazuko Sagawa, Inger M. Darling, Heini Murer and Marilyn E. Morris
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 658-663;
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    Type 4 Phosphodiesterase Inhibitors Attenuate Respiratory Syncytial Virus-Induced Airway Hyper-Responsiveness and Lung Eosinophilia
    Toshihide Ikemura, Jurgen Schwarze, Mika Makela, Arihiko Kanehiro, Anthony Joetham, Kenji Ohmori and Erwin W. Gelfand
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 701-706;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Hepatic and Central Nervous System Cytochrome P450 Are Down-Regulated during Lipopolysaccharide-Evoked Localized Inflammation in Brain
    Kenneth W. Renton and Tara E. Nicholson
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 524-530;
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    Radicicol Suppresses Expression of Inducible Nitric-Oxide Synthase by Blocking p38 Kinase and Nuclear Factor-κB/Rel in Lipopolysaccharide-Stimulated Macrophages
    Young J. Jeon, Young K. Kim, Michael Lee, Sun M. Park, Sang B. Han and Hwan M. Kim
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 548-554;

NEUROPHARMACOLOGY

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    [Nphe1]NC(1-13)NH2 Selectively Antagonizes Nociceptin/Orphanin FQ-Stimulated G-Protein Activation in Rat Brain
    Hartmut Berger, Girolamo Calo', Erika Albrecht, Remo Guerrini and Michael Bienert
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 428-433;
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    Evaluation of Selective NK1 Receptor Antagonist CI-1021 in Animal Models of Inflammatory and Neuropathic Pain
    Maria I. Gonzalez, Mark J. Field, John Hughes and Lakhbir Singh
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 444-450;
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    Systemic Nicotine Stimulates Dopamine Release in Nucleus Accumbens: Re-evaluation of the Role ofN-Methyl-d-aspartate Receptors in the Ventral Tegmental Area
    Yitong Fu, Shannon G. Matta, Wenqing Gao, Victoria G. Brower and Burt M. Sharp
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 458-465;
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    Functional Compartmentalization of Opioid Desensitization in Primary Sensory Neurons
    Gary M. Samoriski and Robert A. Gross
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 500-509;
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    Behavioral Activation Induced by D2-Like Receptor Stimulation during Opiate Withdrawal
    Jonathan P. Druhan, Carrie L. Walters and Gary Aston-Jones
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 531-538;
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    Differential Effect of Local Infusion of Serotonin Reuptake Inhibitors in the Raphe versus Forebrain and the Role of Depolarization-Induced Release in Increased Extracellular Serotonin
    Rui Tao, Zhiyuan Ma and Sidney B. Auerbach
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 571-579;
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    Chronic Administration of the Selective Corticotropin-Releasing Factor 1 Receptor Antagonist CP-154,526: Behavioral, Endocrine and Neurochemical Effects in the Rat
    Lotta Arborelius, Kelly H. Skelton, Karacheri V. Thrivikraman, Paul M. Plotsky, David W. Schulz and Michael J. Owens
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 588-597;
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    Increased Mesolimbic GABA Concentration Blocks Heroin Self-Administration in the Rat
    Zheng-Xiong Xi and Elliot A. Stein
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 613-619;
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    Presynaptic Muscarinic Facilitation of Parasympathetic Neurotransmission after Sympathectomy in the Rat Choroid
    Jena J. Steinle and Peter G. Smith
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 627-632;
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    Ethanol Inhibition ofN-Methyl-d-aspartate Responses Involves Presynaptic γ-Aminobutyric AcidB Receptors
    Scott C. Steffensen, Zhiguo Nie, Jose R. Criado and George R. Siggins
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 637-647;
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    5-Hydroxytryptamine7 Receptor Activation Decreases Slow Afterhyperpolarization Amplitude in CA3 Hippocampal Pyramidal Cells
    William L. Bacon and Sheryl G. Beck
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 672-679;
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    Dopamine D1- and D2-Like Receptor Mechanisms in Relapse to Cocaine-Seeking Behavior: Effects of Selective Antagonists and Agonists
    Taline V. Khroyan, Rita L. Barrett-Larimore, James K. Rowlett and Roger D. Spealman
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 680-687;
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    The Novel 5-Hydroxytryptamine1A Antagonist LY426965: Effects on Nicotine Withdrawal and Interactions with Fluoxetine
    Kurt Rasmussen, David O. Calligaro, Janet F. Czachura, Laura J. Dreshfield-Ahmad, David C. Evans, Susan K. Hemrick-Luecke, Mary Jeanne Kallman, William T. Kendrick, J. David Leander, David L. Nelson, Carl D. Overshiner, David B. Wainscott, Mary C. Wolff, David T. Wong, Theresa A. Branchek, John M. Zgombick and Yao-chang Xu
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 688-700;
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    Prenatal Exposure to a Low Concentration of Carbon Monoxide Disrupts Hippocampal Long-Term Potentiation in Rat Offspring
    Giampaolo Mereu, Maurizio Cammalleri, Mauro Fà, Walter Francesconi, Pierluigi Saba, Maria Tattoli, Luigia Trabace, Andrea Vaccari and Vincenzo Cuomo
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 728-734;
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    Intra-Ventral Tegmental Area Injection of Rat Cocaine and Amphetamine-Regulated Transcript Peptide 55-102 Induces Locomotor Activity and Promotes Conditioned Place Preference
    Heather L. Kimmel, Wenhe Gong, Stephanie Dall Vechia, Richard G. Hunter and Michael J. Kuhar
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 784-792;

TOXICOLOGY

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    Potentiation of Thioacetamide Liver Injury in Diabetic Rats Is Due to Induced CYP2E1
    Tao Wang, Kartik Shankar, Martin J. J. Ronis and Harihara M. Mehendale
    Journal of Pharmacology and Experimental Therapeutics August 2000, 294 (2) 473-479;
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Journal of Pharmacology and Experimental Therapeutics: 294 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 294, Issue 2
1 Aug 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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